• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.2
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• pp.121-128
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• 2020

The purpose of this study is to investigate the distribution patterns of displacement and acceleration fields in a nonlinear soil ground based on the interaction of high-speed train, wheel, rail, and ground. For this purpose, a high-speed train in motion was modeled as the actual wheel, and the vertical contact of wheel and rail and the lateral contact, caused by meandering motion, were simulated; this simulation was based on the moving mass analysis. The soil ground part was given the nonlinear behavior of the upper ground part by using the modified the Drucker-Prager model, and the changes in displacement and acceleration were compared with the behavior of the elastic and inelastic grounds. Using this analysis, the displacement and acceleration ranges close to the actual ground behavior were addressed. Additionally, the von-Mises stress and equivalent plastic strain at the ground were examined. Further, the equivalent plastic and total volumetric strains at each failure surface were examined. The variation in stresses, such as vertical stress, transverse pressure, and longitudinal restraint pressure of wheel-rail contact, with the time history was investigated using moving mass. In the case of nonlinear ground model, the displacement difference obtained based on the train travel is not large when compared to that of the elastic ground model, while the acceleration is caused to generate a large decrease.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.4
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• pp.351-359
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• 2007

Multi-axial compression tests have been frequently conducted to evaluate the in situ properties of rock masses and the mechanical behaviors of rock strata through the model tests. Without the proper boundary condition for the model tests, the mechanical behavior of rock mass would deviate, as can be expected, from the in situ conditions. The boundary condition will affect the internal stress distribution of the specimens and cause some distortion on the measurement. In this study, a design process regarding the steel brush, which has been employed for multi-axial compression test to reduce the frictional restraint along the specimen/loading platen interface, is introduced. The individual brushes are regarded as a simple column and beam to calculate the cross-sectional size and length of the brushes in consideration of the buckling capacity and the allowable deflection.

• Journal of the Korean Geotechnical Society
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• v.29 no.1
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• pp.109-120
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• 2013

This paper presents the results of a laboratory investigation into a study on undrained characteristics of a geogrid-encased stone column (GESC) installed in soft clay under cyclic load. In order to analyze behavior of settlement, pore water pressure, stress concentration ratio and strain of the GESC compared to a stone column, a series of reduced-scale laboratory tests were performed. The model tests show that GESC provides a simple and effective method of deformation resistance and settlement restraint when a short-term cyclic load is applied. The maximum strain of geogrid occurred at 1.2D and 1.5D from the top of the column. This paper highlights the importance of considering overlay effect and replacement ratio on cyclic load supporting GESC.

• Journal of the Korea Concrete Institute
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• v.23 no.5
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• pp.581-590
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• 2011

Since ultra-high performance cementitious composites (UHPCC) not only represents high early age shrinkage strain due to its low water-to-binder ratio (W/B) and high fineness admixture usage but also reduces the cross section of structure from the higher mechanical properties, it generally has more shrinkage cracks from the restraints of formwork and reinforcing bars. In this study, free and restrained shrinkage experiments were conducted to evaluate the suitability of incorporating both expansive admixture (EA) and shrinkage reducing agent (SRA). The test results indi-cated that approximately 40~44% of free shrinkage strain was decreased. Also, the results showed that 35% and 47% of residual tensile stresses were relieved by synergetic effect of SRA and EA, respectively. Residual tensile stresses from ringtest were relaxed by approximately 61% and 64% of elastic shrinkage stresses due to SRA and EA, respectively, because of the tensile creep effect. Therefore, the creep effect should be considered to precisely estimate the restrained shrinkage behavior of concrete structures. The degree of restraint of UHPCC was approximately in the range of 0.78~0.85. The addition of combined EA and SRA showed minute influence on the degree of restraint. However, the effect decreased when thicker concrete ring was used. Tensile creep strains were measured and compared to the predicted values from 4-parametric prediction model considering time dependent restrained forces.

• Journal of Neurogastroenterology and Motility
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• v.24 no.4
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• pp.656-668
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• 2018

Background/Aims MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity in IBS-D remains largely unknown. Methods We established the IBS-D rat model and evaluated it using the nociceptive visceral hypersensitivity test, myeloperoxidase activity assay, restraint stress-induced defecation, and electromyographic (EMG) activity. The distal colon was subjected to miRNA microarray analysis followed by isolation and culture of colonic epithelial cells (CECs). Bioinformatic analysis and further experiments, including dual luciferase assays, quantitative real-time polymerase chain reaction, western blot, and enzyme-linked immunosorbent assay, were used to detect the expression of miRNAs and how it regulates visceral hypersensitivity in IBS-D rats. Results The IBS-D rat model was successfully established. A total of 24 miRNAs were differentially expressed in the distal colon of IBS-D rats; 9 were upregulated and 15 were downregulated. Among them, the most significant upregulation was miR-200a, accompanied by downregulation of cannabinoid receptor 1 (CNR1) and serotonin transporter (SERT). MiR-200a mimic markedly inhibited the expression of CNR1/SERT. Bioinformatic analysis and luciferase assay confirmed that CNR1/SERT are direct targets of miR-200a. Rescue experiments that overexpressed CNR1/SERT significantly abolished the inhibitory effect of miR-200a on the IBS-D rats CECs. Conclusions This study suggests that miR-200a could induce visceral hyperalgesia by targeting the downregulation of CNR1 and SERT, aggravating or leading to the development and progression of IBS-D. MiR-200a may be a regulator of visceral hypersensitivity, which provides potential targets for the treatment of IBS-D.