• Title/Summary/Keyword: risk response

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Dose-response Relationship between Serum Metabolomics and the Risk of Stroke (혈청 대사체와 뇌졸중 발생위험의 용량반응 분석)

  • Jee, Yon Ho;Jung, Keum Ji;Lim, Youn-Hee;Lee, Yeseung;Park, Youngja;Jee, Sun Ha
    • Journal of health informatics and statistics
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    • v.41 no.3
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    • pp.318-323
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    • 2016
  • Objectives: Except the known risk factors for stroke, few studies have identified novel metabolic markers that could effectively detect stroke at an early stage. In this study, we explored the dose-response relationship between serum metabolites and the incidence of stroke. Methods: We studied 213 adults in the Korean Cancer Prevention Study-II (KCPS-II) biobank and estimated dose-response relationship between serum metabolites and stroke (42 cases and 171 controls). Three serum metabolites (Acetylcholine, HexadecylAcetylGlycerol, and 1-acetyl-2-formyl-sn-glycero-3-phosphocholine) were used in this study. The analysis included (1) exploratory nonlinear analysis, (2) estimation of flexion points and slopes at below and above the points. In the model to estimate risk of incidence of stroke, we controlled for conventional risk factors such as age, sex, systolic blood pressure, type 2 diabetes, triglyceride, and smoking status. Results: The relationship between incidence of stroke and log-transformed 1-acetyl-2-formyl-sn-glycero-3-phosphocholine was non-linear with flexion point around intensity score of 8.8, whereas other metabolites, log-transformed Acetylcholine and HexadecylAcetylGlycerol, showed negative linear patterns. Conclusions: The study suggests that metabolic markers are associated with incidence of stroke, particularly, at or above the flexion point. The study result may contribute to developing a novel system for precise stroke prediction.

Risk-based Priority Ranking for Air Pollution Problems in Seoul (서울 지역에서 인체 위해도에 입각한 대기오염물질의 관리 우선 순위 선정에 관한 연구)

  • 김예신;박화성;이용진;임영욱;신동천
    • Journal of Korean Society for Atmospheric Environment
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    • v.19 no.2
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    • pp.205-216
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    • 2003
  • We have gathered exposure data on ambient air quality level and investigated dose-response slope factors of air pollutants such as fine particle, HAPs (metals, VOCs, PAHs) and dioxins in Seoul. Theoretical mortality incidences were estimated from exposure to these pollutants. From the results, priorities were ranked in the order fine particle, metals, VOCs, dioxins and PAHs by ordinal scale, and the uncertainties relative to those risk estimates were described.

Development Plan of Facility Importance, Risk, and Damage Estimation Inventory Construction for Assisting Disaster Response Decision-Making (재난대응 의사결정 지원을 위한 시설물 중요도·위험도·피해액 산정 인벤토리 구축 방안 연구)

  • CHOI, Soo-Young;GANG, Su-Myung;JO, Yun-Won;OH, Eun-Ho;PARK, Jae-Woo;KIM, Gil-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.19 no.1
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    • pp.167-179
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    • 2016
  • The safety of SOC facilities is constantly under threat by the globally increasing abnormal climate. Responding to disasters requires prompt decision-making such as suggesting evacuation paths. For doing so, spatio-temporal information with convergence of disaster information and SOC facility information must be utilized. Such information is being collected separately by the government or related organizations, but not collectively. The collective control of the separately collected disaster information and the generation of SOC facility safety and damage information are required for prompt disaster response. Also, as disaster information requires spatio-temporal convergence in its nature, the construction of an inventory that integrates related information and assists disaster response decision-making is required. A plan to construct a facility importance, risk, and damage estimation inventory for assisting prompt disaster response decision-making is suggested in this study. Through this study, the disaster and SOC facility-related data, which are being managed separately, can be collected and standardized. The integrated information required for the estimation of facility importance, risk, and damage can be provided. The suggested system is expected to be used as a decision-making tool for proactive disaster response.

An Impact on Management Performance by Risk Management System and Risk Management Factor (리스크관리 체계 및 리스크관리 요인이 경영성과에 미치는 영향)

  • Jeung, Jae Hee;Ahn, Yeon S.
    • Journal of Information Technology Services
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    • v.14 no.3
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    • pp.117-129
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    • 2015
  • For the continuous growth of firms, the contributions of effective risk management system are required. This research analyzes the impact on the firm's performance related to risk management structure which includes the risk management system, risk management activity and risk management competency. In this research, the structural equation model considering the variable which contains enterprise risk management system, risk management activity and risk management competency was suggested. Also risk management organization and management procedures are identified as in enterprise risk management system. The implementation activity and control activity were the factors related in risk management activity. And risk management competency can be described as the response level of managing risk in outside and inside the firms' environment. Finally this model was analysed empirically for 112 firms in Korea using SPSS 18.0 and Amos 16.0. As the results, the suggested hypothesis were adopted. So as to manage risk performance for their firms, the development of systematic Risk Management Framework is important for their risk management activity and risk management competency. Ultimately, we can conclude that the focusing to the systematic risk management approach could be effective on the firm's risk management performance.

A Methodology for Driving Risk Evaluation Based on Driving Speed Choice (Focusing on Impacts of Providing In-vehicle Traffic Warning Information) (주행속도선택 기반 주행위험도 평가방법론 개발 (차내 교통안전정보 제공 효과 평가를 중심으로))

  • Kim, Won-Cheol
    • Journal of Korean Society of Transportation
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    • v.29 no.1
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    • pp.95-102
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    • 2011
  • This paper presents a Driving Risk Model (DRM) based on driving speed choices using an Ordered Response Probit (ORP) model. The DRM is conceptualized based on the relation between speed deviation and the occurrence of crashes found by Solomon. The impacts of various driving risk factors are revealed by applying the DRM to evaluate the effectiveness of In-Vehicle Traffic Warning Information (IVTWI) in expressway driving. Regarding driving risk, the results show that: (1) the risk is lower among male drivers, those with more driving experience and those with less accident history, (2) the risk is higher when driving takes place on wet road surface, in the afternoon, and under conditions of low traffic volume, and (3) the risk is also higher on both downgraded and long curve sections. Additionally, the results provide evidence that provision of IVTWI can decrease the driving risk. The proposed DRM provides a solution for assessing the traffic safety impacts of countermeasures on roadways when there is a shortage of traffic accidents data.

Analysis and Quantitative Estimation of Risk Factors of Design-Build (턴키 프로젝트에서 리스크요인 분석 및 정량적 평가)

  • Oh, Guk-Yeol;Lee, Young-Dai
    • Korean Journal of Construction Engineering and Management
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    • v.13 no.5
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    • pp.12-24
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    • 2012
  • The Risks in undertaking a construction project comes from many sources and often involves many participants in the project. This study has identified various kinds of risks, assessed the risk factors quantitatively and suggested risk management method for response pertinent in Design Build(Turn Key)type of projects in Korean context. A questionnaire was designed comprising of 145 possible risks in all types of construction projects. The population from owner, consultant and contractor groups was asked to indicate the risks applicable in DB projects. 25 numbers of critical risks in DB projects were identified and further analyzed for reveling inherent relationship between them through factor analysis. Factor analysis revealed 8 risk factors in DB projects. Construction site related, contract related and design related risk factor consisted about 72% of total risk weight. It has been found out about 6%, while considering the mutual dependency, it is about 10% of total cost of DB project. Therefore, It is suggested that 6% to 10% of construction amount as contingency has to be made provision for risk responses in the DB projects.

A Development of the Risk Identification Checklist through the Re-establishment of Risk Breakdown Structure of Construction Project (건설사업 위험분류체계의 재정립을 통한 위험인지 체크리스트 개발)

  • Chu Hae-Keum;Kim Seon-Gyoo
    • Korean Journal of Construction Engineering and Management
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    • v.4 no.2 s.14
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    • pp.109-117
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    • 2003
  • The construction project is largely exposed to much more risk events over the project life cycle due to its complexity and size than the other industries. Therefore, the construction risk management process to identify and response the risk events is not only performing acutely but also proceeding systematically. The risk identification phase in the risk management process is to identify various risk events and define its characteristics. At this phase, the risk identification system is very useful tool to identify every possible risk events in the project. This study shows some problems of the existing risk identification system and proposes the modified risk identification system based on the project phases and the contract bodies, and also suggests partial but more enough detailed risk checklists to be implemented in the actual risk identification phase than any other existing risk breakdown systems to be examined at this study.

The Effect of Correction of Unaudited Financial Statements on Audit Hours (감사전 재무제표의 수정이 감사시간에 미치는 영향)

  • Park, Hong-Kyu;Park, Kyungho;Lee, Yu-sun
    • Journal of Convergence for Information Technology
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    • v.12 no.4
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    • pp.111-118
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    • 2022
  • This study is an analysis of auditor's response to audit risk. Specifically, audit risk is measured by the amount of correction of the current financial statements, and auditor's response is measured by the rate of change of audit hour in next auditing. The amount of correction can be viewed as audit risk recognized by auditor because the degree of auditor's correction will increase as the company's financial statement preparation ability is lower or the profit management amount is larger. Auditor's response is measured as the rate of change of audit hour because audit risk would be incorporated in audit plan. Although auditing is performed by a team, auditor's response would differ depending on their roles. It is expected the leaders who establish the audit plan and manage the audit quality would respond more sensitively to audit risk than the other auditors. The results show that when the amount of correction is greater than a certain level, auditors recognize it as audit risk and increase total(and leaders') audit hour in next year audit.

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

  • Zhang, Zeng-Li;Sun, Jing;Dong, Jia-Yi;Tian, Hai-Lin;Xue, Lian;Qin, Li-Qiang;Tong, Jian
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2459-2465
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    • 2012
  • Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published case-control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/$m^3$ increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer. Conclusions: This meta-analysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.