• Title/Summary/Keyword: risk-sensitive

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Indoor exposure to hazardous air pollutants and volatile organic compounds in low-income houses in Lagos, Nigeria

  • Luqmon, Azeez;Musa, Olaogun;Mariam, Adeoye;Abdulazeez, Lawal;Babatunde, Agbaogun;Ibrahim, Abdulsalami;Adija, Majolagbe
    • Advances in environmental research
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    • v.1 no.4
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    • pp.277-288
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    • 2012
  • This study investigated exposure to air pollutants in rooms in low-income houses at Shomolu (R1), Mafoluku (R2) and Mushin (R3) in Lagos state. The concentrations of most measured exceeded limits of Illinois Department of Public Health (IDPH) for indoor air quality. Air quality index (AQI) in rooms studied was unhealthy for sensitive people in terms of CO, unhealthy in terms of $SO_2$ and very unhealthy in terms of $NO_2$ while moderate air quality was obtained in terms of $PM_{10}$ in most rooms. High concentrations of carbontetrachloride, formaldehyde and xylene measured could have been responsible for some of the health complaints of the occupants. Factor analysis shows that cooking with kerosene, use of gasoline generator and insecticide were the major contributors to indoor air pollution in these rooms. Therefore, there is need to urgently tackle poverty as all affected by these pollutants were poor who live in substandard houses without kitchens.

Factors associated with Unintentional Injuries to Korean Adolescents at School: A Multilevel Study (다수준 분석을 이용한 청소년의 학교 내 손상 관련 요인)

  • Yu, Jung-Ok;Kim, Myo-Sung
    • Research in Community and Public Health Nursing
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    • v.27 no.4
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    • pp.337-345
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    • 2016
  • Purpose: This study aims at identifying individual- and school-level factors associated with unintentional injuries to Korean adolescents at school by applying multilevel modeling. Methods: From the database of the eleventh Korea Youth Risk Behavior Web-based Survey (KYRBS), the researchers selected 68,043 adolescents from the $7^{th}$ to the $12^{th}$ grades. Data were analyzed using ${\chi}^2$ test for prevalence and multilevel modeling for related factors of unintentional injuries at school. Results: About 22.9 percent of the adolescents had treatment experiences for unintentional injuries at school in the past 12 months. At the individual level, the significant factors associated with unintentional injuries at school included gender, grade, academic achievement, current smoking, alcohol consumption, frequency of high caffeine intake, depression, and relief of fatigue after sleep. At the group level, the significant factors included number of physical education per week and safety education. Conclusion: School based injury prevention programs should be sensitive to both individual- and school-level factors associated with unintentional injury at school among Korean adolescents.

Utility of the pat gene as a selectable marker gene in production of transgenic Dunaliella salina

  • Jung, Hyo Sun;Kim, Dong Soo
    • Fisheries and Aquatic Sciences
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    • v.19 no.7
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    • pp.31.1-31.6
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    • 2016
  • Background: The objective of this study was to develop an efficient selectable marker for transgenic Dunaliella salina. Results: Tests of the sensitivity of D. salina to the antibiotic chloramphenicol and the herbicide Basta$^{(R)}$ showed that cells ($1.0{\times}10^6cells/ml$) treated with 1000 or $1500{\mu}g/ml$ chloramphenicol died in 8 or 6 days, respectively, whereas D. salina cells ($1.0{\times}10^6cells/ml$) treated with 5, 10, 20, or $40{\mu}g/ml$ Basta$^{(R)}$ died in 2 days. Therefore, D. salina is more sensitive to Basta$^{(R)}$ than to chloramphenicol. To examine the possibility of using the phosphinothricin N-acetyltransferase (pat) gene as a selectable marker gene, we introduced the pat genes into D. salina with particle bombardment system under the condition of helium pressure of 900 psi from a distance of 3 cm. PCR analysis confirmed that the gene was stably inserted into the cells and that the cells survived in $5{\mu}g/ml$ Basta$^{(R)}$, the medium used to select the transformed cells. Conclusions: The findings of this study suggest that the pat gene can be used as an efficient selectable marker when producing transgenic D. salina.

Clinical Application of I-123 MIBG Cardiac Imaging (I-123 MIBG Cardiac SPECT의 임상적 적응증)

  • Kang, Do-Young
    • The Korean Journal of Nuclear Medicine
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    • v.38 no.5
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    • pp.331-337
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    • 2004
  • Cardiac neurotransmission imaging allows in vivo assessment of presynaptic reuptake, neurotransmitter storage and postsynaptic receptors. Among the various neurotransmitter, I-123 MIBG is most available and relatively well-established. Metaiodobenzylguanidine (MIBG) is an analogue of the false neurotransmitter guanethidine. It is taken up to adrenergic neurons by uptake-1 mechanism as same as norepinephrine. As tagged with I-123, it can be used to image sympathetic function in various organs including heart with planar or SPECT techniques. I-123 MIBG imaging has a unique advantage to evaluate myocardial neuronal activity in which the heart has no significant structural abnormality or even no functional derangement measured with other conventional examination. In patients with cardiomyopathy and heart failure, this imaging has most sensitive technique to predict prognosis and treatment response of betablocker or ACE inhibitor. In diabetic patients, it allow very early detection of autonomic neuropathy. In patients with dangerous arrhythmia such as ventricular tachycardia or fibrillation, MIBG imaging may be only an abnormal result among various exams. In patients with ischemic heart disease, sympathetic derangement may be used as the method of risk stratification. In heart transplanted patients, sympathetic reinnervation is well evaluated. Adriamycin-induced cardiotoxicity is detected earlier than ventricular dysfunction with sympathetic dysfunction. Neurodegenerative disorder such as Parkinson's disease or dementia with Lewy bodies has also cardiac sympathetic dysfunction. Noninvasive assessment of cardiac sympathetic nerve activity with I-123 MIBG imaging nay be improve understanding of the pathophysiology of cardiac disease and make a contribution to predict survival and therapy efficacy.

An Encrypted Speech Retrieval Scheme Based on Long Short-Term Memory Neural Network and Deep Hashing

  • Zhang, Qiu-yu;Li, Yu-zhou;Hu, Ying-jie
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.6
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    • pp.2612-2633
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    • 2020
  • Due to the explosive growth of multimedia speech data, how to protect the privacy of speech data and how to efficiently retrieve speech data have become a hot spot for researchers in recent years. In this paper, we proposed an encrypted speech retrieval scheme based on long short-term memory (LSTM) neural network and deep hashing. This scheme not only achieves efficient retrieval of massive speech in cloud environment, but also effectively avoids the risk of sensitive information leakage. Firstly, a novel speech encryption algorithm based on 4D quadratic autonomous hyperchaotic system is proposed to realize the privacy and security of speech data in the cloud. Secondly, the integrated LSTM network model and deep hashing algorithm are used to extract high-level features of speech data. It is used to solve the high dimensional and temporality problems of speech data, and increase the retrieval efficiency and retrieval accuracy of the proposed scheme. Finally, the normalized Hamming distance algorithm is used to achieve matching. Compared with the existing algorithms, the proposed scheme has good discrimination and robustness and it has high recall, precision and retrieval efficiency under various content preserving operations. Meanwhile, the proposed speech encryption algorithm has high key space and can effectively resist exhaustive attacks.

Comparative Analysis of Indoor Mixture Gas Patterns and Reference Single Gas Patterns Obtained from E-Nose for Indoor Air Quality Monitoring

  • Choi, Jang Sik;Yu, Joon Boo;Jeon, Jin Young;Lee, Sang Hun;Kim, Jae Hong;Park, Jang Pyo;Jeong, Yong Won;Byun, Hyung Gi
    • Journal of Sensor Science and Technology
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    • v.27 no.4
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    • pp.227-231
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    • 2018
  • Indoor air pollution has become a serious issue, affecting the health and comfort of building occupants. Volatile organic compounds (VOCs) are among the most common indoor contaminants, and are released from numerous indoor emission sources. Among the VOCs, formaldehyde and toluene are toxic chemicals at low levels and are frequently detected indoors. Exposure to formaldehyde and toluene can irritate sensitive tissue and may increase the risk of cancer. Therefore, monitoring formaldehyde and toluene is critical for the health and comfort of residents. In addition, as human indoor activities can generate VOC gases, analysis of their influence on VOCs is needed. In this study, we compared electronic nose (E-Nose) data for formaldehyde and toluene with E-Nose data for indoor mixture gas with consideration for human indoor activities.

Application of in situ Liquid Ferrate(VI) for 2-Bromophenol Removal (2-브로모페놀 제거를 위한 액상 페레이트 적용 연구)

  • Laksono, Fajar Budi;Kim, Il-Kyu
    • Journal of Korean Society of Water and Wastewater
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    • v.29 no.6
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    • pp.685-692
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    • 2015
  • The concern over the risk of environmental exposure to brominated phenols has been increased and has led the researchers to focus their attention on the study of bromophenol treatment. In this study, the effects of pH and ferrate(VI) dose on the degradation of 2-bromophenol were investigated. The results indicated that the oxidation of 2-bromophenol by liquid ferrate(VI) was found to be highly sensitive to the pH condition. Furthermore, the highest removal efficiency was observed at the neutral condition with the removal efficiency of 94.2%. In addition, experimental results showed that 2-bromophenol removal efficiency increased with increasing of ferrate dosage. Ferrate(VI) dose of 0.23 mM was sufficient to remove most of the 2-bromophenol with the efficiency of 99.73% and kapp value of $2982M^{-1}s^{-1}$. Seven compounds were identified as the intermediate products by the GC/MS analysis.

Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma

  • Kelgandre, Deepak Chandrakant;Pathak, Jigna;Patel, Shilpa;Ingale, Pramod;Swain, Niharika
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.1865-1868
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    • 2016
  • Background: The number of patients with oral cancer in India is increasing gradually (especially in younger people). Although the diagnostic modalities and therapeutic management of oral cancer are improving, the treatment outcome and prognosis of oral cancer remain poor. The absence of definite early warning symptoms for most head and neck cancers suggests that sensitive and specific biomarkers are likely to be important in screening for high-risk patients. Aims: To analyze serum adenosine deaminase (ADA) levels in oral squamous cell carcinoma (OSCC) cases who reported to our institute. Materials and Methods: A prospective study was performed on 100 histopathologically proven cases of OSCC (study group) and 100 normal healthy individuals (control group). Independent sample and one sample t-tests and one way ANOVA followed by Tuckey's POST HOC test were conducted for analysis. Results: Statistically significant increase in serum ADA levels was observed in OSCC cases compared to the control group. Also serum ADA level increased significantly with the histopathological grade. Conclusions: Serum ADA levels in OSCC may be a useful diagnostic and prognostic biomarkers in clinical practice and our findings suggest that a large-scale study is warranted to confirm clinical utility as a prognostic and diagnostic biomarker.

Distribution of Fecal Sterols, Nonylphenol, and Polycyclic Aromatic Hydrocarbons in Surface Water from Masan Bay, Korea

  • Choi, Min-Kyu;Park, Yeon-Su;Moon, Hyo-Bang;Yu, Jun;Choi, Hee-Gu
    • Fisheries and Aquatic Sciences
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    • v.13 no.3
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    • pp.236-243
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    • 2010
  • Fecal sterols, nonylphenolic compounds (NPs), and polycyclic aromatic hydrocarbons (PAHs) were determined in surface water from Masan Bay and its adjacent rivers in February 2005. Concentrations of coporstanol (Cop), an indicator of fecal pollution, in surface water ranged from <10 to 13,853 ng/L, and concentrations of nonylphenol, the most toxic of the NPs, ranged from 10.2 to 481 ng/L, and concentrations of PAHs ranged from 8.61 to 223 ng/L. The concentrations of the compounds measured in this study were lower than or comparable to those at other locations in Korea and other countries. The contamination of Cop and PAHs in surface water was associated with the discharge from rivers passing through cities and/or industrial complexes. The NP contamination was associated with wastewater treatment plant (WWTP) effluents through outfalls as well as riverine discharge. Compared to ecotoxicological values, the concentrations of NPs from rivers, the mouths of rivers, and WWTP outfall areas exceeded guidelines, suggesting that hot spot areas may pose a potential risk to sensitive species.

Pysiological Responses of Diploid and Triploid Far Eastern Catfish, Silurus asotus to Water Temperature Stress

  • Lee, Hyo Bin;Kim, Dong Soo;Gil, Hyun Woo;Park, In-Seok
    • Development and Reproduction
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    • v.22 no.2
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    • pp.165-174
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    • 2018
  • The aim of study is to contribute to this knowledge-base by investigating the respiratory function, the metabolic rate and the difference of physiological responses un-der low water temperature ($20^{\circ}C{\rightarrow}15^{\circ}C$) stress be-tween diploid and triploid far eastern catfish, Silurus asotus. During the 48 hrs of water temperature stress exposure time, the respiratory frequencies, $CO_2$ and ${NH_4}^+$ concentrations of diploid had higher values than those of triploid (p<0.05). However, pH of triploid was higher than those of diploid (p<0.05), and oxygen consumption rate was not different between diploid and triploid (p>0.05). The level of plasma cortisol and plasma glucose of triploid was lower than those of the diploid (p<0.05). However, in case of lactic acid, there were not significant between triploid and diploid (p>0.05). These results suggest that diploid was more sensitive for low water temperature stress response than triploid in this species.