• Proceedings of the KIEE Conference
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• 2001.04a
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• pp.63-66
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• 2001

원자력발전소는 지진과 같은 자연재해나 극한 운전조건에서 방사능물질이 외부로 누출되는 것을 방지하도록 설계 되어야한다. 따라서 이와 관련된 안전등급기기는 원전설비의 정상운전조건뿐 아니라 원전설계기준 사고조건(DBE, Design Basis Events)에서도 그 안전성 관련 기능이 검증되어야 한다. 본 연구에서는 국내 원자력 발전소의 다양한 환경조건을 만족하며 엄격한 기기검증요건에 따라 당사가 수행한 안전등급(Class 1E) 저압 유도전동기의 개발사례를 중심으로 방사능노출시험, 가속열노화해석 및 시험, 내진해석 및 시험으로 구성되는 기기검증의 절차와 방법을 제시하였다.

• Journal of Food Hygiene and Safety
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• v.24 no.4
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• pp.318-323
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• 2009

Dahi is yoghurt like fermented dairy products available in Bangladesh made by traditional ways from raw milk. The aim of the present study was to check and compare the present quality status of the market dahi in reference to laboratory made dahi. For this, dahi was prepared in the laboratory (A) and collected from Kishoregonj district (B), Gazipur district (C), Bogra district (D) and Dhaka district (E and F). Consumer acceptance quality was judged on 100 point by a judge panel and chemical and microbiological quality test were done by established methods. 'A' type dahi was superior followed by E, D, F, B and C considering the consumer acceptance quality parameter. From chemical test, it appears that, B possess the lowest pH ($3.75\;{\pm}\;0.05$) and highest was in C ($4.46\;{\pm}\;0.15$). Total solids content of F type dahi ($318.40\;{\pm}\;4.44\;g/kg$) was highest and fat ($52.00\;{\pm}\;2.00\;g/kg$), protein ($44.33\;{\pm}\;2.00\;g/kg$) and ash ($10.76\;{\pm}\;0.31\;g/kg$) content were also higher in F type dahi. E and A type dahi were also with considerable figure in chemical quality parameter. Dahi B was inferior in respect of microbiological quality- total viable count (TVC) (${\times}\;10^5\;cfu/ml$) content was $94.00\;{\pm}\;4.58$, yeast (cfu/ml) content was $183.33\;{\pm}\;15.28$ and mold (cfu/ml) content was $53.33\;{\pm}\;15.28$. The TVC (${\times}\;10^5\;cfu/ml$), yeast (cfu/ml) and mold (cfu/ml) content of A type dahi were $39.67\;{\pm}\;4.51$, $50.00\;{\pm}\;10.00$ and $20.00\;{\pm}\;10.00$, respectively. Considering all the three major quality aspects dahi A was superior than others followed by F, D, E, C and B.

• Molecules and Cells
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• v.37 no.10
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• pp.727-733
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• 2014

Spinosyns A and D are potent ingredient for insect control with exceptional safety to non-target organisms. It consists of a 21-carbon tetracyclic lactone with forosamine and tri-Omethylated rhamnose which are derived from S-adenosyl-methionine. Although previous studies have revealed the involvement of metK1 (S-adenosylmethionine synthetase), rmbA (glucose-1-phosphate thymidylyltransferase), and rmbB (TDP-D-glucose-4, 6-dehydratase) in the biosynthesis of spinosad, expression of these genes into rational screened Saccharopolyspora spinosa (S. spinosa MUV) has not been elucidated till date. In the present study, S. spinosa MUV was developed to utilize for metabolic engineering. The yield of spinosyns A and D in S. spinosa MUV was $244mgL^{-1}$ and $129mgL^{-1}$, which was 4.88-fold and 4.77-fold higher than that in the wild-type ($50mgL^{-1}$ and $27mgL^{-1}$), respectively. To achieve the better production; positive regulator metK1-sp, rmbA and rmbB genes from Streptomyces peucetius, were expressed and co-expressed in S. spinosa MUV under the control of strong $ermE^*$ promoter, using an integration vector pSET152 and expression vector pIBR25, respectively. Here-with, the genetically engineered strain of S. spinosa MUV, produce spinosyns A and D up to $372/217mgL^{-1}$ that is 7.44/8.03-fold greater than that of wild type. This result demonstrates the use of metabolic engineering on rationally developed high producing natural variants for the production.

• Korean Journal of Veterinary Service
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• v.47 no.1
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• pp.19-26
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• 2024

Canine atopic dermatitis (CAD) is an inflammatory and pruritic skin disease with a genetic predisposition, characterized by allergic sensitivity. It is known for its distinctive clinical features, including a high recurrence rate and chronic progression. To manage CAD, medications such as steroids and immunosuppressants are commonly used, but consideration should be given to the potential resistance and side effects associated with long-term use. In order to reduce these risks, various adjunctive factors are currently under consideration. One of these adjunctive agents, probiotics have shown effectiveness in regulating atopic dermatitis by modulating immune responses, as demonstrated in several recent studies. In this study, a substance combining three probiotics-L. plantarum, L. reuteri, and Ped. Acidilactici-was used in patients diagnosed with CAD, and its clinical effects and safety were evaluated. The trial involved four groups: a group receiving conventional treatment for atopic dermatitis (A), a group prescribed low-dose probiotics (B), a group prescribed high-dose probiotics (C), and a group prescribed topical probiotics (D). For assessment, the Canine Atopic Dermatitis Extent and Severity Index (CADESI), Trans-Epidermal Water Loss (TEWL) test, gut microbiome, and serum IgE test were conducted. As a result, the CAD severity index (CADESI-4) significantly decreased in the probiotics groups (B & C). In the serum total IgE test, the groups consuming probiotics showed a significant difference, while the group using topical probiotics (D) did not exhibit a significant change. Also, the TEWL test showed improved scores in the probiotics groups (B & C). Therefore, L. plantarum, L. reuteri, and Ped. Acidilactici probiotic combination could be considered as an effective adjunctive treatment, especially for atopic patients with moderate to severe skin lesions.

• Journal of Korean Society of Transportation
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• v.36 no.3
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• pp.169-183
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• 2018

Aggressive driving leads to a greater crash potential because it threatens surrounding vehicles. This study conducted traffic simulation experiments using driving behavior data obtained from multi-agent driving simulations. VISSIM traffic simulator and surrogate safety assessment model (SSAM) were used to identify the impacts of aggressive driving on traffic stream in terms of safety and operational efficiency. Market penetration rates (MPR) of aggressive driving vehicle, coupled with various traffic conditions, were taken into consideration in analyzing the impacts. As expected, it was identified that aggressive driving vehicles tended to deteriorate the traffic safety performance. From the perspective of operational efficiency, interesting results were observable. Under level of service (LOS) A, B, and C, it was observed that the average travel speed increased with greater MPRs. Conversely, the average travel speed decreased with under LOS D and E conditions. The outcome of this study would be effectively used for developing safety-related policies for reducing aggressive driving behavior.

• Journal of the Institute of Convergence Signal Processing
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• v.23 no.1
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• pp.28-36
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• 2022

Currently, the automation and intelligence of the shipbuilding industry have improved its work production capacity and cost competitiveness, but the reduction rate of safety accidents among industrial site workers is still low and the damage caused by safety accidents is very serious, so there is a need for improvement according to the workplace. This research aims to demonstrate the connectivity between smart safety helmets in the demonstration area to verify the effectiveness along with the development of smart helmets for worker protection and environmental safety in shipyards. For efficient communication between workers, impact noise of over 95dB was confirmed in the workplace, and noise reduction was required. To solve this problem, the filtering performance was compared and analyzed using the Butterworth, Chebyshev, and elliptic algorithms. The connectivity test and noise reduction method between smart helmets proposed in this study will increase the usability and safety of the field through the development of advanced smart helmets tailored to the shipbuilding workplace in the future.

• Journal of the Korean Society of Safety
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• v.15 no.2
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• pp.111-117
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• 2000

In this study, the bearing capacity behavior of strip footing located above a continuous cavity in sand was investigated experimentally. The model footing test was performed in a model box made by using raining method in sand. The model footing test results were compared with those obtained from theoretically proposed equations. The results of the analysis indicate that there is a critical region under the footing. For strip footing, there exists a critical depth below which the presence of the cavity has negligible influence on the footing performance. Only when the cavity is located within this region will the footing performance be significantly affected by the presence of the cavity. The size of the critical region depends on several factors such as footing shape, soil property, cavity size and cavity shape. When the cavity is located within the critical region, the bearing capacity of the footing varies with various factors, such as the size and location of the cavity and the depth of foundation. Based on the experimental study, the following conclusions were induced. 1. The ultimate bearing capacity due to the eccentricity of a underground cavity increases at the rate of the small rather than that due to the depth of a underground cavity. This indicates that the bearing capacity of a strip footing is influenced on the depth rather than the eccentricity of a underground cavity. 2. The critical $depth(D/B)_{cr}$, by underground cavity in sand soil ground that is made by the relative density($D_r$)=55%, 65%, 75%, approaches a range of about 8~10 in case of W/B=1, and about 11~13 in case of W/B=2. 3. In case of the relative density($D_r$) 75%, the most outstanding differential settlement trend is shown in the depth of 4~8cm regardless of the size of cavity, namely, when the value of D/B is 1~2. Therefore, a underground cavity influences on not only the decrease of the bearing capacity but also the differential settlement of a strip footing.

• Journal of the Korean Society of Marine Environment & Safety
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• v.21 no.6
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• pp.751-758
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• 2015

Noise prediction for HVAC(Heating, Ventilating and Air Conditioning) systems are normally performed by empirical method suggested by NEBB(National Environmental Balancing Bureau, 1994). However, the method is not suitable for large ducts in ships. In this paper, computational analysis methods are used to develop a noise prediction method for the large ducts in ships. To develop regression formula of attenuation of sound pressure level in large ducts, Boundary Element Method(BEM) is used. BEM and Computational Fluid Dynamics(CFD) are applied to the analysis of flow-induced noise in ducts with stiffeners inside. Loud noise above 100 dB can be generated in some cases. Breakout noises of large ducts are also analyzed by using BEM and Finite Element Method(FEM). The acoustic pressure level shows about 10-15dB difference between inside and outside of the duct. Utilizing the results of this study, it is expected that shipyard planners can predict noise of the HVAC system for ships.

• Nuclear Engineering and Technology
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• v.45 no.5
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• pp.613-624
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• 2013

Multi-dimensional two-phase phenomena occur in many industrial applications, particularly in a nuclear reactor during steady operation or a transient period. Appropriate modeling of complicated behavior induced by a multi-dimensional flow is important for the reactor safety analysis results. SPACE, a safety analysis code for thermal hydraulic systems which is currently being developed, was designed to have the capacity of multi-dimensional two-phase thermo-dynamic phenomena induced in the various phases of a nuclear system. To validate the performance of SPACE, a two-dimensional two-phase flow test was performed with slab geometry of the test section having a scale of $1.43m{\times}1.43m{\times}0.11m$. The test section has three inlet and three outlet nozzles on the bottom and top gap walls, respectively, and two outlet nozzles installed directly on the surface of the slab. Various kinds of two-dimensional air/water flows were simulated by selecting combinations of the inlet and outlet nozzles. In this study, two-dimensional two-phase void fraction profiles were quantified by measuring the local gap impedance at 225 points. The flow conditions cover various flow regimes by controlling the flow rate at the inlet boundary. For each selected inlet and outlet nozzle combination, the water flow rate ranged from 2 to 20 kg/s, and the air flow rate ranged from 2.0 to 20 g/s, which corresponds to 0.4 to 4 m/s and 0.2 to 2.3 m/s of the superficial liquid and gas velocities based on the inlet port area, respectively.

• Polymer(Korea)
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• v.36 no.4
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• pp.420-426
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• 2012

In this study, we prepared polymer micelles containing quercetin and rutin, known as antioxidants, using poly(${\varepsilon}$-caprolactone)-b-poly(ethylene glycol), and evaluated in vitro skin permeation of the active materials. Quercetin and rutin loaded micelles were characterized by DSC (differential scanning calorimetry), HPLC (high performance liquid chromatography) and DLS (dynamic light scattering) measurements. The particle size of the polymer micelles increased in a concentration dependent manner (0.5~2.0% PCL-b-PEG). The Zeta potential of quercetin and rutin loaded micelles remained constant. To evaluate the skin penetration of PCL-b-PEG micelles, Franz diffusion cell experiment was performed. The aqueous solutions of quercetin and rutin were used as the control groups. Quercetin and rutin loaded PCL-b-PEG micelles showed more efficient skin permeation than the control groups. Safety assessment (patch test) of quercetin and rutin loaded PCL-b-PEG micelles on skin was performed to test application possibility of the polymer micelles to cosmetics. Any adverse symptoms were not observed.