• Title/Summary/Keyword: scientific technologies

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Current strategies using 3D organoids to establish in vitro maternal-embryonic interaction

  • Islam Mohamed Saadeldin;Seif Ehab;Ahmed Elsayed Noreldin;Ayman Abdel-Aziz Swelum;Seonggyu Bang;Hyejin Kim;Ki Young Yoon;Sanghoon Lee;Jongki Cho
    • Journal of Veterinary Science
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    • v.25 no.3
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    • pp.40.1-40.19
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    • 2024
  • Importance: The creation of robust maternal-embryonic interactions and implantation models is important for comprehending the early stages of embryonic development and reproductive disorders. Traditional two-dimensional (2D) cell culture systems often fail to accurately mimic the highly complex in vivo conditions. The employment of three-dimensional (3D) organoids has emerged as a promising strategy to overcome these limitations in recent years. The advancements in the field of organoid technology have opened new avenues for studying the physiology and diseases affecting female reproductive tract. Observations: This review summarizes the current strategies and advancements in the field of 3D organoids to establish maternal-embryonic interaction and implantation models for use in research and personalized medicine in assisted reproductive technology. The concepts of endometrial organoids, menstrual blood flow organoids, placental trophoblast organoids, stem cell-derived blastoids, and in vitro-generated embryo models are discussed in detail. We show the incorportaion of organoid systems and microfluidic technology to enhance tissue performance and precise management of the cellular surroundings. Conclusions and Relevance: This review provides insights into the future direction of modeling maternal-embryonic interaction research and its combination with other powerful technologies to interfere with this dialogue either by promoting or hindering it for improving fertility or methods for contraception, respectively. The merging of organoid systems with microfluidics facilitates the creation of sophisticated and functional organoid models, enhancing insights into organ development, disease mechanisms, and personalized medical investigations.

Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study

  • Yasaman Khazaei;Narges Dehghanseresht;Sara Ebrahimi Mousavi;Matin Nazari;Shekoufeh Salamat;Omid Asbaghi;Anahita Mansoori
    • Clinical Nutrition Research
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    • v.12 no.1
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    • pp.29-39
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    • 2023
  • Previous studies have frequently reviewed how different macronutrients affect liver health. Still, no study centered around protein intake and the non-alcoholic fatty liver disease (NAFLD) risk relationship. This study aimed to examine the association between the consumption of total and different sources of protein and NAFLD risk. We allocated 243 eligible subjects to the case and control groups, including 121 incidence cases of NAFLD, and 122 healthy controls. Two groups were matched in age, body mass index, and sex. We evaluated the usual food intake of participants using FFQ. Binary logistic regression was conducted to estimate the risk of NAFLD in relation to different sources of protein intake. The age of participants was 42.7 years on average, and 53.1% were male. We found Higher intake of protein in total (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11-0.52) was significantly associated with a lower risk of NAFLD, despite adjusting for multiple confounders. in detail, higher tendency to the vegetables (OR, 0.28; 95% CI, 0.13-0.59), grains (OR, 0.24; 95% CI, 0.11-0.52), and nuts (OR, 0.25; 95% CI, 0.12-0.52) as the main sources of protein, were remarkably correlated with lower NAFLD risk. In contrary, increased intake of meat protein (OR, 3.15; 95% CI, 1.46-6.81) was positively associated with a higher risk. Totally, more calorie intake from proteins was inversely associated with lower NAFLD risk. This was more likely when the protein sources were selected less from meats and more from plants. Accordingly, increasing the consumption of proteins, particularly from plants, may be a good recommendation to manage and prevent NAFLD.

Deep-Learning-Based Mine Detection Using Simulated Data (시뮬레이션 데이터 기반으로 학습된 딥러닝 모델을 활용한 지뢰식별연구)

  • Buhwan Jeon;Chunju Lee
    • Journal of The Korean Institute of Defense Technology
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    • v.5 no.4
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    • pp.16-21
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    • 2023
  • Although the global number of landmines is on a declining trend, the damages caused by previously buried landmines persist. In light of this, the present study contemplates solutions to issues and constraints that may arise due to the improvement of mine detection equipment and the reduction in the number of future soldiers. Current mine detectors lack data storage capabilities, posing limitations on data collection for research purposes. Additionally, practical data collection in real-world environments demands substantial time and manpower. Therefore, in this study, gprMax simulation was utilized to generate data. The lightweight CNN-based model, MobileNet, was trained and validated with real data, achieving a high identification rate of 97.35%. Consequently, the potential integration of technologies such as deep learning and simulation into geographical detection equipment is highlighted, offering a pathway to address potential future challenges. The study aims to somewhat alleviate these issues and anticipates contributing to the development of our military capabilities in becoming a future scientific and technological force.

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Comparison of Perception Differences About Nuclear Energy in 4 East Asian Country Students: Aiming at $10^{th}$ Grade Students who Participated in Scientific Camps, from Four East Asian Countries: Korea, Japan, Taiwan, and Singapore (동아시아 4개국 학생들의 핵에너지에 대한 인식 비교: 과학캠프에 참가한 한국, 일본, 대만, 싱가포르 10학년 학생들을 대상으로)

  • Lee, Hyeong-Jae;Park, Sang-Tae
    • Journal of The Korean Association For Science Education
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    • v.32 no.4
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    • pp.775-788
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    • 2012
  • This study was done at a scientific camp sponsored by Nara Women's University Secondary School, Japan. In this school, $10^{th}$ grade students from 4 East Asian countries: Korea, Japan, Taiwan, and Singapore, participated. We made a research on students' perceptions about nuclear energy. Sample populations include 77 students in total, with 12 Korean, 46 Japanese, 9 Taiwanese and 10 Singaporean students. Overall perceptions comparison about nuclear energy shows average values from the order of highest Korea, Taiwan, Singapore, and to lowest, Japan. We implemented a T-test to identify perception differences about nuclear energy, with one group that include 3 countries (Korea, Taiwan and Singapore) and another group that includes all the Japanese students. T-test results of perceptions about nuclear energy shows students from the 3 countries of Korea, Taiwan and Singapore having higher average than Japanese students. (p<.05). Korean average scores regarding overall perceptions about nuclear energy show as the highest in all 4 East Asian countries and also highest in all subcategories. On the contrary in Japan, they have lower and negative perceptions of nuclear energy. In spite of these facts, perceptions of Japanese students about nuclear energy seem lowest and negative mainly because of the recent Fukushima nuclear power plant disaster, caused by the tsunami and its subsequent damages and fears of radiation leaks, etc. This shows that negative information about future disasters and its resulting damages like the Chernobyl nuclear accident could influence more on people's risk perception than general information like nuclear energy-related technologies or the news that the plant is operating normally, etc. Even if the possibility of this kind of accident is very low, just one accident could bring abnormal risks to technology itself. This strong signal makes negative image and strengthens its perceptions to the people. This could bring a stigma about nuclear energy. This study shows that Government's policy about the highest priority for nuclear energy safety is most important. As long as such perception and decision are fixed, we found that it might not be easy to get changed again because they were already fortified and maintained.

Analysis of Modality and Procedures for CCS as CDM Project and Its Countmeasures (CCS 기술의 CDM 사업화 수용에 대한 방식과 절차 분석 및 대응방안 고찰)

  • Noh, Hyon-Jeong;Huh, Cheol;Kang, Seong-Gil
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.15 no.3
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    • pp.263-272
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    • 2012
  • Carbon dioxide, emitted by human activities since the industrial revolution, is regarded as a major contributor of global warming. There are many efforts to mitigate climate change, and carbon dioxide capture and geological storage (CCS) is recognized as one of key technologies because it can reduce carbon dioxide emissions from large point sources such as a power station or other industrial installation. The inclusion of CCS as clean development mechanism (CDM) project activities has been considered at UNFCCC as financial incentive mechanisms for those developing countries that may wish to deploy the CCS. Although the Conference of the Parties serving as the Meeting of the Parties to the UNFCCC's Kyoto Protocol (CMP), at Cancun in December 2010, decided that CCS is eligible as CDM project activities, the issues identified in decision 2/CMP.5 should be addressed and resolved in a satisfactory manner. Major issues regarding modalities and procedure are 1) Site selection, 2) Monitoring, 3) Modeling, 4) Boundaries, 5) Seepage Measuring and Accounting, 6) Trans-Boundary Effects, 7) Accounting of Associated Project Emissions (Leakage), 8) Risk and Safety Assessment, and 9) Liability Under the CDM Scheme. The CMP, by its decision 7/CMP.6, invited Parties to submit their views to the secretariat of Subsidiary Body for Scientific and Technological Advice (SBSTA), SBSTA prepared a draft modalities and procedure by exchanging views of Parties through workshop held in Abu Dhabi, UAE (September 2011). The 7th CMP (Durban, December 2011) finally adopted the modalities and procedures for CCS as CDM project activities (CMP[2011], Decision-/CMP.7). The inclusion of CCS as CDM project activities means that CCS is officially accredited as one of $CO_2$ reducing technologies in global carbon market. Consequently, it will affect relevant technologies and industry as well as law and policy in Korea and aboard countries. This paper presents a progress made on discussion and challenges regarding the issue, and aims to suggest some considerations to policy makers in Korea in order to demonstrate and deploy the CCS project in the near future. According to the adopted modalities and procedures for CCS as CDM project activities, it is possible to implement relevant CCS projects in Non-Annex I countries, including Korea, as long as legal and regulatory frameworks are established. Though Korea enacted 'Framework Act on Low Carbon, Green Growth', the details are too inadequate to content the requirements of modalities and procedures for CCS as CDM project. Therefore, it is required not only to amend the existing laws related with capture, transport, and storage of $CO_2$ for paving the way of an prompt deployment of CCS CDM activities in Korea as a short-term approach, but also to establish the united framework as a long-term approach.

The Contribution of Innovation Activity to the Output Growth of Emerging Economies: The Case of Kazakhstan

  • Smagulova, Sholpan;Mukasheva, Saltanat
    • Journal of Distribution Science
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    • v.10 no.7
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    • pp.33-41
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    • 2012
  • The purpose of this study is to analyse the state of the energy industry and to determine the efficiency of its functioning on the basis of energy conservation principle and application of innovative technologies aimed at improving the ecological modernisation of agricultural sectors of Kazakhstan. The research methodology is based on an integrated approach of financial and economic evaluation of the effectiveness of the investment project, based on calculation of elasticity, total costs and profitability, as well as on comparative, graphical and system analysis. The current stage is characterised by widely spread restructuring processes of electric power industry in many countries through introduction of new technical installations of energy facilities and increased government regulation in order to enhance the competitive advantage of electricity market. Electric power industry features a considerable value of creating areas. For example, by providing scientific and technical progress, it crucially affects not only the development but also the territorial organisation of productive forces, first of all the industry. In modern life, more than 90% of electricity and heat is obtained by Kazakhstan's economy by consuming non-renewable energy resources: different types of coal, oil shale, oil, natural gas and peat. Therefore, it is significant to ensure energy security, as the country faces a rapid fall back to mono-gas structure of fuel and energy balance. However, energy resources in Kazakhstan are spread very unevenly. Its main supplies are concentrated in northern and central parts of the republic, and the majority of consumers of electrical power live in the southern and western areas of the country. However, energy plays an important role in the economy of industrial production and to a large extent determines the level of competitive advantage, which is a promising condition for implementation of energy-saving and environmentally friendly technologies. In these circumstances, issues of modernisation and reforms of this sector in Kazakhstan gain more and more importance, which can be seen in the example of economically sustainable solutions of a large local monopoly company, significant savings in capital investment and efficiency of implementation of an investment project. A major disadvantage of development of electricity distribution companies is the prevalence of very high moral and physical amortisation of equipment, reaching almost 70-80%, which significantly increases the operating costs. For example, while an investment of 12 billion tenge was planned in 2009 in this branch, in 2012 it is planned to invest more than 17 billion. Obviously, despite the absolute increase, the rate of investment is still quite low, as the total demand in this area is at least more than 250 billion tenge. In addition, industrial infrastructure, including the objects of Kazakhstan electric power industry, have a tangible adverse impact on the environment. Thus, since there is a large number of various power projects that are sources of electromagnetic radiation, the environment is deteriorated. Hence, there is a need to optimise the efficiency of the organisation and management of production activities of energy companies, to create and implement new technologies, to ensure safe production and provide solutions to various environmental aspects. These are key strategic factors to ensure success of the modern energy sector of Kazakhstan. The contribution of authors in developing the scope of this subject is explained by the fact that there was not enough research in the energy sector, especially in the view of ecological modernisation. This work differs from similar works in Kazakhstan in the way that the proposed method of investment project calculation takes into account the time factor, which compares the current and future value of profit from the implementation of innovative equipment that helps to bring it to actual practise. The feasibility of writing this article lies in the need of forming a public policy in the industrial sector, including optimising the structure of energy disbursing rate, which complies with the terms of future modernised development of the domestic energy sector.

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The Comparative Analysis of Outcomes on Patents and Papers of Railway Research Institutes in Korea, China and Japan (한국, 중국, 일본 철도연구기관 특허 및 논문실적 비교분석)

  • Baek, Sunghyun;Yi, Yoonju
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.6
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    • pp.455-460
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    • 2020
  • The governments of Korea, China, and Japan have operated comprehensive research institutes for railway technologies. Korea Railroad Research Institute (KRRI), China Academy of Railway Sciences Corporation Limited (CARS), and Railway Technical Research Institute (RTRI) are representatives of comprehensive railway research institutes in each country. KRRI was found to be the most advanced in the quantitative competitiveness of patents. In terms of qualitative competitiveness, KRRI has strength in civil engineering, whereas RTRI has strength in electricity. KRRI was found to have the greatest efforts in securing competitiveness in overseas property rights. By comparing the publication of papers, CARS published the most papers. On the other hand, from 2015, KRRI showed an upward trend and published the most papers. By examining the impact of the papers by the citation, KRRI was found to have higher competitiveness than the other two institutions. In the future, it will be necessary to perform big data analysis on patents and papers of the three organizations, derive the key research areas and promising technology areas for each institute, and establish a mid-to-long-term development plan for railway technology based on scientific evidence.

Scientific Missions and Technologies of the ISSS on board the NEXTSat-1

  • Choi, Cheong Rim;Sohn, Jongdae;Lee, Jun-Chan;Seo, Yong Myung;Kang, Suk-Bin;Ham, Jongwook;Min, Kyoung-Wook;Seon, Jongho;Yi, Yu;Chae, Jang-Soo;Shin, Goo-Hwan
    • Journal of Astronomy and Space Sciences
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    • v.31 no.1
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    • pp.73-81
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    • 2014
  • A package of space science instruments, dubbed the Instruments for the Study of Space Storms (ISSS), is proposed for the Next Generation Small Satellite-1 (NEXTSat-1), which is scheduled for launch in May 2016. This paper describes the instrument designs and science missions of the ISSS. The ISSS configuration in NEXTSat-1 is as follows: the space radiation monitoring instruments consist of medium energy particle detector (MEPD) and high energy particle detector (HEPD); the space plasma instruments consist of a Langmuir probe (LP), a retarding potential analyzer (RPA), and an ion drift meter (IDM). The space radiation monitoring instruments (MEPD and HEPD) measure electrons and protons in parallel and perpendicular directions to the geomagnetic field in the sub-auroral region, and they have a minimum time resolution of 50 msec for locating the region of the particle interactions with whistler mode waves and electromagnetic ion cyclotron (EMIC) waves. The MEPD measures electrons and protons with energies of tens of keV to ~400 keV, and the HEPD measures electrons with energies of ~100 keV to > ~1 MeV and protons with energies of ~10 MeV. The space plasma instruments (LP, RPA, and IDM) observe irregularities in the low altitude ionosphere, and the results will be compared with the scintillations of the GPS signals. In particular, the LP is designed to have a sampling rate of 50 Hz in order to detect these small-scale irregularities.

Slope Failure Prediction through the Analysis of Surface Ground Deformation on Field Model Experiment (현장모형실험 기반 표층거동분석을 통한 사면붕괴 예측)

  • Park, Sung-Yong;Min, Yeon-Sik;Kang, Min-seo;Jung, Hee-Don;Sami, Ghazali-Flimban;Kim, Yong-Seong
    • Journal of the Korean Geosynthetics Society
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    • v.16 no.3
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    • pp.1-10
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    • 2017
  • Recently, one of the natural disasters, landslide is causing huge damage to people and properties. In order to minimize the damage caused by continuous landslide, a scientific management system is needed for technologies related to measurement and monitoring system. This study aims to establish a management system for landslide damage by prediction of slope failure. Ground behavior was predicted by surface ground deformation in case of slope failure, and the change in ground displacement was observed as slope surface. As a result, during the slope failure, the ground deformation has the collapse section, the after collapse precursor section, the acceleration section and the burst acceleration section. In all cases, increase in displacement with time was observed as a slope failure, and it is very important event of measurement and maintenance of risky slope. In the future, it can be used as basic data of slope management standard through continuous research. And it can contribute to reduction of landslide damage and activation of measurement industry.

Study on Legal Issues and Scope of Medical Technologist's Practice (임상병리사 업무 범위와 법률적 고찰)

  • Shim, Moon-Jung;Koo, Bon-Kyeong;Park, Chang-Eun
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.2
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    • pp.55-68
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    • 2017
  • In recent years, medical practice has seen a drastic change due to the rapid, exponential expansion of scientific and medical technologies. Specially, the role of medical technologists (also known as medical laboratory scientists and/or clinical laboratory scientists) are increasing in the development of science of medical technology. As such, their responsibility has also been increasing. Therefore, given their highly specialized knowledge and skills, they are not regarded solely as doctor's assistants. Their independence and deeper specialization have been increasing, as they perform medial practices under the guidance of doctors or dentists pursuant to the "Act on Medical Service Technologists." From a legal point of view, medical guidance and scope of work were examined. As a conclusion, the definition of doctor's superintendency on the "Act on Medical Service Technologists" is required, and the qualification for the Korean license examination and their roles should be stated clearly. Moreover, communications among health professions regarding the roles of medical technologists are necessary to further facilitate clarification of their role. There is a need for independent legislation to expand the field of medical technologists and to strengthen their professionalism.