• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2523-2526
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• 2012

Introduction: Febrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy and improvement in absolute neutrophil count (ANC) has been linked directly to improved outcome. Evaluation of granulocyte colony stimulating factors (GCSFs) for treatment has shown reduced incidences of episodes of prolonged neutropenia and protracted hospitalization. To determine absolute neutrophil counts with GCSF in febrile neutropenic cancer patients admitted to a tertiary care centre and to co-relate the improvement in ANC with mortality and hospital discharge. Methods: A prospective cross sectional study was carried at an oncology ward at Aga Khan University hospital from January 2010 to June 2011. All adult patients who were admitted and treated with GCSF for chemotherapy induced febrile neutropenia were included. Multivariable regression was conducted to identify the factors related with poor outcomes. Results: A total of 131 patients with febrile neutropenia were identified with mean age of 43.2 (18-85) years, 79 (60%) being ${\leq}50$. Seventy-five (57%) had solid tumors and 56 (43%) hematological malignancies, including lymphoma. Fifty seven (43.5%) had an ANC less 100 cells/$mm^3$, 34 (26%) one between 100-300 cells/$mm^3$ and 40 (31%) an ANC greater than 300 cells/$mm^3$. Thirty (23%) patients showed ANC recovery in 1-3 days, and 74(56%) within 4-7 days. Thirteen (10%) patients showed no recovery. The overall mortality was 18 (13.7%) patients. The mean time for ANC recovery seen in hematological malignancies was 6.34 days whereas for solid tumors it was 4.88 days. Patients with ANC <100 cells/$mm^3$ were more likely to die than patients with ANC >300 cells/$mm^3$ by a factor of 4.3. Similarly patients >50 years of age were 2.7 times more likely to die than younger patients. Conclusion: Our study demonstrated that use of GCSF, in addition to intravenous antibiotics, in treatment of patients with chemotherapy induced febrile neutropenia accelerates neutrophil recovery, and shortens antibiotic therapy and hospitalization. We propose to risk classify the patients at the time of admission to evaluate the cost effectiveness of this approach in a resource constrained setup.

• Design & Manufacturing
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• 제14권1호
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• pp.1-7
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• 2020

In this study, the variation of the shrinkage in the thickness direction of the molded parts according to the gate size of the polymer core fabricated through the 3D printer using the SLS method was studied. The polymer cores are laser sintered and the powder material is nylon base PA2200. The polymer cores have lower heat transfer rate and rigidity than the metal core due to the characteristics of the material. Therefore, the injection molding test conditions are set to minimize the deformation of the core during the injection process. The resin used in the injection molding test is a PP material. The packing condition was set to 80, 90 and 100% of the maximum injection pressure for each gate size. The runner diameter used was ∅3mm, and the gates were fabricated in semicircle shapes with cross sections 1, 2, and 3 ㎟, respectively. Thickness measurement was performed for 10 points at 2.5 mm intervals from the point 2.5 mm away from the gate, and the shrinkage to thickness was measured for each point. The shrinkage rate according to the gate size tends to decrease as the cross-sectional area decreases as the maximum injection pressure increases. The average thickness shrinkage rate was close to 0% when the packing pressure was 90% for the gate area of 1mm2. When the holding pressure was set to 100%, the shrinkage was found to decrease by 3% from the standard dimension due to the over-packing phenomenon. Therefore, the smaller the gate, the more closely the molded dimensions can be molded due to the high pressure generation. It was confirmed that precise packing process control is necessary because over-packing phenomenon may occur.

• 한국자동차공학회논문집
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• 제17권2호
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• pp.98-103
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• 2009

The environment and energy related problem has become one of the most important global issues in recent years. One of the most effective ways of improving the fuel efficiency of automobiles is the weight reduction. In order to obtain this goal the hydroforming technology has been adapting for the high strength steel and its application is being widened. In present study, the chassis components (mainly cross members of engine cradle) simulation and development by hydroforming technology to apply high strength steel having tensile strength of 440 MPa grade is studied. In the part design stage, it requires feasibility study and process design aided by CAE (Computer Aided Design) to confirm hydroformability in details. Overall possibility of hydroformable chassis parts could be examined by cross sectional analyses. Moreover, it is essential to ensure the formability of tube material on every forming step such as pre-bending, performing and hydroforming. In the die design stage, all the components of prototyping tool were designed and interference with press was investigated from the point of geometry and thinning.

• 한국자동차공학회논문집
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• 제16권1호
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• pp.86-92
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• 2008

Recently, the use of tubes in the manufacturing of the automobile parts has increased and therefore many automotive manufactures have tried to use hydro-forming technology. The hydro-forming technology may cause many advantages to automotive applications in terms of better structural integrity of the parts, lower cost from fewer part count, material saving, weight reduction, lower spring-back, improved strength and durability and design flexibility. In this study, the whole process of front engine cradle (or front sub-frame) parts development by tube hydro-forming using steel material having tensile strength of 440MPa grade is presented. At the part design stage, it requires feasibility study and process design aided by CAE (Computer Aided Design) to confirm hydro-formability in details. Effects of parameters such as internal pressure, axial feeding and geometry shape on automotive sub-frame by hydro-forming process were carefully investigated. Overall possibility of hydro-formable sub-frame parts could be examined by cross sectional analyses. Moreover, it is essential to ensure the formability of tube material on every forming step such as pre-bending, preforming and hydro-forming. At the die design stage, all the components of prototyping tools are designed and interference with press is examined from the point of geometry and thinning.

• 한국정밀공학회지
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• 제23권4호
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• pp.153-161
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• 2006

Micro-forming is a suited technology to manufacture very small metallic parts(several $mm{\sim}{\mu}m$). Micro-forming of $Zr_{62}Cu_{17}Ni_{13}Al_8$ bulk metallic glass(BMG) as a candidate material for this developing process are feasible at a relatively low stress in the supercooled liquid state without any crystallization during hot deformation. In this study, micro- formability of a representative bulk metallic glass, $Zr_{62}Cu_{17}Ni_{13}Al_8$. was investigated for micro-forging of U-shape pattern. Micro-formability was estimated by comparing $R_f$ values ($=A_f/A_g$), where $A_g$ is cross-sectional area of U groove, and $A_f$ the filled area by material. Micro-forging process was simulated and analyzed by applying finite element method. FEM simulation results showed reasonable agreement with the experimental results when the material properties and simulation conditions such as top die speed, remeshing criteria and boundary conditions were tightly controlled. The micro-formability of $Zr_{62}Cu_{17}Ni_{13}Al_8$ was increased with increasing load and time in the temperature range of the supercooled liquid state. Also, FEM simulation using a commercial software, DEFORM was confirmed to be applicable for the optimization of micro-forming process.

• 한국산학기술학회논문지
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• 제19권9호
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• pp.1-6
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• 2018

하이드로포밍 기술은 지난 20년간 자동차부품의 적용을 중심으로 비약적인 발전을 해 왔다. 이 기술은 자동차 산업응용분야에 많은 장점을 가지고 있는데 이는 더 나은 구조적 강건성, 부품수 감소에 기인한 비용절감, 재료절약, 무게감소, 낮은 스프링백현상, 개선된 강도, 내구성 향상, 설계 유연성 등이다. 하이드로포밍 부품의 성형성 검토를 위하여 다양한 컴퓨터 시뮬레이션 기술 등이 발달해 왔으며 이를 통해 성형 가능성을 검토하는 것과 동시에 성형을 위하여 벤딩 공정, 프리포밍공정, 다이클로징 공정 등의 효율적인 공정을 수립하여 하이드로포밍 부품들을 설계하고 있다. 이에 본 연구에서는 하이드로포밍 부품 설계 시 고려사항 중 성형량, 부품의 단면길이(하이드로포밍 프레스 용량에 맞는), 최소 곡률(하이드로포밍 압력에 따른 곡률 영향 평가) 등을 제시하고 실제 자동차용 리어 서브-프레임 부품의 단면분석을 실시함으로써 하이드로포밍 성형을 위한 설계 방안을 제시하고자 한다. 아울러 하이드로포밍 공정인자 중 프리벤딩, 축피딩, 유압 압력, 프레스 하중, 마찰 등의 효과를 분석하여 이들 공정이 직접적인 하이드로포밍 성형에 필요인자 인지 등을 고찰하였다.

• 농업과학연구
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• 제22권1호
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• pp.11-23
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• 1995

The CAD/CAM system for the manufacturing automation is the newest technology in mechanical engineering area and becomes the important research subject nowadays. Most of all hardwares and softwares for the CAD/CAM system used in the our manufacturing companies such as automobile company are developed by the foreign country and the purchasing price of them is very expensive but their applicability to a certain area is very limited. This study was conducted to develope a CAD/CAM system for the design and the automatic manufacturing of the iron pattern shaped with 3 - dimensional free curved surface, and to test its applicability to the design and the manufacturing of the rotary blade. The results obtained from the study are as follow; 1. The CAD system which can process graphic procedures from the free curved surface shaped data was developed with personal computer. 2. The CAM main program was developed. This main program could produce CL data from CAD data file by checking the tool interference according to the cutting mode. 3. The sub. program which can simulate the tool trace from the CL data was developed. 4. The post processor for the Deckel FP2NC NC milling machine from CL data file was developed and the sub program could transmit NC program through modem to NC milling machine was developed. 5. The developed CAM system seemed to be applicable to any other system. Because the measuring results of the cross sectional thickness of the plastic model from the manufacturing iron pattern by the system showed that this system could properly check the tool interference. 6. In took 75~90 hours to manufacture two iron patterns of rotary blade. For the sake of convenience in applying to the other systems, this system was developed in BASIC and FORTRAN computer language and minimum portion of machine language as possible.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.589-592
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• 2005

Micro-forming is a suited technology to manufacture very small metallic parts(several $mm{\sim}{\mu}m$). Micro-forming of $Zr_{62}Cu_{17}Ni_{13}Al_8$ bulk metallic glass(BMG) as a candidate material for this developing process are feasible at a relatively low stress in the supercooled liquid state without any crystallization during hot deformation. In this study, micro-formability of a representative bulk metallic glass, $Zr_{62}Cu_{17}Ni_{13}Al_8$, was investigated for micro-forging of U-shape pattern. Micro-formability was estimated by comparing $R_f$ values $(=A_f/A_g)$, where Ag is cross-sectional area of U groove, and $A_f$ the filled area by material. Microforging process was simulated and analyzed by applying finite element method. FEM simulation results should reasonable agreement with the experimental results when the material properties and simulation conditions such as top die speed, remeshing criteria and boundary conditions tightly controlled. The micro-formability of $Zr_{62}Cu_{17}Ni_{13}Al_8$ was increased with increasing load and time in the temperature range of the supercooled liquid state. Also, FEM Simulation using DEFORM was confirmed to be applicable for the micro-forming process simulation.

• Design & Manufacturing
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• 제14권4호
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• pp.11-16
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• 2020

In this study, forming of carbon composite parts was performed using an injection/compression molding process. An impregnation of matrix is determined by ability of wet and flow rate between the matrix and reinforcement. The flow rate of matrix passing through the reinforcements is a function of permeability of reinforcement, a viscosity of matrix and pressure gradient on molding, and the viscosity of the matrix depends on the mold temperature, molding pressure and shear strain of matrix. Therefore, compression molding experiment was conducted using a heating mold in order to confirm the possibility of matrix impregnation. The impregnation of the matrix through the porosities between the woven yarns was confirmed by the cross-sectional SEM image of compression molded parts. An injection molding process was also performed at a short cycle time, high molding pressure and low mold temperature than those of compression experiment conditions. Deterioration of impregnation on the surface of molded parts were caused by these injection conditions and it could be the reason of decreasing the maximum tensile strength. In order to improve impregnation of matrix on the surface, injection/compression molding and insert-over molding were applied. As a result of applying injection/compression molding and insert-over molding, it was shown that the improvement of impregnation on the surface and the maximum tensile strength was increased about 2.8 times than the virgin matrix.

• 구강회복응용과학지
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• 제25권2호
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• pp.95-107
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• 2009

본 연구의 목적은 전통적인 소결 방법과 마이크로 웨이브 소결 방법에 의해 제작된 지르코니아 코아의 내부 및 변연 적합도를 알아보는 것이다. 본 실험은 기존의 소결로를 이용하는 $3M^{(R)}$의 Lava(LAV), $Kavo^{(R)}$사의 Everest(EVE), $Cerasys^{(R)}$ CAD/CAM 시스템(CER)과 마이크로웨이브 소결로를 이용하는 Dent. $solution^{(R)}$사의 CAD/CAM 시스템(DEN)에서 시스템별로 12개씩의 코아를 제작하고 실리콘 접착제를 이용하여 금속 다이에 부착시켰다. $Skyscan^{(R)}$ 1076 미세 단층 촬영기를 이용해 각각의 시편을 촬영한 후 재구성하였다. 각 시편에 대해 B-L상, M-D상 절단면 및 치아 장축에 대한 횡단면을 구해내고 각각의 단면에 대해 변연 간격, 축면 간격, 교합면 간격을 측정하였다. 실험에 대한 결과는 다음과 같다. 1. 변연 간격은 EVE가 $36.20{\mu}m$로 가장 작았고, LAV는 $47.67{\mu}m$, DEN는 $52.47{\mu}m$, CER은 $54.63{\mu}m$를 나타내었다. 2. 축면 간격은 EVE가 $63.49{\mu}m$로 가장 큰 값을 나타내었으나 네군간에는 유의차는 없었다. 3. 교합면 간격은 DEN이 $77.06{\mu}m$으로 가장 작은 값을 나타내었으며, EVE와 CER은 $100{\mu}m$를 넘는 값으로 다른 두군과 유의차를 보였다. 본 연구에서 마이크로웨이브 소결을 통해 제작된 CAD/CAM 지르코니아 코아는 임상적으로 허용할 만한 변연 간격 및 축면 간격, 교합면 간격을 보여 주었다.