• Journal of Microbiology and Biotechnology
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• v.26 no.3
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• pp.441-451
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• 2016

Squalene is a linear triterpene formed via the MVA or MEP biosynthetic pathway and is widely distributed in bacteria, fungi, algae, plants, and animals. Metabolically, squalene is used not only as a precursor in the synthesis of complex secondary metabolites such as sterols, hormones, and vitamins, but also as a carbon source in aerobic and anaerobic fermentation in microorganisms. Owing to the increasing roles of squalene as an antioxidant, anticancer, and anti-inflammatory agent, the demand for this chemical is highly urgent. As a result, with the exception of traditional methods of the isolation of squalene from animals (shark liver oil) and plants, biotechnological methods using microorganisms as producers have afforded increased yield and productivity, but a reduction in progress. In this paper, we first review the biosynthetic routes of squalene and its typical derivatives, particularly the squalene synthase route. Second, typical biotechnological methods for the enhanced production of squalene using microbial cell factories are summarized and classified. Finally, the outline and discussion of the novel trend in the production of squalene with several updated events to 2015 are presented.

• Journal of Fisheries and Marine Sciences Education
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• v.3 no.1
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• pp.27-34
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• 1991

History of the fisheries education in the secondary schools in Japan has began in 1901, and it greatly contributed to the development of fishing industry in Japan. Also this education system affected to her some neighboring countries. e.g. Korea, Taiwan, etc. According to the fundamental change of the education system after cease of the 2nd World War, fisheries middle schools were rearranged to fisheries high schools. and the activity of the graduates widely contributed to push up the total catch of fish in Japan to the first world rank since the 1970s. Nevertheless, the education in fisheries high schools is confronted to much problems, because of the rapid decrease of the man power who desires to work in the field of fisheries especially onboard fishing vessels in accordance with the rapid progress of industrialization and service economization. Such problems are taking place not only in Japan but also right now in Korea. To find out some countermeasure against the problems. the auther studied on the present status and the problems confronting in the education of fisheries high schools in Japan through some references. with heartful desires this study to be able to contribute to the sucessive development of the education on fisheries high schools and also the productivity of fisheries in Korea.

• Journal of Korean Academy of Nursing Administration
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• v.8 no.2
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• pp.207-219
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• 2002

The purposes of this research were to: a) define the changing trends of DRGs in comparison to the National Data, b) define the changing trends of Nursing Diagnoses and Nursing Interventions for the 5 most frequently occurring Diagnostic Related Groups (DRGs) across 3 years, and c) define the relationships between nursing diagnoses and nursing Interventions for the 5 most frequently occurring DRGs across the 3 years. This study was a secondary data analysis of medical and nursing data based on the United States Nursing Minimum Data Set and the Uniform Hospital Discharge Data Set retrieved from a Midwestern USA medical center. The results showed interesting comparisons with national statistics as well as practice relevant trends within the nursing data. Additionally, the results showed the possibility that nursing data can be extracted from the medical data, so they can used in the nursing productivity and cost issues etc. In conclusion, this study supports the power of minimum data sets and nursing classifications to begin to describe a more global perspective the inter-relationships and trends of nursing data within the medical diagnosis context.

• 한국생물공학회:학술대회논문집
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• 2000.11a
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• pp.155-158
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• 2000

Production of decursinol angelate, a new potential anticancer agent, in Angelica gigas Nakai root culture was increased by treatment of $H_2O_2$, and various polysaccharides such as $CM-\;{\beta}\;-cyclodextrin$, glucan, $CM-\;{\beta}\;-chitin$, yeast extract and pectin. One mmole $H_2O_2$ enhanced the production of decursinol angelate. However, higher concentrations of $H_2O_2$ were founded to be toxic for root growth whereas specific productivity of decursinol angelate was increased at high concentrations of $H_2O_2$. In the case of polysaccharide elicitors, $CM-\;{\beta}\;-chitin$ was the most effective for enhanced production of secondary metabolite in A. gigas Nakai root culture.

• Fashion, Industry and Education
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• v.14 no.2
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• pp.11-23
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• 2016

This study investigated the comparative advantages of the Bangladeshi and Vietnamese apparel industries using Global Value Chain (GVC) framework. In this study, the GVC framework was expanded to include social and environmental sustainability issues. Secondary data, for the 2012 - 2013 period, were collected and analyzed for each component of the apparel GVC. The findings indicated that while both countries have unique comparative advantages, Vietnam clearly emerged as a leader on many GVC components. Bangladesh's comparative advantage lies in lower wages, producing high volume orders, and lean manufacturing. In spite of Vietnam's higher labor costs, it has comparative advantages in higher productivity, skilled and trained workers, manufacturing of intricate styles of high quality, agility and flexible manufacturing, more developed infrastructure and logistic services as well as greater social and environmental compliances. This study contributes towards insight into best sourcing fit for fashion brand business models. Based on the findings, fashion driven companies offering more complex styles at a faster rate will benefit from choosing Vietnam. In contrast, Bangladesh might be a better choice for high volume driven companies that offer basic apparel and better value for their consumers. From theoretical perspective, the research makes an important contribution by expanding the GVC framework.

• Journal of the Korean Solar Energy Society
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• v.30 no.1
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• pp.25-33
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• 2010

Use of daylight in underground space interacts with physiological need for human beings and provides relief from feeling secluded. Light pipe system can deliver natural light into the space where it is needed and can be used as primary or a secondary light source with benefits of energy, productivity and health. To use light pipe system effectively under various conditions, it is important to investigate the effectiveness of light pipe system with reliable monitoring protocol. This paper presents the results of light pipe system performance used in underground parking lot under different sky conditions. Comparisons were made between the illuminance standards of underground parking lot and the monitored data. The results indicated that adequate illuminance level was shown until 4.5m distance from the light pipe under clear sky condition. However, additional lighting device showed be used under overcast sky to meet the proper illuminance level.

• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.5
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• pp.269-278
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• 2003

Gibberellic acid (GA$_3$) is a commercially important plant growth hormone, which is gaining much more attention all over the world due to its effective use in agriculture and brewing industry. Industrially it is produced by submerged fermentation technique using Ascomycetous fungus Gibberella fujikuroi. Solid state and immobilized cell fermentation techniques had also been developed as an alternative to obtain higher yield of GA$_3$. This review summarizes the problems of GA$_3$ fermentation such as production of co-secondary metabolites along with GA$_3$, substrate inhibition and degradation of GA$_3$ to biologically inert compound gibberellenic acid, which limits the yield of GA$_3$ in the fermentation medium. These problems can be overcome by various bioprocessing strategies e.g. two - stage and fed batch cultivation processes. Further research on bioreactor operation strategies such as continuous and / or extractive fermentation with or without cell recycle / retention system need to be investigated for improvement in yield and productivity. Down stream processing for GA$_3$ isolation is also a challenge and procedures available for the same have been critically evaluated.

• Journal of Microbiology and Biotechnology
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• v.12 no.4
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• pp.687-691
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• 2002

To enhance the production of flavonoids [baicalin, wogonin-7-Ο-glucuronic acid (GA)], which are secondary metabolites of Scutellaria baicalensis Georgi(G.) plant cells, a multilayer perceptron control system was applied to regulate the substrate feeding in a fed-batch cultivation. The optimal profile for the substrate feeding rate in a fed-batch culture of S. baicalensis G. was determined by simulating a kinetic model using a genetic algorithm. Process variable profiles were then prepared for the construction of a multilayer perceptron controller that included massive parallelism, trainability, and fault tolerance. An error back-propagation algorithm was applied to train the multiplayer perceptron. The experimental results showed that neurocontrol incorporated with a genetic algorithm improved the flavonoid production compared with a simple fuzzy logic control system. Furthermore, the specific production yield and flavonoid productivity also increased.

• Journal of the Korean Solar Energy Society
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• v.31 no.2
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• pp.31-36
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• 2011

LED is expected as an environmentally friendly next generation light source with its good reliability and long lifetime. The light sources for illumination have a variety of applications in the indoor and outdoor, and the variation of optical power and color rendering of the light source limits their applications. Therefore, it is necessary to research the LED lamp and its luminaire to minimize the variation of dynamic characteristics and to improve the color rendering due to that illuminating environment. Daylight is very good light source to human and can be used as primary or a secondary light source with benefits of energy, productivity and health.This paper presents the design method of LED lighting system to improve poor property in terms of CR(color redering) characteristic to use daylight effectively.

• The Plant Pathology Journal
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• v.35 no.5
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• pp.406-416
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• 2019

Strawberry, an important fruit crop, is susceptible to a large number of pathogens that reduce fruit quality and productivity. In this study, the effect of a biostimulant prepared from Ascophyllum nodosum extract (ANE) (0.1%, 0.2%, and 0.3%) was evaluated on powdery mildew progression under greenhouse and field conditions. In the greenhouse, application of 0.2% ANE showed maximum reduction in powdery mildew progression as compared to the control. Forty-eight hour post-inoculation, foliar spray of 0.2% ANE reduced spore germination by 75%. Strawberry leaves sprayed with ANE showed higher total phenolic and flavonoid content in response to powdery mildew infection. Furthermore, application of ANE elicited defense response in strawberry plants by induction of defense-related enzymes, such as phenylalanine ammonia lyase, polyphenol oxidase, and peroxidase activity. In field conditions, foliar spray of 0.2% ANE showed a reduction of 37.2% of natural incidence of powdery mildew infection as compared to the control. ANE sprayed plant also reduces the severity of powdery mildew infection under natural conditions. These results indicate that application of ANE induces the strawberry plant's active defense against powdery mildew infection by induction of secondary metabolism and regulating the activities of defense-related enzymes.