• 한국섬유공학회:학술대회논문집
• /
• 한국섬유공학회 2002년도 봄 학술발표회 논문집
• /
• pp.466-469
• /
• 2002

Polyurethane(PU)은 segmented 블록공중합체로써 상온보다 높은 유리전이온도(glass transition temperature, Tg)를 갖는 hard segment(H.S)와 상온보다 낮은 Tg를 갖는 soft segment (S.S)로 구성되어 있다. 이들 두 segment간의 열역학적 불친화성으로 인해 미세 상분리 구조를 갖는다$^1$. 그 결과 hard segment-rich hard domain과 soft segment-rich soft matrix의 구조를 이룬다. 이중 hard domain(HD)은 상온에서 glassy한 성격을 띄므로 물리적 가교점과 충진제의 역할을 하며 soft domain(SD)은 rubbery한 성질을 가지므로 polurethane에 탄성을 부여하는 역할을 한다. (중략)

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권3호
• /
• pp.1115-1118
• /
• 2016

Background: There is controversy about ablation efficacy of low or high doses of radioiodine-131 (RAI) in patients with differentiated thyroid cancers (DTC). The purpose of this prospective study was to determine efficacy of 30 mCi and 100 mCi of RAI to achieve successful ablation in patients with low to intermediate risk DTC. Materials and Methods: This prospective cross sectional study was conducted from April 2013 to November 2015. Inclusion criteria were patients of either gender, 18 years or older, having low to intermediate risk papillary and follicular thyroid cancers with T1-3, N0/N1/Nx but no evidence of distant metastasis. Thirty-nine patients were administered 30 mCi of RAI while 61 patients were given 100 mCi. Informed consent was acquired from all patients and counseling was done by nuclear physicians regarding benefits and possible side effects of RAI. After an average of 6 months (range 6-16 months; 2-3 weeks after thyroxin withdrawal), these patients were followed up for stimulated TSH, thyroglobulin (sTg) and thyroglobulin antibodies, ultrasound neck (U/S) and a diagnostic whole body iodine scan (WBIS) for ablation outcome. Successful ablation was concluded with stimulated Tg< 2ng/ml with negative antibodies, negative U/S and a negative diagnostic WBIS (triple negative criteria). ROC curve analysis was used to find diagnostic strength of baseline sTg to predict successful ablation. Results: Successful ablation based upon triple negative criteria was 56% in the low dose and 57% in the high dose group (non-significant difference). Based on a single criterion (follow-up sTg<2 ng/ml), values were 82% and 77% (again non-significant). The ROC curve revealed that a baseline sTg level ${\leq}7.4ng/ml$ had the highest diagnostic strength to predict successful ablation in all patients. Conclusions: We conclude that 30 mCi of RAI has similar ablation success to 100 mCi dose in patients with low to intermediate risk DTC. A baseline $sTg{\leq}7.4ng/ml$ is a strong predictor of successful ablation in all patients. Low dose RAI is safer, more cost effective and more convenient for patients and healthcare providers.

• Journal of Nutrition and Health
• /
• 제17권4호
• /
• pp.281-289
• /
• 1984

The present studies were designed to observe the effects of both dietary fat levels and P/S ratio on lipid components in plasma and tissues of young rats when cholesterol was supplemented at 1%(w/w) to four dietary groups providing total fat as 10%( LF ) or 45% ( HF ) of calories and P/S ratio as 0.2 or 4.0, Low Fat-0.2 : Low Fat-4.0 : High Fat-0.2 : High Fat-4.0. Plasma total cholesterol was increased almost to the same level in all dietary groups after the cholesterol supplement but the value of HF -0.2 was slightly higher than that of LF -0.2. Plasma TG was also increased in all dietary groups when cholesterol was supplemented but was more significantly increased in LF group than in HF group. HDL-cholesterol was slightly increased by cholesterol supplement but there was no effect by the total dietary fat level of previous diet. However, plasma HDL-cholesterol, total cholesterol and TG levels were slightly reduced in high fat diet of P/S 4.0. Total cholesterol per g -liver was higher in HF group than in LF group before and after cholesterol supplement even though it was increased more in LF group with cholesterol addition. Liver cholesterol was also higher in rats fed diets of P/S 4.0 at high fat level before and after cholesterol supplement. In contrast, total cholesterol per g-muscle was reduced by cholesterol supplement in all groups and it was significantly higher in LF than in HF. There was no significant effect in liver TG by total fat level and P/S ratio when cholesterol was supplemented. Muscle TG was lowered in all groups by cholesterol supplement but no effect by total fat level and P/S ratio.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2002년도 Proceedings
• /
• pp.141-143
• /
• 2002

In 1995, the American Association of Physicists in Medicine (AAPM) Task Group 43 published a report dealing with the dosimetry of interstitial brachytherapy sources, generally known as the TG-43 report. Compared to previously adopted formalisms, a formalism proposed in this report provides a more accurate and systematic brachytherapy dose calculation method, especially for Ir-192 and other low energy gamma sources such as 1-125 and Pd-l03. In this lecture, an overview of the TG-43 formalism will be presented, along with the lecturer's experience in determining the TG-43 parameters by the Monte Carlo method and experimental methods such as TLD and radiochromic film.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2002년도 생물공학의 동향 (X)
• /
• pp.500-503
• /
• 2002

In order to improve the physical properties of food such as texture and food self-life. Transglutaminase(mTG) from Streptoverticillum morbarense was prepared. In the preliminary experiments, presence of proteases in the crude enzyme did not improve the texture of dough, which mean the inteference of mTG reaction by the proteases. Among the cation exchange resins tested for the removal of proteases, Monoplus S 100(Bayer, Germany) was the most efficient resin with 20 fold increase in the mTG/protease activity ratio. By further purification steps with a quaternary ammonia salt resin and a gel permeation chromatography, proteases were effectively removed from the preparation. Therefore, the improvement of flour texture was shown by adding the protease-free mTG.

• 산업융합연구
• /
• 제19권6호
• /
• pp.81-91
• /
• 2021

본 연구는 보수볼을 이용한 발목 근력 강화 운동과 테이핑이 엄지발가락가쪽휨증 환자의 정적과 동적 발바닥 압력에 어떠한 영향을 미치는지 알아보고자 실시하였다. 대상자는 엄지발가락가쪽휨증을 가지고 있는 20대 남녀 26명이며, 테이핑군(Taping group, TG; n=13)과 발목 강화 운동군 (Ankle strengthening group, ASG; n=13)으로 무작위로 배치하였고, 각 군은 총 4주에 걸쳐 해당 중재를 실시하였며, 중재 전과 후에 정적, 동적 발바닥 압력을 측정하였다. 집단 간 변화량의 차이를 알아보기 위해 독립 T검증을 실시하였고, 집단 내의 사전-사후값의 측정값 차이가 유의한지 알아보기 위해 대응표본 T검증을 실시하였다. 통계적 유의수준은 α= .05로 설정하였다. 발의 전체 체중에 대한 비율(Foot)은 왼쪽 발의 ASG가 TG에 비해 집단 내 변화량이 유의하게 감소하였고(p<.05), 발의 표면적(Surface area)에서는 오른쪽 발의 TG가 ASG에 비해 집단 내 변화량이 유의하게 증가하였다(p<.05). 발의 엎침 운동의 정도(MP/change ratio)는 오른발의 TG가 ASG에 비해 집단 내 변화량이 유의하게 감소하였고(p<.05), 발의 힘(Force)에서는 왼발의 TG가 ASG에 비해 집단 내 변화량이 유의하게 증가하였으며(p<.05), 집단 간의 변화에서는 TG의 변화량이 ASG의 변화량보다 유의한 차이가 나타났다(p<.05). 따라서 보수볼을 이용한 발목 강화 운동과 테이핑은 엄지발가락가쪽휨증을 가진 환자에게 효과적인 변화를 주기에는 부족하다고 할 수 있다.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 2006년도 춘계학술대회 및 창립 30주년 심포지엄(논문집)
• /
• pp.5-11
• /
• 2006

K대학 실습선 28명의 선원에 대하여 40일간 원양하기 전과 후의 혈액과 소변의 생화학적 분석을 통하여 볼 때 원양 후 부원 및 모든 연령에서 요소질소와 요산지수(Creatine 및 Uric acid)가 증가된 것으로 보아 선상생활이 신장의 기능을 나쁘게 하거나 기능저하를 초래했다고 판단되어진다. 또 총콜레스테롤(TC)과 고밀도지단백콜레스테롤(HDL-C) 및 저밀도지단백콜레스테롤(LDL-C)은 원양 전보다 후에 유의하게 감소한 반면에 중성지방(TG)은 유의하게 상승하였다. 한편 원양 전과 후 사관부와 부원 그리고 갑판부, 기관부, 사주부간에 증가와 감소의 현상은 보이지만 유의한 차이는 나타나지 않았다. 그러나 연령별로는 TC와 HDL-C가 30대, 40대에서 유의하게 감소하였고, TG는 30대가 유의하게 증가하였는데 특히 30대에서 몇몇 선원에 대해서는 원양 후 TG의 높은 증가를 보여 고지혈증이 의심되고 있다. 또한 소변검사에서도 간세포성기능 및 신장기능의 이상을 진단하는 담즙색소(UBG)와 요담백(PRO)에서 원양 전과 후 모두 양성반응이 나타난 선원이 각각 7명과 5명이었다. 특히 우로빌리노겐(Urobilinogen : UBG)이 원앙 전 1명이 양성이었으나 원양 후 7명이 양성반응이 나타나서 한 달간 원양을 통하여 간세포성기능이 저하되었거나 이상이 있음을 보여주고 있다.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2006년도 춘계 학술발표회 논문집(II)
• /
• pp.197-200
• /
• 2006

The ingress of chloride ions plays a crucial role for service life design of reinforced concrete structures. In view of durability design of concrete structures under marine environment, one of the most essential parameters is the surface chloride content of concrete. However, on the basis of the results of in-situ investigation, this value has been determining in the numerous studies on the durability design of concrete structures. Hence, it is necessary to confirm the range of the surface chloride content in order to establish a unified durability design system of concrete. This study suggests a rational and practical way to calculate the maximum surface chloride content of submerged concrete under marine environment. This approach starts with the calculation of the amount of chloride ingredients in normal sea water. The capillary pore structure is modeled by numerical simulation model HYMOSTRUC and it is assumed to be completely saturated by the salt ingredients of sea water. In order to validate this approach, the total chloride content of the mortar and concrete slim disc specimen was measured after the immersion into the artificial sea water solution. Additionally, the theoretical, the experimental and in-situ investigation results of other researchers are compiled and analyzed. Based on this approach, it will follow to calculate the maximum surface chloride content of concrete at tidal zone, where the environment can be considered as a condition of dry-wetting cycles.

• Biomolecules & Therapeutics
• /
• 제30권4호
• /
• pp.334-339
• /
• 2022

Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase and calcium-independent phospholipase activity. Recently, we reported that PRDX6 plays an important role in dopaminergic neurodegeneration in Parkinson's disease. However, the relationship between PRDX6 function and emotional behavior remains elusive. In the present study, we examined depression- and anxiety-like behaviors in PRDX6-overexpressing transgenic (PRDX6-Tg) mice using the forced swim test, tail suspension test, open field paradigm, and elevated plus-maze. PRDX6-Tg mice exhibited depression-like behaviors and low anxiety. In particular, female PRDX6-Tg mice exhibited anxiolytic behavior in the open field test. Furthermore, the serotonin content in the cortex and 5-hydroxytryptophan-induced head twitch response were both reduced in PRDX6-Tg mice. Interestingly, levels of dopa decarboxylase expression in the cortex were decreased in male PRDX6-Tg mice but not in female mice. Our findings provide novel insights into the role of PRDX6 in 5-HT synthesis and suggest that PRDX6 overexpression can induce depression-like behaviors via downregulation of the serotonergic neuronal system.

• 대한화학회지
• /
• 제63권1호
• /
• pp.7-11
• /
• 2019

Olmutinib, N-[3-({2-[4-(4-methylpiperazine-1-yl)aniline]thieno[3,2-d]Pyrimidin-4-yl}oxy)phenyl]prop-2-enamide dihydrochloride monohydrate, $Olita^{TM}$ is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that was developed by Boehringer Ingelheim and Hanmi Pharmaceutical Co. Ltd for the treatment of non-small cell lung cancer (NSCLC). The aim of this work was to investigate the existence of polymorphs and pseudopolymorphs of olmutinib. Three crystal forms of olmutinib have been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). From the DSC and TG data it was confirmed that Form 1 is monohydrate, Form 2 is dihydrate, Form 3 is 1.5 hydrate. The PXRD patterns of three crystal forms were different respectively. After storage of 1 month at $2^{\circ}C$, 24% RH (Relative Humidity), Form 1, Form 2, and Form 3 were not transformed.