• Journal of Dairy Science and Biotechnology
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• v.28 no.1
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• pp.17-28
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• 2010

A substantial body of evidence has emerged over the last decade in support of the novel concept that dietary calcium and dairy foods play an important role in regulating energy metabolism and thereby promote healthy weight management and reduce obesity risk. This concept has been demonstrated in experimental animals studies, cross-sectional and prospective population studies and a number of randomized clinical trials. Notably, the effects of dairy foods in weight management are more consistent than the effects of supplemental calcium across clinical trials, and calcium per se is responsible for approximately 40-50% of the effects of dairy. The calcium component is only effective in individuals with chronically low calcium intake, as it serves to prevent the endocrine response to low calcium diets which otherwise favors adipocyte energy storage; calcium also serves to promote energy loss via formation of calcium soaps in the gastrointestinal tract and thereby reduce fat absorption. The calcium-independent anti-obesity bioactivity of dairy resides primarily in whey. The key components identified to date are leucine and bioactive peptides resulting from whey protein digestion. The high concentration of leucine in whey stimulates a repartitioning of dietary energy from adipose tissue to skeletal muscle where it provides the energy required for leucine-stimulated protein synthesis, resulting in increased loss of adipose tissue and preservation of skeletal muscle mass during weight loss. Finally, dairy rich diets suppress the oxidative and inflammatory responses to obesity and thereby attenuate the diabetes and cardiovascular disease risk associated with obesity.

• Physical Therapy Korea
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• v.5 no.1
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• pp.63-78
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• 1998

The decrease of muscle power and muscle size between twenties and seventies was about 30% and 40% respectively. The loss of muscle mass by aging resulted in the decrease of muscle power. The loss of muscle mass was due to the decrease of number of Type I fiber and Type II fiber and size of each muscle fiber. The aging skeletal muscle didn't show the loss of glycolysis capacity but showed 20% decrease of the oxidative enzymes and muscle vascularization. The vigorous endurance exercise training with graded intensity played a role in the vascular proliferation, increase of activity of oxidative enzymes and improvement of $VO_2$ max. The graded resistance exercise also played a role in the muscle hypertrophy and increase of muscle power, if it performed with adequate intensity and period. The exercise adaptation of aging skeletal muscle prevented it from sarcopenia, provided the activity of daily living with great effect and provided the aging related disease, that is Type II diabetes mellitus, arteriosclerosis, hypertension, osteoporosis and obesity, with great effect.

• The Journal of the Korea Contents Association
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• v.20 no.11
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• pp.534-545
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• 2020

In the super-aged societies, an increased elderly population living in solitude has been causing many problems. Since the elderly may incur a sense of loss and interest in suicide when living alone, this study investigated the effects of smartphones as well as types of living arrangements on elderly peoples' sense of loss and suicidal thoughts. This study found social roles and relationships were lower for older individuals using smartphones than those using 2G phones. Not surprisingly, those living with family members or a partner had significantly fewer suicidal thoughts than those living in solitude. However, our results indicate subjects' loss of role and relationships was affected more significantly by their smartphone usage (2G phone vs. smartphone) rather than their living arrangements (i.e., living with family or a partner vs. living in solitude). Moreover, smartphone users showed a lower sense of loss in terms of social roles and relationships. Among the elderly, loss of health, social role, and relationships were identified as precedents for increased suicidal thoughts; yet, economic capacity was surprisingly not an indicator of suicidal thoughts.

• BMB Reports
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• v.51 no.9
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• pp.468-473
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• 2018

Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors P2X5 and P2X7 have both been implicated in bone biology, and it has been suggested recently that P2X5 may be a significant regulator of inflammatory bone loss. However, a role for P2X5 in periodontitis is unknown. The present study aimed to evaluate the functional role of P2X5 in ligature-induced periodontitis in mice. Five days after placement of ligature, analysis of alveolar bone revealed decreased bone loss in $P2rx5^{-/-}$ mice compared to $P2rx7^{-/-}$ and WT control mice. Gene expression analysis of the gingival tissue of ligated mice showed that IL1b, IL6, IL17a and Tnfsf11 expression levels were significantly reduced in $P2rx5^{-/-}$ compared to WT mice. These results suggest the P2X5 receptor may regulate bone loss related to periodontitis and it may thus be a novel therapeutic target in this oral disease.

• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.19-24
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• 2006

Mothers against decapentaplegic homolog 4 (SMAD4) is a tumor suppressor gene associated with gastrointestinal carcinogenesis. The aim of the present study was to characterize more precisely its role in the development and progression of human gastric carcinoma. In this study, using tissue microarray analysis of 283 gastric cancers and related lesions, we found loss of SMAD4 protein expression in the cytoplasm (36/114, 32%) and in the nucleus (46/114, 40%) of gastric cancer cells. The loss of nuclear SMAD4 expression in primary tumors correlated significantly with poor survival, and was an independent prognostic marker in multivariate analysis. We also found a substantial decrease in SMAD4 expression at both the RNA and protein level in several human gastric carcinoma cell lines. To identify the genetic and/or epigenetic mechanisms of altered SMAD4 expression in gastric carcinoma, loss of heterozygosity (LOH), promoter hypermethylation, and exon mutations were examined. We found that LOH (20/70, 29%) and promoter hypermethylation (4/73, 5%) were associated with the loss of SMAD4 expression. SMAD4 protein levels wore also affected in certain gastric carcinoma cell lines following incubation with Mc132, a proteasome inhibitor. Taken together, our results indicate that the loss of SMAD4, especially loss of nuclear SMAD4 expression, is involved in gastric cancer progression. The loss of SMAD4 in gastric carcinomas is due to several mechanisms, including LOH, hypermethylation, and proteasome degradation.

• IE interfaces
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• v.7 no.1
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• pp.75-80
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• 1994

In a recent article, Leon et al. lucidly explained the ideas of the Taguchi two-stage procedure for parameter design optimization, and proposed alternative performance measures called PerMIA to the signal-to-noise ratios. On the other hand, Box proposed an empirical approach to the problem based upon monotone transformations of the performance characteristic(y). This paper develops procedures for parameter design optimization under the assumptions that the expected loss(not necessarily a mean squared error loss) is increasing with respect to the variance of the error in y, and that the mean of y satisfies certain conditions of adjustability. It turns out that the variance of the error in y can play the role of PerMIA, and it is further shown that the derived PerMIA can be adapted to the Box empirical procedure for the minimization of the expected loss in the original metric.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.27 no.8
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• pp.67-74
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• 2013

Major utilities have been focusing on R&D and nationwide business of AMI system which plays a vital role in SmartGrid whose concept is to maximize energy efficiency and optimize electric power facility management with exchanging real time information between utilities and consumers based on ICT technologies in power grid. In this paper, we suggest a power loss monitoring method using KEPCO's AMI system which is operating in fields and with the acquisition of AMI data and analyses verify the validation of a power loss monitoring method.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2002.10a
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• pp.43-47
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• 2002

Weight loss experiments have been performed for unidirectional carbon fiber/epoxy laminates under both isothermal and cyclic thermal conditions. It was found that weight losses were the result of both specimen-geometry dependent oxidative degradation and volumetric geometry dependent thermal degradation. Thermal degradation was found to play a major role in the overall weight loss process, and photomicrographs of cross-sectioned, aged specimens confirmed this fact. A method to predict the effect of isothermal environment on the weight loss was introduced and found to be in good agreement with experimental data at temperatures near Tg (glass transition temperature).

• Journal of the Korean Solar Energy Society
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• v.22 no.1
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• pp.73-80
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• 2002

This is study of the planning of thermal insulation to prevent heat loss in a basement, is aimed at investigating the heat loss from the basement space and basement structures. The results analyzed in these researches are as follows; To analyze the heat loss from basement structures, this study experimented on the heat flow phenomenon of a non-insulation structure and two insulation structure models. From the result, the interior surface temperature of two insulation structures(B, C, model) showed an equal temperature, but the interior surface temperature of a non-insulation structure (A model) is different from the two models, Therefore, we understand that the insulator constructed in the basement structure makes a role of preventing the heat loss from the basement. In addition, the exterior surface temperature of two insulation structure models showed an equal temperature. Specially, judging from the temperature difference of C model. we understand that the performance of insulator is low under the definite depth of underground. The thermal insulation design should be constructed under the definite depth of underground considering outdoor and building conditions.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.341-344
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• 2008

The complicated helical flow formed in the regenerative turbomachines is usually decomposed into a peripheral component and a circulatory component. On the basis of the momentum exchange theory, the circulatory flow plays a critical role of imparting angular momentum to the peripheral flow. Therefore, the accuracy of performance prediction is dominated by the circulatory flow modeling. Until now the circulatory flow has been accounted of a standstill flow normal to the peripheral flow. However, the circulatory path from the impeller exit to the re-entrance inlet is exposed to the adverse pressure gradient, so it would be more realistic to describe that the circulatory flow is formed on the skewed plane not perpendicular to the peripheral flow. Present study suggests new circulatory flow loss model including the effect of adverse pressure gradient and modifies the effective circulatory flow rate and circulatory pivot which were previously published.