• Molecules and Cells
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• v.45 no.10
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• pp.695-701
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• 2022

Homeostatic regulation of meristematic stem cells accomplished by maintaining a balance between stem cell self-renewal and differentiation is critical for proper plant growth and development. The quiescent center (QC) regulates root apical meristem homeostasis by maintaining stem cell fate during plant root development. Cell cycle checkpoints, such as anaphase promoting complex/cyclosome/cell cycle switch 52 A2 (APC/C^CCS52A2), strictly control the low proliferation rate of QC cells. Although APC/C^CCS52A2 plays a critical role in maintaining QC cell division, the molecular mechanism that regulates its activity remains largely unknown. Here, we identified SCF^FBS1, a ubiquitin E3 ligase, as a key regulator of QC cell division through the direct proteolysis of CCS52A2. FBS1 activity is positively associated with QC cell division and CCS52A2 proteolysis. FBS1 overexpression or ccs52a2-1 knockout consistently resulted in abnormal root development, characterized by root growth inhibition and low mitotic activity in the meristematic zone. Loss-of-function mutation of FBS1, on the other hand, resulted in low QC cell division, extremely low WOX5 expression, and rapid root growth. The 26S proteasome-mediated degradation of CCS52A2 was facilitated by its direct interaction with FBS1. The FBS1 genetically interacted with APC/C^CCS52A2-ERF115-PSKR1 signaling module for QC division. Thus, our findings establish SCF^FBS1-mediated CCS52A2 proteolysis as the molecular mechanism for controlling QC cell division in plants.

• Wind and Structures
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• v.35 no.2
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• pp.83-92
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• 2022

When the rolling stocks run on the curve, the external rail has to be lifted to a certain level to balance the centrifugal force acting on the train body. Under such a situation, passengers may feel uncomfortable, and the slanted vehicle has the potential overturning risks at high speed. This paper conducted a wind tunnel test in an annular wind tunnel with φ=3.2 m based on a 1/20^th scaled high-speed train (HST) model. The sensitivity of Reynolds effects ranging from Re = 0.37×10⁶ to Re = 1.45×106 was tested based on the incoming wind from U=30 m/s to U=113 m/s. The wind speed covers the range from incompressible to compressible. The impact of roll angle ranging from γ=0° to γ=4° on train aerodynamics was tested. In addition, the boundary layer development was also analyzed under different wind speeds. The results indicate that drag and lift aerodynamic coefficients gradually stabilized and converged over U=70 m/s, which could be regeared as the self-similarity region. Similarly, the thickness of the boundary layer on the floor gradually decreased with the wind speed increase, and little changed over U=80 m/s. The rolling moment of the head and tail cars increased with the roll angle from γ=0° to γ=4°. However, the potential overturning risks of the head car are higher than the tail car with the increase of the roll angle. This study is significant in providing a reference for the overturning assessment of HST.

• Journal of muscle and joint health
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• v.16 no.1
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• pp.55-65
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• 2009

Purpose: The purpose of this study was to determine the effects of water exercise program on physical fitness, pain and quality of life(QoL) in patients with osteoarthritis. Methods: Thirty-four old women were divided into the exercise(EG, n=18) and control groups(CG, n=16) after 6-week self-help education program. The EG carried out 6-week supervised water exercise program(60min/day, 2days/wk). Physical fitness, pain, and QoL were assessed by Senior Fitness Test Manual(Rikli & Jones, 2005), Pain rating scale(0-10) and World Health Organization QoL BREF(Min et al., 2000), respectively. Results: Both EG and CG increased upper and lower-body strength(all, p<.05), which were measured by arm curl and chair stand, respectively. For flexibility test, the EG increased upper and lower body(all, p<.05). Balance of the EG increased(p<.05), but not in the CG. Pain significantly decreased in the EG post training(p=.000). However, both EG and CG did not significantly improve for QoL. Conclusion: Six weeks of water exercise program did induce significant improvement in physical fitness and pain control in patients with osteoarthritis.

• Journal of English Language & Literature
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• v.58 no.6
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• pp.1119-1142
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• 2012

This article examines how Cuban-American writer Cristina García interweaves all possible experiences of Cubans through Dreaming in Cuban in terms of Bakhtin's concepts of heteroglosssia, hybridization, and the chronotope. In so doing, it reaffirms the applicability of these concepts as tools for interpreting speech genres while reevaluating and reexamining the novel in terms of Bakhtinian narratology. García identifies a sociopolitical cacophony in both America and Cuba from an open-minded perspective, striving to maintain a balance between them despite undesirable experiences with her patriotic mother and individuals in the Miami community where she worked as a journalist. In practice, she projects sociopolitical ideas onto her heroines' depictions, representing their consciousnesses in a process of interaction with others. In particular, García allows her three generations of heroines, Celia del Pino, her daughters Lourdes and Felicia, and her granddaughter Pilar Puente to live as staunchly political figures. In this way, García creates a unique novelistic situation by opposing or juxtaposing all aspects of her heroines and pitting them in a dynamic interaction with their environments. As they repeatedly tease, contradict, refute, and do battle with each other, her heroines expose various problems with the sociopolitical ideologies in both the Cuban and American contexts. García succeeds in her attempt by introducing Bakhtin's model of the "becoming" hero and depicting her heroines in dynamic interaction without her own interference. In particular, the devouring inner monologues of Pilar and her Cuban aunt Felicia are presented as the products of their extraordinarily developed self-consciousnesses, through which García attempts a multilateral approach of showing, rather than telling, her heroines' interactive inner worlds as well as introducing sociopolitical contexts. Generic factors such as epistles, diary entries, and ads copy are hybridized into Celia's and Lourdes' stories, serving the heroines' interactive contexts while filling in the many narrative gaps that result from the approach to Cuban and American history. The Bakhtinian perspective permits the interpretation that this generic hybridization enables García to cover narrative gaps resulting from the expansion of chronotopes.

• Journal of People, Plants, and Environment
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• v.22 no.6
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• pp.611-619
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• 2019

This study was conducted to investigate changes in the mental functions of the elderly in nursing facilities affected by a horticultural therapy program based on validation therapy. To meet the purpose, we conducted a horticultural therapy program based on validation therapy with 58 elderly participants (average age 79.12±6.84, men and women) once a week, 50 minutes per session, in a total of 10 sessions. Participants were divided into the control and experimental group with convenience sampling. The program was carried out from March 15 to November 22, 2018. Vibraimage 8 pro(ELSYS, 2014) is a recent, psychologically based, emotional-recognition visual imaging technology that measures pixels microvibration in terms of digital frequency and amplitude parameters. To examine the effects of the horticultural therapy program based on validation therapy, Vibraimage was used to assess aggression, stress, tension, suspect, balance, charm, energy, self-regulation, inhibition, neuroticism and positive, negative, physiological domains of mental functions before and after program. As a result, the mean score of the positive domain in the control group significantly decreased from 63.89±5.09 to 60.74±5.48, but it decreased without statistical significance in the experimental group from 63.98±5.45 to 61.39±6.02. The mean score of neuroticism in the experimental group significantly decreased from 31.64±10.94 to 22.87±13.79. Moreover, the mean score of the physiological domain in the experimental group also significantly decreased from 25.08±6.27 to 19.42±8.80. Accordingly, horticultural therapy program based on validation therapy can be utilized as a program to promote mental health, especially maintaining positive mental health function of the eldery, helping those who live in long-term care facilities enjoy a happier life more happier.

• Convergence Security Journal
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• v.24 no.2
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• pp.133-140
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• 2024

The spread of Direct-to-Consumer (DTC) genetic testing, where users request tests directly, has been increasing. With growing demand, certification systems have been implemented to grant testing qualifications to non-medical institutions, and the scope of tests has been expanded. However, unlike cases in less regulated foreign countries, disease-related tests are still excluded from the domestic regulations. The existing de-identification method does not adequately ensure the uniqueness and familial sharing of genomic information, limiting its practical utility. Therefore, this study proposes the application of fully homomorphic encryption in the analysis process to guarantee the usefulness of genomic information while minimizing the risk of leakage. Additionally, to safeguard the individual's right to self-determination, a privacy preservation model based on Opt-out is suggested. This aims to balance genomic information protection with maintainability of usability, ensuring the availability of information in line with the user's preferences.

• Journal of Preventive Medicine and Public Health
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• v.57 no.2
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• pp.167-175
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• 2024

Objectives: Rural housewives are integral to household management and family care, yet their sedentary lifestyles present significant health risks. This study used the transtheoretical model (TTM) to investigate strategies that encourage and maintain regular exercise habits among rural housewives. Methods: A semi-experimental study was conducted in 2021 with 114 housewives aged 30 to 59 who attended rural health centers in Gorgan, Iran. Participants were randomly assigned to 1 of 2 groups. Data collection involved a validated questionnaire that gathered demographic information and constructs of the TTM. The intervention group participated in a comprehensive educational program, which included four 60-minute sessions. Data were collected again 6 months post-intervention and analyzed using descriptive and inferential statistics in SPSS version 21. Results: The study encompassed women with an average age of 39.75±6.05 years, the majority of whom had educational levels below a diploma, and over 90% were married. We observed strong correlations between the processes of change, self-efficacy, and decisional balance. At the outset, there were no significant differences in demographics or model structures between the 2 groups. However, 6 months post-intervention, the intervention group exhibited statistically significant differences in the mean scores of model structures, stages of change, and body mass index (p<0.05). Conclusions: This study highlights the importance of physical activity training for rural housewives. The findings suggest that the educational intervention, which utilized the TTM, significantly impacted the participants' model structures and their stages of change.

• Korean Circulation Journal
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• v.54 no.6
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• pp.295-310
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• 2024

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vaccines. This review explores the incidence, risk factors, clinical presentation, pathogenesis, management strategies, and outcomes associated with VRM. The incidence of VRM is notably higher in male adolescents and young adults, especially after the second dose of mRNA vaccines. The pathogenesis appears to involve an immune-mediated process, but the precise mechanism remains mostly unknown so far. Most studies have suggested that VRM is mild and self-limiting, and responds well to conventional treatment. However, a recent nationwide study in Korea warns that severe cases, including fulminant myocarditis or death, are not uncommon in patients with COVID-19 VRM. The long-term cardiovascular consequences of VRM have not been well understood and warrant further investigation. This review also briefly addresses the critical balance between the substantial benefits of COVID-19 vaccination and the rare risks of VRM in the coming endemic era. It emphasizes the need for continued surveillance, research to understand the underlying mechanisms, and strategies to mitigate risk. Filling these knowledge gaps would be vital to refining vaccination recommendations and improving patient care in the evolving COVID-19 pandemic landscape.

• The Journal of the Convergence on Culture Technology
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• v.10 no.4
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• pp.105-109
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• 2024

This study analyzes the increasingly severe issue of recruiting military officer personnel due to low birth rates and social changes, and seeks to explore recruitment strategies that consider the characteristics of the MZ generation. The military strives to maintain security amidst ongoing military threats from North Korea, but the sharp decline in birth rates significantly impacts conscription resources and personnel recruitment. Additionally, the shift in values among the MZ generation and the cultural gap between them and the military organization make it challenging to attract outstanding talents. The MZ generation values work-life balance, horizontal relationships, and self-fulfillment, finding the authoritative and hierarchical military culture unattractive. Therefore, this study aims to diagnose the problems in military personnel recruitment and propose tailored recruitment strategies reflecting the characteristics of the MZ generation, ultimately exploring sustainable development directions for the future military.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.3
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• pp.370-378
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• 2015

Oral health is a critical factor for diagnosing overall health, as poor oral health has a negative impact on food intake and results in deterioration of nutritional status. The purpose of this study was to research the needs for food developments for the elderly based on their oral and overall health status. Oral status was significantly associated with self-reported health status, and dry mouth (lack of saliva) especially showed a significant relationship with negative self-perception of both oral and overall health. For both elderly men and women, fish and leafy vegetables were the most preferred side dishes. Bread, rice cake, and beverage-type foods were also preferred for snack development. Disease status of the elderly was significantly related with their preference for food development. For instance, those with diabetes were more likely to ask for anti-diabetic diets. The most important factor for the elderly in choosing food was nutritional balance, and less than 3,000 won was cited as an affordable price. The results could be utilized as basic data to develop foods for the elderly.