• BMB Reports
• /
• v.42 no.12
• /
• pp.829-833
• /
• 2009

Angiogenin is a member of the ribonuclease superfamily that induces the formation of new blood vessels. It has been suggested that the surface loop of angiogenin defined by residues 59-71 plays a special role in angiogenic function (1); however, the mechanism of action is not clearly defined. To elucidate the role of the surface loop on the structure, function and stability of angiogenin, three surface loop mutants were produced in which 14 amino acids in the surface loop of RNase A were substituted for the 13 amino acids in the corresponding loop of angiogenin. The structure, stability and biological functions of the mutants were then investigated using biophysical and biological approaches. Even though the substitutions did not influence the overall structure of angiogenin, they affected the stability and angiogenic function of angiogenin, indicating that the surface loop of angiogenin plays a significant role in maintaining the stability and angiogenic function of angiogenin.

• Applied Microscopy
• /
• v.47 no.4
• /
• pp.226-232
• /
• 2017

Electron microscopy and X-ray diffraction have together played a key role in our understanding of the molecular structure and mechanism of contraction of muscle. This review highlights the role of electron microscopy, from early insights into thick and thin filament structure by negative staining, to studies of single myosin molecule structure, and finally to recent high-resolution structures by cryo-electron microscopy. Muscle filaments are designed for movement. Their labile structures thus present challenges to obtaining near-atomic detail, which are also discussed.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.10 no.1
• /
• pp.54-63
• /
• 2004

The purpose of this study is to identify the factors that influence stress experienced by nursing students and to provide a perceived causal structure model among these variables. The ultimate goal of this study is to develop efficient guidance to clinical nursing education in this population. This study intends to apply perceived causal structure: network analysis method which was developed by Kelly(1983), and has been applied in nursing research. This method is selected to show dynamic relationship of stressor using network method. Data was collected from convenient sample of 186 junior college nursing students who had the clinical practice experience during 10 weeks. Data collection and analysis was conducted in 2 steps from December, 9, 2002 to February, 8, 2003. Step 1.: Data was collected using literature review(10 articles) to identify the causes of stress. Nine causes of stress were extracted. Step 2.: As perceived casual structure network study, data was collected using questionnaires which included 9 extracted cause and stress. The questionnaire contained a 10 X 10 grid table with 10 causes and effects printed. In network analysis, 'Yes' was scored as 1, 'No' was scored as 0, and the mean(maximum 1, minimum 0) was calculated. Construction of the network under inductive eliminative analysis which stopped the construction of the network when the consensual agreement level dropped near 50% was proceeded by adding causes in order of the mean rating level. In this study, construction of the final network was stopped by consensual agreement level of 52% of the total subjects. The results are summarized as follows : Step 1: Investigation of the causes of stress ; The extracted causes of stress from quality data was identified 9 categories ; negative nurse, lack of clinical practice opportunity, ambiguous role, negative patient, lack of nursing knowledge and skill, difficult of personal relations, inefficient clinical practice guidance, gap of theory and practice, lack of support. Step 2 : Construction of the perceived causal structure model ; 1) The most central cause of stress is ambiguous role in the systems of causation. 2) The distal cause of stress is inefficient clinical practice guidance 3) The causes that have a number of outgoing link are negative nurse, ambiguous role. 4) The causes that have a number of incoming link are ambiguous role, gap of theory- practice, lack of clinical practice opportunity, lack of nursing knowledge- skill. 5) There is a mutual relationship between stress and difficult of personal relations, stress and ambiguous role, ambiguous role and negative nurse, ambiguous role and lack of clinical practice opportunity, ambiguous role and lack of nursing knowledge-skill, lack of nursing knowledge-skill and gap of theory- practice. In conclusion, the network suggests that the first centre cause is related on ambiguous role and the second on negative nurse, inefficient clinical practice guidance in the systems of causation

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.29 no.3
• /
• pp.33-42
• /
• 2006

From middle of 90's, SCM had emphasized the importance of connection of all companies which participate to a market, and outsourcing has emphasizes the slim structure of companies for pursing cost reduction and service improvement. But outsourcing as '2-1=1' and integration as '1+1=2' not adapt to the advanced market but return to the former state. Besides, it is impossible of subcontractors and logistics companies to execute these strategies which are win-win strategy and outsourcing. So many logistics companies have sharp competition in price recently. Therefore logistics companies have increased the need for a profitable business model and strategy. This paper researches the limitations of logistics market and redefines the role of logistics through the evolution of logistics. Also this paper proposes new role(Logister) and structure(Velcro structure) for not maker-oriented logistics but market-oriented logistics. The introductory case study will help to understand 2 terms(logister and velcro structure).

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.13 no.4
• /
• pp.37-45
• /
• 2003

Role-based Access Control(RBAC) model has advantage of easy management of access control with constraints such as permission inheritance and separation of duty in role hierarchy. However, previous RBAC studies could not properly reflect the real-world organization structure with its role hierarchy. User who is a member of senior role can perform all permissions because senior role inherits all permissions of junior roles in the role hierarchy. Therefore there is a possibility for senior role members to abuse permissions due to violation of the least privilege principle. In this paper, we present a new model of role hierarchy, which restricts the unconditional permission inheritance. In the proposed model, a role is divided into sub roles(unconditional inheritance. restricted inheritance, private role), keeping organization structure in corporate environment. With restricted inheritance, the proposed model prevents permission abuse by specifying the degree of inheritance in role hierarchy.

• Proceedings of the Korean Society for Language and Information Conference
• /
• 2002.02a
• /
• pp.195-204
• /
• 2002

The purpose of this paper is to analyze the lexical-semantic structure of morphologically derived passive verbs in Korean based on Pustejovsky (1995)'s Generative Lexicon Theory (GL) and to explain the change of the root verb's lexical-semantic structure by means of passivization. Passivization in this paper is defined as the unaccusaztivization. In Argument Structure of derived passive verbs, the agent argument is deleted and the theme argument is realized as a syntactic subject. As for Event Structure, derived passives express left-headed event (achievement), whereas their roots denote right-headed event (accomplishment). In Qualia Structure, passive verbs and root ones have the same Fomal Role, but in Agentive Role of passive verbs, an act weakens to a process. Both Formal and Agentive Roles have the same theme argument.

• The Journal of the Korea Contents Association
• /
• v.22 no.10
• /
• pp.74-82
• /
• 2022

The purpose of this paper is to provide a multi-modular account of double accusative constructions in Korean in the framework of Autolexical Grammar. The grammar views syntactic, semantic, and morphological structures of sentences as modules which are generated simultaneously and independently. Unlike syntactocentric theories, this paper analyzes semantic characteristics of double accusatives through function-argument (F/A) structure along with roles structure (RS) and information structure (IS). In F/A structure of double accusatives, the first accusative becomes an argument of a predicate, unlike the possessive, which is an argument of a relational noun. Furthermore, the first accusative of double accusatives takes the role of patient in RS, which allows it to become the subject of a passive sentence. On the other hand, the second accusative, which is originally the possessee, becomes a focal area in IS. Therefore, the purpose of double accusatives is twofold: one is to turn the possessor into an independent argument of a predicate which takes patient role, and the other is to turn the possessee into a focus. Such semantic characteristics of double accusatives can be expressed by means of multi-dimensional structures of F/A structure, RS, and IS of Autolexical Grammar, which allows an integrated account of the phenomenon.

• The Journal of Korean Medicine
• /
• v.29 no.4
• /
• pp.13-29
• /
• 2008

Because of the changes of a variety of aspects of disease theory alternative to standard medicine, demand for traditional medicine has increased. This study was undertaken to grasp and compare traditional-medicine administrative structure, functions and role between Korea and China. According to our research, both nations promote policy related to traditional-medicine, yet there are various differences because of each nation's scale, political structure, medical system, etc. Especially, compare to the Korean government, the Chinese government not only has paid more attention to traditional medicine but also established and promoted a synthesis development strategy for a long time. Additionally, there is weakness in Korea's traditional medicine policy compared to the Chinese's Synthetic development-strategy, which is the Oriental-policy Department and Korea Food&Drug administration. Therefore, to make up for the weakness, they will have to organize their role better and make a long-term development-strategy plan for traditional medicine.

• Earthquakes and Structures
• /
• v.5 no.6
• /
• pp.679-702
• /
• 2013

During an earthquake, soils filter and send out the shaking to the building and simultaneously it has the role of bearing the building vibrations and transmitting them back to the ground. In other words, the ground and the building interact with each other. Hence, soil-structure interaction (SSI) is a key parameter that affects the performance of buildings during the earthquakes and is worth to be taken into consideration. Columns are one of the most crucial elements in RC buildings that play an important role in stability of the building and must be able to dissipate energy under seismic loads. Recent earthquakes showed that formation of plastic hinges in columns is still possible as a result of strong ground motion, despite the application of strong column-weak beam concept, as recommended by various design codes. Energy is dissipated through the plastic deformation of specific zones at the end of a member without affecting the rest of the structure. The formation of a plastic hinge in an RC column in regions that experience inelastic actions depends on the column details as well as soil-structure interaction (SSI). In this paper, 854 different scenarios have been analyzed by inelastic time-history analyses to predict the nonlinear behavior of RC columns considering soil-structure interaction (SSI). The effects of axial load, height over depth ratio, main period of soil and structure as well as different characteristics of earthquakes, are evaluated analytically by finite element methods and the results are compared with corresponding experimental data. Findings from this study provide a simple expression to estimate plastic hinge length of RC columns including soil-structure interaction.

• Journal of Digital Convergence
• /
• v.3 no.2
• /
• pp.117-130
• /
• 2005

Managing of local government public service is innovation strategy of local government public service using choice and competition principle. Managing strategy of local government public service is new paradigm for innovating public service and role structure of government. It is important to understand properly substance and characteristics of local government public service Accordingly, the purpose of this study understand substance and characteristics of local government public service and describe strategic driving plan of managing local government public service in the future.