• YAKHAK HOEJI
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• v.31 no.5
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• pp.286-295
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• 1987

The relationship between in vitro release and in vivo bioavailability of acetaminophen from suppositories was investigated. Effect of glycyrrhizin on the drug release and rectal absorption in rats was also examined. Suppositories containing 25mg of acetaminophen were prepared with Wecobee FS (fatty base) or PEG (water-soluble base) bases. The release from the suppositories were determined with USP rotating basket dissolution apparatus and with the suppository release tester. The temperature of the dissolution medium was very critical for the dissolution of acetaminophen from Wecobee FS suppositories. The bioavailability of acetaminophen was calculated from the plasma concentration-time curve after rectal administration of the suppositories to the rats. There were no significant differences in AUC following rectal administration of Wecobee FS and PEG suppositories, but the release and absorption from the Wecobee FS suppositories were faster than those from PEG suppositories. The dissolution rate obtained by the suppository release tester was better correlated with in vivo absorption rate constant than that by the USP dissolution apparatus. It suggests that the partitioning between rectal fluid and suppository base is the rate-limiting step in the rectal absorption of acetaminophen from suppositories. Glycyrrhizin was found not to affect in vitro dissolution and rectal absorption of acetaminophen.

• 유체기계공업학회:학술대회논문집
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• 2003.12a
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• pp.678-683
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• 2003

Mixers are used in various industrial fields where it is necessary to intimately mix two reactants in a short period of time. However, despite their widespread use, complex unsteady flow characteristics of industrial mixers are not systematic investigated. The present study aimed to clarify unsteady flow characteristics induced by various impellers in a tank. Impellers are pitched blade turbine and neo-hydrofoil turbine types. A high speed CCD camera and an Ar-Ion laser for illumination were adopted to clarify the time-dependent flow characteristics of the mixers. The rotating speed of impellers increased from 6Hz to 60Hz by 6Hz. The maximum velocity around PBT impeller is higher than the hydrofoil type impeller. These two types of turbine shows that typical flow characteristics of axial turbine and suitable for mixing high -viscosity materials.

• Journal of Drive and Control
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• v.11 no.2
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• pp.1-8
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• 2014

In this study, the authors carried out experiments and numerical simulations in order to clarify the pressure pulsation characteristics in multiple-delivery rotating-cam and stationary-cylinder type radial piston pumps. Also, a tee filter was applied to the pump in order to mitigate the pressure pulsation. Through the experiments and simulations, it was known that pressure pulsation with a magnitude higher than 40% of the mean load pressure could occur in the pump used in the experiments. Moreover, it was confirmed that a tee filter designed in this study could effectively mitigate the pressure pulsation.

• Journal of The Korean Astronomical Society
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• v.2 no.1
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• pp.1-9
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• 1969

On the instantaneous tidal relaxation approximation, formulae are derived for the ellipticities and virial theorem of a slightly flattened homogeneous rotating cluster (the largest axis of the cluster is directed towards the Galactic center), in terms of the Galactic tidal force and the characteristic intrinsic plus orbital angular velocity. The expression for a purely tidally-determined ellipticity is identical to that for an incompressible fluid body of uniform density. Orbital motion generally contributes significantly to the shape of the cluster. The virial theorem is identical to that for an isolated cluster except that the gravitational potential energy is multiplied by (1-${\chi}$), where ${\chi}$ is a positive tidal correction term. To obtain the actual mass of a cluster, the virial theorem mass based on an isolated cluster should be multiplied by the factor 1/(1-${\chi}$). The formulae are applied to open star clusters, the globular cluster ${\omega}$ Centauri, and dwarf elliptical galaxies in the Local Group.

• Journal of the Semiconductor & Display Technology
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• v.17 no.4
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• pp.91-96
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• 2018

In this study temperature distribution and gas flow inside a planetary type reactor in which a number of satellites on a spinning susceptor were rotating were analyzed using numerical simulation. Effects of flow rates on gas flow and temperature distribution were investigated in order to obtain design parameters. The commercial computational fluid dynamics software CFD-ACE+ was used in this study. The multiple-frame-of-reference was used to solve continuity, momentum and energy conservation equations which governed the transport phenomena inside the reactor. Kinetic theory was used to describe the physical properties of gas mixture. Effects of the rotation speed of the satellites was clearly seen when the inlet flow rate was small. Thickness of the boundary layer affected by the satellites rotation became very thin as the flow rate increased. The temperature field was little affected by the incoming flow rate of precursors.

• Design & Manufacturing
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• v.14 no.4
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• pp.1-10
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• 2020

The seal plays a role in preventing oil leakage when the lip and the rotating shaft come into contact with the fluid and air pressure. Recently, micro dimples or micro pockets are processed and used on the lubrication surfaces of thrust bearings, mechanical bearings, and piston rings. Compared to a smooth surface, micro dimples reduce friction and increase the life of parts. This paper analyzed various kinds of micro dimple shapes on the sealing surface, i.e. circle, rectangle, triangle, and trapezoid. For this purpose, Introduced the design of experiments to work out a micro dimple configuration, unlikely to be damaged from cracks and low in contact stress. As a result, the triangular dimple showed the best results. Optimal factors were dimple size 0.15 mm, dimple depth 0.0383 mm, dimple density 40%, and the maximum equivalent stress was 9.1455 MPa, and the maximum contact pressure was 9.6612 MPa. This paper analyzed the optimal shape of dimples by finite element analysis. As a research project, experiments and comparative analysis of micro dimple shapes are needed.

• Journal of Drive and Control
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• v.19 no.4
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• pp.77-84
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• 2022

The aims of this study was to estimate transfer force delivered to cone crusher housing and contribution of force transmission. The rock crushing condition caused vibrations in the cone crusher housing, which were experimentally measured, and frequency response functions (FRF) were also found through modal impact tests. Vibration data and frequency response functions were applied to the transfer path analysis (TPA) model. Next, transfer forces delivered to the cone crusher housing were quantified via the TPA method. Contribution of force transfer was also analyzed based on force estimation results. Finally, this study describes basic concepts and components of the TPA method and reviews its applicability to rotating machinery that experiences impact vibrations and forces.

• Journal of Auto-vehicle Safety Association
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• v.8 no.2
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• pp.24-29
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• 2016

A small-sized turbocharger is generally used in downsizing engine for various vehicles. When a centrifugal compressor, which is one of the crucial units of the turbocharger, is downsized, the compressor has much more possibilities of being damaged because of its high rotating speed, causing insecure structural soundness. Thus, it is of essential to study on the improvement of the structural soundness of a small-sized turbocharger. In this study, numerical analysis on the various blade geometries and mass flow rate of the compressor was performed using the commercial software ANSYS CFX. In addition, the evaluation on the structural soundness of a compressor impeller for respective cases was conducted using ANSYS Mechanical. As a result, it was shown that the compressor had higher efficiency with increasingly secured structural soundness.

• Ocean Systems Engineering
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• v.14 no.2
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• pp.141-156
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• 2024

The turbine system converts the kinetic energy of water flow to electricity by rotating the rotor in a restricted waterway between the seabed and free surface. A turbine system's immersion depth and rotation direction are significantly critical in the turbine's performance along with the shape of the rotor. This study has investigated the hydrodynamic performance of the Savonius hydrokinetic turbine (SHT) according to the immersion depth and rotation direction using computational fluid dynamics (CFD) simulations. The instantaneous torque, torque coefficient, and power coefficients are calculated for the immersion ratios Z/D ranging [0.25, 3.0] and both clockwise (CW) and counterclockwise (CCW) rotations. A flow visualization around the rotor is shown to clarify the correlation between the turbine's performance and the flow field. The CFD simulations show that the CCW rotation produces a higher power at shallow immersion, while the CW rotation performs better at deeper immersion. The immersion ratio should be greater than the minimum of Z/D=1.0 to obtain the maximum power production regardless of the rotation direction.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1997.06a
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• pp.197-201
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• 1997

The momentum, heat and mass trasfer phenomena in the silicon melt of the Czochralki crystal growth system are calculated using a three dimensional numerical simulation thechnique. Even though axisymmetrical boundary conditions are imposed to all calculations in a 3cm diameter crucible, several types of non-axisymmetric profiles of velocities, temperature and oxygen concentration appeared in the melt. Because of the non-axisymmetric profiles of velocities, temperature and oxygen concentration appeared in the melt. Because of the non-axisymmetric profiles and rotations of fluid induced by the crucible rotation, temperatures and oxygen concentrations in the silicon melt fluctuate. The rotating velocity of the profile is calculated from the phase shift of the data of temperature or oxygen at two different points which have same radius from center but 90 degree angular difference. From this calculation, it is found that the rotating veolocity of the oxygen and temperature is different from the crucible rotation rates. Therefore the frequencies of the oscillating temperature and oxygen concentrations are not same to the frequencies of the crucible rotations. Futhermore, the components of the frequencies of the temperature and oxygen concentration at the same point are not same. The fluctuation behaviors of the temperature or oxygen themselves are also different when the points are different. The calculation show that the temperature and the oxygen concentration near the interface also fluctuate. The results suggest that the striation pattern found in the grown silicon single crystals may ben generated by the oxygen concentration and the temperature oscillations of the melt occurred near the interface.