• 통합자연과학논문집
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• 제8권1호
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• pp.75-79
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• 2015

Thromboxane A2 receptors (TXA2-R) are the G protein coupled receptors localized on cell membranes and intracellular structures and play pathophysiological role in various thrombosis/hemostasis, modulation of the immune response, acute myocardial infarction, inflammatory lung disease, hypertension and nephrotic disease. TXA2 receptor antagonists have been evaluated as potential therapeutic agents for asthma, thrombosis and hypertension. The role of TXA2 in wide spectrum of diseases makes this as an important drug target. Hence in the present study, homology modeling of TXA2 receptor was performed using the crystal structure of squid rhodopsin and night blindness causing G90D rhodopsin. 20 models were generated using single and multiple templates based approaches and the best model was selected based on the validation result. We found that multiple template based approach have given better accuracy. The generated structures can be used in future for further binding site and docking analysis.

• International Journal of Quality Innovation
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• 제9권3호
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• pp.57-69
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• 2008

This paper posits that arm's length buyer-supplier relationship as the intermediate type between market exchange relations and strategic partnership might be advisable, and information technology may have a role as a mechanism actualizing the effects of such arm's length relationship by strategic supply-line diversification. Based on the theoretical analysis on interactive feedback relationships among IT level, buyer-supplier relationships, and supply chain structure, we suggest a set of advisable buyer-supplier relationship type for efficient supply chain management. Also, doing so would be helpful in suggesting a dynamic IT investment and adoption model appropriate for the establishment of productive buyer-supplier relationship, and further in providing theoretical foundations and practical guidelines on the role and function of B-to-B E-commerce for efficient SC integration.

• 터널과지하공간
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• 제3권1호
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• pp.96-107
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• 1993

This paper deals with the analysis of rock slope stability using the distinct element method. This method consists in analysis of the interaction of discrete block assemblage delimited by elementary joints, which permits to consider the heterogeneous, anisotropic and discontinuous features of the rock mass. In particular, we were able to show that this method, and especially the BRIG3D software, is an outstanding tool which gives informations of greatest interest in order to analyze the toppling mechanisms. We have confirmed the fundamental role of the rock mass structure with different simulations. In the case of toppling phenomena, the essential parameter is the dip of major discontinuities. It has an influence on the intensity and volume of deformations. The anisotropic and heterogeneous features of the rock mass play also an important role. It is proved by insertion of thick rock bars in the structure or varying rock block sizes in the mass. These models modified considerably the stress distribution and the deformation distribution. Finally, we have analyzed the influence of mechanical parameters such as friction angle and tangential stiffness.

• 한국주거학회논문집
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• 제14권1호
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• pp.107-115
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• 2003

This paper is to clarify a cognitive structure and behaviors of the green environment creation in the Western-Style residential areas. The followings are the results of analysis; 1) Regarding the outside space of houses, yard and garden are differently recognized. While various behaviors are carried out in the yard, the garden is recognized as a space to construct green environment. 2) Most residents of Western-Style houses construct the outside space as a green space, and grow plants and flowers to enjoy their beauties. However they have introvert view of green environment. 3) The roles of outside space use are classified into four groups, the cognitive structures on the green environment creation are different from group to group.

• 통합자연과학논문집
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• 제8권2호
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• pp.81-88
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• 2015

c-Jun N-terminal kinase-3 (JNK3) is a member of the mitogen-activated protein kinase family (MAPK), and plays an important role in neurological disorders. Therefore, identification of selective JNK3 inhibitor may contribute towards neuroprotection therapies. In this work, we performed hologram quantitative structure-activity relationship (HQSAR) on a series of thiophene trisubstituted derivatives. The best predictions were obtained for HQSAR model with $q^2=0.628$ and $r^2=0.986$. Statistical parameters from the generated QSAR models indicated the data is well fitted and have high predictive ability. HQSAR result showed that atom, bond and chirality descriptors play an important role in JNK3 activity and also shows that electronegative groups is highly favourble to enhance the biological activity. Our results could be useful to design novel and selective JNK3 inhibitors.

• 대한가정학회지
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• 제39권2호
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• pp.41-56
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• 2001

The purpose of this study is to find the general trends of sexual harassment at workplace and to investigate the differences of related variables. The data were obtained through 880 employee living in Chonbuk-Province. The major findings were as follows-1) 70.3% of respondent reported that they had experienced the victimization of sexual harassment at workplace at least once. But most respondents reacted passively to the sexual harassment. 2) Most respondents perceived broadly the definition of sexual harassment and attributed sexual harassment to the social structure. The level of perception about the existence of the institution and the law for the sexual harassment problem was low. 3) The most important variable in the experience of sexual harassment was the ideology of sex-role division. 4) The more respondents experienced sexual harassment, the more they demanded the preventive education of sexual harassment .

• 통합자연과학논문집
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• 제7권4호
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• pp.234-240
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• 2014

C-C chemokine receptor type 4 (CCR4) is a chemokine receptor with seven transmembrane helices and it belongs to the GPCR family. It plays an important role in asthma, lung disease, atopic dermatitis, allergic bronchopulmonary aspergillosis, cancer, inflammatory bowel disease, the mosquito-borne tropical diseases, such as dengue fever and allergic rhinitis. Because of its role in wide spectrum of disease processes, CCR4 is considered to be an important drug target. Three dimensional structure of the protein is essential to determine the functions. In the present study homology modeling of human CCR4 was performed based on crystal structure of CCR5 chemokine receptor. The generated models were validated using various parameters. Among the generated homology models the best one is selected based on validation result. The model can be used for performing further docking studies to identifying the critical interacting residues.

• 통합자연과학논문집
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• 제10권1호
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• pp.7-13
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• 2017

Neuromedin U receptor 1 is a GPCR protein which binds with the neuropeptide, neuromedin. It is involved in the regulation of feeding and energy homeostasis and related with immune mediated inflammatory diseases like asthma. It plays an important role in maintaining the biological clock and in the regulation of smooth muscle contraction in the gastrointestinal and genitourinary tract. Analysing the structural features of the receptor is crucial in studying the pathophysiology of the diseases related to the receptor important. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor using 5 different templates. The models were subjected to model validation and two models were selected as optimal. These models could be helpful in analysing the structural features of neuromedin U receptor 1 and their role in disorders related to them.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.545-548
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• 2007

This Viewing angle control of fringe-field switching (FFS)-LCD using only one panel has been investigated. Viewing angle switching cell is composed of main- and sub-pixel, in which the former has a role of image expression and the latter has a role of viewing angle switching.

• 통합자연과학논문집
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• 제10권3호
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• pp.119-124
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• 2017

Glucagon-like peptide 2 receptor, a GPCR, binds with the glucagon-like peptide, GLP-2 and regulates various metabolic functions in the gastrointestinal tract. It plays an important role in the nutrient homeostasis related to nutrient assimilation by regulating mucosal epithelium. GLP-2 receptor affects the cellular response to external injury, by controlling the intestinal crypt cell proliferation. As they are therapeutically attractive towards diseases related with the gastrointestinal tract, it becomes essential to analyse their structural features to study the pathophysiology of the diseases. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor based on single- and multiple template modeling. The models were subjected to model validation and a reliable model based on the validation statistics was identified. The predicted model could be useful in studying the structural features of GLP-2 receptor and their role in various diseases related to them.