• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4993-4998
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• 2012

Vanillic acid, a vegetable phenolic compound, is a strong antioxidant. The aim of the present study was to determine its effects on mitomycin C-induced DNA damage in human blood lymphocyte cultures in vitro, both alone and in combination with mitomycin C (MMC). The cytokinesis block micronucleus test and alkaline comet assay were used to determine genotoxic damage and anti-genotoxic effects of vanillic acid at the DNA and chromosome levels. MMC induced genotoxicity at a dose of $0.25{\mu}g/ml$. Vanillic acid ($1{\mu}g/ml$) significantly reduced both the rates of DNA damaged cells and the frequency of micronucleated cells. A high dose of vanillic acid ($2{\mu}g/ml$) itself had genotoxic effects on DNA. In addition, both test systems showed similar results when tested with the negative control, consisting of dimethyl sulfoxide (DMSO) in combination with vanillic acid ($1{\mu}g/ml$)+MMC. In conclusion, vanillic acid could prevent oxidative damage to DNA and chromosomes when used at an appropriately low dose.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.87-94
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• 2022

Myocardial infarction promotes cardiac remodeling and myocardial fibrosis, thus leading to cardiac dysfunction or heart failure. Peiminine has been regarded as a traditional anti-fibrotic Chinese medicine in pulmonary fibrosis. However, the role of peiminine in myocardial infarction-induced myocardial injury and fibrosis remained elusive. Firstly, rat model of myocardial infarction was established using ligation of the left coronary artery, which were then intraperitoneally injected with 2 or 5 mg/kg peiminine once a day for 4 weeks. Echocardiography and haemodynamic evaluation results showed that peiminine treatment reduced left ventricular end-diastolic pressure, and enhanced maximum rate of increase/decrease of left ventricle pressure (± dP/dt max) and left ventricular systolic pressure, which ameliorate the cardiac function. Secondly, myocardial infarction-induced myocardial injury and infarct size were also attenuated by peiminine. Moreover, peiminine inhibited myocardial infarction-induced increase of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α production, as well as the myocardial cell apoptosis, in the rats. Thirdly, peiminine also decreased the myocardial fibrosis related protein expression including collagen I and collagen III. Lastly, peiminine reduced the expression of p38 and phosphorylation of extracellular signal-regulated kinase 1/2 in rat model of myocardial infarction. In conclusion, peiminine has a cardioprotective effect against myocardial infarction-induced myocardial injury and fibrosis, which can be attributed to the inactivation of mitogen-activated protein kinase pathway.

• Korean Security Journal
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• no.8
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• pp.45-64
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• 2004

The pivotal emphasis of the physical training for the security agents of the security headquarters in the North Korea is to inspire them with the defense physical training-centered ideology and the war spirit. Their special martial arts is the protectee-centered offensive arts rather than the self-centered arts. It puts emphasis on training black belt-holders in diverse martial arts rather than in a certain martial art. Thus, the physical training for security agents in the South Korea should be also developed into the ways to rear them as black belt-holders in diverse martial arts rather than to foster them as high grade-holders in a certain martial art. And also, professors majoring in security and physical science have to develop jointly the measures to improve the physical and mental agility and the basic physical strength to inspire rapid handling and perseverance, to develop the physical training program to reduce mental and physical stress of security guards, to develop the standard for the examination of physical strength suitable for the body figures of Korean people and the regular evaluation with the standard and to apply traditional folk-games such as the swing and the seesaw to the physical training for security guards.

• Food Industry And Nutrition
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• v.11 no.2
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• pp.85-87
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• 2006

• International Journal of Knowledge Content Development & Technology
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• v.13 no.4
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• pp.119-137
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• 2023

In this study, it was intended to explore a way to build a DB which links the resources and areas and regions already registered as cultural assets in connection with a project which is newly building local culture and arts resources. Towards this end, this study first identified the type and scale of existing local culture and arts resources that could be linked. Following which, to link the local cultural resources and collected cultural assets, this study investigated the websites such as the Cultural Heritage Administration's National Cultural Heritage Portal, municipal and provincial tangible cultural festivals, municipal and provincial intangible cultural assets, and Gyeonggi Memory. Furthermore, this study identified the amount of information sources to be built and the current status of each information source to identify detailed information sources. Finally, the metadata of local culture and arts resources were presented by classifying them into material and publication data metadata, document metadata, audiovisual metadata, oral recording metadata, village information metadata, and personal information village information metadata.

• Journal of Electrochemical Science and Technology
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• v.11 no.3
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• pp.248-256
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• 2020

In this study, pyrocatechol violet (Pcv) is proposed for the first time as an efficient electrocatalyst for oxidation of sulfide and flow injection analysis (FIA) of sulfide. A graphite pencil electrode (GPE) was modified with Pcv via immersion of the GPE into 0.01 M Pcv solution for 15 min. Cyclic voltammograms (CVs) demonstrated that Pcv/GPE exhibits a good electrocatalytic performance due to shift in the potential from +400 at bare GPE to +70 mV at Pcv/GPE and obtaining an enhancement in the peak current compared with the bare GPE. A linear range between 0.25 and 250 μM sulfide with a detection limit of 0.07 μM was obtained from the recorded current-time curves in Flow Injection Analysis (FIA) of sulfide. Sulfide in water samples was also successfully determined using the proposed FI amperometric methods.

• Korean Journal of Food Science and Technology
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• v.45 no.6
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• pp.763-769
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• 2013

Soybean oil was stored in polyethylene for 12 weeks at $20^{\circ}C$. The influence of LED (light emitting diode) irradiation on four different wavelengths and fluorescent light was investigated. The pattern changes of volatile components in soybean oil was analyzed by electronic nose based on mass spectrometer. The obtained data from electronic nose were analyzed by discrimination function analysis. Under fluorescent light, the discriminant function first score (DF1) was significantly moved from positive position to negative one after 4-12 weeks. It means that the volatile compounds related to quality of lipid. It was shown to increase slowly due to green light of LED treatment, while blue and white LED light was influenced significantly as well as fluorescent light irradiation. Selection of LED irradiation would provide to keep good quality of soybean oil under distribution chain system.

• Journal of Applied Biological Chemistry
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• v.62 no.2
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• pp.203-209
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• 2019

The inhibition of aldose reductase (AR) by the extracts from sixteen noxious and exotic plants was examined. Among them, Aster pilosus showed the highest inhibition of AR ($IC_{50}$ value $0.11{\mu}g/mL$). This study showed that A. pilosus with promising AR-inhibitory activities can be utilized for the development of natural therapies for treating and managing diabetic complications.

• Korean journal of food and cookery science
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• v.27 no.3
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• pp.95-104
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• 2011

This study was conducted to investigate the effect of red wine on the quality properties and sensory score of seasoned pork meat. Pork meat was treated with 25% water (control), 20% water and 5% red wine (RW5), 15% water and 10% red wine (RW10), or 10% water and 15% red wine (RW15). The moisture, crude protein, crude fat, $L^*$ value, springiness, cohesiveness, gumminess, chewiness, and VBN content were not significantly different among the samples. Cooking yield, moisture retention, and fat retention were significantly higher in the RW5, RW10, and RW15 (p < 0.05) compared to those in the control. The $a^*$ value of RW5 was the highest among the samples, and the $b^*$ value increased significantly in the control and RW5 (p < 0.05). The hardness of the control was the highest among all samples (p < 0.05). The pH was significantly lower in RW5, RW10 and RW15 (p < 0.05) compared to that in the control. The TBARS value and total bacteria were significantly lower in RW5, RW10, and RW15 (p < 0.05) compared to those in the control. Adding red wine altered the fatty acid and free amino acid of cooked seasoned pork. These results suggest the possibility that red wine could be used an additive to improve the quality of cooked seasoned pork.

• Molecules and Cells
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• v.19 no.2
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• pp.228-231
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• 2005

Recent characterization of several genes involved in plant defense responses suggested that ubiquitin-mediated protein degradation has a role in these responses. We isolated two cDNAs (NtUBA1 and NtUBA2) encoding ubiquitin-activating enzyme (E1) from Nicotiana tabacum cv. BY-2. The open reading frames of both encoded 1080 amino acids, corresponding to molecular masses of 120 kDa. The E1s and corresponding transcripts were upregulated by infection with tobacco mosaic virus (TMV) and tomato mosaic virus (ToMV), and to a lesser extent by cucumber mosaic virus (CMV). Furthermore, they were also upregulated by wounding stress, and the plant hormones salicylic acid, jasmonic acid and the ethylene precursor, aminocyclopropane-1-carboxylic acid (ACC). Our findings support the idea that the ubiquitin-proteasome system plays a role in plant disease defenses.