• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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• pp.4-4
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• 2002

Male germ cell apoptosis has been extensively explored in rodent. In contrast, very little is known about their susceptibility to apoptosis stimuli of developing germ cell stages at the time when germ cell depletion after busulfan treatment occurs. Furthermore, it is still unanswered how spermatogonial stem cells are resistant to busulfan treatment. Spontaneous apoptosis of germ cells was observed in the testis of adult mice and experimentally induced busulfan treated mice increased this apoptosis to such an extent that there was a decrease in the weight of the testis. (omitted)

• Reproductive and Developmental Biology
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• 제36권3호
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• pp.155-161
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• 2012

Germ cell-specific hyaluronidases such as sperm adhesion molecule 1 (SPAM1) and hyaluronoglucosaminidase 5 (Hyal5) are in part responsible for dispersal of the cumulus cell mass, which is a critical step in establishing fertilization in mammals. In this study, we identified two testis-hyaluronidases, SPAM1 and Hyal5, in hamster and rat. These two genes were expressed specifically in the testis. At the protein level, hamster SPAM1 and Hyal5 display 78.7% and 75.4% identity with mouse SPAM1 and Hyal5. Further, the activity of the enzymes with respect to cumulus cell dispersion did not differ, although we observed that the enzymatic activity differed in pH range. These studies suggest that different sperm hyaluronidases are capable of dispersing the cumulus cell mass despite differences in enzyme activity.

• 로봇학회논문지
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• 제4권1호
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• pp.34-42
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• 2009

Rodents, specially rats, can recognize distance and shape of an object and also pattern of the textures by using their whiskers. Mechanoreceptors surrounding the root of whisker in their follicle measure deflection of the whisker. Rats can move their whisker back and forth freely. This ability, called active whisking or active sensing, is one of characteristics of rat behaviours. Many researches based on the mechanism have been progressed. In this paper, we test a simple and accurate method based on deflection of the whisker: we designed biomimetic whiskers modeling after a structure of follicle using the microphone. The microphone sensor measures a mechanical vibration. Attaching an artificial whisker beam to the microphone membrane, we can detect a vibration of whisker and this can show the deflection amount of whisker indirectly.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.342.3-343
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• 2002

Non-insulin dependent diabetes mellitus (NIDDM) is characterized by hyperglycemia, hyperinsulinemia. and impaired insulin action. Insulin resistance is considered to be the underlying mechanism in the pathogenesis of type 2 diabetes. which also leads to dyslipidemia, hypertension. and obesity. Thazolidinediones are a class of oral insulin-sensitizing agents that improve glucose utilization without increasing insulin release. They significantly reduce glucose, lipid and insulin levels in rodent models of NIDDM and obesity, and recent clinical data support theri efficacy in obese diabetic patients. (omitted)

• Animal Systematics, Evolution and Diversity
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• 제3권1호
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• pp.24-40
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• 1987

한국산 설치류 중 등줄쥐(Apodemus agrarius)의 분류학적 연구를 위해서 제주도산 등줄쥐(Apodemus agrarius chejuensis)를 채집하였으며 형태적 및 염색체 분석을 한반도 내의 등줄쥐(A. agrarius coreae)와 비교 실시하였다. A. agrarius coreae와 A. agrarius chejuensis는 염색체 핵형에서는 같았으나, 형태적 형질에 있어서는 전자는 작은 형이었으며 후자는 큰 형이었다.

• Asian-Australasian Journal of Animal Sciences
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• 제14권4호
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• pp.587-596
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• 2001

In the last decade, rapid developments in molecular biotechnology and of genomic tools have enabled the creation of dense linkage maps across whole genomes of human, plant and animals. Successful development and implementation of interval mapping methodologies have allowed detection of the quantitative trait loci (QTL) responsible for economically important traits in experimental and commercial livestock populations. The candidate gene approach can be used in any general population with the availability of a large resource of candidate genes from the human or rodent genomes using comparative maps, and the validated candidate genes can be directly applied to commercial breeds. For the QTL detected from primary genome scans, two incipient fine mapping approaches are applied by generating new recombinants over several generations or utilizing historical recombinants with identity-by-descent (IBD) and linkage disequilibrium (LD) mapping. The high resolution definition of QTL position from fine mapping will allow the more efficient implementation of breeding programs such as marker-assisted selection (MAS) or marker-assisted introgression (MAI), and will provide a route toward cloning the QTL.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2379-2381
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• 2014

It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to l imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.

• Parasites, Hosts and Diseases
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• 제31권2호
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• pp.165-168
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• 1993

서울주걱흡충의 냉동절편에서 효소조직화학법을 이용하여 조직융해구(trlbocytic organ)와 맹장에 acid phosphatase, non-specific esterase 활성도가 있음을 알 수 있었다. 이 두 기관이 표피 이외에 중요한 흡수기관일 것이다. 이 흡충의 우리말 이름을, 이미 회원들에 의해 제안된 "쥐주걱흉충"은 쥐만 적절한 숙주로 생각할 수 있으므로 발견 장소가 학명에 포함된 것을 감안하여 "서울주걱흡충"이라고 고쳐 쓰고 싶다. 준말로 쓸 때는 "서울흡충"이 나을 것이다.

• Reproductive and Developmental Biology
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• 제36권1호
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• pp.79-85
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• 2012

Minipigs are regarded as one of the most important laboratory animal in that anatomical and physiological properties are similar to human and their reproduction efficiency is relatively higher compared to other large animal species. Particularly, several diseases that cannot be mimicked in rodent models are successfully occurred or induced in pig models therefore it has been interested in a valuable model for human diseases. Pigs are also 'standard' species in xenotransplantation research. To maximize experimental outcome using minipigs, establishment and management of proper animal facility, right animal husbandry and control of pathogens are very important. In this review, we summarized several international guidelines related with minipigs published by several companies or governments and discuss optimal conditions for providing informative ideas to the researchers who want to use minipigs in their future studies.

• KSBB Journal
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• 제13권6호
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• pp.656-661
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• 1998

Hantaan virus belonging to the genus Hantavirus and family Bunyaviridae causes an acute severe illness of human, Haemorrhagic Fever with Renal Syndrome (HFRS). It is a rodent host-borne pathogen and distributed in Asia and Eastern Europe. Hantaviruses have three major antigens, i.e., G1, G2 glycoproteins and nucleocapsid protein (N). Among them, nucleocapsid protein was reported to be the most invaluable antigen as for diagnosis. We have cloned and expressed Hantaan viral nucleocapsid gene in E. coli BL21(DE3). In this study, we have tried to purify the nucleocapsid protein produced by recombinant E. coli, and could attained a purity of >90% by anti-N monoclonal antibody-coupled immunoaffinity chromatography or phenyl sepharose hydrophobic interaction chromatography.