• Clinical and Experimental Pediatrics
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• 제48권11호
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• pp.1239-1243
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• 2005

목 적 : 체내에 축적된 철은 간에서 인슐린제거를 늦게 해 고인슐린혈증을 유발하며, 인슐린 작용을 저해시키고 이로 인해 당신생이 증가해 이차적으로 당뇨병을 유발할 수 있는 것으로 알려져 있다. 따라서 체내의 저장 철을 알 수 있는 가장 좋은 지표인 ferritin을 측정해 2형 당뇨병 발생과의 연관성을 조사하기 위한 연구를 시행하였다. 방 법 : 연세의료원에서 진료받고 있는 1형 당뇨 환자군 36명, 2형 당뇨 환자군 8명, 내당능 장애군 18명을 대상으로 하였으며, 2004년 학교 신체 검사에서 정상 대조군 29명을 선정하여, ferritin과 기타 혈청학적 및 임상적 검사를 실시하였다. 결 과 : 1) 정상대조군, 내당능 장애군, 2형 당뇨 환자군에서 평균 Log ferritin은 각각 $1.33{\pm}0.32$, $1.63{\pm}0.19$, $1.90{\pm}0.30$였으며 정상 대조군에 비해 내당능 장애군(P<0.01)과 2형 당뇨 환자군(P<0.01)에서 유의하게 증가되어 있었다. 2) Log ferritin과 각 변수인자와의 상관관계는 체질량 지수(P<0.01), 수축기 혈압(P<0.01), 공복시 혈당(P<0.01), 공복시 인슐린(P<0.01)과 유의한 관계를 보였다. 결 론 : 정상 대조군에 비해 내당능 장애군과 2형 당뇨 환자군에서 ferritin이 의미 있게 높았으며 ferritin의 증가는 인슐린 저항성과 2형 당뇨병 발생의 유발인자로서의 가능성을 시사한다.

• 대한약침학회지
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• 제16권3호
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• pp.23-29
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• 2013

Objectives: Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the $15^{th}$ day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated. Results: The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P < 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P < 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner. Conclusion: The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.

• Journal of Nutrition and Health
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• 제39권7호
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• pp.684-691
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• 2006

Abdominal obesity (AO) is a strong risk factor for type 2 diabetes and cardiovascular disease, which has shown a remarkable increase in Korea. This study aimed to identify prevalence of AO and related risk factors in Korean adults. A total of 5,132 men and women aged 20-85 years old from the 2001 Korean National Health and Nutrition Examination Survey were included in the analyses. AO was defined as waist circumference >=90 cm in men and >=85 cm in women as proposed by Korean Society of Obesity. Multiple logistic regression was carried out to identify risk factors for AO. Three models were specified: (i) demographic and socioeconomic factors (model 1: age, education, poverty income ratio, employment), (ii) lifestyle factors and covariates (model 2: physical activity, cigarette smoking, alcohol consumption, dietary quality, type 2 diabetes, co-morbidity) and (iii) demographic, socioeconomic and lifestyle factors (model 3). The prevalence of AO was 24.1 % in men, 23.5% in women. High poverty income ratio in men and low education attainment in women were risk factors for AO in model. 1. There was a significant association of AO with alcohol consumption, physical inactivity and dietary quality in men, alcohol consumption and cigarette smoking in women. These factors except alcohol consumption in men became insignificant in model 3. This findings underscore the importance of developing AO prevention programs in Korea that target the at risk groups identified in this study. A program focusing on low income men or less educated women would be more efficient.

• Journal of Nutrition and Health
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• 제40권6호
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• pp.509-516
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• 2007

The purpose of this study was to investigate the impact DM duration on cardiovascular disease risk factors in Korean Type 2 diabetes mellitus patients. The subject were 250 (male: 134, female: 118) Korean Type 2 DM patients recruited from a general hospital's DM clinic. Anthropometric and hematological variables and dietary intake were assessed. The subject's mean age was 60.2 years and duration of diabetes was 9.5 years. As far as DM duration was concerned, male subjects with long duration (${\geq}$ 5 years and longer) showed significantly lower weight, fat free mass, skeletal muscle mass, BMI (p < 0.05) and higher 2hrs-postprandial plasma glucose (p < 0.05) and concentration of Hemoglobin A1c (p < 0.01) compared to those with less 5years of duration. In female subjects, same trend was found. Female subjects with long duration (${\geq}$ 5 years and longer) showed significantly higher fat free mass (p < 0.05) and skeletal muscle mass (p < 0.05), Hemoglobin A1c (p < 0.01), HDL-cholesterol (p < 0.01) and triglyceride (p < 0.05), dietary intakes of protein (p < 0.05) and fat (p < 0.05) compared to those with less 5years of duration. In conclusion, Type II DM patients of long duration had higher blood lipid concentrations and higher carbohydrates intakes. Subjects followed diet prescription strictly showed lower blood lipid concentration, suggesting the effectiveness of diet to manage Type 2 DM patients.

• 보건행정학회지
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• 제32권1호
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• pp.45-52
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• 2022

Background: There are regional variations in the incidence of coronavirus disease 2019 (COVID-19), which means that some regions are more exposed to the risk of COVID-19 than others. Therefore, this study aims to investigate regional variations in the incidence of COVID-19 in Korea and identify risk factors associated with the incidence of COVID-19 using community-level data. Methods: This study was conducted at the districts (si·gun·gu) level in Korea. Data of COVID-19 incidence by districts were collected from the official website of each province. Data was also obtained from the Korean Statistical Information Service and the Community Health Survey; socio-demographic factor, transmission pathway, healthcare resource, and factor in response to COVID-19. Community risk factors that drive the incidence of COVID-19 were selected using a least absolute shrinkage and selection operator regression. Results: As of June 2021, the incidence of COVID-19 differed by more than 80 times between districts. Among the candidate factors, sex ratio, population aged 20-29, local financial independence, population density, diabetes prevalence, and failure to comply with the quarantine rules were significantly associated with COVID-19 incidence. Conclusion: This study suggests setting COVID-19 quarantine policy and allocating resources, considering the community risk factors. Protecting vulnerable groups should be a high priority for these policies.

• 보건교육건강증진학회지
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• 제27권1호
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• pp.81-89
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• 2010

Objectives: To investigate the relationship between experience of hunger in childhood or adolescence and diabetes mellitus in old age. Methods: Stratified national samples of 421 men and 554 women aged 60-89 in South Korea were analyzed. Diabetes diagnosed by a doctor was used as the dependent variable. Experience of hunger in childhood was assessed with the question, "In your childhood, have you ever gone hungry with skipping a meal?" and "In your childhood, have you ever eaten porridge or some bran cake as main dish instead of rice because of lack of food?" Odds ratios (ORs) and 95% confidence interval (CI) were calculated by multiple logistic regressions. Results: ORs of diabetes by experience of hunger in childhood were 1.64(95% CI 0.95-2.83) for men and 1.58(95% CI 1.01-2.47) for women. Significant association of experience of hunger in childhood with prevalence of diabetes persisted in men after adjustment for adulthood and old age socioeconomic position indicators and other risk factors(OR 1.88(95% CI 1.04-3.41)). The effect of experience of hunger in 10-19 years was more prominent than that in less than 10 years in both gender. Conclusion: Experience of hunger in childhood or adolescence may increase the risk of diabetes in Korean elders.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2000년도 춘계학술대회
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• pp.3-5
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• 2000

Of 16 million diabetic patients in the USA, 2.4 millions have experienced diabetic foot ulcer and 67,000 have amputations every year. For treatment of diabetic foot ulcer, Americans spend more than $1 billion each year, including $36,000 per patient for complete treatment and $60,000 for each amputation. Neuropathy and ischemia, two common complications of diabetes mellitus, are the primary underlying risk factors for development of diabetic foot ulcers. Ischemic ulcers develop as a result of low perfusion pressure in the foot with inadequate blood supply, whereas neuropathic ulcers develop from loss of protective sensation. In addition, diabetes also increases the risk of infection by impairing the body's ability to eliminate bacteria. From these circumstances, results are chronic wounds with impaired healing ability.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.675-678
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• 2015

Background: There are several validated risk factors for breast cancer. However the legitimacy of elevated fasting blood glucose (FBG) is not well established. This study was designed to assess this parameter as a risk factor for breast cancer among pre- and post-menopausal women. Materials and Methods: This case-control study was conducted at Department of Biochemistry, University of Karachi from June 2010 to August 2014. Simple random sampling technique was used to collect data of study subjects comprising 175 diagnosed breast cancer patients with positive histopathology from Breast Clinic, surgical unit-1, Civil Hospital, Karachi and 175 healthy controls from various screening programs. Blood samples were analyzed for FBG and serum insulin. Results: FBG, HOMA-IR, systolic and diastolic blood pressure were significantly raised in breast cancer cases when compared to control subjects. Cases and controls were further categorized in to two groups using cutoff value of 110mg/dl to distinguish subjects into normal fasting glucose (<110mg/dl) and having impaired fasting glucose (${\geq}110-{\leq}125mg/dl$) or diabetes (${\geq}126mg/dl$). Odds ratios were found to be 1.57, 2.15 and 1.17 in overall, pre-menopausal and post-menopausal groups, respectively. (all p < 0.05). Conclusions: A statistically significant risk of breast cancer exists in women having elevated fasting blood glucose levels, corresponding to prediabetes and diabetes, among pre and postmenopausal ages, with comparatively greater effects in the premenopausal group.

• 한국산학기술학회논문지
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• 제21권6호
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• pp.592-602
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• 2020

본 연구는 한국인 심혈관질환 발생에 기여하는 위험인자들의 기여도를 평가해보고자 하였다. 연구대상은 2005년~2013년 국민건강영양조사 자료를 이용하였으며 30세~74세 대상자 중 심혈관질환 기왕력이 없고, 6개 위험인자 관련 응답이 모두 존재하는 20,012명을 연구대상으로 하였다. 자료 분석은 SAS 9.3으로 수행하였으며 가중치를 적용한 복합표본설계분석을 수행하였고 기여도는 준부분상관제곱분석(squared semi-partial correlation)을 적용하여 구하였다. 연구결과, 남성은 연령(63.9%), 흡연(17.3%), 수축기 혈압(7.9%), 당뇨병(6.9%), 고혈압 치료약물 복용(3.0%), 체질량지수(0.9%) 순이었으며, 반면 여성은 연령(54.1%), 수축기 혈압(23.5%), 당뇨병(13.6%), 고혈압 치료약물 복용(5.1%), 흡연(3.1%), 체질량지수(0.6%) 순이었다. 심혈관질환 발생 위험인자 중에서 연령이 남녀 모두에게 기여도가 가장 높았다. 연령대별 분석결과는 남성은 흡연(51.8~33.7%)이 전 연령대에서 가장 높은 위험인자였으며, 그 다음으로 30대는 연령(26.6%), 40대 이상은 수축기 혈압(17.3%~21.0%) 이었다. 여성은 수축기 혈압(56.2~40.5%)이 전 연령대에서 가장 높았으며 그 다음으로 30대는 연령(24.0%), 40대 이상은 당뇨병(13.6%~32.6%)이었다. 소득수준별로는 기여도에 큰 차이가 없었다. 본 연구결과 향후 심혈관질환 예방을 위해서는 어떤 위험인자를 중점 관리해야 하는지 확인할 수 있었다. 심혈관질환 발생 예방을 위해서는 위험인자의 기여도가 반영된 심혈관질환 예방·관리 프로그램이 개발되어야 하며, 본 연구결과에서 보여준 결과가 기초자료로 활용되기를 제안한다.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.14-26
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• 2001

Objective : Stroke is a serious disease despite of the recent improvement in medical treatment. Hence, identification of modifiable risk factors for stroke is important. This case-control study was done to demonstrate that relation between risk factors(familial history of stroke, hypertension, diabetes mellitus and heart disease), lifestyle factors(alcohol drinking, psychologic stress, exercise, liking salty and hot foods) and the incidence of stroke. Methods : We interviewed 214 stroke patients(116 in men, 98 in women) as case group and 205 non-stroke patients(118 in men, 87 in women) as control group from January 1, 2001 to July 31, 2001 in oriental hospital of Kyung Hee medical center. We investigated risk factors, lifestyle factors of stroke in all patients and stroke-subtype of case group. Stroke-subtype consists of cerebral infarction and cerebral hemorrhage. Results : The percentage of familial history in the case group was significantly higher than that of control group, especially in the patients of cerebral infarction. The most ordinary preceding disease was hypertension. And the preceding disease of hypertension, diabetes mellitus was associated positively with the risk of stroke. The percentage of exercise was significantly higher than that of control group. The percentage of alcohol drinking, psychologic stress within 1 week and liking salty and hot foods was higher in the case group. However, there was no significant difference between case and control group. Conclusion : According to the above results, we found that familial history of stroke, preceding disease(hypertension, diabetes mellitus) affected to the incidence of stroke and exercise might be predisposing risk factors for stroke.