The importance of dietary intake in the treatment of type 2 diabetes was emphasized. This study was performed to investigate the dietary intakes of Korean type 2 diabetes patients according to the treatment and duration of diabetes and to examine the relationships between their diet and serum lipid profiles. The subjects were 111 type 2 diabetic patients who were treated by medical nutrition therapy only, oral hypoglycemic agents (OHA), or insulin with medical nutrition therapy. Dietary intake was assessed by a registered dietitian using semi-quantitative food frequency questionnaires Comparisons according to treatment type were made using covariance analyses. General linear models identified the independent effects of the different treatments after covarying for age, duration of diabetes, and 2-way interactions. There were no significant differences in age and BMI but was in duration of diabetes according to treatment type in these subjects. Carbohydrate to energy ratio was higher in the OHA group (P < 0.05), whereas the fat to energy ratio was higher in the insulin group for males (P < 0.05). Carbohydrate ($R^2$ = 0.24, P = 0.005) and fat ($R^2$ = 0.26, P = 0.02) to energy ratios were independently associated with the duration of diabetes after covarying for age, sex, treatment, and 2-way interactions. The levels of triglyceride (TG; $R^2$ = 0.32, P = 0.02) and total cholesterol (TC) were associated independently with energy intake and the carbohydrate ($R^2$ = 0.15, P = 0.02) and fat ($R^2$ = 0.15, P = 0.01) to energy ratios, respectively. The concern that the independent association of dietary intake with either duration of diabetes or dietary factors affects blood lipid levels could suggest that specific dietary recommendations may work better for identifiable groups of diabetes patients.
Kim, Sang-Uk;Chi, Myung-Whan;Yoon, Chang-No;Sung, Ha-Chin
BMB Reports
/
v.31
no.5
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pp.459-467
/
1998
A new set of functional group interaction energy descriptors relevant to the ACE (Angiotensin-Converting Enzyme) inhibitory peptide, QSAR (Quantitative Structure Activity Relationships), is presented. The functional group interaction energies approximate the charged interactions and distances between functional groups in molecules. The effective energies of the computationally derived geometries are useful parameters for deriving 3D-QSAR models, especially in the absence of experimentally known active site conformation. ACE is a regulatory zinc protease in the renin-angiotensin system. Therapeutic inhibition of this enzyme has proven to be a very effective treatment for the management of hypertension. The non bond interaction energy values among functional groups of six-feature of ACE inhibitory peptides were used as descriptor terms and analyzed for multivariate correlation with ACE inhibition activity. The functional group interaction energy descriptors used in the regression analysis were obtained by a series of inhibitor structures derived from molecular mechanics and semi-empirical calculations. The descriptors calculated using electrostatic and steric fields from the precisely defined functional group were sufficient to explain the biological activity of inhibitor. Application of the descriptors to the inhibition of ACE indicates that the derived QSAR has good predicting ability and provides insight into the mechanism of enzyme inhibition. The method, functional group interaction energy analysis, is expected to be applicable to predict enzyme inhibitory activity of the rationally designed inhibitors.
In the event of a severe accident, the reactor core may melt due to insufficient cooling. the high-temperature core melt will have a strong interaction (FCI) with the coolant, which may lead to steam explosion. Steam explosion would pose a serious threat to the safety of the reactors. Therefore, the study of steam explosion is of great significance to the assessment of severe accidents in nuclear reactors. This research focuses on the development of a two-dimensional steam explosion integrated analysis code called SEINA. Based on the semi-implicit Euler scheme, the three-phase field was considered in this code. Besides, the influence of evaporation drag of melt and the influence of solidified shell during the process of melt droplet fragmentation were also considered. The code was simulated and validated by FARO L-14 and KROTOS KS-2 experiments. The calculation results of SEINA code are in good agreement with the experimental results, and the results show that if the effects of evaporation drag and melt solidification shell are considered, the FCI process can be described more accurately. Therefore, it is proved that SEINA has the potential to be a powerful and effective tool for the analysis of steam explosions in nuclear reactors.
Kim, Mi-Yang;Suh, Il;Nam, Chung-Mo;Yoon, Jee-Young;Shim, Jee-Seon;Oh, Kyung-Won
Journal of Nutrition and Health
/
v.35
no.2
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pp.250-262
/
2002
This study was conducted to develop a simple flood frequency questionnaire (FFQ) based on the results of contributions of specific floods to absolute intake and between-person variance in nutrients using semi-quantitative FFQ with 93 flood items. The subjects were 554 healthy adults for development of a simple FFQ, and 37 students for a validation test of a developed simple FFQ. The contribution of specific floods to 80% absolute nutrient intake was measured by assessing their percentage in total consumption of a nutrient. To assess the contributions of floods to the between-person variance in the intake of each specific nutrient, stepwise multiple regressions were performed. The number of floods necessary to account for the respective 80% of absolute intake was 11-36, depending on the nutrient, while flower floods (5-16 floods) were required for the corresponding percentage of between-person variation for all nutrients. Important floods for between-person variance include Tangsuyuk (pork) and snacks for energy and fat, fish for protein and polyunsaturated fatty acids (PUFA) and snacks for carbohydrates. Spearman correlation coefficients between 93-itemed FFQ and 63-itemed FFQ ranged from 0.91 for vitamin A to 0.99 for fat in the population data used in developing a simple FFQ. Also, the correlation coefficients between the two FFQs were 0.82-7.92 in the population for the validation test. This study suggests that useful information on dietary intake could be obtained using a simple semi-quantitative FFQ in a large-scale dietary survey in Korea.
The experiment was conducted to know the varietal difference in changing aspect of daily filling sink during of rice using three cultivars; ‘Suweon 295’ (japonica), ‘Suwoen 264’ and ‘IR 1317-70-1’ (semi-dwarf indica) cultivated in the field and green house of the Crop Experiment Station in 1983. There was not significant varietal difference in flowering habit and duration of flowering period each panicle. Semi-dwarf indica cultivars showed shorter days to physiological maturity of rice kernel than the japonica one. The former also displayed earlier decrease in water content of rice grain during ripening than the latter. Japonica variety revealed larger difference in ripening advancement between vigorous florets and inferior one than semi-dwarf indica varieties. The semi-dwarf indica rice cultivars expressed significantly shrewder parabola of daily filling of sink per panicle during ripening than the japonica one. The time showing maximum capacity of daily filling of sink per panicle during ripening was 10-12 days after anthesis. The filling capacity of daily sink filling per panicle for 'IR 1317-70-1', 'Suweon 264' and 'Suweon 265' at this time were about 240 mg, 165 mg and 145 mg, respectively. Pattern of sink filling per panicle during ripening was slightly changed by the cultural environment. ‘Suweon 295’ showed slightly sharper parabola and 2-3 days earlier time showing maximum capcity of daily sink demand per panicle during ripening in the field than those in the green house.
Kim, Deok-Gil;Lee, Eun-Kyeong;Kim, Mu-Chan;Song, Sung-Kyu;Cho, Kwang-Soo
Journal of the Korean Society for Marine Environment & Energy
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v.15
no.3
/
pp.257-262
/
2012
This study was conducted to verify the performance of the solar water circulation apparatus that was installed in a semi-closed sea area of Tongyeong to improve the water quality through removing thermocline and oxygen depleted water mass, and to prevent the occurrence of red tides caused by eutrophication. From 8 weeks of experiments, we found that the thermocline in the semi-closed sea area has been removed gradually after installation of the apparatus. The initial temperature of surface and bottom was $27.9^{\circ}C$ and $23.8^{\circ}C$, respectively and it was changed to $22.1^{\circ}C$ in both depth. In case of DO concentration, there was a big gap between surface (5.49 mg/L) and bottom (2.61 mg/L) and was an oxygen depleted water mass in the bottom area at initial. However DO concentration in bottom layer has increased gradually after operation (6.19 mg/L) and the oxygen depleted water mass has removed. Due to the effects of seasonal variation and the operation of the solar water circulation apparatus for 8 weeks, COD concentration decreased from 5.61 mg/L to 2.36 mg/L in surface area, and from 6.08 mg/L to 1.73 mg/L in bottom area. Dissolved inorganic nitrogen concentration also decreased from 0.135 mg/L to 0.050 mg/L in surface area, and from 0.076 mg/L to 0.051 mg/L in bottom area. This research was conducted from July to September, and it might be possible that the variation of water quality was affected by both seasonal variation and the operation of the water circulation apparatus. Hence a further research is required to verify the performance of the water circulation apparatus itself and to monitor dissolved inorganic nitrogen and phosphorous concentrations as well as Chl-a.
The transmission of vibration energy through beam-plate junctions in vibration intensity analysis called power new analysis (PFA) has been studied. PFA is an analytic tool for the prediction of frequency averaged vibration response of built-up structures at medium to high frequency ranges. The power transmission and reflection coefficients between the semi-infinite beam and plate are estimated using the wave transmission approach. For the application of the power coefficients to practical complex structures, the numerical methods, such as finite element method are needed to be adapted to the power flow governing equation. To solve the discontinuity of energy density at the joint, joint matrix is developed using energy flow coupling relationships at the beam-plate joint. Using the joint matrix developed in this paper, an idealized ship stem part is modeled with finite element program, and vibration energy density and intensity are calculated.
In this study, a complete set of recirculating cooling water system and the required instruments were built in a semi-industrial-scale and a 50 g/h ozone generation plant and a chlorine system were designed for cooling water treatment. Both chlorination and ozonation treatment methods were studied and the results were analyzed during two 45-days periods. The concentrations of ozone and chlorine in recirculating water were constant at 0.1 mg/lit and 0.6 mg/lit, respectively. In ozone treatment, by increasing the concentration cycle to 33%, the total water consumption decreased by 26% while 11.5% higher energy efficiency achieved thanks to a better elimination of bio-films. In case of Carbon Steel, the corrosion rate reached to 0.012 mm/yr and 0.025 mm/yr for the ozonation and chlorination processes, respectively. Furthermore, consumptions of the anti-corrosion and anti-sedimentation materials in the ozone cooling water treatment were reduced about 60% without using any oxidant and non-oxidant biocides. No significant changes in sediment load were seen in ozonation compared to chlorination. The Chemical Oxygen Demand of the blow-down in ozonation method decreased to one-sixth of that in the chlorination method. Moreover, the soluble iron and water turbidity in the ozonation method were reduced by 97.5% and 70%, respectively. Although no anaerobic bacteria were seen in the cooling water at the proper concentration range of ozone and chlorine, the aerobic bacteria in chlorine and ozone treatment methods were 900 and 200 CFU/ml, respectively. The results showed that the payback time for the ozone treatment is about 2.6 years.
This study was carried out to evaluate the iron nutrition status of 212 middle school students(106 males and 106 females) residing in Seoul(13-14 years old ) using eating patterns and a measurement of anthropometrical determination and hematological indices. Fasting blood samples were taken from all subjects, serum iron (SI) and total iron binding capacity(TIBC) concentrations were measured, and transferrin saturation(TS) levels were calculated. Iron and other nutrient intakes were estimated by a semi-quantitative frequency questionnaire. The level of TS(%) which was calculated with TIBC and SI in females(20.4$\mu\textrm{g}$/dl) was significantly lower(p<0.050 than that of males (27.4$\mu\textrm{g}$/㎗). The prevalence of iron deficiency was found to be 36.7% when defined by TS(%) (<05%). Mean daily intake of total iron in the study subjects was 14mg and heme iron intake was 5.4mg(38.1%) . There was a significant negative correlation between the level of SI and the income level and a positive correlation with the level of TIBC and the income level. TIBC had a positive correlation with the anthropometric variables(Ht, Wt, BMI, RI and PIBW). SI and TS had a negative correlation with body fat percentage. There was a positive correlation between energy intake and TIBC only among females. The logistic regression analysis revealed that income level, body fat percentage , weight and energy intake were major determinants of low SI levels. Among the determinants of abnormal TIBC levels were weight , height, income level and energy intake. Finally , among those of low TS% were iron and energy intake and income level. These observations suggest that physical status, body fat percentage energy and iron intakes and income level are risk factors for iron-deficiency anemia among the middle school students in Seoul.
Kim, Ji-Hyeon;Son, Hyeong-Min;Kwon, Hyuck-Sam;Kim, Jong-Gon;Lee, Bum-Sik
Land and Housing Review
/
v.7
no.4
/
pp.299-305
/
2016
This study aims to provide basic materials for expanding application of green roof afforestation by analyzing structures' energy consumption reduction effects according to green roof afforestation as a planning means to cope with climate change. As the subjects, recently completed apartment buildings and service facilities of apartment houses where green roof afforestation was applied were selected. green roof afforestation of Extensive Green Roof(soil depth: 20cm) and Semi-Intensive Green Roof(soil depth: 40cm) in construction types was applied and design builders were utilized in order to compare energy reduction amount according to the application of green roof afforestation. According to the analysis result, all the buildings had energy reduction effect when green roof afforestation was applied.
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