• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.6
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• pp.11-27
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• 2019

The second venture "boom" diffusion strategy can be confirmed to be focused only on financing investment and finance, including achieving 5 trillion won annually in new venture investments, creating 20 unicorns, activating M&As and creating dynamic recovery markets. Of course, existing studies show that the fund is a very important policy for corporate growth, but various policy support will be needed to effectively scale up. To overcome these limitations, the scale-up support policies already in operation are analyzed by introducing scale-up policies in advanced countries such as the U.S. and Britain. It also aims to analyze domestic scale-up policies to draw up implications for establishing more effective scale-up policies. Academically, we are very lacking in research on scale-up at home and abroad, and we propose suggestions through this comparative study of policy cases to contribute to the promotion of various studies related to the scalability aspects of future research topics related to scale-up.

• The Microorganisms and Industry
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• v.16 no.2
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• pp.49-52
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• 1990

발효공업이 발달되면서 발효조의 scale-up에 대한 문제는 꾸준하게 연구되어져 왔다. 이 scale-up은 미생물 뿐만 아니라 최근에는 동물이나 식물 그리고 곤충세포의 대량배양을 위해서도 계속적으로 연구되고 있는 분야이다. 수많은 생물반응기가 개발되었고 또 개발중에 있는데, 각 반응기에 대한 scale-up의 방법은 서로 상이할 수 있기 때문에 본 고에서는 현재 산업계에서 가장 많이 사용되고 있는 전통적인 교반조 발효기에 대한 scale-up의 원리와 응용을 다루고자 한다.

• Journal of Environmental Science International
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• v.6 no.1
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• pp.25-31
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• 1997

The variations of gas hold-up, overall volumetric oxygen mass transfer coefficients and liquid circulation velocity in an internal loop reactor were investigated to manifest scale-up effect. The relationship between superficial gas velocity and gas hold-up were found as Ugr = 0.045 $\varepsilon$r in the pilot-scale and Ugr = 0.056 $\varepsilon$r in the bench-scale reactor. The overall volumetric oxygen mass tractsfer coefficient, KLa was slightly increased in the pilot-scale than in the bench-scale reactor. Flow regime was changed from the bubble flow to the churn-turbulent flow when the superficial gas velocity reached to 3.5 - 4 cm/sec in the pilot-scale.

• Journal of Korean Physical Therapy Science
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• v.15 no.3
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• pp.1-8
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• 2008

The purpose of this study was to compare the relationship among the Dynamic Gait Index(DGI), Berg Balance Scale(BBS) scores, Timed Up & Go Test(TUG), and subject characteristics. The subjects were fifteen stroke with hemiplegia were chosen in the Konyang University Hospital. Dynamic balance was measured Dynamic Gait Index(DGI), and balance was measured using Berg Balance Scale(BBS). Timed Up & Go Test(TUG) was used to evaluate functional mobility. Data were analyzed using Spearman correlation. There was significant correlated among Dynamic Gait Index(DGI), Berg Balance Scale(BBS) and Timed Up & Go Test(TUG)(p<.01). The correlation among subject characteristics and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG) score was significant result in r = -.527 from Dynamic Gait Index(DGI) and pathogenesis(p<.05). There were no significant statistical differences among the types of spasticity and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG). The comparison among the sex, type of hemiplegia, pain, pathogenesis and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG) score was significant result in pathogenesis(p<.05). The results of this study showed that there was high correlations among the Dynamic Gait Index(DGI) and balance test of people with stroke.

• Journal of Korean Society of Rural Planning
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• v.29 no.1
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• pp.11-17
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• 2023

In this study, the effect of orchard expansion, structural improvement, and potential demand of the orchard scale-up project implemented since 2004 to strengthen the competitiveness of orchard farmers was examined. The results of the analysis are summarized as follows. First, looking at the effect of scale-up by checking the standard income data of the Rural Development Administration, it was possible to confirm the effect of scale-up in that the income per unit area increases as the scale increases. Second, through the scale-up project, the effect of structural improvement in transferring the orchards of the aged farm households to the younger farm households was confirmed to be 13 years old on average in the case of a sale business and 16 years old in the case of a lease business. Third, it was found that income increased at a statistically significant level after participating in the orchard scale-up project for major fruit crops such as apples, pears, and peaches. Fourth, it was found that age and cultivated area had a statistical effect on the probability of participating in the orchard scale-up project for farmers who did not participate in the project. The potential business demand using the estimated results was found to be between 25,203 and 37,089.

• Journal of Microbiology and Biotechnology
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• v.9 no.6
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• pp.773-777
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• 1999

Scale-up experiments for hydrolysis of beef tallow, fat, and palm kernel with lipase derived from Candida cylindracea were carried out in 1-1, 100-1, and 10,000-1 reactors. The optimum agitation speed for the hydrolysis of the 1-1 reactor was investigated and found to be 350rpm, and this was a basis for the scale-up of agitation speed. The hydrolysis system in this work was the oil-water system in which the hydrolysis seems to process a heterogeneous reaction. An emulsion condition was the most important factor for determining the reaction rate of hydrolysis. Therefore, the scale-up of agitation speed was performed by using the power n = 1/3 in an equation of the rules of thumb method. The geometrical similarity for scaling-up turned out to be unsatisfactory in this study. Thus, the working volume per one agitator was used for the scale-up. In the case of scale-up from a 1-1 reactor to a 100-1 reactor, the hydrolysis of palm kernel was very much scaled-up by initiating the rules of thumb method. However, the hydrolysis of fat and beef tallow in a 100-1 reactor was a little higher than that of the 1-1 reactor because of the difference of geometrical similarity. The scale-up of hydrolysis from the 100-1 reactor to the 10,000-1 reactor was improved compared to that of the 1-1 to 100-1 reactor. The present results indicated that the scale-up of hydrolysis in the oil-water system by the rules of thumb method was more satisfactory under the condition of geometrical similarity. Even in the case where geometrical similarity was not satisfactory, the working volume per one agitator could be used for the scale-up of a heterogeneous enzyme reaction.

• Journal of the Korean Society of Combustion
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• v.1 no.1
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• pp.1-10
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• 1996

An effective scale-up methodology of fluidized bed incinerators for low calorific value industrial wastes such as paper sludge and sewage sludge has been developed based on the similarity rules. Conventional scale-up theories are briefly reviewed and a new simple theory defining the diffusion Fourier number is established taking account of the lateral mixing of fuels in the fluidized bed. From the design and the operating conditions of the pilot FBC plant at Inchon, important design data for the full-scale incinerators are calculated and discussed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.5
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• pp.1-14
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• 2021

Innovation and Scale-up of Start-up companies are becoming important national tasks. In the past, it was spread the start-up policy paradigm such as 'Start-up America', 'Start-up Chile', 'Start-up Britain' to overcome the recession globally. However as the economic recovery has become more visible recently in advanced economies, it is shifting from a start-up support policy to a scale-up oriented policy paradigm such as 'Scale-up America', Scale-up UK', 'Scale-up Denmark'. It is necessary to enter the scale-up phase beyond the start-up phase to increase the number of high-quality jobs and to continue economic growth. Therefore, it is necessary to grow the start-up into a strong medium-sized company and to lay the foundation for survival. Therefore, the purpose of this study is to consider the antecedent factors that influence the scale-up aspiration for the start-up firm to grow into a scale-up company, and empirically identifies the differences between the stages of economic development and entrepreneurs in the country. In order to accomplish the purpose, this study predicted scale-up by aspiration which is a predictor of scale-up behavior because it is difficult to achieve visible growth in a short period of time due to the characteristics of start-up companies. In order to empirically explore these relationships, the data were collected from nascent entrepreneurs who have less than 3.5 years of the Adult Population Survey(APS) among the subjects surveyed by the Global Entrepreneurship Monitor(GEM) and the national economic development stage are divided into Innovation-driven, Efficiency-driven, Factor-driven type economies. For the test hypotheses, this study adopted the multi-level model analysis for comparison between national economic development stages and using the R 3.5.0 program. The results of this study are as follows. There is difference between the national economic development and the entrepreneur in the relationship between innovation orientation of entrepreneurs and scale-up aspirations. As the economy of the country develops, the innovation activity of the entrepreneur becomes more active. Since start-ups are heavily influenced by entrepreneurs, there is a difference in the degree of aspiration depending on how innovative an entrepreneur is in the same environment. In terms of the relationship between innovation orientation and scale-up aspiration, the fear of failure was found to differ between national economic development and entrepreneurs. The fear of failure differ from country to country, and this is one of the important factors affecting entrepreneurial activities. It is expected that the factors influencing the growth of the start-up companies which are identified through the results of these studies, will be used to create a suitable scale-up ecosystem according to the national economic development stage.

• Applied Chemistry for Engineering
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• v.28 no.1
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• pp.17-22
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• 2017

This review deals with scale-up strategies for optimized chemical processes particularly for micron and submicron products. The method of finding scale-up factors was also introduced for two systems, a system with chemical reaction and a system without chemical reaction. This review is expected to serve as an initial guideline for process engineers who are to scale up their current chemical processes for small products of micron or submicron size.

• KSBB Journal
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• v.13 no.6
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• pp.700-705
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• 1998

Studies were made to investigate effects of the scale-up of stirred tank bioreactors on cell growth and alkaloids production for suspension cultures of Eschscholtzia californica. In the 1.5 L STR, cell lysis was observed at 110 rpm or higher agitation speed. The agitation speed of 30 L STR was 43.7 rpm to maintain the same shear stress developed in 1.5 L STR of 100 rpm. As a result of scale-up from 1.5 L to 30 L STR, the specific growth rate was decreased from 0.12 to 0.07 day-1. The alkaloids productivity was also decreased from 0.24 to 0.14 mg/L-day. Changes of mixing performance and oxygen transfer were studied to explain the decrease of cell growth and alkaloids production. Decreased oxygen transfer rate coefficient(KLa) and increased mixing time by the scale-up was observed at various aeration rates.