• Journal of Oral Medicine and Pain
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• v.37 no.2
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• pp.81-91
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• 2012

It has been known that saliva may affect the most of oral diseases. On the contrary, several systemic conditions may affect salivary flow and cause oral dryness and psychosocial stress especially may a crucial role in the etiology of hyposalivation and oral dryness. Many studies have focused on macroscopic effects of the stress on the salivary glands by autonomic respose, but on the other hand it has hardly been reported on cellular microscopic effects of the stress on the salivary glands. Therefore, this study was performed to examine clusterin, a antiapoptotic and cytoprotective protein, in the parotid glands under restraint stress condition. For this study, 10 rats were divided into 3 groups; 1) 2 rats of group I were selected as a normal control. 2) 2 rats of group II, as a experimental control were placed in the restraint cone for 2 hours 3) 6 rats of group III were placed in the restraint cone for 2 hours once a day. The rats were sacrificed immediately(group II, as a experimental control), 24, 48, and 72 hours after application of the stress and the parotid glands were excised. Western blotting and immunohistochemistry were performed. The finding were as follows: 1. In parotid glands, clusterin was mildly increased and clearly expressed in the ductal cell under restraint stress immediately after application of the stress. 2. In parotid glands, clusterin was significantly decreased and slightly stained in the ductal cell under restraint stress 24 and 48 hours after experiment. 3. In parotid glands, clusterin was prominently increased again and densely stained in the ductal cell under restraint stress 72 hours after experiment.

• Journal of Trauma and Injury
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• v.28 no.3
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• pp.98-103
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• 2015

Purpose: To compare injury sustained and severity of child occupant according to the types of safety restraint systems in motor vehicle crashes. Methods: This was a retrospective observational study. The study subjects were child occupants under the age of 8 years who visited a local emergency center following a motor vehicle crash from 2010 to 2014. According to safety restraint: child restraint systems (CRS), belted, and unbelted, we compared injuries sustained and injury severity using the maximal Abbreviated Injury Scale (MAIS) and Injury Severity Score (ISS), and analyzed the characteristics of severe injuries (AIS2+). Results: Among 241 subjects, 9.1% were restrained in CRS, 14.5% were only belted, and 76.3% was unbelted at the time of the crashes. Fourteen had severe injuries (AIS2+), all of whom didn't be restrained by CRS. Injuries in face and neck were the highest in unbelted group, and MAIS and ISS were the lowest in CRS group. Conclusion: Among safety restraint systems for child occupant in motor vehicle crashes, the CRS have the preventive effect of face and neck injuries, and are the most effective safety restraint systems.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.177-193
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• 2003

Objective : The present studies investigated the effects of 120Hz high frequency electroacupunctue(EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormone and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used. Methods: Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but he number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment. The cold-restraint stress also induced an increase in catecholamine response involving epinephrine, norepinephrine and dopamine, but an slight decline were observed in EA pre-treated rats compared with cold-restrained rats. Results: The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained ones, $PGE_2$ content in the gastric mucosa of EA pre-treated rats was also different from that observed in cold-restrained rats. Cold-restraint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor(TNF)-${\alpha}$, but these expression were down-regulated in EA pre-treated rats. Immunohistochemecal analysis showed that while the inhibitory-${\kappa}B{\alpha}$ an TNF-${\alpha}$ immunoreaction in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls. Conclusions : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through a activation of pituitary adrenal system. it could be concluded that 120 hz high frequency electroacupuncture affords a good protective potential against stress-induce gastrointestinal dysfunction.

• Journal of Microbiology and Biotechnology
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• v.22 no.3
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• pp.422-430
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• 2012

Previous studies have demonstrated that repeated restraint stress in rodents produces increases in depression and anxiety-like behaviors and alters the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. The current study focused on the impact of Bupleurum falcatum (BF) extract administration on repeated restraint stress-induced behavioral responses using the forced swimming test (FST) and elevated plus maze (EPM) test. Immunohistochemical examinations of tyrosine hydroxylase (TH) expression in rat brain were also conducted. Male rats received daily doses of 20, 50, or 100 mg/kg (i.p.) BF extract for 15 days, 30 min prior to restraint stress (4 h/day). Hypothalamic-pituitary-adrenal axis activation in response to repeated restraint stress was confirmed base on serum corticosterone levels and CRF expression in the hypothalamus. Animals that were pre-treated with BF extract displayed significantly reduced immobility in the FST and increased open-arm exploration in the EPM test in comparison with controls. BF also blocked the increase in TH expression in the locus coeruleus of treated rats that experienced restraint stress. Together, these results demonstrate that BF extract administration prior to restraint stress significantly reduces depression and anxiety-like behaviors, possibly through central adrenergic mechanisms, and they suggest a role for BF extract in the treatment of depression and anxiety disorders.

• Journal of Sasang Constitutional Medicine
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• v.20 no.3
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• pp.151-163
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• 2008

1. Objective This study was done to identify the anti-stress effect of Hyeongbangdojeok-san (HDS), Yanggyeoksanhwa-tang(YST) in Soyangin. 2. Methods Experimental animals were composed of YST, HDS+stress groups which were administered each by 200mg/kg, 400mg/kg and the Saline+stress group. On the 1st day, making the rats forced swim and on the 2nd day, applying Forced swimming test to the rats. After FST, the levels of Corticosterone in the blood were measured. For the study of learning retardation, memory ability and anxiety reaction, experimental animals were composed of YST, HDS+restraint stress groups which were administered each by 400mg/kg, no stress group and the Saline+restraint stress group. Restraint stress were applied 2 hours a day for 3 weeks. On the last day of the 3rd week, Elevated Plus Maze(EPM) was applied to the groups and Morris Water Maze(MWM) was applied to the groups for 7 days. 3. Results 1. As the results of measuring FST which reflects depression, the YST+stress group and the HDS+stress group showed significant effect in comparison with the Saline+stress group. The levels of Corticosterone in the blood were decreased only in the 400mg/kg YST+stress group. 2. As the results of measuring how long EPM which reflects anxiety reaction stayed in the open arm, there was the trend which can suppress anxiety reaction in the HDS+restraint stress group bur no statistical significance. But there was any suppression of anxiety reaction in the YST+restraint stress group. 3. According to the result of MWM, the saline+restraint stress group showed the learning retardation which means increased time arriving at goal compared to the normal group at the second and third day of measurement. On the contrary, a learning retardation was significantly decreased in the YST+restraint stress group at the third day of measurement. 4. Among the Probe trial test a memory loss occurred in the saline+restraint stress group, but memory ability was significantly increased in the YST+restraint stress group. 4. Conclusion: As the results above, Soyangin Yanggyeoksanhwa-tang has significant influence to the antidepression effect, the learning retardation, the anxiety reaction and also in the Hormone level. Hyeongbangdojeok-san has significant influence to the antidepression effect, in the Hormone level, bur not to the learning retardation and anxiety reaction. prefer to drink cold water, and who are suffering from chronic gastritis.

• Biomolecules & Therapeutics
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• v.18 no.2
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• pp.219-225
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• 2010

We tested whether ginsenosides $Rg_3$-standardized ginseng extract (RGE) has anti-stress effects in restraint-stressed animals. RGE increased time spent in the open arms and open arm entries in the elevated plus-maze test. In addition, RGE blocked the reduction of center zone distance and stereotypes behaviors in the open-field test. RGE also increased head dips in stressed mice, indicating anxiolytic-like effects. Stress decreased movement distance and duration, burrowing, and rearing frequency but increased face washing and grooming. RGE significantly reversed burrowing and rearing activity in stressed mice. In addition, we measured sleep architecture in restraint stressed rats using EEG recorder. Stress increased rapid eye movement (REM) sleep, but total sleep and non-rapid eye movement (NREM) sleep were not changed. RGE did not affect sleep architecture in stressed rats. These behavioral experiments suggest that RGE has anti-stress effects in restraint-stressed animal models.

• Journal of Korean Academy of Nursing
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• v.31 no.1
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• pp.43-54
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• 2001

The purpose of this study was to investigate the relationship between health locus of control (HLOC) and the eating behaviors in obese high school girls. The sample consisted of 262 obese high school girls in Seoul and Kangwon-Do. The results of this study were as follows: 1. The average scores of HLOC were HLOC- Internal; 4.06, HLOC-External; 2.47, and HLOC-Chance; 2.15. 2. The average scores of eating behavior factors were Disinhibition ; 2.91, Hunger ; 2.73, Dietary Restraint ; 2.55. 3. The HLOC-Internal and eating behavior (dietary restraint, disinhibition and hunger) were correlated positively. The HLOC- Chance and hunger was correlated positively. But HLOC-Chance and other eating behavior factors (dietary restraint & disinhibition) were not correlated in the level of statistical significances. The HLOC-External and eating behavior (dietary restraint, disinhibition and hunger) were correlated positively. 4. There was not a significant difference in HLOC depending on the existence of an obese sibling. There were significant differences in HLOC-Internal and HLOC- External depending on the evaluation of one's body figure. 5. There were significant differences in disinhibition and hunger depending on the existence of obese sibling. Also, there were significant difference in dietary restraint according to self perception of who is obese or not (t=3.342, p=.001). This study has shown a correlation between HLOC and eating behavior. As a result of these findings, clinical and school nurses should be involved in management and counselling obese girls concerning individual health locus of control and eating behavior.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.26 no.3
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• pp.93-104
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• 2018

It is mandatory to use car seats for infants and children in the private vehicles in accordance with the traffic law of Korea. Recently, legislation has also been proposed to expand the use car seats to express and intercity buses. This reflects a growing consensus that mandatory infant and child car seats, both for private and commercial vehicles, are essential. However, Korean laws concerning infants and children on board aircraft allow parents or guardians to hold children under two years of age on their laps without any restraint devices. It is not possible for a parent to physically restrain an infant or child, especially during a sudden acceleration or deceleration, unanticipated or severe turbulence, or impact. The use of CRS provides an equivalent level of safety to infants and children as that afforded to adult passengers wearing seat belts. But there is no regulation even about Child Restraint Systems on board aircraft in Korea. To enhance their safety, infants and children should be restrained in an approved child restraint system that is appropriate to their weight and height. It is necessary to examine whether infants and children in flight can achieve the same level of safety as an adult.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.1
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• pp.29-37
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• 2018

Inrush current and fault current in a transformer need to be distinguished from one another. In order to do this, KEPCO uses a 2nd harmonic restraint/block method. We use two setting values for 2nd harmonic restraint; 15% and 10%. We also apply per-phase blocking method among various harmonic restraint methods. If the transformer is located at the radial system, we adjust 10% in the 2nd harmonic restraint, but this method is not enough to prevent mal-operations of the current differential relay and let us spend more time to change setting value again as the power system changes. In this paper, a more reasonable setting value for a 2nd harmonic blocking scheme in KEPCO is proposed. To present a proposed method, the fault data of the current differential relays which have occurred since 2009 are analyzed. To evaluate the performance of the proposed method, the results of the RTDS test for the current differential relay of the transformer by KEPCO are analyzed.

• Steel and Composite Structures
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• v.23 no.3
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• pp.331-338
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• 2017

Cold-formed lipped channel columns (CFLCCs) have been widely used in light gauge steel constructions. The distortional buckling is one of the important buckling modes for CFLCCs and the distortional buckling critical load depends significantly on the rotational restrain stiffness generated by the web to the lipped flange. First, a simplified explicit expression for the rotational restraint stiffness of the lipped flange has been derived. Using the expression, the characteristics of the rotational restraint stiffness of the lipped flange have been investigated. The results show that there is a linear coupling relationship between the applied forces and the rotational restraint stiffness of the lipped flange. Based on the explicit expression of the rotational restraint stiffness of the lipped flange, a simplified analytical formula has been derived which can determine the elastic distortional buckling critical stress of the CFLCCs subjected to axial compression. The simplified analytical formula developed in this study has been shown to be accurate through the comparisons with results from the distortional buckling analyses using the ANSYS finite element software. The developed analytical formula is easy to apply, and can be used directly in practical design and incorporated into future design codes and guidelines.