• Korean Journal Plant Pathology
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• v.11 no.3
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• pp.271-277
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• 1995

The RNA nucleotide sequences of the 3/-noncoding regions (3'-NCRs) of two Korean strains of turnip mosaic virus (TuMV), Ca and cqs, have been determined from their cDNA clones that encompassed the 3'-terminal regions of the viral genomic RNAs. The 3'-NCRs of both strains were 209 nucleotides long, terminated with GAC residues and poly (A) tails. The potential polyadenylational signal motif, UAUGU, was located 140 nucleotides upstream from the poly (A) tail in each of the virus. A highly conserved hexanucleotide sequence [A G U G A/U G/C], which was common in the 3'-NCRs of the potyvirus RNAs, was also found at the regions of 119 bases upstream from the 3'-end. Comparison of the 3'-NCRs of the two Korean isolates with those of four strains from Canada, China and Japan showed significantly identical genotypes (94.3∼99.5%). The secondary structure of three loops with long stems was found within the 3'-NCRs by sequence analysis. The substituted bases in the region among the six TuMV strains did not alter their secondary structures. Length of the 3'-NCRs of the know 11 potyviral RNAs and TuMV RNAs was different from one another and their nucleotide sequences showed 55.7% to 24.0% of homology. The 3'-NCR, therefore, is considered to be useful for phylogenetic studies in potyviruses.

• International Journal of Human Ecology
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• v.8 no.2
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• pp.75-83
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• 2007

Korean secondary school students (n=263) responded to surveys measuring their family contexts and school adjustment during the time period August-September 2004. Structure Equation Modeling tests were conducted to identify the nested model on school adjustment, a latent variable constructed with peer relations, teacher-adolescent relations, and academic attitude. In the nested model, parental involvement was a powerful predictor for school adjustment. Family conflict had a negative impact on school adjustment and was statistically significantly when correlated with the other predictors in the model. These finding suggested that family contexts play an important role in Korean adolescents' school adjustment. Hence, adolescents' perceived GPA level and satisfaction for school were important predictors for school adjustment.

• Genomics & Informatics
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• v.11 no.3
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• pp.155-160
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• 2013

Structural information has been a major concern for biological and pharmaceutical studies for its intimate relationship to the function of a protein. Three-dimensional representation of the positions of protein atoms is utilized among many structural information repositories that have been published. The reliability of the torsional system, which represents the native processes of structural change in the structural analysis, was partially proven with previous structural alignment studies. Here, a web server providing structural information and analysis based on the backbone torsional representation of a protein structure is newly introduced. The web server offers functions of secondary structure database search, secondary structure calculation, and pair-wise protein structure comparison, based on a backbone torsion angle representation system. Application of the implementation in pair-wise structural alignment showed highly accurate results. The information derived from this web server might be further utilized in the field of ab initio protein structure modeling or protein homology-related analyses.

• Computers and Concrete
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• v.31 no.4
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• pp.337-348
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• 2023

Shear wall is commonly used as a lateral force resisting system of concrete mid-rise and high-rise buildings, but it brings challenges in providing relatively large space throughout the building height. For this reason, the structure system where the upper structure with bearing, non-bearing and/or shear walls that sits on top of a transfer plate system supported by widely spaced columns at the lower stories is preferred in some regions, particularly in low to moderate seismic regions in Asia. A thick reinforced concrete (RC) plate has often been used as a transfer system, along with RC transfer girders; however, the RC plate becomes very thick for tall buildings. Applying the post-tensioning (PT) technique to RC plates can effectively reduce the thickness and reinforcement as an economical design method. Currently, a simplified model is used for numerical modeling of PT transfer plate, which does not consider the interaction of the plate and the upper structure. To observe the actual behavior of PT transfer plate under seismic loads, it is necessary to model whole parts of the structure and tendons to precisely include the interaction and the secondary effect of PT tendons in the results. This research evaluated the seismic behavior of shear wall-type residential buildings with PT transfer plates for the condition that PT tendons are included or excluded in the modeling. Three-dimensional finite element models were developed, which includes prestressing tendon elements, and response spectrum analyses were carried out to evaluate seismic forces. Two buildings with flat-shape and L-shape plans were considered, and design forces of shear walls and transfer columns for a system with and without PT tendons were compared. The results showed that, in some cases, excluding PT tendons from the model leads to an unrealistic estimation of the demands for shear walls sit on transfer plate and transfer columns due to excluding the secondary effect of PT tendons. Based on the results, generally, the secondary effect reduces shear force demand and axial-flexural demands of transfer columns but increases the shear force demand of shear walls. The results of this study suggested that, in addition to the effect of PT on the resistance of transfer plate, it is necessary to include PT tendons in the modeling to consider its effect on force demand.

• Proceedings of the KSME Conference
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• 2008.11b
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• pp.2589-2593
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• 2008

In a fuel cell vehicle using polymer electrolyte membrane fuel cell(PEMFC), hydrogen is over-supplied to gain higher stack efficiency. So it is needed considering fuel efficiency to re-circulate hydrogen which is not reacted in stack. And to re-circulate hydrogen, a blower or an ejector is used. Ejector re-circulation system has several merits compared with blower system, for example no parasite energy, simple structure and no lubrication system. But the secondary flow of an ejector in fuel cell vehicle, has high humidity because of crossover problem in stack. Therefore in this paper, ejector is designed by 1-D modeling and CFD with the primary and secondary flow of hydrogen. And the ejector which has the primary and secondary flow of air, is designed to have the same Reynolds number and Mach number at the nozzle exit as the hydrogen ejector's. And this air ejector is tested while the humidity of the secondary flow is varied.

• Structural Engineering and Mechanics
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• v.89 no.1
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• pp.23-31
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• 2024

Ratcheting is the cyclic buildup of inelastic strain on a structure resulting from a combination of primary and secondary cyclic stress. It can lead to excessive plastic deformation, incremental collapse, or fatigue. Ratcheting has been numerically investigated on a cantilever beam, considering the current study's primary and secondary bending loads. In addition, the effect of input frequency on the onset of ratcheting has been investigated. The non-linear dynamic elastic-plastic approach has been utilized. Analogous to Yamashita's bending-bending ratchet diagram, a non-dimensional ratchet diagram with a frequency effect is proposed. The result presents that the secondary stress values fall sequentially with the increase of primary stress values. Moreover, a displacement amplification factor graph is also established to explain the effect of frequency on ratchet occurrence conditions. In terms of frequency effect, it has been observed that the lower frequency (0.25 times the natural frequency) was more detrimental for ratchet occurrence conditions than the higher frequency (2 times the natural frequency) due to the effect of dynamic displacement. Finally, the effect of material modeling of ratcheting behavior on a beam is shown using different hardening coefficients of kinematic hardening material modeling.

• Journal of Photoscience
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• v.9 no.2
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• pp.66-69
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• 2002

Zinc chlorin 1 possessing tertiary 3$^1$_hydroxy and 13$^1$-oxo groups was synthesized as a model for the antenna chlorophylls of photosynthetic green bacteria. Self-aggregation of 1 in nonpolar organic solvents was examined and compared to 2 and 3 possessing a secondary and primary 3$^1$_hydroxy group, respectively. Zinc chlorin 1 self-aggregated in I％(v/v) CH$_2$Cl$_2$-hexane to form oligomers and showed a red-shifted Qy maximum at 704 nm compared to the monomer (648 nm in CH$_2$CI2$_2$). This red-shift is larger than that of 3$^1$S-2 (648 to 697 nm) and comparable to that of3$^1$R-2 (648 to 705 nm), but smaller than that of 1 (648 to 740 nm), indicating that while a single 3$^1$-methyl group (primary to secondary OH) suppressed tight and/or extended aggregation, the additional 3$^1$-methyl group (secondary to tertiary OH) did not further suppress aggregation. The relative stability of the aggregates was in the order 3> 3$^1$R-2∼ 1 > 3$^1$S-2 as determined by visible spectral analyses. Molecular modeling calculations on oligomers of zinc chlorins 1, 3$^1$ R-2 and 3 gave similar well-ordered energy-minimized structures, while 3 stacked more tightly than 3$^1$ R- 2 and 1. In contrast, 3$^1$S-2 gave a relatively disordered (twisted) structure. The calculated oligomeric structures could explain the visible spectral data of 1-3 in nonpolar organic solvents. Moreover, self- aggregation of synthetic zinc 13$^1$_oxo-hlorins 4-6 possessing a 2-hydroxyethyl, 3-hydroxypropyl and 3- hydroxy-I-propenyl group at the 3-position in nonpolar organic solvents was discussed.

• Health Policy and Management
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• v.11 no.2
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• pp.123-140
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• 2001

Hypotheses In health services research are becoming increasingly more complex and specific. As a result, health services research studies often include multiple independent, intervening, and dependent variables in a single hypothesis. Nevertheless, the statistical models adopted by health services researchers have failed to keep pace with the increasing complexity and specificity of hypotheses and research designs. This article introduces a statistical model well suited for complex and specific hypotheses tests in health services research studies. The covariance structure modeling(CSM) methodology is especially applied to regional relevance indices(RIs) to assess the impact of health resources and healthcare utilization. Data on secondary statistics and health insurance claims were collected by each catchment area. The model for RI was justified by direct and indirect effects of three latent variables measured by seven observed variables, using ten structural equations. The resulting structural model revealed significant direct effects of the structure of health resources but indirect effects of the quantity on RIs, and explained 82% of correlation matrix of measurement variables. Two variables, the number of beds and the portion of specialists among medical doctors, became to have significant effects on RIs by being analyzed using the CSM methodology, while they were insignificant in the regression model. Recommendations for the CSM methodology on health service research data are provided.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1684-1689
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• 2003

This paper concerns the analytical modeling and dynamic analysis of advanced cantilevered blade structure implemented by a dual approach based on structural tailoring and viscoelastic materials technology. Whereas structural tailoring uses the directionality properties of advanced composite materials, the passive materials technology exploits the damping capabilities of viscoelastic material(VEM) embedded into the host structure. The structure is modeled as a composite thin-walled beam incorporating a number of nonclassical features such as transverse shear, secondary warping, anisotropy of constituent materials, and rotary inertias. The case of VEM spreaded over the entire span of the structure is considered. The displayed numerical results provide a comprehensive picture of the synergisitic implications of the application of both techniques, namely, the tailoring and damping technology on vibration response of thin-walled beam structure exposed to external time-dependent excitations.