• Journal of Practical Engineering Education
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• v.13 no.2
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• pp.327-332
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• 2021

Materials used for education include SM20C, Al6061, and acrylic. SM20C materials are used a lot in certification tests and functional competitions as carbon steel, but they are also used in industrial sites. Al6061 is said to be a material that produces a lot of tools because it has lower hardness than carbon steel and is highly flexible. When practical guidance is given to students using acrylic materials, it is a material that causes vibration and tool damage due to excessive cutting. In this process, we examine how impact on the 5-axis equipment 2NC head can affect precision control. The weakest part of a five-axis equipment is the head that controls the AC axis. In the event of precision and cumulative tolerances in this area, the precision of all products is reduced. Thus, a key part of the 2NC head, the spindle housing was carried out using Al7075 T6 (U.S. Alcoasa) material and the entire body using FCD450 (spherical graphite cast iron). In the vibration and cutting process acting on these two materials, the analysis was carried out to determine the value of applying the force as a finite element analysis under extreme conditions. We hope that using these analytical data will help students see and understand the structure of 5-axis machining rather than 5-axis cutting.

• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.833-845
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• 2021

Parkinson's syndrome is a degenerative brain disease that presents characteristic motor symptoms of tremor, rigidity, and gait disturbance. In addition to these motor symptoms, Parkinson's syndrome also presents non-motor symptoms (NMSs) such as sleep disturbance and cognitive decline. NMSs reduce patient's quality of life and psychosocial functioning and cause economic burden on the patient, so appropriate evaluation and treatment are required. Lewy body dementia is one of the several diseases belonging to Parkinson's syndrome. Its symptoms such as cognitive function, memory impairment, and hallucinations occur with Parkinsonism. Although drug therapy is being used with drug treatment to treat non-motor symptoms, it has limitations such as side effects, which stimulated interest in other complementary treatment methods such as oriental medicine treatment, dance, and yoga. The patient in this case complained of tremor in the right upper extremity, muscle hypertension and pain, and persistent vision, memory, and cognitive decline. The patient was diagnosed with probable Lewy body dementia. The patient was hospitalized for 4 months and received acupuncture and herbal medicines. After treatment, the patient's NMS scale scores decreased from 90 to 63, and the Unified Parkinson's Disease Rating Scale scores (summed I, II, and III) decreased from 17 points to 8 points. The Beck Depression Inventory score decreased from 22 points to 13 points. In addition, the patient's subjective evaluation revealed improvement. In this case, a patient diagnosed with probable Lewy body dementia who did not respond to the standard treatment and did not want to take medications showed improvement in not only motor symptoms but also NMSs after integrative Korean medicine treatment.

• Journal of Aerospace System Engineering
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• v.13 no.3
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• pp.23-31
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• 2019

The design requirements of modern satellites vary depending on the purpose of operation. Like conventional medium and large-scale satellites, small satellites which operate on low orbit may also serve military purposes. As a result, there is increased demand for high-resolution photos and videos and multi-target observation becomes important. The most important design parameter for multi-target observation is the satellites' maneuverability. For increased maneuverability, the miniaturization is required to increase the stiffness of the satellite as this decreases the mass moment of inertia of the satellite. In the case of a solar panel having relatively low stiffness compared to the satellites' body, vibrations are generated when the attitude maneuver is performed, which greatly influences the image acquisition. For verification of such vibrational characteristics, the satellites is modeled as a reduced model, and experimental zig for simulating attitude maneuver is introduced. A rigidity simulator for simulating the stiffness of the satellite is also proposed. Additionally, the objective of the experimental method is to simulate the maneuvering angle of the satellite based on the winding length of the wire using a step motor, and to experimentally verify the vibration characteristics of the satellite body and the solar panel generated during the maneuvering test.

• Journal of the Society of Disaster Information
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• v.15 no.3
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• pp.418-426
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• 2019

Purpose: After analyzing the seismic capability of low-rise RC grid structures with insufficient seismic performance, the purpose of the project is to install steel slab hysteretic dampers (SSHD) to improve the seismic performance of beams and columns, and to suggest measures to minimize damage to the structure and human damage when an earthquake occurs. Method: The evaluation of the seismic performance of a structure is reviewed based on the assumption that the seismic performance is identified for the grid-type subway systems that are not designed to be seismic resistant and the installation of an SSHD system, a method that minimizes construction period, if insufficient, is required. Result: After the application and reinforce of structure with SSHD, and the results of eigenvalue analysis are as follows. The natural periodicity of longitudinal direction was 0.55s and that of vertical direction was 0.58s. Conclusion: As results of cyclic load test of structure with SSHD, the shear rigidity of damper is 101%, the energy dissipation rate is 108% and, plastic rotation angle of all column and beam is satisfied for $I_o$ level and therefore it is judged that the reinforce effect is sufficient.

• 재활복지
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• v.18 no.4
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• pp.237-255
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• 2014

Idiopathic Parkinson disease(IPD) is an neurodegenerative disease caused by the loss of dopamine cells in the substantia nigra, a region of midbrain. Its major symptoms are muscular rigidity, bradykinesia, resting tremor, and postural instability. An estimated 70~90% of patients with IPD also have hypokinetic dysarthria. Subthalamic nucleus deep brain stimulation (STN-DBS) has been reported to be successful in relieving the core motor symptoms of IPD in the advanced stages of the disease. However, data on the effects of STN-DBS on speech performance are inconsistent. A medline literature search was done to retrieve articles published from 1987 to 2012. The results were narrowed down to focus on speech performance under STN-DBS based perceptual, acoustic, and/or aerodynamic analyses. Among the 32 publications which dealt with speech performance after STN-DBS indicated improvement(42%), deterioration(29%), mixed results(26%), or no change(3%). The most favorite method was found to be based upon acoustic analysis by using a vowel prolongation and Unified Parkinson's Disease Rating Scale(UPDRS). For the purpose of verifying the effect of the STN-DBS, speech evaluation should be undertaken on all speech components such as articulation, resonance, phonation, respiration, and prosody by using a contextual speech task.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.5
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• pp.675-687
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• 2019

In recent years, the needs for double deck-tunnels have increased in large cities due to the increase in traffic volume and high land compensation costs. In Korea, a network type tunnel which is smaller than general road tunnels and crosses another tunnel underground is planned. In the shield tunnel joints between the existing shield tunnel and the box-type enlargement section, a partial steel-concrete joint is proposed where the bending moment is large instead of the existing full-section steel joint. In order to analysis the enlargement section of the shield tunnel diverged section to reflect the three-dimensional effect, the two-dimensional analysis model is considered to consider the column effect and the stiffness effect of the longitudinal member. A two-dimensional analysis method is proposed to reflect the stiffness of the longitudinal member and the column effect of the longitudinal point by considering the rigidity of the longitudinal member as the elastic spring point of the connecting part in the lateral model. As a result of the analysis of the model using the longitudinal member, it was considered that the structural safety of the partial steel-concrete joint can be secured by reducing the bending moment of the joint and the box member by introducing the longitudinal member having the stiffness equal to or greater than a certain value.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.606-612
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• 2019

The main causes of subsidence and sinkholes in the lower part of urban roads are sewage line foundation and inadequate compaction of backfill material. This leads to many problems, such as the breakage of joints in sewer pipes, poor connection, pipe breakage, and cracks. To solve this problem, the support factor related to the sewer foundation and the safety factor according to the excavation depth were evaluated. For the foundation of rigidity tolerance, crushed stone foundation, and abandoned concrete foundation, a recently newly developed site assembly-type lightweight plastic foundation were used. Backfill materials were applied on site (sandy soil and clayey soil) and fluid backfill was recycled onsite. To evaluate the depth of excavation and the safety factor of each sewer pipe foundation, the design load considering the load factor and the support factor was evaluated. The support coefficients were 0.377 for a crushed stone foundation, 0.243 and 0.220 for an abandoned concrete foundation ($180^{\circ}$ and $120^{\circ}$), and 0.231 for a lightweight plastic foundation and fluid backfill. Overall, the safety factor was low when using the crushed stone foundation, and the safety rate was the highest when the foreclosed concrete foundation ($180^{\circ}$) was used. In addition, when the combination of lightweight plastic and fluid backfill materials was used, the safety factor was higher than that of abandoned concrete foundation ($120^{\circ}$), which means that the newly developed lightweight plastic foundation can be used as another alternative base of a steel pipe.

• Journal of Life Science
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• v.29 no.2
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• pp.191-197
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• 2019

Parkinson's disease (PD) is a progressive neurodegenerative disease that mainly affects motor system with clinical features such as bradykinesia, rigidity, tremor and abnormal posture. PD is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, which is associated with accumulation of oxidative stress and dysregulation of intracellular signaling pathway. Quercetin-3-O-glucuronide (Q3GA), a major metabolite of quercetin, has been reported to have neuroprotective effects. In this study, we examined the neuroprotective effect of Q3GA against 1-methyl-4-phenyl pyridinium ($MPP^+$)-induced neurotoxicity of PD and the underlying molecular mechanisms in SH-SY5Y cells. MTT and LDH assay showed that Q3GA significantly decreased $MPP^+$-induced cell death, which is accompanied by a reduction in poly (ADP-ribose) polymerase (PARP) cleavage. Furthermore, it attenuated $MPP^+$-induced intracellular reactive oxygen species (ROS) with the reduction of Bax/ Bcl-2 ratio. Moreover, Q3GA significantly increased the phosphorylation of Akt and cAMP response element binding protein (CREB), but it has no effects on the phosphorylation of extracellular signal-regulated kinase (ERK). Taken together, these results demonstrate that Q3GA significantly attenuates $MPP^+$-induced neurotoxicity through ROS reduction and Akt/CREB signaling pathway in SH-SY5Y cells. Our findings suggest that Q3GA might be one of the potential candidates for the prevention and/or treatment of PD.

• Korean Journal of Veterinary Service
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• v.42 no.1
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• pp.39-42
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• 2019

Tetanus is an acute, often fatal, and infectious disease of all species of domestic animals caused by the neurotoxin of Clostridium tetani (C. tetani). This disease is usually known to develop after microbial contamination in the deep or penetrating wound sites. In February 2017, a farmer who was raising 76 cows injected foot and mouth disease vaccine to three or more cows with one syringe. Their clinical symptoms were observed 2 to 16 days after the vaccination. The initial symptoms were stiffness, rigidity of the neck and limbs, pricked ears, and prolapse of the third eyelid. Subsequently, there was recumbency with extension of the limbs, convulsions and opistotonus and the affected 20 cows were all died. Two dead cows were submitted to Animal and Plant Quarantine Agency for disease diagnosis. At necropsy, a focal edematous abscess of 15 to 20 cm in diameter was grossly observed in the subcutaneous and intramuscular tissue of scapular region and filled with a large amount of greenish pus. The feed was full in oral cavity and slightly observed in the trachea and lobes of lung. Histopathologically, focal granulomatous nodules with eosinophilic materials in the tissue were observed. In the lung, aspiration pneumonia and gram (+) bacteria were seen. The C. tetani was isolated in samples anaerobically cultured using reinforced clostridial medium and identified by PCR. To our knowledge, no previous outbreak of tetanus in cattle has affected such a high number of animals; neither has it been associated with misuse of the same syringe and needle to administer multiple individuals.

• Wind and Structures
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• v.28 no.4
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• pp.255-270
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• 2019

Aerodynamic configurations of bridge decks have significant effects on the aerostatic torsional divergence and flutter forsuper long-span bridges, which are onset for selection of suitable bridge decksfor those bridges. Based on a cable-stayed bridge with double main spans of 1500 m, considering typical twin-box, stiffening truss and closed-box section, which are the most commonly used form of bridge decks and assumed that the rigidity of those section is completely equivalent, are utilized to investigate the effects of aerodynamic configurations of bridge decks on aerodynamic instability performance comprised of the aerostatic torsional divergence and flutter, by means of wind tunnel tests and numerical calculations, including three-dimensional (3D) multimode flutter analysis and nonlinear aerostatic analysis. Regarding the aerostatic torsional divergence, the results obtained in this study show twin-box section is the best, closed-box section the second-best, and the stiffening truss section the worst. Regarding the flutter, the flutter stability of the twin-box section is far better than that of the stiffening truss and closed-box section. Furthermore, wind-resistance design depends on the torsional divergence for the twin-box and stiffening truss section. However, there are obvious competitive relationships between the aerostatic torsional divergence and flutter for the closed-box section. Flutter occur before aerostatic instability at initial attack angle of $+3^{\circ}$ and $0^{\circ}$, while the aerostatic torsional divergence occur before flutter at initial attack angle of $-3^{\circ}$. The twin-box section is the best in terms of both aerostatic and flutter stability among those bridge decks. Then mechanisms of aerostatic torsional divergence are revealed by tracking the cable forces synchronous with deformation of the bridge decksin the instability process. It was also found that the onset wind velocities of these bridge decks are very similar at attack angle of $-3^{\circ}$. This indicatesthat a stable triangular structure made up of the cable planes, the tower, and the bridge deck greatly improves the aerostatic stability of the structure, while the aerodynamic effects associated with the aerodynamic configurations of the bridge decks have little effects on the aerostatic stability at initial attack angle of $-3^{\circ}$. In addition, instability patterns of the bridge depend on both the initial attack angles and aerodynamic configurations of the bridge decks. This study is helpful in determining bridge decksfor super long-span bridges in future.