• 한국임상약학회지
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• 제31권1호
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• pp.21-26
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• 2021

Background: Pharmacogenomics is the study of how genetic mutations in patients affect their response to drugs. Pharmacogenomic studies aim to maximize drug effects and minimize adverse drug events. The Food and Drug Administration and the European Medicine Agency published guidelines for pharmacogenetics in 2005 and 2006, respectively; the Korean Ministry of Food and Drug Safety followed suit in 2015. Methods: This study analyzed pharmacogenomic information in the Korean Ministry of Food and Drug Safety's integrated drug information system to evaluate whether domestic pharmaceutical products reflect the current research on pharmacogenomic differences. Results: In June 2020, the Korean pharmacogenomic database contained genomic data on 90 compounds. Of these, 45 compounds were classified as "Antineoplastic and immunomodulating agents." The other 45 non-antineoplastic agents were in the following categories: Anti-infectives, Mental & behavior disorder, Hormone & metabolism related diseases, Cardiovascular system, Skin & subcutaneous tissue disease, Genito-urinary system and sex hormones, Blood and blood forming organs, Nervous system, Alimentary tract and metabolism, Musculo-skeletal system, and Other conditions including the respiratory system. In addition, 30 additives unrelated to the main ingredient were associated with genetic precautions. Conclusion: This study showed that antineoplastic and immunomodulating agents accounted for half the drugs associated with pharmacogenetic information. For antitumor and immunomodulatory drugs, genomic tests were recommended depending on the indication; this was in contrast to genomic testing recommendations for non-antineoplastic medications. Genomic tests were rarely requested or recommended for non-antineoplastic medications because the relationships between genotype and efficacy among those drugs were relatively weak.

• 한국건설관리학회논문집
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• 제20권3호
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• pp.113-121
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• 2019

우리나라의 사망사고만인율은 주요 국가와 비교하면 2~3배 높으며 그 중 건설현장의 추락사고는 가장 많은 사망사고를 유발하고 있다. 기존연구와 국가기관의 조치를 살펴보면 추락사고에 집중된 산업재해 관리의 미흡과 계절별 안전관리 대책의 미비가 그 원인인 것으로 판단된다. 본 연구에서는 기존 연구 및 조치의 한계점을 해결하기 위하여 계절별 건설현장 추락사고 특징을 도출하고, 추락사고 방지책을 마련하는데 필요한 적정 정보를 제공하고자 한다. 정보의 제공을 위하여 사고발생 인과간계에 대하여 기술한 계절별 건설현장 추락사고 기사데이터 387건을 수집 후, 주성분분석과 군집분석을 활용한 텍스트 마이닝을 실시하였다. 분석결과 계절별 특징으로서 봄에는 강설, 리프트를 포함한 장비의 무리한 운용 등이 원인이며, 여름에는 거푸집, 점검미비, 설치작업 등이 원인으로 나타났다. 그리고 가을에는 바람과 태풍의 날씨요인 등이 원인이며 겨울에는 자재운반 및 외벽작업, 안전수칙 미 준수 등이 추락사고의 원인으로 나타났다.

• 한국식품위생안전성학회지
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• 제36권4호
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• pp.342-346
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• 2021

최근 원액상태로 장시간 보관이 용이하고 특유의 향을 유지할 수 있는 콜드브루커피가 남녀노소에게 크게 인기를 얻음에 따라 커피판매업체의 규모와 수가 증가하고 있으며, 명절 선물용으로도 각광을 받고 있다. 콜드브루커피는 차가운 물로 장시간 추출한 커피이므로 세균에 노출될 가능성이 크다. 따라서 본 연구는 시중판매되고 있는 콜드브루커피의 안전성을 조사하여 소비자에게 올바른 정보와 건강한 먹거리를 제공하고자 하였다. 총 75건의 콜드브루커피를 대상으로 식품공전 액상커피의 규격기준(세균수, 대장균군)과 식중독균 9종 및 카페인 함량검사를 실시하였다. 조사한 결과 온라인에서 구매한 9개 제품의 세균수가 규격기준을 크게 초과하여 검출되었으며, 대장균군 및 식중독균 9종은 검출되지 않았다. 또한 조사한 콜드브루 제품의 평균 카페인 함량은 1.6 mg/mL(240 mL 제품의 경우 카페인 384 mg 함유)이며, 카페인 과다 섭취 시 불면증, 신경과민 등 부정적인 작용들이 존재하므로 성인 기준으로 카페인 최대 일일섭취권고량 400 mg/day을 초과하지 않도록 주의가 필요한 것으로 나타났다.

• Journal of Preventive Medicine and Public Health
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• 제31권3호
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• pp.414-423
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• 1998

Metal fume fever has been known as an occupational disease is induced by intense inhalation of fresh metal fume with a particle size smaller than $0.5{\mu}m\;to\;1{\mu}m$. The fumes originate from heating metals beyond their boiling point, as happens, for example, in welding operations. Oxidation usually accompanies this process. In most cases, this syndrome is due to exposure to zinc oxide fumes; however, other metals like copper, magnesium, cadmium, manganese, and antimony are also reported to produce such reactions. Authors report a case of metal fume fever suspected to be associated with copper fume inhalation. The patient was a 42-year-old male and was a smoker. He conducted inert gas tungsten arc welding on copper-coated materials without safety precautions such as a protective mask and adequate ventilation. Immediately after work, he felt metallic taste in his mouth. A few hours after welding, he developed headache, chilling sensation, and chest discomfort. He also complained of myalgia, arthralgia, feverish sensation, thirst, and general weakness. Symptoms worsened after repeated copper welding on the next day and subsided gradually following two weeks. Laboratory examination showed a transient increase of neutrophil count, eosinophilia, elevated erythrocyte sedimentation rate, and positive C-reactive proteinemia. Blood and urine copper level was also increased compared to his wife. Before this episode, he experienced above complaints several times after welding with copper materials but welding of other metals did not produce any symptoms. It was suggested that copper fume would have induced metal fume fever in this case. Further investigations are needed to clarify their pathogenic mechanisms.

• The Korean Journal of Pain
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• 제29권3호
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• 대한교통학회지
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• 제25권3호
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• pp.77-85
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• 2007

철도건널목에서 발생하는 사고는 도로상의 차량 사고에 비해 그 빈도수는 적지만 대형사고로 이어져 막대한 사회적 경제적 손실을 초래한다. 건널목의 기하구조측면에서 차량운전자는 철도건널목을 사전에 인지하여 이에 대응하여야 하나, 그렇지 못한 상황에서 사고위험이 존재한다. 그러므로, 철도건널목에 접근하는 차량에 대해 철도건널목의 시인성 확보는 철도건널목의 안전한 운영을 위해 필수적이라 할 수 있다. 하지만, 이와 관련된 연구가 국내에서는 거의 전무한 상태로 철도건널목 시인성 평가 및 이를 토대로 한 시인성 확보 노력이 절실한 상황이다. 따라서 본 연구에서는 국내 철도건널목에서 현장조사를 실시하여 이를 토대로 철도건널목 시인성을 평가할 수 있는 모델을 개발하였다. 건널목의 기하구조 및 접근도로의 제한속도 등 쉽게 구할 수 있는 변수들을 이용하였으며, 모델의 오차는 약 17.9m으로 나타났다. 개발된 모델을 이용하여 시인성에 영향을 미치는 요인에 대해 민감도 분석을 간편하게 할 수 있게 되어 시인성을 확보하기 위한 여러 가지 대안을 비교 평가할 수 있게 되었으며, 향후 건설되는 철도건널목의 설계에 반영하여 건널목에서 발생하는 사고를 미연에 방지하고 철도건널목 사고로 인하여 발생하는 막대한 사회적, 경제적 손실을 감소시킬 수 있게 되었다.

• 한국화재소방학회논문지
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• 제31권2호
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• pp.74-81
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• 2017

이 논문에서는 1회용 가스라이터의 규제실태, 화재발생 실태, 화재 및 사고의 발생원인, 예방대책을 조사 분석하였다. 1회용 가스라이터에 어린이 보호기능이 의무화된 이후에는 미국과 일본 등과 마찬가지로 전체화재 중 불장난으로 인한 화재의 비율이 감소하고 있다. 1회용 가스라이터로 인한 화재는 방화와 불장난을 제외하면 잔화, 의도하지 않은 점화, 큰 화염 발생, 고온장소 방치로 인한 파열 또는 폭발 등에 의해 발생하고 있다. 예방대책은 어린이 불장난 도구로 이용될 수 없게 조치, 잔화로 인한 화재사례 홍보, 차량 대시보드 위 또는 고온장소 방치의 위험성 홍보, 차량 의자 레일 멈춤 부분의 보호용 합성수지 커버의 개선, 서랍 등에 보관 시 주의사항 홍보, 폐기방법 홍보 등을 제안한다.

• 한국과학교육학회지
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• 제15권3호
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• pp.250-262
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• 1995

Investigation on the appendices was carried out to acquire teaching materials about improvement of a appendices and development of teaching-learning activities for science textbooks in Korean middle schools. We analysed the appendices for 30 kinds of science textbooks used in Korean middle schools during $1969{\sim}1994$ years. In the results there were three kinds of pattern for the appendices, such as appendix, non-appendix, and similar appendix without appendix title. The content of appendices were summarized as six categories. such as list of science and scientist history, SI unit-constants and symbols, handling methods of instruments for basic experiments, measuring methods and inquiry activity, safety and precautions, and supplementary data with figures and tables. The appendices of six categories were mostly a content of general and integrated science, and were concentrated in the first grader's textbooks. There were many appendices about the methods for basic experiments such as 'How to Use of Experimental Appliances' in the first grader's science textbooks, but there was no or lack of them in the second and the third grader's science textbooks in the middle school. By the ratio to the pages of appendices which were included according to curriculum changes. the ratio was found to be 4.47% which was the highest in middle school science textbooks at the second curriculum and to be 3.47% which was the highest in high school biology textbooks at the second curriculum. The results of this study indicated that the science textbooks should include as many appendices as possible, because teachers could utilize them in teaching activities and students should be able to be given much help in self-learning.

• 대한임상독성학회지
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• 제9권1호
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• pp.34-38
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• 2011

Vinegar is a very popular ingredient used in many cuisines. It is also known for its beneficial health, beauty and possible weight-loss properties. The authors report on a patient who presented to the emergency department with unstable vital signs complaining of generalized abdominal pain after ingestion of 450 ml of apple cider vinegar. We documented a case of corrosive gastrointestinal injury with persistent metabolic acidosis occurring after ingesting apple cider vinegar with an acetic acid concentration of 12~14%. Toxic damage to the liver and kidney were also observed, peaking on post-ingestion day 3. The patient received supportive care and hemoperfusion for three days without much clinical improvement and died in the seventh day of intensive care due to disseminated intravascular coagulation and multi organ failure. Edible vinegar, when taken in large amounts, is capable of inducing corrosive injuries of the GI tract as well as severe systemic toxicities, such as metabolic acidosis. Safety precautions regarding vinegar deserve more public attention and clinicians also should be astute enough to recognize the potential damage accompanying vinegar ingestion.

• 간호행정학회지
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• 제8권3호
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• pp.361-372
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• 2002

Purpose : The purpose of study was to identify to analysis of core nursing interventions performed by Operating Room nurses. Method : The subjects of the study were arbitrarily selected nurses(n=104) working in Operating Room. The period for data collection was 15 days from July, 15, 2002 to July, 30. 2002. The instrument for study was 486 Nursing Interventions Classification developed by McClosky & Bulechek(2000) and was translated into Korean. In 486 nursing interventions, 57 nursing interventions were selected by more than half of 47 professional nurses group of Operating Room. 57 nursing interventions were used as a secondary questionnaire. In the secondary questionnaire, labels and definitions of all 57 interventions were listed. The collected data were self reported by Operating Room nurses. The data were analysed with SPSS program. Result : In 57 nursing interventions, the 'Behavior' domain was the most frequently used. Core interventions of Operating Room were performed several times a day by more than 50% of Operating Room nurses. Core interventions of Operating Room were 16 Core interventions, 7 classes, 5 domains. In the core interventions, the 'Physiological:Complex' domain was the most frequently used. Core interventions of Operating Room were Surgical Preperation, Infection Control:Intraoperative, Surgical Precautions, Fall Prevention, Documentation, Surgical Assistance, Environmental Management:Safety, Skin Surveillance, Physical Restraint, Pressure Ulcer Prevention, Environmental Management:Comfort, Infection Protection, Presence, Emotional Support, Specimen Management, Shift Report. Conclusion : Core interventions of Operating Room have implications for nursing care practice, nursing education, nursing research, and nursing information system in Operating Room.