• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.34-45
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• 2006

Chemical toxicants are metabolically converted to numerous metabolites in the body. Toxicokinetic characteristics of metabolites could be therefore used as biomarker of exposure for human risk assessment. Biologically based dose response (BBDR) model was proposed for future direction of risk assessment. However, this area has not been developed well enough for human application. Benzo(a)pyrene (BP), for example, is a well-known environmental carcinogen and may produce more than 100 metabolites and BPDE-DNA adduct, a covalently bound form of DNA with benzo(a)pyrene diolepoxides (BPDES), has been applied to qualitatively or quantitaively estimate human exposure to BP. In addition, di(2-ethylhexyl) phthalate (DEHP), a widely used plasticize. in the polymer industry, is one of endocrine-disrupting chemicals (EDCs) and has been monitored in humans using urinary or serum concentrations of DEHP or its monomer MEHP for exposure and risk assessment. However, it is difficult to estimate the actual level of toxicants using these biomarkers in humans using. This presentation will discuss a methodology of exposure and risk assessment by application of metabolic profiling kinetics.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.103-110
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• 2022

In the era of the 4th Industrial Revolution, smart technology being considered to improve productivity breakthroughs is in the spotlight as a means to replace traditional construction technology in the construction industry. However, various problems are occurring in construction sites using smart technology and causing negative impacts on construction projects. Therefore, the objective of this study is to identify risk factors that occur when smart technologies are used in construction projects. To achieve this purpose, this study investigated the difficulties at construction projects using smart technology, and risk factors were derived based on site surveys and literature. The risk factors were measured by experts, and then a total of 19 risk factors was derived by exploratory factor analysis. As a result, risks were classified as 5 factors, the institutional factor is the most difficult response, and the government needs anticipative system improvement and a long-term plan. The research findings provide practical implications for construction experts trying to apply smart technology in construction sites and construction policy-makers to revitalize smart technology.

• Toxicological Research
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• v.6 no.2
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• pp.205-213
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• 1990

The regulation of neurotoxicants has usually been based upon setting reference doses by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that theoretically account for interspecies and intraspecies extraploation of experimental results in animals to humans. Recently, we have proposed a four-step alternative procedure which provides quantitative estimates of risk as a function of dose. The first step is to establish a mathematical relationship between a biological effect or biomarker and the dose of chemical administered. The second step is to determine the distribution (variability) of individual measurements of biological effects or their biomarkers about the dose response curve. The third step is to define an adverse or abnormal level of a biological effect or biomarker in an untreated population. The fourth and final step is to combine the information from the first three steps to estimate the risk (proportion of individuals exceeding on adverse or abnormal level of a biological effect or biomarker) as a function of dose. The primary purpose of this report is to enhance the certainty of the first step of this procedure by improving our understanding of the relationship between a biomarker and dose of administered chemical. Several factors which need to be considered include: 1) the pharmacokinetics of the parent chemical, 2) the target tissue concentrations of the parent chemical or its bioactivated proximate toxicant, 3) the uptake kinetics of the parent chemical or metabolite into the target cell(s) and/or membrane interactions, and 4) the interaction of the chemical or metabolite with presumed receptor site(s). Because these theoretical factors each contain a saturable step due to definitive amounts of required enzyme, reuptake or receptor site(s), a nonlinear, saturable dose-response curve would be predicted. In order to exemplify this process, effects of the neurotoxicant, methlenedioxymethamphetamine (MDMA), were reviewed and analyzed. Our results and those of others indicate that: 1) peak concentrations of MDMA and metabolites are ochieved in rat brain by 30 min and are negligible by 24 hr, 2) a metabolite of MDMA is probably responsible for its neurotoxic effects, and 3) pretreatment with monoamine uptake blockers prevents MDMA neurotoxicity. When data generated from rats administerde MDMA were plotted as bilolgical effect (decreases in hippocampal serotonin concentrations) versus dose, a saturation curve best described the observed relationship. These results support the hypothesis that at least one saturable step is involved in MDMA neurotoxicity. We conclude that the mathematical relationship between biological effect and dose of MDMA, the first step of our quantitative neurotoxicity risk assessment procedure, should reflect this biological model information generated from the whole of the dose-response curve.

• Journal of Internet Computing and Services
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• v.16 no.6
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• pp.57-67
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• 2015

This paper proposes an Fuzzy-based Risk Reasoning Driving Strategy on VANET. Its first reasoning phase consists of a WC_risk reasoning that reasons the risk by using limited road factors such as current weather, density, accident, and construction, a DR_risk reasoning that reasons the risk by combining the driving resistance with the weight value suitable for the environment of highways and national roads, a DS_risk reasoning that judges the collision risk by using the travel direction, speed. and distance of vehicles and pedestrians, and a Total_risk reasoning that computes a final risk by using the three above-mentioned reasoning. Its second speed reduction proposal phase decides the reduction ratio according to the result of Total_risk and the reduction ratio by comparing the regulation speed of road to current vehicle's speed. Its third risk notification phase works in case current driving speed exceeds regulation speed or in case the Total_risk is higher than AV(Average Value). The Risk Notification Phase informs rear vehicles or pedestrians around of a risk according to drivers's response. If drivers use a brake according to the proposed speed reduction, the precedent vehicles transfers Risk Notification Messages to rear vehicles. If they don't use a brake, a current driving vehicle transfers a Risk Message to pedestrians. Therefore, this paper not only prevents collision accident beforehand by reasoning the risk happening to pedestrians and vehicles but also decreases the loss of various resources by reducing traffic jam.

• Journal of Korea Water Resources Association
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• v.56 no.8
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• pp.485-496
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• 2023

Recently, South Korea has been making efforts to mitigate the risk of water scarcity during droughts by utilizing various drought response measures in dam operations. While various studies have been conducted on this topic, there is currently a lack of research on the economic effects of drought response measures. In this study, we evaluated the economic effects of drought response measures on nationwide multipurpose dams by using a long-term simulated inflow model based on ARIMA and Copula and a dam operation model that reflects drought response measures. The results showed that the expected benefits per unit flow rate were highest for coordinated operation and alternative water supply measures, at KRW 1,176 and KRW 1,139, respectively, while the benefits of emergency water supply utilization and water supply adjustment were estimated at KRW 956 and KRW 875, respectively. Additionally, when we examined the changes in the economic benefits of drought response measures based on the assumption of increased drought severity in the future, the changes in the drought risk resulting from reduced inflow increased the economic benefits of all drought response measures. The economic benefits of water supply adjustment increased by 2.6% compared to the baseline, while the economic benefits of coordinated operation and alternative water supply measures increased by 11.7% compared to the baseline. This suggests that dam-network-based measures, such as coordinated operation and alternative water supply measures, are crucial as drought risk increases. This study is expected to serve as a fundamental reference for selecting and utilizing drought response measures in the future.

• Magazine of the Korea Concrete Institute
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• v.6 no.5
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• pp.183-192
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• 1994

Seismic safety of RC structure can be evaluated by numerical analysis considering randomness of earthquake motion and hysteretic behavior of reinforced concrete, which is more rational than determirustic analysis. In the safety assessment of aseismatic structures by the deterministic theory, it is not easy to consider th effects of random variables but the reliability theory and random vibration theory are useful to assess seismic safety with considering random effects. This study aims at the evaluation of sesmic damage and risk of the RC frame structure by stochastic response analysis of hysteretic system and then the calculation stages of the prob ability of failure are presented.

• The Korean Journal of Nuclear Medicine
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• v.26 no.1
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• pp.8-13
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• 1992

Low doses of ionizing radiation from external or internal sources cause heterogeneous distribution of energy deposition events in the exposed biological system. With the cell being the individual element of the tissue system, the fraction of cells hit, the dose received by the hit, and the biological response of the cell to the dose received eventually determine the effect in tissue. The hit cell may experience detriment, such as change in its DNA leading to a malignant transformation, or it may derive benefit in terms of an adaptive response such as a temporary improvement of DNA repair or temporary prevention of effects from intracellular radicals through enhanced radical detoxification. These responses are protective also to toxic substances that are generated during normal metabolism. Within a multicellular system, the probability of detriment must be weighed against the probability of benefit through adaptive responses with protection against various toxic agents including those produced by normal metabolism. Because irradiation can principally induce both, detriment and adaptive responses, one type of affected cells may not be simply summed up at the expense of cells with other types of effects, in assessing risk to tissue. An inventory of various types of effects in the blood forming system of mammals, even with large ranges of uncertainty, uncovers the possibility of benefit to the system from exposure to low doses of low LET radiation. This experimental approach may complement epidemiological data on individuals exposed to low doses of ionizing radiation and may lead to a more rational appraisal of risk.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.33 no.12
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• pp.3-10
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• 2017

Climate change not only has various impacts such as human shoes, economics, the environment, industry, etc. but the damage caused by this is also increasing, it is expected that severe damage will not occur without efforts to respond to climate change ing. Therefore, as the impact of climate change like the extreme weather phenomenon is dailyized and its strength tends to become stronger, as much as the mitigation measures of climate change, as a comparative effort to reduce the negative impact of climate change, adaptation to climate change is necessary. Especially when the damage caused by climate change (intense heat, torrential rain, cold wave and heavy snow etc.) as an institution responsible for the provision of public services such as public institutions, the socio-economic spread to the nation and the people The effect is very large. We confirmed the level of response to climate change for the entire public institution, and selected climate change risk which is relatively important for specific facilities and business establishments of public institutions, climate change adaptation measures We will try to utilize it as basic material of establishment.

• Geomechanics and Engineering
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• v.24 no.3
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• pp.281-293
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• 2021

Uncertainties in geomechanical input parameters which mainly related to inappropriate data acquisition and estimation due to lack of sufficient calibration information, have led wellbore instability not yet to be fully understood or addressed. This paper demonstrates a workflow of employing Quantitative Risk Assessment technique, considering these uncertainties in terms of rock properties, pore pressure and in-situ stresses to makes it possible to survey not just the likelihood of accomplishing a desired level of wellbore stability at a specific mud pressure, but also the influence of the uncertainty in each input parameter on the wellbore stability. This probabilistic methodology in conjunction with Monte Carlo numerical modeling techniques was applied to a case study of a well. The response surfaces analysis provides a measure of the effects of uncertainties in each input parameter on the predicted mud pressure from three widely used failure criteria, thereby provides a key measurement for data acquisition in the future wells to reduce the uncertainty. The results pointed out that the mud pressure is tremendously sensitive to UCS and SHmax which emphasize the significance of reliable determinations of these two parameters for safe drilling. On the other hand, the predicted safe mud window from Mogi-Coulomb is the widest while the Hoek-Brown is the narrowest and comparing the anticipated collapse failures from the failure criteria and breakouts observations from caliper data, indicates that Hoek-Brown overestimate the minimum mud weight to avoid breakouts while Mogi-Coulomb criterion give better forecast according to real observations.

• East Asian Journal of Business Economics (EAJBE)
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• v.12 no.1
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• pp.23-33
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• 2024

Purpose: This paper explores the nuanced approaches undertaken by private companies in formulating and implementing business continuity plans (BCPs) in response to the unprecedented challenges posed by the global COVID-19 pandemic. Research design, data, and methodology: Utilizing a mixed-methods research design, the study delves into the multifaceted strategies employed by private sector entities, ranging from risk assessment and remote work policies to supply chain diversification and employee well-being initiatives. Result: The findings contribute to a deeper understanding of the evolving landscape of business continuity planning during a pandemic, offering valuable insights for academia, industry practitioners, and policymakers. The research findings present a detailed account of how private companies have tailored their business continuity plans in response to the unique challenges posed by the pandemic. Conclusion: This academic exploration sheds light on the dynamic landscape of business continuity planning in private companies responding to the global pandemic. Insights into the effectiveness of remote work policies, supply chain diversification, employee safety measures, and financial strategies contribute to the understanding of best practices and areas requiring further attention. These recommendations aim to inform future business continuity planning efforts, enhance organizational resilience, and mitigate the impact of global health crises on private sector operations.