• Genomics & Informatics
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• v.6 no.2
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• pp.72-76
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• 2008

Hypoxia-inducible factor $1{\alpha}\;(HIF1{\alpha})$ is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of $HIF1{\alpha}$ is responsible for the negative regulation of $HIF1{\alpha}$ in normoxia. The interactions of the $HIF1{\alpha}$ ODD domain with partner proteins such as von Hippel-Lindau tumor suppressor (pVHL) and p53 are mediated by two sequence motifs, the N- and C-terminal ODD(NODD and CODD). Multiple sequence alignment with $HIF1{\alpha}$ homologs from human, monkey, pig, rat, mouse, chicken, frog, and zebrafish has demonstrated that the NODD and CODD motifs have noticeably high conservation of the primary sequence across different species and isoforms. In this study, we carried out molecular dynamics simulation of the structure of the $HIF1{\alpha}$ CODD motif in complex with the p53 DNA-binding domain (DBD). The structure reveals specific functional roles of highly conserved residues in the CODD sequence motif of $HIF1{\alpha}$ for the recognition of p53.

• Journal of Advanced Marine Engineering and Technology
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• v.30 no.8
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• pp.853-862
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• 2006

The present study is numerically investigated the flame structure of non-premixed counterflow jet flames using the laminar flamelet model Detailed flame structures with the fuel composition of 40% CO, 30% $H_2$. 30% $N_2$ and an oxidizer composition of 79% $N_2$ and 21% $O_2$ in a non-premixed counterflow flame are studied numerically. This study is aimed to investigate the effects of axial velocity gradient and combustion atmosphere pressure on flame structure. The results show that the role of axial velocity gradient on combustion processes is globally opposite to that of combustion atmosphere pressure. That is, chemical nonequilibrium effects become dominant with increasing axial velocity gradient, but are suppressed with increasing ambient pressure. Also, the flame strength is globally weakened by the increase of axial velocity gradient but is augmented by the increase of ambient pressure. However, flame extinction is described better on the basis of only chemical reaction and in this study axial velocity gradient and ambient pressure play a similar role conceptually such that the increase of axial velocity gradient and ambient pressure cause flame not to be extinguished and extend the extinction limit, respectively. Consequently it is suggested that a combustion process like flame extinction is mainly influenced by the competition between the radical formation reaction and the third-body recombination reaction.

• Culinary science and hospitality research
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• v.23 no.4
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• pp.144-162
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• 2017

This research utilized integrated package program of PASW Statistics 18.0 and AMOS 22.0 to analyze how the influence of service quality factor of coffee chains affects customer satisfaction and intention of customer behavior. The utilized statistics techniques were frequency analysis, exploratory, confirmatory factor analysis, covariance structure analysis, multiple group structure equation model analysis, etc. As a result of hypothesis verification, first of all, it was verified that the service quality factor of coffee chains affected positive (+) effect on service justice. Second, it was verified that the service justice affected positive (+) effect on customer satisfaction. To see it detailed, it is possible to see that all factors, perception of interactive justice, distributive justice, procedural justice, were adopted as the case of affecting service satisfaction (p<.001). Third, it was verified that among the circumstances that service quality affected to satisfaction, justice played a role as intermediary role. Fourth, it was verified that service satisfaction affected positive (+) effect on customer satisfaction, finally, the influence that customer satisfaction affecting behavioral intention has no effect on behavioral intention by brands of domestic or abroad.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.74-74
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• 2003

We report here the results on N-acetyl-N'-methylamide of oxazolidine (Ac-Oxa-NHMe) calculated using the ab initio molecular orbital method with the self-consistent reaction field (SCRF) theory at the HF level of theory with the 6-3l+G(d) basis set. The displacement of the $\square$-CH$_2$ group in proline ring by oxygen atom has affected the structure of proline, cis$\^$∼/ trans equilibrium, and rotational barrier. The up-puckered structure is found to be prevalent for the trans conformers of the Oxa amide. The higher cis populations of the Oxa amide can be interpreted due to the longer distance between the acetyl methyl group and the 5-methylene group of the ring for the trans conformer of the Oxa amide than that of the Pro amide. The changes in charge of the prolyl nitrogen and the decrease in electron overlap of the C$\^$∼/ N bond for TS structures seem to play a role in lowering rotational barriers of the Oxa amide compared to that of the Pro amide. The calculated preferences for cis conformers in the order of Oxa > Pro amides and for trans-to-cis rotational barriers in the order of Pro > Oxa amide in water are consistent with experimental results on Oxa-containing peptides. The pertinent distance between the prolyl nitrogen and the N$\^$∼/ H amide group to form a hydrogen bond might indicate that this intramolecular hydrogen bond could contribute in stabilizing the TS structures of Oxa and Pro amides and play a role in prolyl isomerization.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.380.2-380.2
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• 2002

Peroxisome proliferator-activated receptor (PPAR)-$\gamma$ is a nuclear hormone receptor family that plays an important role in the transcriptional regulation of genes in cellular lipid and energy metabolism. In our search for Iigands for PPAR-$\gamma$ from natural resources. two phenylpropanoids. 3.4.5-Trimethoxy cinnamylalcohol (1) and 3.4.5- Trimethoxy cinnamaldehyde (2). were isolated as PPAR-$\gamma$ agonists from the MeOH extracts of Zanthoxylum schinifolium Sieb. & ZUCCo (Rutaceae) by activity-guided fractionation. These two compoundS bind and activated PPAR-$\gamma$ transcriptional activity in a dose dependent manner assessed by ligand-binding assay. While the maximum activities for PPAR-$\gamma$ of these compounds were comparable with that of rosiglitazone. which is currently used in the treatment of Type II diabetes. the potency of these compounds were much weaker than rosiglitazone ($ED_{50}$=t.2$\mu\textrm{M}$) with the $ED_{50}$ values of 9.08 and 4.08 $\mu\textrm{M}$. respectively. To examine the structure-activity relationship of phenylpropanoids. we prepared several phenylpropanoid derivatives and measured the activity. We observed that substituents at 4'- position could playa key role in determining the potency for PPAR-$\gamma$ agonistic activity .

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.39 no.3
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• pp.56-64
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• 2021

Pavilion is an important landscape installation in the traditional landscaping and a representative facility that organizes space. To interpret and succeed the traditional landscape space, researches on the shape and structure of the traditional pavilion are also needed. However, researches on the style and structure of the traditional pavilion are difficult to be found. Accordingly this study aimed to identify the structural characteristics of roof part that occupied the largest portion in determining the shape of pavilion. Our research findings are as follows. As a result of analyzing 15 traditional Single-room square pavilions whose structure could be identified, it was found that the main building elements that distinguished the type of roof part in the Single-room square were crossbeam, ridge pole, and baluster. Depending on the presence of roofing members, pavilion was classified into five types: crossbeam, crossbeam+ridge pole, crossbeam+baluster, ridge pole, and baluster. In addition, as a result of analyzing the load and joint that worked on crossbeam based on the shape classification of roof part, it was found that in the traditional Single-room square pavilion, crossbeam was designed to play a balancing role between pillar and load. This study is significant in that it attempted to make a close interpretation of the shape of roof part in the pavilion and the role and function of building elements in terms of size, ratio, and load.

• Journal of Families and Better Life
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• v.10 no.1 s.19
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• pp.207-228
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• 1992

This study investigated the relationship between personality characteristics of individual and adjustment in the mid-life. The subjects of the study consisted of 374 married persons(185 men and 189 women) who live in Seoul and are 40 to 50 years old and whose last child is in middle school. Bem's short form BSRI, Rotter(1966)'s Internal-External Scale and Hayes & Stinnett(1977)'s MYLSS were used as measurements tools. The major results of the study were summarized as follows ; 1) While sex-role identity of middle aged men appeared in the follwing order ; Androgynous, masculine, undifferentiated, feminine, sec-role identity of middle aged women appeared in the following order ; Undifferentiated, androgynous, feminine, masculine. Both men and women had the moderate scores on the locus of control. The middle aged expressed a moderate level of life satisfaction with middle aged men reporting significantly a higher life satisfaction than did women. 2) Socio-demographic variables such as age, education, occuption and income have turned out to be significant on the life satisfaction of middle aged men. As for the life satisfacton of middle aged women, age, education, husband's occuption and religon had significant influences However, employment status of women, family structure, marital duration, number of child, status of last child, status of first child had no significant influences on Mid-life satisfaction. 3) Mid-life satisfaction of men and women was influenced significantly by sex-role identity and internal-external locus of control. Those men described as masculine and those women androgynous in the sex-role identity had the highest life satisfaction. On the other hand those of undifferentiated in the sex-role identity had the lowest life satisfaction. High levels of internal control were associated with high levels of life satisfaction. 4) The variables affecting the life satisfaction of middle aged men and women were education, income, sex-role identity, internal control. These 4 variables explained 27% of the life satisfaction of middle aged men and 24% of the life satisfaction of middle aged women.

• Management & Information Systems Review
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• v.10
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• pp.1-31
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• 2002

As the modern society is called the narcissistic society, the narcissism is widespread in the personality of individuals and the society at large. In consideration of this side, this study explored for several characteristics of the narcissistic personality and the job stress, and explored for the relationships between the two things theoretically. The narcissism is an attempt to repair self-esteem weakened by the splitting anxiety, the lack and the pathological fusion of self-structure. The job stress is a factor that a characteristic of the job influenced on the behavioral and affective response of the person on the job directly or indirectly. This study selected organizational justices, organizational constraints, role conflict, role ambiguity, role overload, organizational climate, interpersonal relations and career development as factors of the job stress. This study viewed that the stress is made from an interaction between environmental stimulus and personal particular reaction by defining the stress as an interaction model of stimulus-response and personal reaction is caused by psychological adjustment process, personal differences. On this occasion, this study discussed that the narcissistic personality is easy to get stress and weak in the job stress with regarding the personality as a mediation variation of psychological process. As a result, the narcissists estimated themselves positively and their self-esteem is high, but they excessively showed a self biased cognitive and affective response about the negative feedback to protect themselves. Moreover, this positive estimate on themselves and high self-esteem was vulnerable and weak in the self threat. In this view, the narcissistic personality is easy to get more job stress such as organizational justices, organizational constraints, role conflict, role ambiguity, role overload, organizational climate, interpersonal relations and career development.

• Journal of Microbiology and Biotechnology
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• v.18 no.10
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• pp.1655-1658
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• 2008

Cyanobacteria, blue-green algae, are a rich source of bioactive secondary metabolites with many potential applications. The ubiquitin-proteasome proteolytic system plays an important role in selective protein degradation and regulates cellular events including apoptosis. Cancer cells are more sensitive to the proapoptotic effects of proteasome inhibition than normal cells. Thus, proteasome inhibitors can be potential anticancer agents. Cyanobacteria have been shown to be a rich source of highly effective inhibitors of proteases. A proteasome inhibitor was screened from an extract of the culture of Scytonema hofmanni on the basis of its inhibitory activity, which led to the isolation of nostodione A with an $IC_{50}$ value of 50${\mu}M$. Its structure was determined by spectroscopic methods such as $^{1}H$-NMR and ESI-MS spectral analyses.

• Journal of the Korea Institute of Building Construction
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• v.12 no.1
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• pp.98-107
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• 2012

Reinforcing bars (rebar) comprise an integral part of a concrete structure, and play a major role in the safety and durability of the building. However, the actual placement or installation of rebar is not planned and controlled by the detailer. Recently, 4D simulations, using 3D model and scheduling software, have been used to improve the efficiency of the construction phrase. However, 4D simulators have not been introduced at the detailed level of work, such as rebar placement. Therefore, this paper suggests a BIM-based simulator for rebar placement to determine the sequence with which rebar is placed into the form. The system using Autodesk Revit API automatically generates rebar placement plans for a building structure, and labels the placement sequence of each individual bar or set of bars with ascending numbers. The placement sequence is then visualized using Autodesk Revit Structure 2012. This paper provides a short description of a field assessment and limits.