• 한국전자통신학회논문지
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• 제8권10호
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• pp.1601-1608
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• 2013

의학계는 2020년 국내노인성 치매환자가 60만명을 넘을 것으로 예상하고 있다. 현재 연령별 치매 환자 비율은 70대 3%, 85~89세 23%, 95세 이상이 58%로 나이에 따라 급격히 증가한다는 것도 주목해야 할 일이다. "21세기의 병"이라 불리우고 있는 치매는 환자 자신뿐 아니라 가족들의 삶까지도 심각한 영향을 미치고 있으며 삶의 질을 떨어뜨려 결국은 가족을 황폐화시킬 정도로 많은 부담과 고통을 동반하고 사회적으로도 심각한 문제가 되고 있다는 지적도 있다. 본 논문은 치매예방센터를 운영하는 대학의 치매예방센터의 프로그램에 참여하여 일정기간 노인들과 함께 프로그램에 참여하며 치매예방 프로그램에 대한 적극적인 개발과 치매예방 인력의 전문화를 위해 노인들과 함께 했다.

• 한국생활과학회지
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• 제12권1호
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• pp.15-24
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• 2003

The purpose of this study was to investigate the family care-givers' perceptions of welfare facility for the elderly people with dementia, to analyze the related variables, and to provide the suggestions from the perspectives of the well-being of family care-givers. The survey was done using questionnaires in 1999, and the subjects were 198 primary care-givers for senile dementia patients. Frequency distribution, mean, t-test, and one way ANOVA were used to analyze the data. The major findings of this study were as follows: The family care-givers' perceptions of the welfare facility for elderly people with dementia was relatively low. The variables associated were sex, education level, occupation and relationship with the demented elderly. The conclusion suggested from this study was that the social welfare facilities and services were necessary for both the demented elderly people themselves and their family care-givers.

• 생물정신의학
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• 제3권2호
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• pp.203-210
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• 1996

알쯔즈하이머형 치매 환자의 뇌자기공명영상(腦磁氣共鳴影像)에 나타난 뇌위축(腦萎縮) 및 백질병변(白質病變)과 치매 발병연령(發病年齡)과의 상관관계(相關關係)를 밝히기 위해, NINCDS-ADRDA 진단기준(診斷基準)에 의한 조발성(早發性)(n=9) 및 만발성(慢發性)(n=18) 알쯔하이머형 치매군과 각각의 정상대조군(n=10 : n=11)에서 뇌위축(腦萎縮)은 대뇌피질위축(大腦皮質萎縮)과 뇌실확장(腦室擴張)의 체적(體積)을 계측(計測)하고 백질병변(白質病變)은 뇌실주변, 심부백질, 기저핵 및 천막하영역의 백질(白質) 신호(信號) 고강도(高剛度)의 반정량적(半定量的) 평가척도(評價尺度)로 측정하였다. 조발성(早發性) 환자군의 뇌위축(腦萎縮)은 대조군보다 유의하게 컸고(p<0.05) 백질병변(白質病變)에서는 모든 영역에서 차이가 없었으며, 만발성(慢發性) 환자군은 뇌위축(腦萎縮) 정도에서는 대조군과 차이가 없었으나 백질병변(白質病變)은 심부백질 및 시상에서 유의한 차이(p<0.05)를 보였고 나머지 모든 영역에서도 대조군보다 심한 경향을 보였다. 알쯔하이머형 치매가 (1) 뇌위축(腦萎縮)을 주로 보이고 백질병변(白質病變)은 심하지 않은 조기발병군(早期發病郡)과, (2) 백질병변(白質病變)이 두드러지고 뇌위축(腦萎縮)은 심하지 않은 만기발병군(晩期發病郡)으로 나누어질 가능성과 양군의 병태생리(病態生理)가 상이(相異)할 가능성이 시사되었다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.38-40
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• 1995

There have reports suggested that cerebral blood flow (CBF) has decreased in patients with both senile dementia of the Alzheimer's type and multi-infarct dementia, which are characterized by marked cognitive impairments. In addition, recent studies have demonstrated that decrease of CBF precedes the onset of multi-infarct dementia. These findings further suggest that chronic reduction of CBF may play an important role in the formation and progression of cerebral vascular dementia. Although transient cerebral ischemia, based upon vascular “reperfusion”, is apparently not paralleling the clinical condition, the transient cerebral ischemia model is one of the major methods investigated and the other is the cerebral embolism operation. Cognitive impairment and neuronal damages have been fully studied using these transient and/or embolic ischemia models. There are, however, few investigations focused the attention on the influence of chronic decrease of CBF on cognitive processes. In the present study, we have chosen a chronic ischemic model which is produced by permanent occlusion of bilateral common carotid arteries (2VO) in rats to investigate the neuronal damage and cognitive deficits through radial maze performance. We investigated furtherly the effects of tetramethylpyrazine (TMP), a constituent isolated from Ligusticum Chuanxiong on such a model.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.28.1-28.1
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• 2008

• 대한간호학회지
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• 제25권1호
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• pp.45-60
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• 1995

This study investigated the effects of education program conducted through individual home visit by CHPs, which was developed ,by the operational re-search technique for families of dementia patients. (Yeo Shin Hong et at,1994) The study was conducted in the form of a primary experimental design with 43 people as subjects, including dementia patients and family member in several Myon areas of Chungcheong Namdo between June 10 and August 20, 1994. The data was collected by questionnaires through the home visit by the CHPs. The results of study are as follows. 1. There is no difference in the quality of life between before and after the education program. 2. Role stress 'before the education program' was significantly different than 'after the education program'. 3. There was no difference in the feeling of burden between before and after the education program. 4. There was a significant difference in the abnormal behaviors of patients between before and after the education program. 5. The knowledge of dementia by the patient's family increased significantly after the education program, compared to that of 'before the education program'. 6. There was a significant difference in the attitude of family members toward the education program on dementia between before and after the education program. 7. The results of analysis on the coefficient relationship of various variables showed that the age of patients and family members have a significant correlation with role stress(p=.01). 8. In the subjective evaluation of family members on changes in actual nursing actions and the improvement of knowledge and technique in terms of daily living, (including abnormal behavior of patients, adjustment of environment for patients, activity programs for patients, communication technique with patients, ensuring the safety of patients, clothing, meals and elimination, 60-65% of family members responded that their knowledge had increased. As for improvement in techniques for each item, the technique for communication with patients showed the greatest improvement while the action program method for patients showed the least change. As for the nursing service provided to patients, most respondents showed a positive change. The specific items for which more than 80% respondents answered positively were as follows : recognizing the demand of patients, getting patients to do simple house works, talking softly and gently, removing dangerous things, preparing comfortable clothes that are easy to put on and take off, and limiting water consumption at night. As a result of study, the following suggestions can be made. The purpose of the study was to examine the effect of an education program developed and applied for dementia patients and family members in the community. This needs to be compared with a similar study conducted in the urban setting. In addition, a community service program (ex : nursing hem and shelter) including the application of the education program should be developed and the study done to investigate its effect.

• 동의생리병리학회지
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• 제35권3호
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• pp.104-116
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• 2021

In order to reduce the social and economic costs due to the increase in dementia patients, which is a representative senile disease in an aging society, it will be important to prevent dementia and to detect and treat early in high-risk groups. This study reported the results of treatment for the elderly with high risk of dementia and depression who received Korean medicine (KM) treatment in 9 KM clinics. Medical charts were surveyed on 116 patients with high risk of dementia and depression who received KM treatment at 9 KM clinics in Gangseo-gu from September 1, 2020 to December 31, 2020. The majority of the patients were female(76.72%), the average age was 71.66±7.18 years old, and the average education level was 8.96±3.91 years. The average treatment period was 61.47±10.30 days, the average number of treatments was 15.38±1.06 times, and both acupuncture and herbal medicine were administered. After receiving KM treatment, cognitive assessment scores such as MMSE-DS and MoCA-K, depression-related GDSSF-K score, dementia knowledge, attitude, and preventive behavior, blood debilitation scale, and GQOL-D score were improved compared to before. There was no specific adverse reaction except that one patient with elevated AST and ALT levels was observed. This study showed improvement in cognitive function, depression, dementia-related scale, and quality of life in high-risk groups for dementia and depression over 60 years old who received KM treatment. More systematic and large-scale planned clinical studies will be needed.

• Journal of Preventive Medicine and Public Health
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• 제46권sup1호
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• pp.22-27
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• 2013

The purpose of this study was to examine the beneficial effects of a new cognitive intervention program designed for the care and prevention of dementia, namely Learning Therapy. The training program used systematized basic problems in arithmetic and Japanese language as training tasks. In study 1, 16 individuals in the experimental group and 16 in the control group were recruited from a nursing home. In both groups, all individuals were clinically diagnosed with senile dementia of the Alzheimer type. In study 2, we performed a single-blind, randomized controlled trial in our cognitive intervention program of 124 community-dwelling seniors. In both studies, the daily training program using reading and arithmetic tasks was carried out approximately 5 days a week, for 15 to 20 minutes a day in the intervention groups. Neuropsychological measures were determined simultaneously in the groups both prior to and after six months of the intervention. The results of our investigations indicate that our cognitive intervention using reading and arithmetic problems demonstrated a transfer effect and they provide convincing evidence that cognitive training maintains and improves the cognitive functions of dementia patients and healthy seniors.

• 한국산학기술학회논문지
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• 제16권7호
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• pp.4805-4815
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• 2015

치매노인과 부양가족, 간호제공자를 대상으로 치매노인의 문제행동의 유형과 이에 따른 간호제공자의 대처방법과의 관계를 규명하기 위한 분석은 기술통계, t-test, ANOVA, discrete variable를 이용하여 상관 분석하였다. 연구결과는 부양가족 및 간호제공자가 경험한 치매노인 문제행동으로 초조행동이 가장 높게 나타났고, 세부영역별로는 '같은 질문을 반복하거나 같은 요구를 반복한다.' 와, '이상한 소리를 내거나 소음을 낸다.' 그리고 '.간호제공자의 말을 안 듣고 고집을 부린다.'등으로 나타났다. 또한 본 연구에서 나타난 치매노인의 문제행동에 따른 대처행동으로는 '언어적토론', '발생요인제거', '행동제한'이 순 상관관계가 있는 것으로 나타났다. 이에 본 연구자는 치매노인을 돌보는 관련 기관 및 재가에서는 간호제공자에게 치매노인의 문제행동 중 빈번하게 나타나는 문제행동별로 대처 할 수 있도록 정기적인 교육이 필요하다고 사료되고, 치매노인의 문제행동에 대한 개별화된 간호중재프로그램이 개발되는데 기초자료로 제공될 것이다.

• 약학회지
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• 제37권5호
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• pp.442-452
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• 1993

Previous experimental and clinical investigations suggest a possible role of new nootropic drug, oxiracetam, in improving cognitive performances in patients affected by organic brain syndrome. In this study, the cognitive and behavioral effects of oxiracetam treatment in patients with clinical symptoms of organic brain syndrome were evaluated. Sixty-six patients were enrolled and assigned to either oxiracetam or placebo, according to a randomized, double-blind design between two patient-groups. Either oxiracetam or placebo was orally given bid for 8 weeks ; daily dose of oxiracetam was 1600mg. All the patients, enrolled in this study, were diagnosed as having mild to moderate cognitive dysfunction as defined by a baseline Mini Mental State ExaminationKorean version (MMSE-K) score between 14 and 25. The patients under-went, at baseline, 4 weeks and 8 weeks after, routine laboratory study (CBC, SMA12, U/A, EKG) and the following neuropsychological tests ; MMSE-K, modified Korean Wechsler Intelligence Scale(MKWIS), Nurses' Observation Scale for Geriatric patients(NOSGER). Fifteen patients of whom were dropped out or excluded from the analysis because of poor compliance or violation of the protocol. Fiftyone patients (aged 54~78 years, male 25, female 26) were analyzed (vascular dementia, 30 ; senile dementia of Alzheimer type, 9 ; mixed type, 5 ; other cause, 7). Statistical analysis of the data demonstrated that the two groups were comparable at baseline. At the end of each study period the oxiracetam group scored significantly better on the majority of the tests evaluating cognitive function, psychometricity and the improvement rating scale of subjective symptoms than placebo group, in which worsening trends or no changes were seen on the whole. No side effects were noted during oxiracetam treatment. The present study, showing positive clinical findings after oxiracetam therapy, confirmed that this drug can be useful pharmacological treatment in organic brain syndrome.