• Journal of the Korean earth science society
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• v.43 no.6
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• pp.691-711
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• 2022

The state-of-the-art Earth system model as a virtual Earth is required for studies of current and future climate change or climate crises. This complex numerical model can account for almost all human activities and natural phenomena affecting the atmosphere of Earth. The Unified Model (UM) from the United Kingdom Meteorological Office (UK Met Office) is among the best Earth system models as a scientific tool for studying the atmosphere. However, owing to the expansive numerical integration cost and substantial output size required to maintain the UM, individual research groups have had to rely only on supercomputers. The limitations of computer resources, especially the computer environment being blocked from outside network connections, reduce the efficiency and effectiveness of conducting research using the model, as well as improving the component codes. Therefore, this study has presented detailed guidance for installing a new version of the UM on high-performance parallel computers (Linux clusters) owned by individual researchers, which would help researchers to easily work with the UM. The numerical integration performance of the UM on Linux clusters was also evaluated for two different model resolutions, namely N96L85 (1.875° ×1.25° with 85 vertical levels up to 85 km) and N48L70 (3.75° ×2.5° with 70 vertical levels up to 80 km). The one-month integration times using 256 cores for the AMIP and CMIP simulations of N96L85 resolution were 169 and 205 min, respectively. The one-month integration time for an N48L70 AMIP run using 252 cores was 33 min. Simulated results on 2-m surface temperature and precipitation intensity were compared with ERA5 re-analysis data. The spatial distributions of the simulated results were qualitatively compared to those of ERA5 in terms of spatial distribution, despite the quantitative differences caused by different resolutions and atmosphere-ocean coupling. In conclusion, this study has confirmed that UM can be successfully installed and used in high-performance Linux clusters.

• Spatial Information Research
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• v.23 no.6
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• pp.31-41
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• 2015

This research is primarily intended to explore a novel way to monitor desiccation of inland wetland by combining MNDWI (Modified Normalized Difference Water Index) and NDVI (Normalized Difference Vegetation Index). The changes for vegetation and water condition on Upo Wetland located at southeastern Korea were investigated by MNDWI and NDVI derived from 2002, 2010 and 2015 Landsat data. The integrated use of MNDWI and NDVI made it possible to identify area-wide vegetation cover changes and to assess water storage changes on multi-annual time scales simultaneously. Comparing MNDWI with NDVI reveals the quantitative evidences for anthropogenic and environmental influences (such as road, building, water) causing an accelerated wetland desiccation. In fact, our monitoring approach raises critical issues regarding the hydrological cycle and its inter-annual changes for inland wetland under threat of drying up and highlights the important role of MNDWI and NDVI integration for any urgent or long-term treatment plan. This research presents scientific and objective evidences to support integrated approach of NDVI and MNDWI in exploring drying up trends of wetlands.

• Journal of the Korea Convergence Society
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• v.7 no.4
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• pp.199-208
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• 2016

This study aims to examine the influence of laughter therapy program on successful aging and stress of elderly by applying 60 minutes of laughter therapy program twice a week for 10 weeks to elderly. By the selection standard, 25 subjects for experimental group at cultural center located in city S, 25 subjects each for comparative group and control group are convenience sampled at senior citizen center located in city S. The data analysis of this study utilized SPSS 19,0 to conduct Analysis of Covariate(ANCOVA). As for the result of conducting laughter therapy program for 10 weeks, the experimental group showed increased successful aging of elderly and reduced stress than the comparative or control group.Therefore, this study has prepared a ground to apply and verify the scientific basis of laughter therapy program in the current condition where various aging problems are emerging due to the aging society.

• International Journal of Knowledge Content Development & Technology
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• v.8 no.1
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• pp.25-36
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• 2018

Research data must be testable. Science is all about verification and testing. To make data testable, tools used to produce, collect, and examine data during the research must be available. Quite often, however, these data become inaccessible once the work is over and the results being published. Hence, information and the related context must be provided on how research data are preserved and how they can be reproduced. Open Science is the international movement for making scientific research data properly accessible for research community. One of its major goals is building data repositories to foster wide dissemination of open data. The objectives of this research are to examine the features of research data, common repository platforms, and community requests for the purpose of designing functional requirements for research data repositories. To analyze the features of the research data, we use data curation profiles available from the Data Curation Center of the Purdue University, USA. For common repository platforms we examine Fedora Commons, iRODS, DataONE, Dataverse, Open Science Data Cloud (OSDC), and Figshare. We also analyze the requests from research community. To design a technical solution that would meet public needs for data accessibility and sharing, we take the requirements of RDA Repository Interest Group and the requests for the DataNest Community Platform developed by the Korea Institute of Science and Technology Information (KISTI). As a result, we particularize 75 requirement items grouped into 13 categories (metadata; identifiers; authentication and permission management; data access, policy support; publication; submission/ingest/management, data configuration, location; integration, preservation and sustainability, user interface; data and product quality). We hope that functional requirements set down in this study will be of help to organizations that consider deploying or designing data repositories.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.30 no.4
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• pp.251-262
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• 1994

The speed of vertical migration and the volume backscattering strength of the scattering layers during the evening and morning transitions between day and night were measured in November 1990-1992 in thermally stratified waters of the East China Sea. Acoustical measurements were carried out using a scientific echo-sounder operating at t재 frequencies of 25 and 100kHz, and using an echo-integration system connected with a micro-computer. Biological sampling was accomplished by bottom trawling to identify fish species recorded on the echo sounder, and the species and length compositions were determined. The values of scattering strength were allocated to group of fishes according to the fish traces on the echo recording paper and the species composition of trawl catches. The vertical velocities of migration derived from the changes in the depths and the values of peak scattering strength of the dense layer vertically migrating toward the bottom or toward the surface. The trawl data suggest that snailfish and fishing frog were the most abundant fishes in all research stations. As sunrise approached, the fish formed a strong concentration just above the thermocline. The the highest values of scattering strength in the entire water column appeared in the depth strata above the thermocline just before the begining of downward migration. As soon as the fish began to migrate downwards across the thermocline, the values of the scattering strength in the depth strata above the thermocline rapidly decreased, while the values for the scattering layer moving slowly toward the bottom gradually increased. During the 1992 surveys, the speed of the vertical migration was estimated to be 0.38m/min in the upward migration and 0.32m/min in the downward migration, respectively. That is the rate of vertical migration was slightly higher at dusk than at dawn. Similar migration patterns were observed on different stations and under different weather conditions during the surveys in 1990.

• Proceedings of the KSAR Conference
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• 2000.10a
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• pp.7-8
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• 2000

Transgenic animals are very useful for scientific, pharmaceutical, and agricultural purposes. In livestock, transgenic technology has been used forthe genetic alteration of farm animals, the production of human proteins inlarge quantities in the milk of transgenic farm animals, and the generation of animals with organs suitable for xenotransplantation. To date, the transfer of foreign genes into farm animals has been performed mainly by microinjection of DNA into the pronuclei of fertilized eggs. However, the overall success rate of transgenic animals in livestock so far has been disappointingly low, eg., the efficiency is 0∼5% in swine, and less than 1% in sheep and cattle, compared with the rate in mice where 5% microinjected develop into transgenic animals. Recently, McGreath et al. (2000) have succeeded in producing the gene targeted sheep by the use of nuclear transfer from cultured somatic cells transfected with a foreign gene in vitro. However, we may need plenty of time until currently employ this method for gene transfer to farm animals. We have been studying to exploit the method for improving production efficiencies of transgenic animals with emphasis of its application to farm animals. The present paper describes three approaches that we have made in our laboratory to improve production efficiencies of transgenic animals, based on the DNA microinjection method. 1. Co-injection of restriction enzyme with foreign DNA into the pronucleus for elevating production efficiencies of transgenic animals. 2. Efficient selection of transgenic mouse embryos using EGFP as a marker gene. 3. Phenotypes of tansgenic mice expressing WAP/hGH-CAG/EGFP fusion gene produced by selecting transgenic embryos. 4. Efficient site-specific integration of the transgene targeting an endogenous lox like site in early mouse embryos.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.38 no.6
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• pp.620-628
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• 2010

Small satellites can be used for various space research and scientific or educational purposes due to advantages in small size, low-cost, and rapid development. Small Satellites have many advantages of application to Responsive Space. Compared to traditional larger satellites, however, Small satellites have many constraints due to limitations in size. Therefore, it is difficult to expect high performance. To approach maximum capability with minimal size, weight, and cost, standard modular platform of Small satellites is necessary. Modularity supports plug-and-play architecture. The result is Small satellites that can be combined quickly and reliably using plug-and-play mechanisms. For communication between modules, standard bus interface is needed. Controller Area Network(CAN) protocol is considered optimum data bus for modular Small satellite. CAN can be applied to data communication with high reliability. Hence, design optimization and simplification can also be expected. For ease of assembly and integration, modular design can be considered. This paper proposes development method for standardized modular Small satellites, and describes design of data interface based on CAN and a method of testing for modularity.

• Journal of Pharmacopuncture
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• v.16 no.1
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• pp.12-20
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• 2013

Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future. Tumor dormancy therapy is a novel therapeutic approach that may improve these shortcomings, promote quality of life, and prolong survival. The aim of this study was to analyze studies on dormancy therapy, especially studies using traditional Oriental herbal medicine, so as to evaluate the efficacy of dormancy therapy with traditional oriental herbal medicine. Methods: We conducted a systematic literature review using Scientific and Technical Information Integration Services (NDSL), PubMed, and RISS. We searched for clinical reports, papers, and books related to tumor metastasis, recurrence, immunotherapy, tumor dormancy, and traditional oriental herbal medicine with anticancer effects. Seventy-nine (79) experimental and clinical articles in both Korean and English were reviewed. This study was conducted from March 1, 2012 to May 31, 2012. Results: This approach, Tumor dormancy therapy, rather than seeking to remove the tumor, includes combination of low-dose chemotherapy, immunotherapy, immunosurveillance, and other methods to stabilize tumor growth and to enhance the host is immunity against disseminated tumor cells and thus to manage cancer as a chronic disease while maintaining quality of life. In particular, integrative use of Oriental herbal medicine has been shown to induce or maintain tumor dormancy, increase the effectiveness of conventional chemotherapy, improve quality of life, and prolong survival. Conclusion: Tumor dormancy therapy is a promising novel therapeutic approach that may be especially effective with Oriental herbal medicine. Further research is needed to determine its potential mechanisms and therapeutic applications.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.260-266
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• 2008

Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.9
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• pp.3590-3598
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• 2010

It is necessary to collect the coastal zone data, to prepare the objective analysis methods, and to build the scientific and technical support system for the efficient management of coastal zone in local aspect. This study analyzes the coastal zoning methods and the integrated methods of different kind data by case study of U.S.A coastal zone. The characteristics of coastal zone management methods in U.S.A are as follows; the concrete indices and methods of establishing coastal zone which can respond to the local values and land use, related data analysis methods for supporting spatial decision making, and establishment and administration of bureau for the spatial information construction and integration of coastal zone. This study suggest the technical implications which can build the domestic coastal zone management in local level on the basis of the common values of the coastal zoning methods and integrated methods of heterogeneous data in U.S.A.