• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3139-3145
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• 2016

Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage normal dividing cells, leading to adverse effects in the body. In view of great advances in cancer therapy, which are increasingly reported each year, we quantitatively and qualitatively evaluated the papers published between 1981 and December 2015, with a closer look at the highly cited papers (HCPs), for a better understanding of literature related to cytotoxicity in cancer therapy. Online documents in the Web of Science (WOS) database were analyzed based on the publication year, the number of times they were cited, research area, source, language, document type, countries, organization-enhanced and funding agencies. A total of 3,473 publications relevant to the target key words were found in the WOS database over 35 years and 86% of them (n=2,993) were published between 2000-2015. These papers had been cited 54,330 times without self-citation from 1981 to 2015. Of the 3,473 publications, 17 (3,557citations) were the most frequently cited ones between 2005 and 2015. The topmost HCP was about generating a comprehensive preclinical database (CCLE) with 825 (23.2%) citations. One third of the remaining HCPs had focused on drug discovery through improving conventional therapeutic agents such as metformin and ginseng. Another 33% of the HCPs concerned engineered nanoparticles (NPs) such as polyamidoamine (PAMAM) dendritic polymers, PTX/SPIO-loaded PLGAs and cell-derived NPs to increase drug effectiveness and decrease drug toxicity in cancer therapy. The remaining HCPs reported novel factors such as miR-205, Nrf2 and p27 suggesting their interference with development of cancer in targeted cancer therapy. In conclusion, analysis of 35-year publications and HCPs on cytotoxicity in cancer in the present report provides opportunities for a better understanding the extent of topics published and may help future research in this area.

• Journal of Korea Multimedia Society
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• v.9 no.10
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• pp.1332-1343
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• 2006

This paper proposes an educational community service system that manages information of good quality intensively without overlapping, and that provides an effective searching function by using a personal community with many user layers. This system raises the efficiency of searching and management by using Metadata and Category. It is a self-leading educational community system that brings merits into relief and improves weak points. We constructed an autogenous Blog chain service as a tool which verifies this system, which is called 'EduLOG(Educational Blog) service' Especially we extracted Metadata suitable for this service, which is on the basis of worldfamous Dublin Core Metadata. And we made a new category on the basis of categories which were proposed by some educational community sites and public educational authorities, and we applied it to this system. To ascertain whether this service system provide adequate function or not, we made a questionnaire on the basis of the appraisal table in websites, and evaluated it at the request of experts. In view of the results so far achieved, it returned good scores (above 3.5/5.0) in accuracy of evaluation, low-end reappearance ratio, easiness of registering and approaching information, and intensive management of a categorical information, confirming the efficiency of the ECSS system. Therefore we believe firmly that the ECSS system will play a efficient information storing and searching roles in the near future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.271-279
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• 2019

In extreme environment regions, unmanned rovers equipped with various sensors and devices are being developed for long-term exploration on behalf of humans. On the other hand, due to the harsh weather conditions and rough terrain, the rover camera has limited visible distance and field of view. Therefore, the rover cameras should be located for safe navigation and efficient terrain mapping. In this regard, to minimize the cost and time to manufacture the camera system on a rover, the simulation method using the rover design is presented to optimize the camera locations on the rover efficiently. In the simulation, a simulated terrain was taken from cameras with different locations and angles. The visible distance and overlapped extent of camera images, and terrain data accuracy calculated from the simulation were compared to determine the optimal locations of the rover's cameras. The simulated results will be used to manufacture a rover and camera system. In addition, self and system calibrations will be conducted to calculate the accurate position of the camera system on the rover.

• The Korean Society of Law and Medicine
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• v.17 no.2
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• pp.257-279
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• 2016

Recently, the Well-dying Act was legislated in Korea, and it will come into effect in August 4, 2017. This Act allows to withdraw the life sustaining treatment from impending death patients and also provide the hospice and palliative treatment to terminal patients. In the Supreme Court's case so called "Madam Kim", medical condition of Madam Kim was a persistent vegetative status owing to brain damage and her family members wanted to remove the artificial ventilation. In 2009, the Supreme Court allowed to withdraw the artificial ventilation under the specific conditions. We applied this new Well-dying Act to the Madam Kim's case hypothetically in order to know this Act can reasonably solve the problem of life sustaining treatment for dying or terminal patients. For the impending patients, the Well-dying Act has the problem not to withdraw the futile treatment due to the advance directives of patients. Vice versa, the terminal patients have no chance to withdraw the life sustaining treatment due to the this Act impose the duty to provide the hospice and palliative treatment despite of advance directives. We need to ruke out the persistent vegetative patients from the terminal patients caused by the cancer, acquired immune deficiency syndrome, chronic obstructive lung disease and chronic liver cirrhosis, In addition, we have to discuss the effect of the advance directives of terminal patients in view of self determination right.

• Journal of the Korean association of regional geographers
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• v.2 no.1
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• pp.87-114
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• 1996

This paper is the second part of a research which aims to look into the regional development process and the quality of life of Youngnam area. and to suggest a prospect and tasks for the future development of the region. All cities and regions including Youngnam area seem to be involved in a rapidly changing process of conditions for development, because of a recent economic and political transformation in the national and global scale. It can be thus said that, taking such a process into consideration seriously, each city or region needs to establish a long-term prospect and goal, and to set up and practicize its development plan. From this point of view, this paper reconsiders the changing process of conditions for development of Youngnam region, and suggests an alternative development plan. At the first, the changing conditions of regional development are investigated in economic, political, social, cultural and environmental aspects. Secondly, some actual planning practices in this regions are examined and their problems are pointed out. Thirdly, an alternative model for regional development is suggested and development tasks in each aspects are discussed in relation to each other. Finally some regional development strategies are provided in the spatial as well as the sectoral dimision. As a results of this research, it is argued that the development of Youngnam region should pursue both an improvement of socio-cultural and ecological institutions for ensuring humane life of dwellers within the region, and a enforcement of economic and political self-sufficiency in an organic relation between regions and to the whole society. This kind of argument can be applied to every city or region. But it would more significant for Youngnam region, because this region, which once experienced a rapid economic growth but now is fallen into a serious economic stagnation, tends to contrive material plans to redevelop regional economy, while ignoring social plans to improve quality of life.

• Journal of Christian Education in Korea
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• v.62
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• pp.43-74
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• 2020

This paper examines the epistemology of the body and the direction of Christian education based on it. Looking at Merleau-Ponty, Damagio, and Nelson's epistemology of the body, it found that they had a common point, even though they studied in different areas like philosophy, brain science, and body theology; the body is a subject that perceives the world in a sensuous and direct way, and is a channel that mediates humans and the world, and plays a decisive role in human self-formation. In particular, theology of body revealed, that the body is a pathway for our understanding of God just as a pathway for our understanding the world. In addition, theology of body revealed that the body is regarded as the place of 'embodiment of God', and in the end, the world in which our incarnated body participates should also become the place of 'God's incarnation'. It also examined Christian education based on the epistemology of the body, focusing on 'education starting from the senses', 'education as a participation', and 'incarnational education'. From these three concepts, it found that epistemology of body suggests an alternative view of traditional knowledge-based education or schooling education. It suggests an open paradigm centered on sense and experience, personal participation, non-verbal experience, and field of education, beyond a fixed and closed paradigm of doctrine-centered, objective knowledge mediation, language-centered, and content-centered. Furthermore, this paper found that the body is like a well that can pump up metaphors that provide a basic metaphor for re-conceptualizing Christian education.

• Journal of Christian Education in Korea
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• v.62
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• pp.75-99
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• 2020

What means the Waldorf school based on integrative imagination to our educational reality in our days? This is the key question in this article. This article seeks to the fundamental meaning of the Waldrof school to know our educational problems. For this purpose this article explore understanding on the theosophy of Rudolf Steiner in the insufficient research until now. The theosophy of Rudolf Steiner in this article is investigated with the understanding of Triune God, human, and educational arts. The understanding of triune God is identified as the critiques to the view point of materialism, the meaning of logos in the scripture of John, the Christ as the foundation of all creatures. The understanding of human being is distinguished as the nature of body, soul, and spirit in the theosophy. Especially the nature of spirit is to see the invisible in the visible things through the eyes of mind that means esoteric spirituality not unrealistic spirituality of monasticism but integrative spirituality of overcoming the dualism between spirit and material. The educational characteristics for the integrative spirituality and imagination is called as the educational arts by Rudolf Steiner. The educational arts includes contents of the soul life, the education of freedom with individuality, and integrative education. The educational arts intends to the wholistic education with harmonious interaction of intellect, feeling, and willing to equip the individual human being in the spirit. And the educational arts educates with the harmony of story, play, art, and integrative curriculum of subject contents. The educational arts is to intend for reformation in christian education including church school and alternative school, etc. The Waldorf school needs to emphasizing the christian spirituality in the educational arts.

• Journal of dental hygiene science
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• v.15 no.1
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• pp.38-45
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• 2015

This research was attempted in order to investigate the correlation of the conflict level and job satisfaction of the dental hygienists in the dental clinic agency. The subjects were 249 dental hygienists working with more than five dental hygienists at dental clinics in Daegu, eight dental clinics were randomly chosen, the researcher visited them personally and the data was obtained by self-administrated questionnaires from March 2 to March 31, 2011. In conclusion, the higher ages, monthly income and total career were, the higher levels of conflict were, and job satisfaction was significantly high when monthly income and total career were higher. Correlation between level of conflict and job satisfaction showed as level of conflict are lower, job satisfaction was significantly high. Regression analysis of the factors affecting job satisfaction, it was significantly high as monthly income was higher, friction of view and ignorance was lower. Therefore, the conflict level is reduced, the job satisfaction degree of the dental hygienist is enhanced, the dental hygienist duty efficiency is enhanced and dental service of the good quality is provided.

• Korean Journal of Applied Biomechanics
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• v.15 no.4
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• pp.85-95
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• 2005

The purpose of this study was to investigate the relations between the segments of the body, the three dimensional anatomical angle during One Hand Backhand Stroke and Two Hand Backhand in tennis. For the movement analysis three dimensional cinematographical method(APAS) was used and for the calculation of the kinematic variables a self developed program was used with the LabVIEW 6.1 graphical programming(Johnson, 1999) program. By using Eular's equations the three dimensional anatomical Cardan angles of the joint and racket head direction were defined. 1. In three dimensional maximum linear velocity of racket head the X axis and Y axis(horizontal direction) showed $-11.04{\pm}2.69m/sec$, $-9.31{\pm}0.49m/sec$ before impact, the z axis(vertical direction) maximum linear velocity of racket head did not show at impact but after impact this will resulted influence upon hitting ball. It could be suggest that Y axis velocity of racket head influence on ball direction and z axis velocity influence on ball spin after impact. The stance distance between right foot and left foot was mean $75.4{\pm}5.86cm$ during one hand backhand stroke and $72.6{\pm}4.67cm$ during two hand backhand stroke. 2. The three dimensional anatomical angular displacement of trunk in interna rotation-external rotation showed most important role in backhand stroke. and is follwed by flexion-extension. the three dimensional anatomical angular displacement of trunk did not show significant difference between one hand backhand stroke and two hand backhand stroke but the three dimensional anatomical angular displacement of trunk was bigger than one hand backhand stroke. 3. while backhand stroke, the flexion-extension and adduction-abduction of right shoulder joint showed significant different between one hand backhand stroke and two hand backhand stroke. the three dimensional anatomical angular displacement of right shoulder joint showed more flex and abduct in one hand backhand stroke. 4. The three dimensional anatomical angular displacement of left shoulder showed flexion, adduction, and external rotation at impact. after impact, The angular displacement as adduction-abduction of left shoulder changed motion direction as abduction. angular displacement of left shoulder as flexion-extension showed bigger than the right shoulder.

• The Journal of Industrial Distribution & Business
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• v.9 no.11
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• pp.55-66
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• 2018

Purpose - Present research aimed at identifying the effects of ambient pride type on judgement difference between existing preference and final preference formed after being exposed to the preference inconsistent information from others representing a conflict between consumer's own perspective and the others' perspective. And this study also explored the roles of empathic concerns and motive type in the ambient pride type's effects on the judgement difference. Research design, data, and methodology - 2(information type: consistent versus inconsistent) × 2(pride type: hubristic versus authentic) between-subjects design was employed. Data for empirical analysis were from 252 undergraduate students who participated in questionnaire survey. To verify hypotheses, Anova and regression analysis were used. Results - First, there was the judgement difference among the experimental groups. The difference was greater at the authentic pride group than at the hubristic pride group. And the difference was greater at the inconsistent information group than at the consistent information group. The interaction effect of pride type and information type was significant. Second, when consumers who had made their preference were exposed to the inconsistent information from other, those of the hubristic pride group showed more defense motive and less empathic concerns than those of the authentic pride group. And there were the mediation roles of the empathic concerns and the interaction roles of the motive type in the effects of pride type on the judgement difference. Third, the self validity did not affect the difference even that become increased by defense motive rather than accuracy motive. Conclusions - This research could advance the information processing theory related to pride type by exploring the effects of the pride type on judgement difference between existing preference and final preference formed by the inconsistent information from others, and by identifying the mediation roles of the empathic concerns and the interaction roles of the motive type in the effects of the pride type. In view of the results from current study, marketers should make efforts of inducing defense motive and developing and communicating the consistent information to persuade consumers under hubristic pride who have the belief that attributes of their brand are better than those of the competitors' brand, and they also should conduct marketing acts by using the inconsistent information to persuade consumers under authentic pride who have the belief that attributes of the competitors' brand are better than those of their brand.