• Food Science and Biotechnology
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• 제16권3호
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• pp.392-397
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• 2007

We investigated whether ethanol extracts of the safflower seeds containing phenolic compounds were responsible for the bone-protecting effects. Crude ethanol extract (CEE) of the safflower seeds was fed for 4 weeks at the level of 1% in diet to female Sprague-Dawley rats that had been subjected to bilateral ovariectomy (OVX). The CEE effects (OVX+CEE) were evaluated by comparing results obtained from OVX, Sham, and OVX injected with $17{\beta}$-estradiol ($OVX+E_2$) groups. OVX resulted in a dramatic reduction in the trabecular bone mass of the proximal tibia (approximately 40% of the Sham group) and an increase in fat deposition in bone marrow. In $OVX+E_2$ group, the bone loss was completely prevented as well as marrow adiposity. In OVX+CEE group, approximately 80% of the bone mass was maintained compared with Sham group and fat deposition in the bone marrow was prevented. Meanwhile, the partially purified ethanol extract containing the phenolic compounds stimulated proliferation of the ROS 17/2.8 osteoblast-like cells in a dose-dependent manner, as potently as positive controls of $E_2$ and genistein. The present data demonstrate that the ethanol extracts of safflower seeds reduced bone loss caused by estrogen deficiency. The bone-protecting effect of safflower seeds seems to be mediated, at least partly, by the stimulating effect of the phenolic compounds on the growth of osteoblasts.

• 한국약용작물학회지
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• 제26권1호
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• pp.32-41
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• 2018

Background: To obtain useful safflower resources for breeding and research of functional materials, the present study was conducted to determine fatty acid compositions and antioxidant activities of 281 safflower accessions collected from East Asia including South Korea. Methods and Results: Lipid contents and fatty acids compositions were evaluated using soxhlet extraction and gas chromatography, respectively. A antioxidant activities were analyzed using a spectrophotometer. The evaluation range of safflower accessions showed very wide variation. In terms of lipid contents, the China accessions were higher than the collection from other regions, whereas antioxidant activities did not differ among regions. The result of the principal component analysis showed that the first and second principal component cumulatively explained 90.6% of the total variation. In clustering the safflower accessions, the tree showed four major clades. Group II (16 accessions) was high in lipid content, oleic acid and linoleic acid, whereas group III (50 accessions) exhibited higher antioxidant activities than other groups. Conclusions: It was recommended that the China collections be utilized as a useful resource for research on functional oil materials. These results provided valuable information for safflower breeders and researchers of functional food.

• 한국자원식물학회지
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• 제28권6호
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• pp.704-709
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• 2015

Safflower (Carthamus tinctorius L.) seeds have long been clinically used in Korea to promote bone formation and prevent osteoporosis. In addition, the safflower buds (SB) were found to have more useful functional ingredients than safflower seed. Thus, we investigated the preventive effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E₂ 10 μg/kg, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 3%) to OVX rats markedly increased trabecular formation in femur compared to OVX rats. Feeding of SB diet (0.3% or 3%) to OVX rats also decreased TRAP activity compared to OVX rats. These results suggest that SB diets have bone sparing effects by the decrease of osteoclast activity. We also observed that OVX rats fed with SB diet (0.3% or 3%) exhibited the decrease of calcium and phosphorus in serum compared to OVX-induced rats. Therefore, SB may be beneficial for the patients of osteoporosis, especially in postmenopausal women.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.149-150
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• 2010

• 한국작물학회지
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• 제26권1호
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• pp.96-102
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• 1981

본 실험은 홍화에 대한 파종기 7수준(3월 17일부터 5월 16일까지 10일 간격)과 질소 비료 5개 수준(무배비, 0.5배비, 표준비, 1.5배비 및 2배비)으로 각각 파종하여 알맞는 파종 적기 및 시비량 수준에 따른 형질간의 변이를 구명하기 위하여 상지대학 농학과 실습 포장에서 실시하였다. 얻어진 결과를 요약하면 다음과 같다. 1. 발아율은 파종기가 늦어짐에 따라 감소되고 발아세는 파종기가 늦어질 수록 증가하였다. 발아 최감기는 위의 결과와 반대로 반종기가 늦어질수록 단축되였다. 발아 소요 기간도 파종기가 늦어갈 수록 단축되었다. 2.초장, 분지수, 치경에서도 파종기가 늦어질 수록 감소되는 경향을 보여주었다. 또한 질소 시비량이 증가할 수록 초장 및 분지수는 증가되는 경향을 보였다. 3. 꼬투리와 1,000입중도 파종기가 지연될수록 감소되었고 1,000입중은 파종기가 이를 수록 무거워지는 경향을 보였다. 또한 질소 시비량이 증가함에 따라 꼬뚜리수와 수량에서토 현저한 증가를 보여 주었다. 4. 파종기 차이에 따른 등황색 및 등홍색 꽃의 중량은 4월 상순 파종구가 가장 무거웠다. 그러나 질소 시비량의 증가는 개화에 영향을 주지 않는 것으로 나타나고 있었다. 5. 본 실험의 결과로서 파종 적기는 4월 상순이라고 믿어졌고 홍화 재배에서는 다비의 효과가 있는것으로 나타나고 있었다.

• Preventive Nutrition and Food Science
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• 제8권1호
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• pp.46-53
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• 2003

The current study investigated the effect of Korean safflower (Carthamus tinctorius L.) seed powder and its water and ethanol extracts on bone metabolism during recovery from rib-fracture induced by surgical operation in rats. 10-week-old male Sprague-Dawley rats weighing about 320 g were divided into 9 groups after arrival: 10d control (AIN 76 semi-purified diet), 10d safflower seed powder (10d SS-powder), 10d safflower seed ethanol extract (10d SS-EtOH), 10d safflower seed water extract (10d SS-$H_2O$), 20d control (AIN-76 semi-purified diet), 20d safflower heed powder (20d SS-powder), 20d safflower seed ethanol extract (20d SS-EtOH), 20d safflower seed water extract (20d SS-$H_2O$), and 20d sham-operation (20d sham), The dietary level for all the supplements was 5% based on the raw material weight. The rats were fed the experimental diets for 10 days before the rib fracture operation and for a further 10 or 20 days after the operation. A number 9 rib was fractured surgically and a sham-operation also performed. The rats were then sacrificed on the l0th or 20th day after the operation. The body weight initially decreased after the operation in all the rib-fractured groups, then gradually recovered. The concentrations of plasma osteocalcin were higher in the control group than in all the safflower-supplemented groups 10 and 20 days after the rib-fracture (p < 0.05). The bone-specific ALP (alkaline phosphatase) activity was significantly higher in the SS-EtOH group than in the other groups 20 days after the rib-fracture (p < 0.05). The level of urinary DPD (deoxypridinoline) was significantly higher in the SS-EtOH and SS-$H_2O$ groups than in the other groups 10 days after the rib-fracture. When comparing the PTH (parathyroid hormone) and calcitonin levels, the SS-$H_2O$ group exhibited the highest PTH level among the groups 10 and 20 days after the rib-fracture. Thus, it was concluded that the bone turnover during the fracture-healing period was more rapid in the rats supplemented with safflower seed powder or its fractions than in the control rats. Furthermore, the SS-$H_2O$ fraction was identified as the most effective in stimulating bone remodeling, as bone resorption and bone formation were both significantly increased during fracture healing when compared to the control group.

• 한국축산식품학회지
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• 제41권1호
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• pp.122-134
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• 2021

Recently, yogurt has been extensively studied to further enhance its functions using edible plant extracts. This study was conducted to investigate whether safflower petal (SP) as a natural food additive can be used to develop functional yogurt with improved health benefits. SPs were extracted with ethanol (SPE) and hot water (SPW), and then safflower yogurt was prepared by adding 0%-1.0% of those extracts to plain yogurt. With an increase in the fermentation duration, the pH of SPE and SPW yogurt samples was decreased, whereas titratable acidity and microbial counts were increased. The concentration of total polyphenols and total flavonoids, the activity of antioxidants, and the inhibitory effect on reactive oxygen species (ROS) were higher in SPW yogurt than SPE yogurt. Furthermore, α-glucosidase and lipase activity inhibitory effects of SPW yogurt were higher than those of SPE yogurt. In particular, free radical-scavenging activities, ROS inhibitory effect, and α-glucosidase activity inhibitory effects were significantly increased in SPW yogurt in a dose-dependent manner. Overall, these results suggest that SP extract possesses antioxidant activities and that it can downregulate α-glucosidase and lipase activities. The SP extract may have potential benefits as a natural food additive for the development of functional yogurt.

• Applied Biological Chemistry
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• 제35권4호
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• pp.272-275
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• 1992

한국산 녹차 종자(Camellia sinecis L.)에 함유된 단백질, 탄수화물, 조지방, 조회분 함량은 해바라기(Helianthus annuus)씨나 잇꽃종실(Carthamus tinctorius L.) 등과 대등하였으나, 조사포닌은 12.2%로 참깨(0.29%)나 땅콩(0.63%)보다 월등히 높게 함유하였고, oleic acid를 비롯한 불포화 지방산 조성은 82%였다. Tocopherol은 ${\alpha}-form$만 $22\;{\mu}g/g$ 보였을 뿐 일반종자보다 현저히 낮은 수준으로 함유하였다.

• 한국식품저장유통학회지
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• 제9권3호
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• pp.309-314
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• 2002

홍화씨의 식품재료로서의 이용성을 증가시키기 위한 목적으로서 양갱의 주원료인 건조 팥소 분말에 대한 볶은 홍화씨 분말 20, 35, 45 및 60mesh별로 첨가한 제품과 홍화씨 45mesh분말의 첨가량을 0, 5, 10, 15 및 20%로 하여 제조한 제품 및 배합수로 녹차추출물을 이용한 제품의 품질특성을 조사하였다. 수분함량은 20mesh 체분리 분말 첨가 제품에서 가장 낮은 27.6% 이었고, 동일한 45mesh 분말의 첨가량에 따른 양갱제품의 수분함량은 분말의 첨가량이 증가할수록 증가하는 경향을 보였다. 수분활성도는 60mesh 홍화씨 분말 첨가 제품에서 0.93로 가장 높았고, 45mesh분말의 첨가량에 따른 수분활성도는 분말의 첨가량이 증가할수록 높아지는 경향이었다. 색도는 분말의 mesh 수가 증가할수록 L값과 a값이 다소 낮아지는 경향이었고 반대로 b값은 다소 증가하였다. 동일한 입자크기를 가진 분말의 첨가량 증가에 따른 L, a 및 b값은 전반적인 증가현상을 보였다. 또한, 조직감 특성 중 견고성과 부숴짐성은 홍화씨 분말의 입도가 미세한 첨가구가 상대적으로 증가하였고 동일한 입도를 가진 홍화씨 분말 첨가량이 증가함에 따라 견고성과 부숴짐성은 증가하였고, 접착성과 탄력성은 감소하는 경향을 나타내었다. 관능평가에서도 전반적기호도, 조직감 및 부숴짐성이 홍화씨 분말의 입도가 미세한 첨가구가 상대적으로 증가하는 결과를 보였고, 증류수를 배합수로 제조한 제품과 증류수와 녹차추출물을 1:1로 혼합하여 제조한 제품에서 거의 같은 수준의 높은 관능점수를 얻었다.

• 한국작물학회지
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• 제50권spc1호
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• pp.187-190
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• 2005

홍화의 노지및 하우스재배의 생육과 수량 및 수확시기별 종실의 품질에 대한 시험결과를 요약하면 다음과 같다. 하우스비가림재배가 노지재배에 비해 출현기는 3일, 개화기는 8일이 빨랐으며, 생육도 양호하여 10g당 종실수량도 노지재배 보다 $25\%$ 증수되어 노지재배 보다 비가림재배가 유리하였다. 조지방함량은 비가림하우스재배가 노지재배보다 높았고 종자의 색택도 비가림하우스재배에서 변색없이 흰색이었으나 노지재배에서는 변색되어 품질이 나빴다. 노지재배의 조지방 함량은 수확기까지 높아졌으며 개화성기 20일 이후 수확에서는 차이가 없었으나, 종실의 색깔은 개화성기 30일 이후 점차 변하여 개화성기 후 40일 수확은 흑갈색으로 종실품질이 크게 떨어져 종실의 수확시기는 개화성기 후 20일에서 30일 사이가 가장 좋았다.