• Environmental Mutagens and Carcinogens
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• v.26 no.3
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• pp.77-85
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• 2006

2,3,7,8-Tetrachlorodibenzo-$\rho$-dioxin(TCDD) displays high toxicity in animals and has been implicated in human carcinogenesis. Although TCDD is recognized as potent carcinogens, relatively little is known about their role in the tumor promotion and carcinogenesis. It is known that TCDD can increase of cancer risk from various types of tissue by a mechanism possibly involving the aryl hydrocarbon receptor (AhR) activation. In this study, effects of TCDD on cellular proliferation of normal human skin and lung fibroblasts, Detroit551 and WI38 cells were investigated. In addition, to enhance our understanding of TCDD-mediated carcinogenesis, we have investigated process in which expression of Erk1/2, cyclinD1, oncogene such as Ha-ras and c-myc, and their cognate signaling pathway. TCDD that are potent activators of AhR-mediated activity was found to induce significant increase of cytochrome P4501A1 mRNA expression, suggesting a presence of functional AhR. These results support that CYP1A1 enzyme may be involved in the generation of TCDD-induced toxicity. Moreover mitogen-activated protein kinases (MARKs) phosphorylation and cyclin D1 overexpression are induced by TCDD, which corresponded with the progression of cellular proliferation. However, TCDD did not affected Ha-ras and c-myc mRNA expression. Taken together, it seems that TCDD are could be a part of cellular proliferation in non-tumorigenic normal human cells such as Detroit551 and WI38 cells through the upregulation of MAPKs signaling pathway regulating growth of cell population. Therefore, AhR-activating TCDD could potentially contribute to tumor promotion and Detroit551 and WI38 cells have been used as a detection system of tumorigenic effects of TCDD.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.4
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• pp.743-755
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• 2013

In recent years, the malicious apps with malicious code in normal apps are increasingly redistributed in Android market, which may incur various problems such as the leakage of authentication information and transaction information and fraudulent transactions when banking apps to process the financial transactions are exposed to such attacks. Thus the financial authorities established the laws and regulations as an countermeasures against those problems and domestic banks provide the integrity verification functions in their banking apps, yet its reliability has not been verified because the studies of the safety of the corresponding functions have seldom been conducted. Thus this study suggests the vulnerabilities of the integrity verification functions of banking apps by using Android reverse engineering analysis techniques. In case the suggested vulnerabilities are exploited, the integrity verification functions of banking apps are likely to be bypassed, which will facilitate malicious code inserting attacks through repackaging and its risk is very high as proved in a test of this study. Furthermore this study suggests the specific solutions to those vulnerabilities, which will contribute to improving the security level of smartphone financial transaction environment against the application forgery attacks.

• Journal of Korean Society of Rural Planning
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• v.22 no.4
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• pp.131-138
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• 2016

Recently, the cultivated area is reduced, the ratio of upland-field in the total cultivated area is increasing relative appeared in 36.2% in 1990 from 43.7% in 2013. If upland-field can be applied well designed-infrastructure, good income crop production is possible, however, maintenance of infrastructure and a significant portion of the upland-field is maintained under insufficient infrastructure. While imports of agricultural products expanded since the 2000s in progress, looking at the self-sufficiency of upland-field crops, it is reduced to from 90% to 42% for the pepper, it is from 90% to 74% for the garlic, cereals is reduced from 42% by 26%. As a result of these conditions, the competitiveness of farmers has weakened, the risk to meet the challenges of this area of production and supply reduction increased. This study was the first to conduct a basic evaluation index, data analysis and evaluation of indicators to diagnose the agricultural production capacity of the upland field. 12 kinds classified index of producing conditions from the natural environment and eight factors for the cultivation and production capabilities have developed for the assessment of productivity of upland-field (especially Kimchi cabbage). Through this regional imbalance was found, based on the production capabilities conditions are good in Haenam, Gangneung, Pyeongchang. 3 Regions have been low and the lowest Youngwol to 0.8992. Climate(Cultivation conditions) indicators of Mungyeong region is the highest, relatively low areas were in Taebaek. In particular, it is determined to be preferred that the area required for the enhancing the production environment based on providing the convenience for the producing and maintenance of the first production area. It is necessary Increasing part of mechanization, agro-industrial competitiveness through aggressive management plans for facilities as required in the process of post-harvest storage, processing, distribution line can be improved.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.863-871
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• 2007

Objects : To gain better insights of East-west integrated treatment of ischemic stroke. We analyzed 89 patients with severe acute ischemic stroke who were admitted to the East-west integrated intensive care unit. Methods : Subjects enrollment was from the East-west integrated intensive care unit of Kyung Hee Medical Center from March 2006 to February 2007. Patients were admitted within 14 days after the onset of ischemic stroke. We assessed the subjects' general characteristics, risk factors, admitting routes and periods, diagnostic imaging, process of western treatment and Korean traditional treatment, complication and consequence. Results : The proportion of males was 50.6%, of females 49.4%, average age was male 66.0$\pm$10.3 and female 71.1$\pm$10.5. Average length of hospital stays was 19.5 days. Monthly admissions were highest in November and December. The admission route was through emergency room (61.8%) or ward (34.8%). Mean Glasgow coma scale score was 10.0$\pm$2.5, average time from symptom of onset to hospital admission was 2.3$\pm$2.2 days. Dominant ischemic vascular territory was middle cerebral artery (66.3%). Initial western treatment was argatroban (22.5%), urokinase (28.1%), and heparinization (38.2%). Distribution of Sasang constitution of So-yang to Tae-eum to So-eum was equal to 5.4 to 2.9 to 1.5. Major complications were observed in 40 (42.7%) patients. In hospital mortality was 12.4% (11 deaths), all of them caused by aggravation of neurological deficit and only 3 of them with major complications. There appears to be a significant positive relationship between length of hospital stay and occurrence of complications (P<0.05). After discharge from the ICU, 64 (71.9%) patients were improved, 11 (12.4%) patients had expired, and 14 (15.8%) patients were transferred. Conclusions : From this study, we suggest that patients with severe acute ischemic stroke should be treated with East-west integrated therapy for more favorable consequences and decreased mortality.

• Journal of Korean society of Dental Hygiene
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• v.3 no.1
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• pp.73-87
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• 2003

This study was performed on 17 female dental hygienists to find an appropriate method to reduce the hygienists' body discomfort while scaling, and provide a foundation to educate them how 10 posture during the process. To assess the arm abduction, elbow flexion, neck flexion, trunk flexion and trunk lateral bending through Video 2D(two dimensional motion) analysis and assessing the risk through the Action level of RULA(rapid upper limb assessment) checklist, an ergonomic analysis method. Correlation analyses on the posture angles and on body discomfort were performed. ANOVA analysis on scaling treatment position and the scaling treatment region of patients was also performed. The results are as following. 1. 20 analysis while scaling, arm abduction was $40{\sim}79.9^{\circ}$, elbow flexion $20{\sim}110^{\circ}$, neck flexion $50{\sim}100^{\circ}$, trunk flexion $60{\sim}80^{\circ}$, and trunk lateral bending $5{\sim}19.9^{\circ}$. 2. The Action level of RULA was 2. 3 resulted from scores 4 and 5 of group A which includes upper arm, lower ann, wrist, and scores 2 and 4 of group B which includes neck, trunk, legs. It means that the scaling treatment posture causes a high incidence rate of musculoskeletal that an additional investigation and improvement should be followed without hesitation. 3. There were significant differences among the maxilla right, maxilla anterior, maxilla left, mandible left, mandible anterior, and mandible right of a patient of the right and left upper arm, lower arm, neck, trunk, group A, group B, final RULA score while scaling treatment. 4. There were significant differences among the time position of 8, 9, 10, 11, 12, 13 of the right and left upper arm, lower arm, neck, trunk, group A, group B, final RULA score while scaling treatment, 5. As for the body discomfort, neck, right shoulder, left shoulder, right back, right wrist etc. were listed on top. As a conclusion, performing the time position of 12 which shows low right and left final RULA scores is better than the time position of 8 and 10 which show high final RULA scores to reduce the body discomfort while scaling treatment.

• Journal of Astronomy and Space Sciences
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• v.21 no.4
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• pp.329-342
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• 2004

In this paper, we present preliminary feasibility studies on three types of solar observation payloads for future Korean Science and Technology Satellite (STSAT) programs. The three candidates are (1) an UV imaging telescope, (2) an UV spectrograph, and (3) an X-ray spectrometer. In the case of UV imaging telescope, the most important constraint seems to be the control stability of a satellite in order to obtain a reasonably good spatial resolution. Considering that the current pointing stability estimated from the data of the Far ultraviolet Imaging Spectrograph (FIMS) onboard the Korean STSAT-1, is around 1 arc minutes/sec, we think that it is hard to obtain a spatial resolution sufficient for scientific research by such an UV Imaging Telescope. For solar imaging missions, we realize that an image stabilization system, which is composed of a small guide telescope with limb sensor and a servo controller of secondary mirror, is quite essential for a very good pointing stability of about 0.1 arcsec. An UV spectrograph covering the solar full disk seems to be a good choice in that there is no risk due to poor pointing stability as well as that it can provide us with valuable UV spectral irradiance data valuable for studying their effects on the Earth's atmosphere and satellites. The heritage of the FIMS can be a great advantage of developing the UV spectrograph. Its main disadvantage is that two major missions are in operation or scheduled. Our preliminary investigations show that an X-ray spectrometer for the full disk Sun seems to be the best choice among the three candidates. The reasons are : (1) high temporal and spectral X-ray data are very essential for studying the acceleration process of energetic particles associated with solar flares, (2) we have a good heritage of X-ray detectors including a rocket-borne X-ray detector, (3) in the case of developing countries such as India and Czech, solar X-ray spectrometers were selected as their early stage satellite missions due to their poor pointing stabilities, and (4) there is no planned major mission after currently operating Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI) mission. Finally, we present a preliminary design of a solar X-ray spectrometer covering soft X-ray (2 keV) to gamma ray (10 MeV).

• Horticultural Science & Technology
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• v.32 no.2
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• pp.184-192
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• 2014

Various types of unit packaging methods were applied for 'Fuji' apples during short-term cold storage and export simulation. Gas tightness of the package was controlled stepwise in the successive two-year experiments using different perforation treatments (none, punch hole, or pinhole) and sealing methods (tie v s. heat seal). Risk of tight packaging and effectiveness of macroperforation on weight loss and quality maintenance were analyzed as related to changes in gas concentration inside the packages. Immediately after harvest, each 5 apple units were packaged in $40{\mu}m$ polypropylene (PP) film bags, stored 4 weeks at $0^{\circ}C$, and then put on the shelf for one week at ambient temperature in the preliminary experiment, In the main experiment, export process was imposed after storage simulating 2 week refrigerated container shipment at $0^{\circ}C$ plus one week local marketing at ambient temperature. Non-perforated film packaging with relatively high gas tightness induced flesh browning caused by carbon dioxide accumulation regardless of the sealing methods. Among perforated film packaging, in contrast, atmospheric modification was partly established only in the pinhole treatment and flesh browning symptom was not observed in all the treatments. Even the punch hole perforated film packaging without gas tightness effectively reduced the weight loss, whereas had slight benefits for quality maintenance. Reduced perforation using pinhole treatment seemed to improve sensory texture, while effects on physicochemical quality were insignificant. Overall results suggest the need of more minute perforation treatments on the packaging film to ensure modified atmosphere effects on quality maintenance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.145-154
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• 2017

Technology innovation is regarded as the quintessential process to acquire a competitive advantage. This is especially true in high-tech industries, and firms that recognize the importance of technological innovation concentrate their capacities on developing new technologies, new products, and new processes. In general, such research requires many resources, but not all technological breakthroughs are followed by positive feedbacks. Consequently, the firms in high-tech industries are compelled to find new directions in acquiring technologies. This study examines the factors that influence technological innovation and empirically tests the effect these factors have on its diffusion. Radicality, discontinuity, and exploitation/exploration were selected as the factors from the previous literature on technological innovation and organizational learning. For the empirical test, patent data from the US semiconductor industry were used to describe innovation activities from various fields. From the result, these three factors (Ed- is this what you mean, i.e., radicality, discontinuity, and exploitation/exploration?)were found to have significant meaning as proxies for the diffusion of technological innovation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.16-22
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• 2017

This study examined the status of resident evacuation sites notified to nearby communities, centered on business sites subject to the risk management plan of Incheon, Siheung, and Ansan. Through an analysis of the meteorological data, the direction of improvement of the site selection process for the safe evacuation of chemical accidents was studied. Among a total of 111 evacuation sites, 30 schools were selected the most, and 2-3 sites were usually selected for evacuation. As a result of an analysis of the Incheon meteorological data of 2016, the frequency of occurrences was 18.8525% in the NNE wind direction, 18.0328% in the NNW wind direction, 12.2951% in the WSW wind direction, 9.0164% in the SSE direction, 8.4700% in the SW direction, 6.5574% in the W direction, and 5.7376% in the S direction. The NNE wind direction showed the highest frequency, but the other winds showed a relatively high frequency, indicating that the annual wind direction was not biased toward one side.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9631-9634
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• 2014

Background: : In 2012, the breast cancer estimate worldwide stood at 1.67 million new cases, these accounting for 25% of all types of cancer diagnosed in women. For 2014, 57,120 new cases are expected, with a risk estimated at 56.1 cases for every 100,000 women. The objective of this study was to analyze the satisfaction regarding the use of external breast prostheses by women undergoing mastectomy. Materials and Methods: This cross-sectional study was conducted with 76 women who used an external breast prosthesis (EBP), registered in the services of the Cuiaba Center for Comprehensive Rehabilitation, Mato Grosso, Brazil, from 2009 to 2012. Data were collected from the records of women who had requested the opening of a process of external breast prosthesis concession. Results: Satisfaction with the EBP was identified in 56.6% of the women. Those satisfied with the EBP reported that its weight was not annoying (p<0.01). Although the women felt body sensations of stitches, pains, pulling, dormancy and phantom limb, they are satisfied with the EBP. The variable related to the displacement of the breast prosthesis during activity of everyday life has demonstrated that even though the women have reported the possibility of displacements, they are satisfied with the EBP. The satisfaction with the use of external breast prosthesis did not affect the sexuality of the women with mastectomy. Conclusions: Learning the specificities of the EBP, taking into consideration the satisfaction of its use, allows the rehabilitation team, by listening to their clientele more attentively, following up this woman throughout her life journey, supporting and guiding the best way of use, with an eye to her personal, emotional and social life, as well as to her self-esteem.