• 대한구순구개열학회지
• /
• 제4권2호
• /
• pp.9-18
• /
• 2001

구순구개열은 악안면 영역의 선천기형 중 발생빈도가 가장 높으며 출생시부터 성장완료 시기까지 일관된 치료계획에 의한 종합적 진료체계가 필수적이다. 구순구개열의 개선을 위한 구개부 및 입숭? 조기 봉합 후의 반흔조직의 형성은 치열궁 협착 뿐 아니라 상악골 열성장에 의한 중안모의 함몰을 야기하며 이러한 상악골의 열성장 경향은 연령이 증가할수록 점진적으로 증가하는 성향을 보인다. 따라서, 성장잠재력을 이용한 조기의 악정형치료는 구순구개열 환자에서 반드시 필요하며, 적절한 치료 결과를 얻어내기 위하여 환자의 전후방 골격 형태 뿐 아니라, 성장 방향에 대한 고려가 필요하다. 그러나 혼합치열기의 악정형치료는 좋은 결과를 얻었다 하더라도 높은 재발 성향 및 잔여성장에 의한 악골관계의 변화가 예상되므로 장기간의 보정이 필수적이며 성장에 대한 지속적 평가가 이루어져야 할 것이다.

• Journal of Microbiology and Biotechnology
• /
• 제30권3호
• /
• pp.341-351
• /
• 2020

To shed light on the genetic differences among food-originated coagulase-negative Staphylococcus (CNS), we performed pan-genome analysis of five species: Staphylococcus carnosus (two strains), Staphylococcus equorum (two strains), Staphylococcus succinus (three strains), Staphylococcus xylosus (two strains), and Staphylococcus saprophyticus (one strain). The pan-genome size increases with each new strain and currently holds about 4,500 genes from 10 genomes. Specific genes were shown to be strain dependent but not species dependent. Most specific genes were of unknown function or encoded restriction-modification enzymes, transposases, or prophages. Our results indicate that unique genes have been acquired or lost by convergent evolution within individual strains.

• 한국전산유체공학회:학술대회논문집
• /
• 한국전산유체공학회 2000년도 추계 학술대회논문집
• /
• pp.129-134
• /
• 2000

An efficient numerical method to solve the unsteady incompressible Navier-Stokes equations is developed. A fully implicit time advancement is employed to avoid the CFL(Courant-Friedrichs-Lewy) restriction, where the Crank-Nicholson discretization is used for both the diffusion and convection terms. Based on a block LU decomposition, velocity-pressure decoupling is achieved in conjunction with the approximate factorization. Main emphasis is placed on the additional decoupling of the intermediate velocity components with only n th time step velocity The temporal second-order accuracy is Preserved with the approximate factorization without any modification of boundary conditions. Since the decoupled momentum equations are solved without iteration, the computational time is reduced significantly. The present decoupling method is validated by solving the turbulent minimal channel flow unit.

• BMB Reports
• /
• 제38권2호
• /
• pp.191-197
• /
• 2005

Although the human genome has been nearly completely sequenced, the functions and the roles of the vast majority of the genes, and the influences of single nucleotide polymorphisms (SNPs) in these genes are not entirely known. A modified mutation detection method was developed for large-scale cloning of the possible SNPs between tumor and normal cells for facilitating the identification of genetic factors that associated with cancer formation and progression. The method involves hybridization of restriction enzyme-cut chromosomal DNA, cleavage and modification of the sites of differences by enzymes, and differential cloning of sequence variations with a designed vector. Experimental validations of the presence and location of sequence variations in the isolated clones by PCR and DNA sequencing support the capability of this method in identifying sequence differences between tumor cells and normal cells.

• 미생물학회지
• /
• 제24권2호
• /
• pp.86-90
• /
• 1986

The DNA methylated by Hpa II methylase was not cleaved by Sma, I, Ava I and Nae I endonucleases. This experimental data could be interpreted as strong evidences that Sma I, Ava I and Nae I methylases which yet to be isolated would methylate on the inmost cytosine nucleotide within their hexameric recognition sequences. The facts that Sma I, Ava I and Nae I endonucleases can not cleave the DNA methylated by Hpa II methylase are the valuable informations for protecting DNAs upon cleavage reactions by Sma I, Ava I and NAe I endonucleases especially for cDNA insertion experiments into vector DNAs using Sma I, Ava I and Nae I oligonucleotide linkers. In the case of Xma I endonuclease, partially cleaved DNA fragments were observed although the reaction rate was greatly decreased. This result implies that the methylation site of Xma I methylase which yet to be isolated would not be the same as that of Hpa II methylase in Xma I sequence.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1986년도 한국자동제어학술회의논문집; 한국과학기술대학, 충남; 17-18 Oct. 1986
• /
• pp.352-355
• /
• 1986

In this paper, some candidates suggested for the improvement of the robustness in adaptive control systems are shortly surveyed. Using dead zone concept of error in adaptation process, gain retardation methods such as .sigma.-modification and parameter restriction method are those considered. Feedforward compensation and normalized adaptation technique are also considered. New modeling technique suggested by Donati et al is used for the indirect control of plants containing unmodeled dynamics. The frequency band of input signal, which is used as a test signal and control signal simultaneously, is directly related to the control of plants containing high frequency parastics. Computer simulation results of the some selected algorithms are shown.

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2007년도 춘계학술대회 논문집
• /
• pp.1336-1343
• /
• 2007

The HVAC takes the most important role in the Electric Multiple Unit for maintaining the healthy and comfortable indoor environment, however we also should consider the outdoor environment in terms of "environment's friendly" because the refrigerant used for the HVAC system is strongly related with the issues of "the Protection of environment" such as "the Global Warming" and "The Ozone layer Depletion". Therefore we survey (1)the potentially harmful impact on human health and the environment through modification of the ozone layer and the Green house effect, and (2)the international and the domestic environment's policies and (3)the potential alternative refrigerants usable for the EMU HVAC in terms of "the environment friendly properties", "the performance" and (4) "the applicabilities of the refrigerant for the EMU HVAC".

• 한국식물병리학회:학술대회논문집
• /
• 한국식물병리학회 1995년도 Proceedings of special lectures on Molecular Biological Approaches to Plant Disease National Agricultural Science and Technology Institute Suwon, Korea
• /
• pp.21-25
• /
• 1995

;Bacterial blight caused by Xanthomonas oryzae pv. Olyzae is one of the most important diseases of rice. Host resistance, which relies on single, dominant resistance genes, is the only reliable method to control the disease at present. Pathogenic variation of the bacteria has been shown to follow the deployment of resistance genes in commercial cultivars. Information on the factors and the mechanisms for genetic variation of this pathogen is limited. Further, we have no clear evidence of whether population variability is due to sexual recombination or to variation introduced by mutations or intragenic recombination in a clonally maintained population.(omitted)itted)

• BMB Reports
• /
• 제45권11호
• /
• pp.671-676
• /
• 2012

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney. Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.

• Nutrition Research and Practice
• /
• 제15권1호
• /
• pp.38-53
• /
• 2021

BACKGROUND/OBJECTIVES: Abdominal obesity is associated with metabolic disorders, and, in recent years, its prevalence in Korea has continuously increased. The change of lifestyle, particularly diet, is critical for the reduction of abdominal obesity. This study evaluated the effectiveness of an intervention focused on dietary self-efficacy and behaviors on the improvement of abdominal obesity. SUBJECTS/METHODS: Abdominally obese adults with additional cardiovascular risk factors were recruited through 16 medical facilities in South Korea from the year 2013 to 2014. The participants were randomly divided into 2 groups: an intensive intervention group (IG) that received a multi-component intervention to reduce abdominal obesity, by mainly focusing on dietary attitude and dietary behavior change, and a minimal information intervention group (MG) that received a brief explanation of health status and a simple recommendation for a lifestyle change. The interventions were provided for 6 mon, and health examinations were conducted at baseline, 3-, 6-, and 12-mon follow-ups. A path analysis was conducted to identify the process governing the changes in abdominal obesity. RESULTS: The IG showed an improvement in self-efficacy for eating control and diet quality at 6-mon follow-up. Abdominal obesity improved in both groups. Waist circumference was observed to be decreased through the path of "improved self-efficacy for eating control in food availability-eating restriction-improved dietary quality" in IG. Most changes in follow-ups were not significantly different between two groups. CONCLUSIONS: The intensive program targeting the modification of dietary behavior influenced management of abdominal obesity, and the effect occurred through a step-by-step process of change in attitude and behavior. Generally, improvements were also seen in the MG, which supports the necessity of regular health check-ups and brief consultation. The results can be used for further development and implementation of more successful interventions.