• Genomics & Informatics
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• 제21권1호
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• pp.6.1-6.8
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• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• 한국농공학회논문집
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• 제65권6호
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• pp.51-63
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• 2023

To improve the problem that the settlement curve of the consolidation theory of Terzaghi does not match well with the actual settlement curve, we included a secondary compression settlement and analyzed it by varying the beginning point and then obtained the following results. The current methods of calculating the compression index from the  log𝜎 curve and the coefficient of consolidation from the time-dependent settlement curve for each consolidation pressure proved that the final settlement amount will be consistent after a long time, but the actual settlement amount will always be smaller than the predicted settlement amount during the settlement progress stage. The consolidation factors estimated by the curve fitting with the condition that the secondary compression begins in the second half of the primary compression showed similar values to the consolidation factors estimated by the curve fitting for the primary compression only, and the settlement curves were in better agreement throughout the compression. It showed different values, showing low validity. It can be inferred that secondary compression acts from the point when a significant portion of the excess pore water pressure is dissipated, and the loading stress begins to have more influence on the skeletal structure of the soil. Analysis results show that secondary compression begins at the range of 91 % to 98 % on the average degree of primary consolidation.

• 대한소아치과학회지
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• 제51권1호
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• pp.22-31
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• 2024

The objective of this study was to assess the wear resistance of tooth-colored materials used in crown restoration for primary molars with a chewing simulator. In this study, four groups-three experimental groups and one control group-were included. They consisted of three-dimensional (3D) printed resin crowns (NextDent and Graphy), milled nano-hybrid ceramic crowns (MAZIC Duro), and prefabricated zirconia crowns (NuSmile). Twelve mandibular second molar specimens were prepared from each group. In the wear experiment, 6.0 × 10⁵ cycles were conducted with a force of 50 N, and a 6 mm-diameter steatite ball was used as an antagonist. The amount of wear was calculated by comparing the scan files before and after the chewing simulation using 3D metrology software, and the worn cross-section was confirmed by scanning electron microscopy (SEM). The resin and ceramic groups did not exhibit any statistically significant differences. However, compared to other crown groups, the zirconia crown group demonstrated notably reduced levels of wear (p < 0.05). In SEM images, layers and cracks were observed in the 3D-printed resin crown groups, which differed from those in the other groups.

• 대한소아치과학회지
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• 제26권2호
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• pp.446-452
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• 1999

제 1 대구치의 이소 맹출이란 제 1 대구치가 비정상적인 맹출 경로를 취해 제 2 유구치의 비정상적인 조기 흡수를 일으키는 경우를 뜻한다. 비가역적 이소 맹출의 경우 제 2 유구치의 조기상실은 공간 상실, 제 1 대구치의 근심 경사, 제 2 소구치의 함몰, 총생과 대합치의 과맹출등을 야기시킨다. 치료의 주목적은 (1) 제 2 유구치의 조기 상실을 막아 공간 유지의 역할을 하게하고 (2) 상실된 치열장을 회복해 제 2 소구치의 정상적인 맹출을 돕는 것이다. 치료 방법은 제 1 대구치의 맹출 정도, 제 1 대구치의 위치 변화, 제 1 대구치가 걸려있는 제 2 유구치의 enamel ledge양, 제 2 유구치의 동요도, 동통이나 염증의 유무에 의해 결정된다. 제 1 대구치의 근심 경사의 치료에 사용되는 대부분의 편측성 장치는 결과적으로 공간 상실을 증가시키는 힘을 가하게 된다. 따라서 고정원의 보강을 위해 holding arch와 같은 양측성 고정원의 사용이 추천되고 있다. 본 증례 보고는 삼성 서울 병원을 내원한 환아중 제 1 대구치의 비가역적 이소 맹출로 제 2 유구치의 치근 흡수와 동요도 증가를 보이는 환아에서 양측성 고정원을 이용한 장치를 사용해 제 2 소구치의 정상적인 맹출에 필요한 충분한 공간을 유지할수 있었기에 이에 보고하는 바이다.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제17권1호
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• pp.15-27
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• 2013

Division of fractions is always a difficult topic for primary school students. Most of the presentations in teaching the topic in textbooks are procedural, asking students to invert the second fraction and multiply it with the first one, that is, $$\frac{a}{b}{\div}\frac{c}{d}=\frac{a}{b}{\times}\frac{d}{c}$$. Such procedural approach in teaching diminishes both the understanding of structure in mathematics and the interest in learning the subject. This paper discussed the formulation of teaching the division of fractions, which based on research lessons in some primary five classrooms. The formulated lessons started with an analogy to division of integers and working with division of fractions with equal denominators and then extended to division of fractions in general. It is found that the using of analogy helps students to invent their procedure in working the division problem. Some procedures found by students are discussed, with the focus on the development of their invention and mathematical thinking.

• 대한인간공학회지
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• 제31권1호
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• pp.157-163
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• 2012

Objective: This study is to understand medical management method in shipbuilding industry. Background: In shipbuilding industry, medical management for prevention of work-related musculoskeletal diseases due to limitations of engineering measures may be important measure. Results: Medical management of musculoskeletal diseases can be divided into primary, secondary, tertiary preventions. Primary preventions consist of symptom survey, appropriate work placement with work capacity evaluation, health promotion. Second preventions are early detection of symptomatic patient and appropriate treatment. Tertiary preventions are rehabilitation treatment and early return-to-work by return-to-work evaluation. In addition, patients with psychological counseling for emotional problems are needed. Conclusion: Medical management measures such as improving the work environment to be made are expected to exert greater effects.

• 한국식품영양과학회지
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• 제32권4호
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• pp.645-653
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• 2003

Taste receptor cells respond to gustatory stimuli using a complex arrangement of receptor molecules, signaling cascades and ion channels. When stimulated, these cells produce action potentials that result in the release of neurotransmitter onto an afferent nerve fiber that in turn relays the identity and intensity of the gustatory stimuli to tie brain. A variety of mechanisms are used in transducing the four primary tastes. Direct interaction of the stimuli with ion channels appears to be of particular importance in transducing stimuli reported as salty or sour, whereas tile second messenger systems cyclic AMP and inositol trisphosphate are important in transducing bitter and sweet stimuli. In addition to the four basic tastes, specific mechanisms exist for the amino acid glutamate, which is sometimes termed the fifth primary taste. The emerging picture is that not only do individual taste qualities use more than one mechanism, but multiple pathways are available for individual tastants as well.

• Journal of Chest Surgery
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• 제23권2호
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• pp.396-401
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• 1990

This report is an review of 5 cases of congenital esophageal atresia associated with tracheoesophageal fistula which were treated in the Department of Thoracic and Cardiovascular Surgery, Chonnam University Hospital from January, 1987 to February, 1989. First patient that was associated with VATER’s syndrome and moderate pneumonia, i.e., Waterston Category C was treated by gastrostomy, colostomy and primary anastomosis, but expired. Second patient that was weighed 2.2 Kg, suffered from moderate pneumonia was treated by gastrostomy, but died from asphyxia. The other patients were treated by primary repair. Any anastomotic leakage or gastroesophageal reflux was not found in these cases, but mild anastomotic strictures were found in these patients by postoperative esophagography. However, esophageal dilatation of anastomotic strictures was successful using the Griintzig balloon catheter.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1994년도 가을 학술발표회 논문집
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• pp.200-204
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• 1994

Low temperature associated damage mechanism is not well known for asphalt concrete. Many studies have related the thermal cracking of pavement in the roadway in cold region with overall shrinkage of the pavement surface under assumption of homogeneous material. This study, however, was intiated based on the assumption that thermal incompatibility of materials (heterogeneous) in asphalt concrete mixture would be the primary cause of the damages. Acoustic emission technique and microscopic obsevation were employed to evaluate damage mechanism of asphalt concrete due to low temperature. The first method showed the sufficient evidence that asphalt concrete could be damaged by lowered temperature only. The second method showed that the damage by temperature resulted in micro-cracks at the interface between asphalt matrix and aggregate particle. It was concluded that these damage mechanisms were the primary cause of major thermal cracking of asphalt pavement in cold region.

• 한국학교보건학회지
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• 제1권1호
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• pp.148-159
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• 1988

For the evaluation of physical assessment by school nurses, this study was designed in two steps physical assessment. The first step is the primary health screening by school health nurses. The second step is the Physicians' physical examination of ill health students selected by school nurses. This study was conducted on a total of 3,525 students of three primary schools located in urban, township, and rural area during the period from May to June, 1987, all data were collected through direct observation & survey method. The main findings are as follows 1. The number of ill health students selected by two step method was more than that of one step method by the physician. 2. The types of ill health students selected by two step method had more diversity than that of one step method by the physician. 3. Budgets and time consumption for two step method were more reductive than that of one step method by the physician.