• Biomedical Science Letters
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• v.24 no.3
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• pp.143-149
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• 2018

Excessive exposure to estrogens is the most important risk factor for the development of hormone-sensitive cancers, especially breast cancer. Estrogen stimulates the expression of genes and proteins involved in cell proliferation by binding to estrogen receptor (ER). Another possible mechanism of ER-independent carcinogenicity of estrogens is based on the hydroxylation of estradiol resulting in the formation of catechol estrogens. Catechol estrogen 4-hydroxyestradiol ($4-OHE_2$) is further oxidized to catechol estrogen-3,4-quinones, the major carcinogenic metabolites of estrogens. Evidence increasingly supports the critical role of $4-OHE_2$ in hormonal carcinogenesis via DNA adduct formation or production of reactive oxygen species, which finally contribute to the transformation of normal mammary epithelial cells and the enhanced growth of breast cancer cells. It is also reported that the level of $4-OHE_2$ or its quinones is highly up-regulated in urine or tissues of breast cancer patients. Thus, we highlight the oncogenic roles of $4-OHE_2$ in catechol estrogen-induced breast carcinogenesis.

• Journal of Ocean Engineering and Technology
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• v.30 no.4
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• pp.320-326
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• 2016

Rip current forecasts, based on intensity, are marked in four levels—notice, watch, warning, and danger. However, numerical results are represented by current vectors, whose magnitudes are then converted into predictive levels. In the present study, the rose diagram is adapted as a determinative forecasting index and examined for the case of an ideal rip channel consisting of surface, bottom, and averaged currents. Further, it is employed in the sensitivity analysis of wave-induced currents generated by wave conditions at the Haeundae Beach. The simulation of surface onshore and bottom undertow currents is accomplished by including a mass flux term in the wave-averaged continuity equation.

• Safety and Health at Work
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• v.2 no.4
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• pp.380-384
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• 2011

The chronic and acute effects of hyperglycemia affecting cognition and work are as important as those of hypoglycemia. Its impact, considering that majority of diabetic patients fail to reach therapeutic targets, would be potentially significant. Self monitoring of blood glucose, recognition of body cues and management interventions should be geared not only towards avoidance of disabling hypoglycemia, but also towards unwanted hyperglycemia. Over the long term, chronic hyperglycemia is a risk for cognitive decline. Acute episodes of hyperglycemia, above 15 mmol/L have also been shown to affect cognitive motor tasks. Maintaining blood sugar to avoid hyperglycemia in diabetic workers will help promote safety at work.

• Annual Conference of KIPS
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• 2022.05a
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• pp.264-267
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• 2022

Recently, federated learning (FL) has increased prominence as a viable approach for enhancing user privacy and data security by allowing collaborative multi-party model learning without exchanging sensitive data. Despite this, most present FL systems still depend on a centralized aggregator to generate a global model by gathering all submitted models from users, which could expose user privacy and the risk of various threats from malicious users. To solve these issues, we suggested a safe FL framework that employs differential privacy to counter membership inference attacks during the collaborative FL model training process and empowers blockchain to replace the centralized aggregator server.

• Journal of the Ergonomics Society of Korea
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• v.14 no.1
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• pp.69-81
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• 1995

Few studies on the biomechanical analysis of hand postures and tool handling tasks exist because of the lack of appropriate measurement techniques for hand force. A measurement system for the finger forces and joint angles for the analysis of manual tool handling tasks was developed in this study. The measurement system consists of a force sensing glove made from twelve Force Sensitive Resistors and an angle-measuring glove (Cyberglove$^{TM}$, Virtual technologies) with eighteem joint angle sensors. A biomechanical model of the hand using the data from the measurement system was also developed. Systems of computerized procedures were implemented inte- grating the hand posture measurement system, biomechanical analysis system, and the task analysis system for manual tool handling tasks. The measurement system was useful in providing the hand force data needed for an existing task analysis system used in CTD risk evaluation. It is expected that the hand posture measurement developed in this study will provide an efficient and cost-effective solution to task analysis of manual tool handling tasks.s.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.28 no.3
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• pp.681-694
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• 2018

This paper studied the effects of risk cognition of personal information and self-expression information on conation of privacy protection. In the first study, 88 college students who volunteered for this research were surveyed about risk cognition of personal information and conation to protect it. In the second study, after an information-seeking expert collected and organized the self-expression information that 88 volunteers had expressed on SNS, and then showed the organized self-expression information to 88 volunteers, and then 88 volunteers were surveyed about risk cognition of self-expression information and conation to protect it. As results of the first data analysis, the risk cognition of personal information had the greatest influence on non-disclosure of personal information, followed by reduction of the disclosure scope and law institutionalization requirement. As results of the second data analysis, SNS users openly expressed their opinion or life-style, but when they realized that self-expression information can be accumulated and become sensitive information, they had conation to protect their self-expression information such as non-disclosure, reduction of disclosure scope, and law institutionalization requirement. The implication of this study is that we have overcome the limitations of existing researches that can not explain information protection behavior on SNS.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.2
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• pp.343-361
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• 2015

The financial industry in South Korea has witnessed a paradigm shift from selling traditional loan/deposit products to diversified consumption channels and financial products. Consequently, personification of financial services has accelerated and the value of finance-related personal information has risen rapidly. As seen in the 2014 card company information leakage incident, most of major finance-related information leakage incidents are caused by personnel with authorized access to certain data. Therefore, it is strongly required to confirm whether there are problems in the existing access control policy for personnel who can access a great deal of data, and to complement access control policy by considering risk factors of information security. In this paper, based on information of IT personnel with access to sensitive finance-related data such as job, position, sensitivity of accessible data and on a survey result, we will analyze influence factors for personnel risk measurement and apply data access control policy reflecting the analysis result to an actual case so as to introduce measures to minimize IT personnel risk in financial companies.

• Journal of Environmental Health Sciences
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• v.43 no.6
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• pp.447-456
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• 2017

Objectives: Pregnant women and those of childbearing age are a well-known sensitive population for human mercury exposure. Therefore, this study was conducted to reveal and enrich basic information for effective risk communication to reduce the adverse health effects of mercury exposure. Methods: A self-administered questionnaire survey was conducted among 432 women aged 19-44 years, recruited conveniently from three different regions (Busan, Ulsan, and Gumi City). Questionnaires were developed by referring to the existing literature and through expert meetings. They consisted of questions on knowledge and awareness of mercury exposure risks, health information literacy, and relevant information. Results: The rank of perceived mercury health risk score was 5 out of 16 environmental risk factors, and 41.7% of participants thought that even a very little mercury could lead to an adverse health effect. Although 90.3% of participants had knowledge that childbearing age women must pay attention to fish intake, only 38.9% of participants knew the national fish intake guidelines for pregnant women. Conclusions: Although risk perception and knowledge of pregnancy-specific features of mercury were relatively high, the national fish intake guidelines were still not well recognized. It could be an effective strategy to provide evidence-based and targeted information articulated by professionals using internet based communication channels.

• Korean Journal of Environmental Biology
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• v.30 no.2
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• pp.128-135
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• 2012

The individual toxicity of lead (Pb) and zinc (Zn) has been investigated by using the sea urchin (Hemicentrotus pulcherrimus) germ cell and pluteus-larvae. The gametotoxic and embryotoxic effects of Pb and Zn on H. pulcherrimus were each investigated at 31, 63, 125, 250, 500 ppb and 16, 31, 63, 125, 250 ppb, respectively. Spawning was induced by 0.5 M KCl solution and the fertilization and normal embryogenesis rates test were performed for 10 min and 64 h after fertilization, respectively. In exposure to Pb, the fertilization rate was not significantly changed compared with control but normal embryogenesis rate was significantly decreased with concentration dependent manner. Fertilization and normal embryogenesis rates showed a significant decreased with concentration dependent manner in exposed to Zn. The normal embryogenesis rates were significantly inhibited in exposed to Pb ($EC_{50}$=45.13 ppb, 95% Cl=40.12~50.05 ppb) and Zn ($EC_{50}$=19.82 ppb, 95% Cl=18.26~21.31 ppb). In exposure to Pb and Zn, the NOEC of normal embryogenesis rate was <31.25 and <15.63 ppb, respectively. The LOEC showed each 31.25 and 15.63 ppb in exposed to Pb and Zn. These results suggest that the early embryo development of H. pulcherrimus is highly sensitive to heavy metals such as Pb and Zn, H. pulcherrimus can be used as a test organism for risk assessment in marine ecosystems.

• Biomedical Science Letters
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• v.11 no.1
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• pp.51-56
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• 2005

The detection of high-risk human papilloma virus (HPV) allows us to predict the presence and future development of cervical intraepitheliallesion. In this study, we compared Hybrid Capture II and DNA chip methods for detection of HPV in cervical swab samples. And we evaluated the clinical efficacy and diagnostic performance of HPV DNA chip and Hybrid Capture II for detecting HPV in cervical neoplastic lesions. Seventy four patients were classified into three groups according to their histologic diagnosis: Group I (nonspecific chronic cervicitis), Group II (low-grade squamous intraepithelial lesion (SIL); koilocytosis, and mild dysplasia), and Group III (high-grade SIL;, moderate, severe dysplasia and in situ carcinoma). Cytologic diagnosis were based on the Bethesda System. Hybrid Capture II and DNA chip methods were performed to detect HPV. In 41 of the 74 cervical samples $(55.4\%)$, HPV DNAs were detected by Hybrid Capture II. In Group III, HPV-positive cases were detected in 15 $(20.3\%)$ of 74 patients by Hybrid Capture II. 25 patients with ASCUS cytology were histopathologically examined: 9 cases $(36\%)$ were Group II. In 18 patients with low-grade SIL cytology, 13 cases $(72.2\%)$ were Group II and 3 cases $(16.7\%)$ were Group III. 12 cases $(92.3\%)$ were Group ill of 13 patients with high-grade SIL cytology. The sensitivity of each test was $82\%$ in Hybrid Capture II and $53.9\%$ in DNA chip test. And the specificity was $74.3\%,\;85.7\%$ in Hybrid Capture II and DNA chip. In conclusion, Hybrid Capture II test is more sensitive than DNA chip in detecting women with cervical neoplastic lesions. Especially, in diagnosing of ASCUS, Hybrid Capture II test is more sensitive. Therefore, Hybrid Capture II test for cancer-associated HPV DNA is a viable option in the management of women with ASCUS.