• Dementia and Neurocognitive Disorders
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• v.17 no.3
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• pp.110-119
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• 2018

Background and Purpose: To analyze $^{18}F-THK5351$ positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). Methods: Thirty-one participants, including those with Alzheimer's disease (AD, n=13), navPPA (n=3), and those with normal control (NC, n=15) who completed 3 Tesla magnetic resonance imaging, $^{18}F-THK5351$ PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of $^{18}F-THK5351$ in navPPA patients. Results: In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal lobes, bilateral precentral gyri, and bilateral basal ganglia. Patients with navPPA showed higher levels of THK retention in bilateral frontal lobes (mainly left side) compared than NC in voxel-wise analysis. Conclusions: In our study, THK retention in navPPA patients was mainly distributed at the frontal region which was well correlated with functional-radiological distribution of navPPA. Our results suggest that tau PET imaging could be a supportive tool for diagnosis of navPPA in combination with a clinical history.

• The Journal of Korean Medicine
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• v.22 no.4
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• pp.158-163
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• 2001

Clinical symptoms of acute stroke include loss of consciousness, aphasia, dysphagia, hemiplegia, without urination or defecation, headache, dizziness, chest discomfort, etc. As methods of oriental medical treatment at acute stroke state, acupuncture, fumigating, emetic, sternutatory therapy etc. were known. We treated a 69-year-old female patient who was unconscious after acute stroke with acupuncture and herbal medicine. Also, we chose Croton seed (Crotonis Fructus) Tansy (Artemisiae Argi Folium)-hwan for treatment and fumed it on the patient's nose once a day. After 7 days of treatment with fumigating therapy, we observed improvement in consciousness on the Glasgow coma scale, and other symptoms (aphasia, dysphagia, hemiplegia, without urination or defecation)

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.88-88
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• 1996

본 연구목적은 한국어판 실어증감별진단검사를 이용하여 2회 이상 경과를 검토할 수 있었던 Broca실어의 3증례에 있어서의 개선경과를 초회평가시의 실어증 중등도가 거의 같은 일본의 장기 관찰예와 비교하여 장애 pattern의 검출 및 개선경과의 추적에 있어서의 한국판 실어증 감별진단검사의 유효성을 검토하였다. 그 결과, 신경학적으로 안정되어있는 실어증환자의 경우 중증도별로 보면, 언어과정 전반의 득점 profile은 유사성이 높았으며, 치료경과에 양국어의 일반성과 특수성이라고 하는 면에서는 금후 한층 더 상세한 토의가 요구되었다.

• Korean Journal of Cognitive Science
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• v.9 no.1
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• pp.41-46
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• 1998

The argument-structure distributions of predicates in the speech of two roca-type aphasic patients and one Conduction-type patient are compared with both matched controls and each other on the basis of narrative production data. Whereas English-speaking agrammatics have been reported to have difficulties producing noncopular unaccusative predicates (Kegl 1995) Korean-speaking agrammatics are found not to have particular difficulties with unaccusative predicates. On the assumption that agrammatics lack specific syntactic knowledge for the processing of displaced arguments from their lexically specified positions. it is proposed that unaccusatives in Korean do not involve the displacement of arguments for Case-theoretic reasons or involve a vacuous movement. if any.

• Proceedings of the KSLP Conference
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• 2003.11a
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• pp.148-148
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• 2003

목적 : 베르니케실어증환자의 치료에 있어서 전통적 기법은 청각적 이해력을 높이기 위해 청각변별력을 직접적으로 치료한다. 그에 반해 Helm-estabrooks 등(1991)에 의해 개발된 TWA(Treatment for Wernicke's Aphasia)는 읽고 이해하기(reading comprehension), 구두읽기(oral reading), 따라 말하기(repetition)등의 과정을 통해 재청각화(reauditorization)를 유발하여 청각이해력(auditory comprehension)을 향상시키는 언어치료 프로그램이다. 본 연구자들은 TWA가 베르니케실어증을 가진 한국인의 재청각화에도 효과적인지를 알아보고자 하였다. (중략)

• Journal of Music and Human Behavior
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• v.2 no.2
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• pp.57-67
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• 2005

Most of stroke patients have not only physical difficulty but speech and neurological disorder because of hemiplegia and such unexpected changes cause psychologic disadaptability and absent-mindedness. Particularly, lowering of physical ability can lead to serious emotional problem from failure or frustration in daily life. Generally, treatment of patient with stroke put emphasis on physical rehabilitation but actually this patient had considerable speech disorder such as aphasia or articulation disorder. Moreover, failing of recognition function, mental disorder as hypochondria, and even visual and auditory disorder are represented. So it is effective to integrate verbal remediation and other treatments in medical care environment. In particular, patients with language disorder very often wither psychologically therefore it is efficient to use of music therapy that gives opulent emotion to aphasia patients. And primarily to investigate the effects of 10 sessions treatments; change in spoken total number of syllables, to confirm their own value by success of given task and reassure about themselves ability. All of 10 sessions stages were scored by MIT manual and its improvement were measured, that is, accomplishment was analyzed within each level in order to prove detail change of spoken total number of syllables. The result of this program organized from 2 syllables to 4 syllables is summarized as follows. Subject A completed in preliminary stage Level I, in 2 syllables case advanced to Level III in fifth session and to Level IV in seventh session, in 3 syllables case advanced to Level III in seventh session and to Level IV in ninth session, and in 4 syllables case showed 8% low success rate in first session but after repeated practice increased considerably in sixth session and in advanced to Level III in eighth session to Level IV in tenth session. Subject B also completed in preliminary stage Level I, in 2 syllables case advanced to Level III in forth session and to Level IV in sixth session, in 3 syllables case advanced to Level III in fifth session and to Level IV in seventh session, and in 4 syllables case showed 10% low success rate in first session and increased considerably in fifth session and in advanced to Level III in seventh session but could not reach to Level IV until tenth session. As a result, it was shown that music therapy using MIT was not statistically meaningful but improved spoken total number of syllables and success rate of task had improved as a whole. Therefore, music intervention using MIT it has positive affect on verbal ability of patients with Broca's Aphasia and their language rehabilitation.

• Korean Journal of Cognitive Science
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• v.13 no.2
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• pp.15-23
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• 2002

This paper reports an experiment on Broca's aphasics' comprehension of a class of English constructions involving empty categories. Based on Grodzinsky's (1986) account of chance-level performance of agrammatic understanding of movement constructions and their thematic role assignments. I show that Grodzinsky's notion of invisible empty categories can be further extended to include pronomical anaphors (PRO's) in Chomsky's (1981) sense and that the asymmetry in their poor comprehension of subject- and object-control constructions can be explained by the heuristic mechanism of the default thematic role assignment rule. eventually supporting Grodzinsky's claim that empty categories are not visible In agrammatic's syntactic representation.

• Speech Sciences
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• v.15 no.2
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• pp.111-118
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• 2008

We identified the characteristic impairmants of linguistic semantic memory in patients with prodromal Alzheimer's disease(AD) and mild AD. To elucidate the earliest changes of semantic language function in subjects with AD, performances on confrontation naming test and verbal fluency task were compared among patients with AD patients (n=20), mild AD patients (n=27) and healthy elderly controls (n=20). Tasks in this study included the confrontation naming test of Test of Lexical Processing in Aphasia(TLPA/Japanese) and one-minute verbal fluency task (semantic/ phonetic categories). The results were as follows: 1) Performances of the prodromal AD group showed the comparable to those of the control group on the confrontation naming test, 2) In the semantic/phonetic verbal fluency tasks, the performances of the control group were better than those of the prodromal AD and mild AD groups, but no significant differences were shown between the prodromal AD and the mild AD group.

• Journal of Korean Biological Nursing Science
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• v.23 no.3
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• pp.217-226
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• 2021

Purpose: The aim of this study was to investigate the risk factors for brain reperfusion injury in ischemic stroke patients and to analyze the clinical outcomes. Methods: A retrospective study was conducted in 168 patients who underwent mechanical thrombectomy. The data were analyzed using descriptive statistics, t-test, Mann-Whitney U test, Chi-Square test, Fisher's exact test, and logistic regression with IBM SPSS/WIN 24.0. Results: Brain reperfusion injury occurred in 67 patients (39.9%) with a low favored outcome (𝛘²=6.01, p=.014). On multivariable analysis, blood urea nitrogen (Odds ratio [OR]=1.14, 95% Confidence interval [CI]=1.06-1.23), aphasia (OR=6.16, CI=1.62-23.40), anosognosia (OR=4.84, CI=1.13-20.79), presence of both aphasia and anosognosia (OR=7.33, CI=1.20-44.60), and time required to achieve targeted blood pressure (OR=1.00, CI=1.00-1.00) were identified as risk factors for brain reperfusion injury. A statistically significant difference was detected in clinical outcomes, including hemorrhagic transformation (𝛘²=6.32, p=.012), intensive care unit length of stay (Z=-2.08, p=.038), National Institute of Health Stroke scale score at discharge (Z=-3.14, p=.002), and modified Rankin Scale score at discharge (Z=-2.93, p=.003). Conclusion: This study identified the risk factors and presented the clinical outcomes of brain reperfusion injury. It is necessary to consider these risk factors for evaluating the patients and to establish nursing interventions and strategies.

• Herbal Formula Science
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• v.24 no.3
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• pp.225-231
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• 2016

Objectives : Liver cancer usually appears in the setting of underlying liver disease. Liver transplantation has potentials to improve survival for patients with liver cancer. This case report was designed to assess the clinical effect of Korean medicine on liver transplant patient's cerebral infarction.Methods : We provided Chiganpung Granule(Chodeungsan) to a patient who was 58 year old man complained of cognitive impairment and dysarthria. We checked the change of symptoms(K-MMSE, Aphasia Rapid Test) and liver function test and kidney function test.Results : We observed that Chiganpung Granule(Chodeungsan) decreased cognitive impairment and dysarthria. Liver function test and Kidney function test was improved.Conclusions : From the above results, it is considered that Korean medicine treatments is effective on liver transplant patient's cerebral infarction.