• Biomolecules & Therapeutics
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• v.13 no.4
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• pp.199-206
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• 2005

Cell therapy (CT) is a group of techniques to treat human disorders by transplantation of cells which have been processed and propagated independent of the living body. Blood transfusion and bone marrow transplant have been the primary examples of cell therapy. With introduction of stem cell (SC) technologies, however, CT is perceived as the next generation of biologies to treat human diseases such as cancer, neurological diseases, and heart disease. Despite potential of cell therapy, insufficient guidelines have been implemented concerning safety test and regulation of cell therapy. This review addresses the safety issues to be resolved for the cell therapy, especially SC therapy, to be successfully utilized for clinical practice. Adequate donor cell screening must preceed to ensure safety in cell therapy. In terms of SC culture, controlled, standardized practices and procedures should be established. Further molecular studies should be done on SC development and differentiation to enhance safety level in cell therapy. Finally, animal model must be further installed to evaluate toxicity, new concepts, and proliferative potential of SC including alternative feeder layer of animal cells.

• Journal of the Korean Society of Safety
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• v.25 no.4
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• pp.7-12
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• 2010

The average growth in the wind power energy market during the past five years has been 26% per year. Renewable energy resources, of which wind energy is prominent, are part of the solution to the global energy problem. Wind power system and the rotor blade concepts are reviewed, and loadings by wind and gravity as important factors for the mechanical performance of the materials are considered. So, the mechanical properties of fiber composite materials are discussed. In addition, it is necessary to analyze and evaluate the stress distribution and deformation for them in the design level. This study shows the result that CFRP rotor blade of wind turbine satisfies the strength and deformation through numerical analysis using the commercial finite element analysis program.

• The Journal of Sustainable Design and Educational Environment Research
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• v.10 no.2
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• pp.20-29
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• 2011

The purpose of this study is to suggest a scheme to provide children safer and more comfortable walking circumstances by survey current walking circumstances of schoolzone ways. A scheme suggested in this study was based on the analysis of survey to elementary school in 3 Newtowns(Dongtan, Dongbaek and Gumdan Districts) and actually surveyed data on school zone, the scheme can be summed up as follows; First, to avoid pedestrian roads being interrupted and to expend waiting space near schoolzone ways, several measures are needed including fixing roads and building additional gateway. Second, to secure pedestrians' safety in school zone ways should be planned and established more security concepts und facilities Third, to improve the walking safety in schoolzone way should be established specially "schoolzone B-plan".

• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.173-177
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• 2019

This study is door safety device for the structural analysis are described. Recently emerged as a key point of the door safety and increase the need of a door safety device. In order to improvement this inconvenience, the door safety device was design and structural analysis by using CATIA. CATIA utilizes door safety device element model for displacement, stress and strain energy were obtained. Consideration of door open angles were $95^{\circ}$, $100^{\circ}$, $105^{\circ}$, $110^{\circ}$, $115^{\circ}$, $120^{\circ}$. These results will be provided to develop new concepts of door safety device as initial data.

• Smart Media Journal
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• v.13 no.8
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• pp.79-86
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• 2024

In design studies, there has been extensive prior research on accident and disaster prevention, but it mainly focuses on visualization methods to improve visibility. Most accidents and disasters are caused by human factors. However, there is little design research that considers human characteristics that manifest in dangerous situations. This study aims to identify the concepts and characteristics of safety information design that reflects human traits. It examines the concepts of risk and safety from a social science perspective and looks into human visual information processing from a cognitive neuroscience perspective. Additionally, it explores the relationship between human information processing and accident rates in dangerous situations from a psychological perspective. Based on these analyses, the study distinguishes between conventional information design and safety information design, ultimately identifying the features of safety information design that incorporates human traits. The key findings are as follows: First, information should be presented considering the human tendency to suspend rational judgment in dangerous situations. Second, appropriately dispersing or concentrating attention according to the level of risk can serve as an opportunity to minimize harm. Third, it was found that sensory and perceptual characteristics should be given top priority in the field of risk and safety information design. Through these findings, the study concludes that a design approach that reflects human traits in safety information design can ultimately be a key indicator for improving safety levels.

• Korean Journal of Health Education and Promotion
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• v.7 no.1
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• pp.10-26
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• 1990

In Korean education, the health contents are scattered in various course subjects throughtout the primary and junior high school curriculum. So it is very difficult to provide systematic health education. The purpose of this study was to provide a guide for health education using health topic areas and major concepts that represent the scope of material that should be covered in health instruction. The steps used in selecting these health topic areas and major concepts were as follows: 1. A review of the literature related to health and health education was done to develop the rationale underlying this study. 2. Health topic areas basic to the growth and development characteristics of children, to human needs and to societal needs for healthful living were indentified. 3. The major concepts for each health topic area based on health sciences and children's growth and development levels were selected. 4. The major concepts selected were organized in sequence to guide health education from grade one to grade nine. The results of this study were as follows: 1. The identification of eleven health topic areas essential for health education. These include: personal habits and health healthy growth and development nutrition and health prevention of disease and disorders drugs and health mental health family life and health sex education accident prevention consumer health community health 2. The identification of the major concepts(generalizations) for each health topic area: 33 major concepts were identified as a guide in determining the health content of health education programs. These are 1) body cleaniness, 2) health of the sensory organs, 3) dental health, 4) exercise and rest, 5) growth and development, 6) body structure and function, 7) developmental tasks, 8) balanced nutrition, 9) eating habits, 10) food preparation and food storage, 11) sources of disease and disorders, 12) disease preventive behavior, 13) care during illness, 14) drug use and misuse, 15) drug addiction, 16) emotional responses, 17) human relationship, 18) self concept, 19) social adjustment, 20) health habits of the family, 21) interdependence of family members, 22) origin of life, 23) characteristics of man and woman, 24) sexual instinct, 25) safety behavior, 26) emergency measures, 27) criteria for selection of health products, 28) proper use of health information, 29) utilization of health and medical services, 30) environmental conservation, 31) environmental pollution, 32) population control, 33) function of public health services. 3. The organization of the concepts(generalizations) in sequence and for continuity in health instruction at the primary and junior high school level.

• Journal of the Ergonomics Society of Korea
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• v.35 no.2
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• pp.111-123
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• 2016

Objective: The objective of this research is to study preceding literature on safety culture surveying tools and indicators used in aviation organizations to help the further understanding of aviation safety culture by presenting Korea-Safety Culture Survey Indicator (K-SCSI) as a relevant case. Background: The aviation field puts a great deal of effort in preventive safety management through the application of Safety Management System (SMS), which was co-developed by international aviation organizations such as ICAO and FAA. To successfully operate safety management system, safety culture factors such as the organization member's level of consciousness, attitude and faith regarding safety must be put together. However, the aviation field currently lacks programs to promote safety culture and the exact understanding of some safety culture concepts. Method: This research inquired into the definition of safety culture in the aviation field and the surveying tools used to measure it. It then described the development and application process of the Korea-Safety Culture Survey Indicator (K-SCSI) mainly focusing on case studies. Results: In this research are presented safety culture promoting programs that can be applied to subordinate indicators of K-SCSI such as organization commitment, management involvement, rationality of reward system, employee empowerment and reporting system. Conclusion: For a mature safety culture to settle successfully, it is essential that safety culture survey indicators are developed and applied in a way that fits the organization's features. Also, behavior measuring indicators are required to develop a more objective indicator and thus must be standardized. Application: Cases that deal with the development and application of safety culture measuring tools within the aviation field can be studied and applied in other domains to spread safety culture.

• Nuclear Engineering and Technology
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• v.49 no.7
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• pp.1431-1441
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• 2017

The Fukushima accident reveals the vulnerability of existing active nuclear power plant (NPP) design against prolonged loss of external electricity events. The passive safety system is considered an attractive alternative to cope with this kind of disaster. Also, the passive safety system enhances both the safety and the economics of NPPs. The adoption of a passive safety system reduces the number of active components and can minimize the construction cost of NPPs. In this paper, reflecting on the experience during the development of the APR+ design in Korea, we propose the concept of an innovative Power Reactor (iPower), which is a kind of passive NPP, to enhance safety in a revolutionary manner. The ultimate goal of iPower is to confirm the feasibility of practically eliminating radioactive material release to the environment in all accident conditions. The representative safety grade passive system includes a passive emergency core cooling system, a passive containment cooling system, and a passive auxiliary feedwater system. Preliminary analysis results show that these concepts are feasible with respect to preventing and/or mitigating the consequences of design base accidents and severe accidents.

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.498-508
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• 2021

Micro reactors are increasingly being considered for utilization as distributed power sources. Hence, the probabilistic safety assessment (PSA) of a direct supercritical-CO₂-cooled fast reactor, called micro modular reactor (MMR), was performed in this study; this reactor was developed using innovative design concepts. It adopted a modular design and passive safety systems to minimize site constraints. As the MMR is in its conceptual design phase, design weaknesses and valuable safety insights could be identified during PSA. Level 1 internal event PSA was carried out involving literature survey, system characterization, identification of initiating events, transient analyses, development of event trees and fault trees, and quantification. The initiating events and scenarios significantly contributing to core damage frequency (CDF) were determined to identify design weaknesses in MMR. The most significant initiating event category contributing to CDF was the transients with the power conversion system initially available category, owing to its relatively high occurrence frequency. Further, an importance analysis revealed that the safety of MMR can be significantly improved by improving the reliability of reactor trip and passive decay heat removal system operation. The findings presented in this paper are expected to contribute toward future applications of PSA for assessing unconventional nuclear reactors in their conceptual design phases.

• Journal of Food Hygiene and Safety
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• v.22 no.1
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• pp.1-14
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• 2007

The term, "food safety", has traditionally been viewed as a practical science aimed at assuring the prevention acute illnesses caused by biological microorganisms, and only to a minor extent, chronic diseases cause by chronic low level exposures to natural and synthetic chemicals or pollutants. "food safety" meant to prevent microbiological agents/toxins in/on foods, due to contamination any where from "farm to Fork", from causing acute health effects, especially to the young, immune-compromised, genetically-predisposed and elderly. However, today a broader view must also include the fact that diet, perse (nutrients, vitamins/minerals, calories), as well as low level toxins and pollutant or supplemented synthetic chemicals, can alter gene expressions of stem/progenitor/terminally-differentiated cells, leading to chronic inflammation and other mal-functions that could lead to diseases such as cancer, diabetes, atherogenesis and possibly reproductive and neurological disorders. Understanding of the mechanisms by which natural or synthetic chemical toxins/toxicants, in/on food, interact with the pathogenesis of acute and chronic diseases, should lead to a "systems" approach to "food safety". Clearly, the interactions of diet/food with the genetic background, gender, and developmental state of the individual, together with (a) interactions of other endogenous/exogenous chemicals/drugs; (b) the specific biology of the cells being affected; (c) the mechanisms by which the presence or absence of toxins/toxicants and nutrients work to cause toxicities; and (d) how those mechanisms affect the pathogenesis of acute and/or chronic diseases, must be integrated into a "system" approach. Mechanisms of how toxins/toxicants cause cellular toxicities, such as mutagenesis; cytotoxicity and altered gene expression, must take into account (a) irreversible or reversal changes caused by these toxins or toxicants; (b)concepts of thresholds or no-thresholds of action; and (c) concepts of differential effects on stem cells, progenitor cells and terminally differentiated cells in different organs. This brief Commentary tries to illustrate this complex interaction between what is on/in foods with one disease, namely cancer. Since the understanding of cancer, while still incomplete, can shed light on the multiple ways that toxins/toxicants, as well as dietary modulation of nutrients/vitamins/metals/ calories, can either enhance or reduce the risk to cancer. In particular, diets that alter the embryo-fetal micro-environment might dramatically alter disease formation later in life. In effect "food safety" can not be assessed without understanding how food could be 'toxic', or how that mechanism of toxicity interacts with the pathogenesis of any disease.