• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.101-101
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• 2003

Main strategy for a treatment of Parkinson's disease (PD), due to a progressive degeneration of dopaminergic neurons, is a pharmaceutical supplement of dopamine derivatives or ceil replacement therapy. Both of these protocols have pros and cons; former exhibiting a dramatic relief but causing a severe side effects on long-term prescription and latter also having a proven effectiveness but having availability and ethical problems Embryonic stem (ES) cells have several characteristics suitable for this purpose. To investigate a possibility of using ES cells as a carrier of therapeutic gene(s), human ES (hES, MB03) cells were transfected with cDNAs coding for tyrosine hydroxylase (TH) in pcDNA3.1 (+) and the transfectants were selected using neomycin (250 $\mu /ml$). Expression of TH being confirmed, two of the positive clone (MBTH2 & 8) were second transfected with GTP cyclohydrolase 1 (GTPCH 1) in pcDNA3.1 (+)-hyg followed by selection with hygromycin-B (150 $\mu /ml$) and RT-PCR confirmation. By immune-cytochemistry, these genetically modified but undifferentiated dual drug-resistant cells were found to express few of the neuronal markers, such as NF200, $\beta$-tubulin, and MAP2 as well as astroglial marker GFAP. This results suggest that over-production of BH4 by ectopically expressed GTPCH I may be involved in the induction of those markers. Transplantation of the cells into striatum of 6-OHDA- denervated PD animal model relieved symptomatic rotational behaviors of the animals. Immunohistochemical analyses showed the presence of human cells within the striatum of the recipients. These results suggest a possibility of using hES cells as a carrier of therapeutic gene(s).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.622-628
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• 2016

As the suction pad-supporting bike carrier attached to a car may be subject to an excessive dynamic load due to random vibrations and centrifugal forces during driving, its structural safety is of great concern. To examine this, the finite-element method with a fluid-structure interaction should be used because the pressure on the pad bottom is changed in real time according to the fluctuations of the force or the moment applied on the pad. This method, however, has high computing costs in terms of modeling efforts and software expense. Moreover, the accuracy of computation is not easily guaranteed. Therefore, a new method combining the experiment and computation is proposed in this paper: the bottom pressure and contact area of the pad under varying loads was measured in real time and the acquired data are then used in the nonlinear elastic finite-element calculations. The computational and experimental results obtained with the product under development showed that the safety margin of the pad under the axial loading is relatively sufficient, whereas with an excessive rotational loading, the pad is vulnerable to separation or a local surface damage; hence, the safety margin may not be secured. The predicted contact behavior under the variation of the magnitude and type of the loading were in good agreement with the one from the experiment. The proposed analysis method in this study could be used in the design of similar vacuum pad systems.

• Journal of the Earthquake Engineering Society of Korea
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• v.15 no.4
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• pp.45-54
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• 2011

A simple model for reinforced concrete shear walls with boundary elements is proposed, which is a macro-model composed of spring elements representing flexure and shear behaviors. The flexural behaviour is represented by vertical springs at the wall ends, where the moment strength and rotational capacity of the wall are based on section analysis. The shear behaviour is represented by a horizontal spring at the wall center, where the key parameters for the shear behavior are based on the flexural behaviour since the shear walls with boundary elements are governed by the flexure. The proposed model was prepared with the results of hysteretic tests of the shear walls, and then the reliability of the hysteretic rule and variables was investigated by nonlinear dynamic analyses. Using parametric study with nonlinear dynamic analyses, the effect of the variables on demand and capacity, which are major parameters in seismic performance evaluation, are investigated. Results show that the measured and calculated shear forces versus the shear distortion relationships are slightly different, but the global response is well simulated. Furthermore, the demand and capacity are also changed in a similar way to the change in the major parameters so that the proposed model may be appropriate for reinforced concrete shear walls with boundary elements.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.10
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• pp.983-989
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• 2017

This paper presents the bearing strength for laminates in advanced composite materials in bolted joints. Bolted single lap joint tests were experimentally investigated with respect to stabilized and unstabilized lap joints. Stabilized bolted single lap joints refer to joints with out-of-plane rotational constraints. Unstabilized bolted single lap joints refer to joints with absence of out-of-plane deflection constraints. The bearing strength values of laminates in the bolted joint showed that the percentages of ply angle for 0, 45, -45, and 90 degrees were not affected. The bearing strength value in the unstabilized bolted joint was smaller than the bearing strength value in the stabilized bolted joint because of the influence of the out-of-plane behavior. The composite material studied in this paper is a carbon/epoxy unidirectional (UD) tape prepreg cured at $177^{\circ}C(350^{\circ}F)$. In the laminate reference system, the standard angles of 0, 45, -45, and 90 degrees were used for ply orientation within the laminate. A total of 112 bolted single lap joint tests were conducted on specimens from eight distinct laminates. The ASTM-D-5961M standards were adhered to for the stabilized and unstabilized bolted single lap joint tests.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.327.1-327.1
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• 2014

Nitrides-on-silicon structures are considered to be an excellent candidate for unique design architectures and creating devices for high-power applications. Therefore, a lot of effort has been concentrating on growing high-quality III-nitrides on Si substrates, mostly Si(111) and Si(001) substrates. However, there are several fundamental problems in the growth of nitride compound semiconductors on silicon. First, the large difference in lattice constants and thermal expansion coefficients will lead to misfit dislocation and stress in the epitaxial films. Second, the growth of polar compounds on a non-polar substrate can lead to antiphase domains or other defective structures. Even though the lattice mismatches are reached to 16.9 % to GaN and 19 % to AlN and a number of dislocations are originated, Si(111) has been selected as the substrate for the epitaxial growth of nitrides because it is always favored due to its three-fold symmetry at the surface, which gives a good rotational matching for the six-fold symmetry of the wurtzite structure of nitrides. Also, Si(001) has been used for the growth of nitrides due to a possible integration of nitride devices with silicon technology despite a four-fold symmetry and a surface reconstruction. Moreover, Si(110), one of surface orientations used in the silicon technology, begins to attract attention as a substrate for the epitaxial growth of nitrides due to an interesting interface structure. In this system, the close lattice match along the [-1100]AlN/[001]Si direction promotes the faster growth along a particular crystal orientation. However, there are insufficient until now on the studies for the growth of nitride compound semiconductors on Si(110) substrate from a microstructural point of view. In this work, the microstructural properties of nitride thin layers grown on Si(110) have been characterized using various TEM techniques. The main purpose of this study was to understand the atomic structure and the strain behavior of III-nitrides grown on Si(110) substrate by molecular beam epitaxy (MBE). Insight gained at the microscopic level regarding how thin layer grows at the interface is essential for the growth of high quality thin films for various applications.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.4
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• pp.329-334
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• 2017

The structures, which are made up with the huge number of degrees-of-freedom and the assembly of substructures, have a great complexity. In order to increase the computational efficiency, the analysis models have to be simplified. Many substructuring techniques have been developed to simplify large-scale engineering problems. The techniques are very powerful for solving nonlinear problems which require many iterative calculations. In this paper, a modal derivatives-based model order reduction method, which is able to capture the stretching-bending coupling behavior in geometrically nonlinear systems, is adopted and investigated for its performance evaluation. The quadratic terms in nonlinear beam theory, such as Green-Lagrange strains, can be explained by the modal derivatives. They can be obtained by taking the modal directional derivatives of eigenmodes and form the second order terms of modal reduction basis. The method proposed is then applied to a co-rotational finite element formulation that is well-suited for geometrically nonlinear problems. Numerical results reveal that the end-shortening effect is very important, in which a conventional modal reduction method does not work unless the full model is used. It is demonstrated that the modal derivative approach yields the best compromised result and is very promising for substructuring large-scale geometrically nonlinear problems.

• Korean Journal of Agricultural Science
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• v.22 no.1
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• pp.103-109
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• 1995

The model foods were prepared by simulating mositure, protein and starch, and they were heated for 30 mins, at $80^{\circ}C$ and then cooled at $25^{\circ}C$ in water bath. Their rheological properties were investigated by the use of Brookfield wide-gap rotational viscometer at $30{\sim}60^{\circ}C$, and the rotation speed ranged from 0.6 to 6 rpm and solid content ranged from 8% to 11%, the results obtained were as follows. 1. All the model foods ($P_1S_3$, $P_2S_2$, $P_1S_1$, $P_2S_1$, $P_3S_1$, $P_4S_0$) exhibited pseudoplastic behaviors with yeild stress and were thixotropic foods which showed time - dependent structural decays, but the starch food of 8 ~ 11 % solid content did not show the flow behavior. 2. The correlation between the rheological parameters and the protein content of model foods in various moisture content did not appeared a constant relationship. 3. The change of shear stress against shear rate in high starch foods was larger than that in high protein foods and the structure at initial shear time was decayed with a quatic equation according to the Tiu's Model and structural decay was in parallel with the increase of shear rate. 4. The temperature dependency of the apparent viscosity of $P_1S_2$, and $P_2S_1$ was fully expressed by Arrhenius equation and activation energies of their food were 2.35 and $1.34Kcal/g{\cdot}mol$, respectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.1
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• pp.1-11
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• 2021

In order to reuse existing onshore turbine foundations, it is important to redesign and reinforce the existing foundations according to the upgraded tower diameter and turbine load. In the present study, a slab extension reinforcement method and structure details of an anchorage part were examined in consideration of the reuse of spread footings, which are the most widely used foundation type in onshore wind turbine foundations. Experiments were conducted to evaluate the load resistance performance of a reinforced spread footing according to structure details of an anchorage part. The results showed that (1) the strength of an anchorage part could be increased by more than 30 % by adding reinforcement bars in the anchorage part, (2) pile-sleeves attached to an anchor ring contributed to an increase in rotational stiffness by preventing shear slip behavior between the anchor ring and the concrete, and (3) slab connectors contributed to an increase in the strength and deformation capacity by preventing the separation of new and old concrete slabs.

• Journal of Astronomy and Space Sciences
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• v.22 no.2
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• pp.147-174
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• 2005

To understand the physical processes that control the high-latitude lower thermospheric dynamics, we quantify the forces that are mainly responsible for maintaining the high-latitude lower thermospheric wind system with the aid of the National Center for Atmospheric Research Thermosphere-Ionosphere Electrodynamics General Circulation Model (NCAR-TIEGCM). Momentum forcing is statistically analyzed in magnetic coordinates, and its behavior with respect to the magnitude and orientation of the interplanetary magnetic field (IMF) is further examined. By subtracting the values with zero IMF from those with non-zero IMF, we obtained the difference winds and forces in the high-latitude 1ower thermosphere(<180 km). They show a simple structure over the polar cap and auroral regions for positive($B_y$ > 0.8|$\overline{B}_z$ |) or negative($B_y$ < -0.8|$\overline{B}_z$|) IMF-$\overline{B}_y$ conditions, with maximum values appearing around -80$^{\circ}$ magnetic latitude. Difference winds and difference forces for negative and positive $\overline{B}_y$ have an opposite sign and similar strength each other. For positive($B_z$ > 0.3125|$\overline{B}_y$|) or negative($B_z$ < -0.3125|$\overline{B}_y$|) IMF-$\overline{B}_z$ conditions the difference winds and difference forces are noted to subauroral latitudes. Difference winds and difference forces for negative $\overline{B}_z$ have an opposite sign to positive $\overline{B}_z$ condition. Those for negative $\overline{B}_z$ are stronger than those for positive indicating that negative $\overline{B}_z$ has a stronger effect on the winds and momentum forces than does positive $\overline{B}_z$ At higher altitudes(>125 km) the primary forces that determine the variations of tile neutral winds are the pressure gradient, Coriolis and rotational Pedersen ion drag forces; however, at various locations and times significant contributions can be made by the horizontal advection force. On the other hand, at lower altitudes(108-125 km) the pressure gradient, Coriolis and non-rotational Hall ion drag forces determine the variations of the neutral winds. At lower altitudes(<108 km) it tends to generate a geostrophic motion with the balance between the pressure gradient and Coriolis forces. The northward component of IMF By-dependent average momentum forces act more significantly on the neutral motion except for the ion drag. At lower altitudes(108-425 km) for negative IMF-$\overline{B}_y$ condition the ion drag force tends to generate a warm clockwise circulation with downward vertical motion associated with the adiabatic compress heating in the polar cap region. For positive IMF-$\overline{B}_y$ condition it tends to generate a cold anticlockwise circulation with upward vertical motion associated with the adiabatic expansion cooling in the polar cap region. For negative IMF-$\overline{B}_z$ the ion drag force tends to generate a cold anticlockwise circulation with upward vertical motion in the dawn sector. For positive IMF-$\overline{B}_z$ it tends to generate a warm clockwise circulation with downward vertical motion in the dawn sector.

• Journal of dental hygiene science
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• v.9 no.3
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• pp.319-326
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• 2009

The purpose of this study was to examine the Influence of the experience of Childcare Teacher about oral health education on oral health behaviors. For this, Questionnairs to be self-filled up about experience of oral health education were carried out to 267 childcare teachers who are working in nurseries in Geongnam province. The date was analysed using the SPSS 12.0 program. The obtained result were as follows. Among the respondents who are not under stress of oral health. 8.1% respondents had the oral health education and 7.7% others didn't have it. For toothbrushing methods, it was found that 25.3% used manual toothbrushing with experience in dental education(up and down toothbrushing monement) and 35.4% used semi automatic toothbrushing(rotational movement). 37.1% respondents had experiences in oral health education, 69.7% respondents were instructed in the oral health at public health center, and 61.6% respondents were instructed in the oral health a theory(toothbrushing guidance). Among the respondents who answered that oral health education should be necessary, 83.4% of those have already had oral health education where as 73.8% respondents have not had the education. 67.7% of the respondents who want to participate in the oral health education is corresponding to those with experience in dental education, 66.1% respondents with no education feel the necessity of the oral health education.