• Title/Summary/Keyword: sennoside A

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Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase

  • Hwang, In Young;Jeong, Choon Sik
    • Biomolecules & Therapeutics
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    • v.23 no.5
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    • pp.458-464
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    • 2015
  • Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of $HCl{\cdot}tOH$-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin $E_2$ ($PGE_2$) levels and inhibited $H^+/K^+$-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased $PGE_2$ in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

Quantitative Analysis of Sennoside A and Anthraquinones for the Guideline for the Quality Control of Rhubarbs (유통 대황의 Sennoside A 및 Anthraquinone 함량분석을 통한 품질관리 기준에 관한 연구)

  • Choi, Hee-Kyoung;Kim, Kyung-Hee;Seo, Yong-Taek;Yook, Chang-Soo;Jang, Young-Pyo
    • Korean Journal of Pharmacognosy
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    • v.42 no.2
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    • pp.144-148
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    • 2011
  • Rhubarb (Rhei Rhizoma) has been used for the various clinical purposes such as purgative, stomach protective and pain relief for a long time. However, rhubarb in current market has a problem of quality control under which many of rhubarb fail to meet the standard specified in Korean Pharmacopoeia. This study was carried out to validate the method for the evaluation of the quality of five rhubarbs and Rumex species; Rheum palmatum, R. officinale, R. tanguticum, R. franzenbachii, R. undulatum, and Rumex species. The content of sennoside A with five anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) in five rhubarbs and one Rumex has been performed by using HPLC quantitation analysis. In results, only four samples in Palmata sect. were qualified with sennoside A and those samples were R. officinale and R. tanguticum. Samples of R. palmatum did not meet the standard contents of sennoside A. The contents of anthraquinones in Palmata sect. were two times larger than those in Rhapontica sect. Moreover the content variations of anthraquinones were smaller than those of sennoside A. Thus, anthraquinones can be the key characterizing molecules to control quality of rhubarb.

The Simultaneous Analysis of Sennoside A and Rhaponticin in Rhei Rhizoma using Liquid Chromatography-Diode Array Detecter (HPLC/DAD를 이용한 대황의 Sennoside A와 Rhaponticin 동시분석)

  • Kim, Ouk-Hee;Kwak, Jae-Eun;Jung, Sam-Ju;Kim, Dong-Gyu;Han, Eun-Jung;Han, Chang-Ho;Kim, Bok-Soon;Choi, Byung-Hyun;Kim, Min-Young
    • YAKHAK HOEJI
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    • v.54 no.1
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    • pp.39-48
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    • 2010
  • The objective of this study was to analyze sennoside A and rhaponticin simultaneously according to sennoside A of Rhei Rhizoma determination in Korean Pharmacopoeia. $NaHCO_3$ solution in KP was compared with methanol which usually used as solution to extract rhaponticin in Rhei Rhizoma. The method was validated through the guidelines of linearity, LOD, LOQ, specificity and accuracy. Two solution weren't different about validation parameter and passed. So this method were applied to the determination of 6 commercial Rhei Rhizoma samples and 2 samples were suitable for the legal standards.

Studies on the Processing of Herbal Medicines(VIII) - HPLC Analysis of Standard Compounds of Processed Rhei rhiaoma from root of R. Tanguticum - (한약재 수치에 관한 연구(VIII) - 당고특대황으로부터 조제한 주초대황의 주성분 함량변화 -)

  • Lee, Yun-Mi;Lee, Sang-Won;Kim, Hyun-Jung;Cho, Jung-Hee;Kim, Jin-Sook
    • Korean Journal of Oriental Medicine
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    • v.10 no.2
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    • pp.93-99
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    • 2004
  • Rhei rhizoma was processed into Jucho Daewhang according to the method of chinese pharmacopoeia. The contents of Sennoside A, B, Aloe-emodin, Chrysophanol, Emodin, and Rhein were analyzed by HPLC.

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Scientific Analysis of Formulation Theory of Chungpesagan-tang; The purgative Action of Chungpesagan-tang

  • Jeon, Young-Wan;Bae, Hyung-Sup;Joh, Ki-Ho;Kim, Young-Suk;Lee, Kyung-Sup;Park, Eun-Kyung;Kim, Dong-Hyun
    • Natural Product Sciences
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    • v.5 no.4
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    • pp.186-189
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    • 1999
  • To analyze scientifically the fundamental formulation theory and drug interaction on the purgative action of Chungpesagan-tang, which is one of the traditional Korean medical prescriptions that has been most frequently used for stroke, water extracts of herbal medicines with Rhei Rhizoma were administered into mice and the purgative action was measured. Water extracts of Raphani Semen or Cimicifugae Rhizoma with Rhei Rhizoma had more potent purgative activity than Rhei Rhizoma alone, although Raphani Semen alone displayed no purgative action. However, Platycodi Radix and Puerariae Radix inhibited the purgative action of Rhei Rhizoma. When Rhei Rhizoma with Raphani Semen or Cimicifugae Radix was extracted with water, sennoside A content in the water extract was increased. However, Puerariae Radix and Platycodi Radix decreased the content of sennoside A in the extracted water. The transforming rate of sennoside A of Rhei Rhizoma was inhibited by Puerariae Radix and Platycodi Radix. The transforming rate of sennoside A of Chungpesagan-tang to rheinan-throne by human intestinal microflora and its purgative activity were similar to those of Rhei Rhizoma. Finally we thought that the purgative action of Chungpesagan-tang could be controlled by the addition and subtraction of Chungpesagan-tang-composing herbal medicines.

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Quantitative Analysis of Anthraquinone and Stilbene Derivatives in Various Rhubarbs (대황류 생약의 인트라퀴논 및 스틸벤 유도체 함량분석)

  • Ko, Sung-Kwon;Han, Sung-Tai;Yang, Byung-Wook;Shin, Cha-Gyun;Hahm, Young-Tae;Cho, Soon-Hyun;Whang, Wan-Kyun
    • Korean Journal of Pharmacognosy
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    • v.36 no.4 s.143
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    • pp.257-262
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    • 2005
  • This study was carried out to obtain the basic information that can be used to index rhubarbs in six regions of China and Korea. The anthraquinone and stilbene contest in various rhubarb produced in th different area were quantitatively analysed by HPLC. The average of sennoside A content of the Chinghai rhubarb was higher than that of the other palmata rhubarbs(high-quality rhubarbs) produced in China. As a result, the order of the sennoside A content was 1) Chinghai rhubarb, 2) Tsuchan rhubarb, 3)Kansu rhubarb 4) Neimenggu rhubarb. On the other hand, the total stilbenes content of each of the cultivated Korean rhubarb(Rheum undulatum) were higher than that of the Chinese rhapontica rhubarb(low-quality rhubarbs).

The Purgative Action of Rhei Rhizoma Is Increased by Raphani Semen

  • Kim, Jung-Jin;Kim, Young-Suk;Joh, Ki-Ho;Bae, Hyung-Sup;Lee, Kyung-Sup;Park, Eun-Kyung;Kim, Dong-Hyun
    • Natural Product Sciences
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    • v.6 no.4
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    • pp.161-164
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    • 2000
  • Herbal medicinal interaction on the purgative action of Chungpesagan-tang, which is one of the traditional Korean medical prescriptions that has been most frequently used for stroke was investigated. Chungpesagan-tang had more potent purgative activity than Rhei Rhizoma alone. When each Chungpesagan-tang composing herbal medicine with Rhei Rhizoma was extracted with water, water extract of Raphani Semen with Rhei Rhizoma had the most potent purgative activity. However, Raphani Semen had not purgative activity. When Rhei Rhizoma with Raphani Semen was extracted, sennoside A content in the water extract was increased. The transformation of sennoside A of Rhei Rhizoma to rheinanthrone by human intestinal microflora was weakly induced by Raphani Semen. These results suggest that the purgative action of Chungpesagan-tang could be controlled by the addition and subtraction of Chungpesagan-tang-composing herbal medicines.

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