• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권1호
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• pp.34-42
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• 2023

Purpose: We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps. Methods: Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared. Results: A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R2=0.5718, β=73.62, p<0.001). The median FC level was 400 mg/kg (interquartile range [IQR], 141.6-1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9-20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225-1,000) to 26.5 mg/kg (11.5-51) (p<0.001). Conclusion: FC levels significantly correlated with polyp size in children and adolescents with JPs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8325-8330
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• 2014

Background: It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk. Materials and Methods: We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status. Results: Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively). Conclusions: These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.

• 대한수학교육학회지:수학교육학연구
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• 제11권2호
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• pp.363-384
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• 2001

The purpose of this thesis is, through analysing the characteristics of the definitions in Korean school mathematics textbooks, to explore the levels of them and to make suggestions for definition - teaching as a mathematising activity, Definitions used in academic mathematics are rigorous. But they should be transformed into various types, which are presented in school mathematics textbooks, with didactical purposes. In this thesis we investigated such types of transformation. With the result of this investigation we tried to identify the levels of the definitions in school mathematics textbooks. And in school mathematics textbooks there are definitions which carry out special functions in mathematical contexts or situations. We can say that we understand those definitions, only if we also understand the functions of definitions in those contexts or situations. In this thesis we investigated the cases in school mathematics textbooks, when such functions of definition are accompanied. With the result of this investigation we tried to make suggestions for definition-teaching as an intellectual activity. To begin with we considered definition from two aspects, methods of definition and functions of definition. We tried to construct, with consideration about methods of definition, frame for analysing the types of the definitions in school mathematics and search for a method for definition-teaching through mathematization. Methods of definition are classified as connotative method, denotative method, and synonymous method. Especially we identified that connotative method contains logical definition, genetic definition, relational definition, operational definition, and axiomatic definition. Functions of definition are classified as, description-function, stipulation-function, discrimination-function, analysis-function, demonstration-function, improvement-function. With these analyses we made a frame for investigating the characteristics of the definitions in school mathematics textbooks. With this frame we identified concrete types of transformations of methods of definition. We tried to analyse this result with van Hieles' theory about levels of geometry learning and the mathematical language levels described by Freudenthal, and identify the levels of definitions in school mathematics. We showed the levels of definitions in the geometry area of the Korean school mathematics. And as a result of analysing functions of definition we found that functions of definition appear more often in geometry than in algebra or analysis and that improvement-function, demonstration-function appear regularly after demonstrative geometry while other functions appear before demonstrative geometry. Also, we found that generally speaking, the functions of definition are not explained adequately in school mathematics textbooks. So it is required that the textbook authors should be careful not to miss an opportunity for the functional understanding. And the mathematics teachers should be aware of the functions of definitions. As mentioned above, in this thesis we analysed definitions in school mathematics, identified various types of didactical transformations of definitions, and presented a basis for future researches on definition teaching in school mathematics.

• 한국학교보건학회지
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• 제25권2호
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• pp.222-230
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• 2012

Purpose: This study was done to identify levels of health teacher's perception and performance on abdominal pain management in elementary schools. Methods: The participants were 207 health teachers in elementary school in B metropolitan city. In a descriptive cross-sectional study, the structured self-report questionnaire was developed based on the literatures and school health care guidelines by the researchers. The data were analyzed using the PASW 18.0 program. Results: The mean scores (${\pm}SD$) on perception and performance of abdominal pain management were $4.02{\pm}0.43$ (range 1~5) and $3.47{\pm}0.41$ (range 1~5), respectively. Their perception and performance of abdominal pain management had a statistically significant correlation (r=.27, p<.001). In a regression analysis, the performance of abdominal pain management was significantly influenced by perception of abdominal pain management, career of health teachers, self-confidence in abdominal pain management, and total number of classes in a school. The regression model explained 19% of the variance of performance of abdominal pain management. Conclusion: These findings showed that the performance levels were lower than its perception levels of elementary school health teachers on abdominal pain management for students. It suggests that the standardized abdominal pain management guideline is developed to improve the performance of school health teachers.

• 한국과학교육학회지
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• 제22권1호
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• pp.12-21
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• 2002

이 연구의 목적은 정량적 현상제시와 정성적 현상제시를 하였을 때, 중학교 학생들의 갈등 정도를 알아보는 것이다. 연구 대상은 부산광역시 소재의 중학교 2학년 297명 을 대상으로 하였다. 검사 문항은 역학의 작용반작용 문항과 전기의 전구의 불의 밝기를 비교하는 문항을 사용하였고, 인지적 갈등을 측정하는 검사지는 권혁구(1999) 등이 개발한 도구를 사용하였다. 먼저, 정량적 현상제시 집단과 정성적 현상제시 집단의 인지갈등 점수를 비교해 보았다. 그리고 현상제시 후 자신의 선개념을 바꾼 학생들과 고수한 학생들의 갈등 점수를 비교해 보았다. 마지막으로, 선개념의 확신 정도와 갈등 정수와의 상관관계를 비교해보았다. 그 결과를 보면, 첫째, 선개념에서 오답을 선택한 학생들은 정성적 현상제시보다 정량적 현상제시에서 갈등 점수가 높게 나타났으며, 선개념에서 정답을 선택한 학생들은 정량적 현상제시보다 정성적 현상제시에서 갈등 점수가 높게 나타났다. 둘째, 자신의 선개념을 바꾼 학생들이 고수한 학생들에 비해 갈등 점수가 높게 나타났다. 마지막으로, 선개념의 확신정도와 갈등 점수와의 상관관계를 보면, 정량적 현상을 제시한 집단의 학생들 중 선개념에서 오답을 택한 학생들은 정적 상관을 보였고, 선개념에서 정답을 택한 학생들은 부적상관을 보였다. 정성적 집단은 뚜렷한 경향을 보이지 않았다.

• Clinical and Experimental Pediatrics
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• 제58권9호
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• pp.325-329
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• 2015

Purpose: In addition to regulating calcium and phosphorus homeostasis and bone metabolism, vitamin D is known as an immune modulator. Recently, there has been increased worldwide interest in the association between low levels of vitamin D and allergic diseases. The purpose of this study was to assess the relationship between serum vitamin D levels and allergic/vasomotor rhinitis (AR/VR) in children. Methods: This study included 164 patients. The sample included 59 patients with AR, 42 patients with VR, and 63 controls. Their ages ranged from 0 to 16 years. We examined the levels of 25-hydroxyvitamin D, Immunoglobulin E, specific IgE, and eosinophil cationic protein; peripheral blood eosinophil count; and the results of a skin prick test. Results: Serum 25-hydroxyvitamin D levels were $19.0{\pm}8.5ng/mL$ in the AR group, $25.5{\pm}10.9ng/mL$ in the VR group, and $26.9{\pm}10.7ng/mL$ in the control group. After adjustment for body mass index and season at the time of blood sampling, vitamin D levels in the AR group were lower than those of the VR group (P=0.003) and control group (P<0.001). Vitamin D levels were inversely correlated with Immunoglobulin E levels (r=-0.317, P<0.001). AR patients with food allergy or atopic dermatitis did not have lower levels of 25-hydroxyvitamin D than AR patients without these diseases. Conclusion: This study demonstrates a possible relationship between vitamin D levels and allergic rhinitis in Korean children.

• Journal of Preventive Medicine and Public Health
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• 제47권2호
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• pp.124-128
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• 2014

Objectives: To evaluate the monthly variation in the airborne $(1{\rightarrow}3)-{\beta}$-D-glucan level throughout one year and its relationship with climatic factors (temperature, relative humidity, wind speed, hours of daylight, cloud cover, and pollen counts). Methods: A total of 106 samples were collected using a two-stage cyclone sampler at five outdoor sampling locations (on top of 5 university buildings). The kinetic limulus amebocyte lysate assay was used to obtain $(1{\rightarrow}3)-{\beta}$-D-glucan levels. Results: Airborne $(1{\rightarrow}3)-{\beta}$-D-glucan levels were significantly higher in the spring, particularly in April, and temperature was significantly related to $(1{\rightarrow}3)-{\beta}$-D-glucan levels (r=0.339, p<0.05). Conclusions: $(1{\rightarrow}3)-{\beta}$-D-glucan levels may be highest in the spring, and outdoor temperature may influence $(1{\rightarrow}3)-{\beta}$-D-glucan levels.

• Child Health Nursing Research
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• 제10권4호
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• pp.442-450
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• 2004

Purpose: The purpose of this study was to identify the relation between personality traits and awareness of gender equality. Method: A descriptive survey design was used and 688 students in fifth and sixth grades in 3 elementary schools were selected as participants. Result: 1. Level of gender equality awareness among the students was 2.82. This is higher than average and was most influenced by awareness of family life, followed by awareness in education, work environment and social-cultural life. 2. Students with higher levels of extraversion-introversion had higher levels of awareness of gender equality in family life, work environment, and education. Students with higher levels of tough-mindedness showed lower levels of gender equality awareness in family life and work environment, while those with higher levels of lying showed lower levels of gender equality awareness in social-cultural life. Conclusion: Personality traits and awareness of gender equality were correlated to some degree. However, in order to understand the characteristics of childhood personality traits and the behaviors of our children though the mediation of the gender equality awareness as society changes, and to let them grow with understanding of gender equality, it is essential to implement various kinds of education in families, schools, and the society.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1399-1404
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• 2016

We investigated the urinary levels of 14-3-3 protein beta/alpha to evaluate their diagnostic significance with regard to clear cell renal cell carcinoma (ccRCC) and angiomyolipoma (AML). Urine samples from 91 patients with ccRCC, 16 patients with AML and 24 healthy volunteers were assessed. We used an enzyme-linked immunosorbent assay (ELISA) to quantify 14-3-3 protein beta/alpha levels in urine. Values were higher in patients with ccRCC than in those with AML and in healthy volunteers. High levels were associated with pathologic stage, lymph node status, distant metastasis and poor survival. Urinary levels of 14-3-3 protein beta/alpha were significantly increased in patients with small-sized carcinoma, irrespective of being less than 4.0 cm and 2.0 cm, compared with levels in patients with AML. This study is the first to report that increased expression of 14-3-3 protein beta/alpha in urine is associated with advanced stage and poor survival in patients with ccRCC. In addition, urinary 14-3-3 protein beta/alpha may differentiate AML from RCC, even when small sized. These results suggest that examination of urinary 14-3-3 protein beta/alpha could serve as a diagnostic and prognostic marker in patients with ccRCC.

• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.163-168
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• 2014

Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.