• Journal of Ginseng Research
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• v.41 no.4
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• pp.548-555
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• 2017

Background: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red ginseng extract (Rg3-RGE) to examine its role in platelet physiology. Methods: To examine the effect of Rg3-RGE on platelet activation in vitro, platelet aggregation, granule secretion, intracellular calcium ($[Ca^{2+}]_i$) mobilization, flow cytometry, and immunoblot analysis were carried out using rat platelets. To examine the effect of Rg3-RGE on platelet activation in vivo, a collagen plus epinephrine-induced acute pulmonary thromboembolism mouse model was used. Results: We found that Rg3-RGE significantly inhibited collagen-induced platelet aggregation and $[Ca^{2+}]_i$ mobilization in a dose-dependent manner in addition to reducing ATP release from collagen-stimulated platelets. Furthermore, using immunoblot analysis, we found that Rg3-RGE markedly suppressed mitogen-activated protein kinase phosphorylation (i.e., extracellular stimuli-responsive kinase, Jun N-terminal kinase, p38) as well as the PI3K (phosphatidylinositol 3 kinase)/Akt pathway. Moreover, Rg3-RGE effectively reduced collagen plus epinephrine-induced mortality in mice. Conclusion: These data suggest that ginsenoside Rg3-RGE could be potentially be used as an antiplatelet therapeutic agent against platelet-mediated cardiovascular disorders.

• Journal of the Korea Computer Graphics Society
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• v.23 no.2
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• pp.29-39
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• 2017

This paper presents a unified framework to efficiently and realistically simulate surface and wave foams. The framework is designed to first project 3D water particles from an underlying water solver onto 2D screen space in order to reduce the computational complexity of determining where foam particles should be generated. Because foam effects are often created primarily in fast and complicated water flows, we analyze the acceleration and curvature values to identify the areas exhibiting such flow patterns. Foam particles are emitted from the identified areas in 3D space, and each foam particle is advected according to its type, which is classified on the basis of velocity, thereby capturing the essential characteristics of foam wave motions. We improve the realism of the resulting foam by classifying it into two types: surface foam and wave foam. Wave foam is characterized by the sharp wave patterns of torrential flow s, and surface foam is characterized by a cloudy foam shape even in water with reduced motion. Based on these features, we propose a technique to correct the velocity and position of a foam particle. In addition, we propose a kernel technique using the screen space density to efficiently reduce redundant foam particles, resulting in improved overall memory efficiency without loss of visual detail in terms of foam effects. Experiments convincingly demonstrate that the proposed approach is efficient and easy to use while delivering high-quality results.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.43 no.4 s.310
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• pp.37-45
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• 2006

In this paper, we propose the development of MHLA(Modulatory Hippocampus Learning Algorithm) which remodel a principle of brain of hippocampus. Hippocampus takes charge auto-associative memory and controlling functions of long-term or short-term memory strengthening. We organize auto-associative memory based 3 steps system(DG, CA3, CAl) and improve speed of learning by addition of modulator to long-term memory learning. In hippocampal system, according to the 3 steps order, information applies statistical deviation on Dentate Gyrus region and is labelled to responsive pattern by adjustment of a good impression. In CA3 region, pattern is reorganized by auto-associative memory. In CAI region, convergence of connection weight which is used long-term memory is learned fast by neural networks which is applied modulator. To measure performance of MHLA, PCA(Principal Component Analysis) is applied to face images which are classified by pose, expression and picture quality. Next, we calculate feature vectors and learn by MHLA. Finally, we confirm cognitive rate. The results of experiments, we can compare a proposed method of other methods, and we can confirm that the proposed method is superior to the existing method.

• Management & Information Systems Review
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• v.39 no.1
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• pp.75-91
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• 2020

The purpose of this study is to examine the application of in-depth interviews in terms of exploration on the basis of the theoretical basis of various aspects of consumer empathy, and the question of whether the consumer can expand to the process of self empathy. Most studies related to consumer empathy divide the responsive dimension of consumer empathy into rational and emotional dimension based on empathy theory, and look at the empathic response perceived by consumers to the stimulus presented from the current point of view. In this study, however, we want to go one step further and confirm that the consumers themselves can ultimately go to the self-empathy stage by forming a creative street of reproduction and redevelopment. As a result of exploratory research through in-depth interviews, it was indirectly confirmed that consumer's empathetic response to specific marketing stimulus exists at the level of creative and self-empathetic as well as the emphasis of previous studies. Based on these findings, this study confirmed that consumer empathetic responses could go beyond a single dimension to form a multidimensional structure and move toward an expanded structure of empathic self-creation. This suggests that consumers' empathic responses should be grasped in terms of continuity of empathic responses rather than explained in a specific dimension. Although this study is meaningful as an early research of exploratory nature, it is necessary to supplement various content validity and refine the research method through subsequent studies. This study is expected to expand the understanding that consumer's empathy can be extended to other people's empathy and to be self-empathy.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.405-408
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• 2004

Several hydroxamic acid derivatives are synthesized to observe retinoidal effect and transactivation potential for $RAR{\alpha}/{\gamma]$ is screened. Among the synthesized compounds, N-(4-N-hydroxycarbamoyl )phenyl) [4-(tert-butyl )phenyl] carboxamide (2f) showed the best compatibility for potent $RAR{\alpha}/{\gamma].$ The acidic hydroxy of hydroxamic acid was easily deprotonated to form an enolate. A formed enolate has a similar role like that of all-trans-retinoic acid. This is the first example of the hydroxamic acid derivative with retinoidal activity. The retinoidal activity of 2f was further confirmed by enhancing activity for the expression of retinoid-responsive genes. To evaluate the possibility for anti.-aging agent, effect on the expression of MMP-1 was measured comparing with all-trans-retinoic acid and retinol. At 10 uM treatment, compound 2f inhibited the expression of MMP-1. These results suggest that new hydroxamic acid derivative 2f could be used as a promising anti-aging agent.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.7
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• pp.18-25
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• 2014

To increase wireless capacity, the concurrent use of multiple wireless interfaces on different frequency bands, called aggregation, can be considered. In this paper, we focus on aggregation of multiple Wi-Fi interfaces with packet-level traffic spreading between the interfaces. Two aggregation schemes, link bonding and multipath TCP (MPTCP), are tested and compared in a dualband Wi-Fi radio system with their Linux implementation. Various test conditions such as traffic types, network delay, locations, interface failures and configuration parameters are considered. Experimental results show that aggregation increases throughput performance significantly over the use of a single interface. Link bonding achieves lower throughput than MPTCP due to duplicate TCP acknowledgements (ACKs) resulting from packet reordering and filtering such duplicate ACKs out is considered as a possible solution. However, link bonding is fast responsive to links' status changes such as a link failure. It is shown that different combinations of interface weights for packet spread in link bonding result in different throughput performance, envisioning a spatio-temporal adaptation of the weights. We also develop a mathematical model of power consumption and compare the power efficiency of the schemes applying different power consumption profiles.

• The Journal of the Convergence on Culture Technology
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• v.6 no.1
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• pp.43-53
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• 2020

The purpose of this study is to reduce the anxiety factors of fires by following evacuation tips in case of fire in an apartment household. This study analyzed the moderating effects of the control offices' competence in control on safety awareness and fire response. The study results were as follows. First, the residents and control staff's safety awareness had a positive effect on the fire response performance. This indicates that the higher the residents and control staff's safety awareness level, the higher the fire responsive performance. Second, the higher the control offices' control competence level, the better the apartment residents and control staff's safety awareness had a positive effect on the fire response performance. These results indicate that the higher the control office heads' leadership, the higher the apartment residents' housing satisfaction and that the more communicative the control office heads' attitude toward the residents, the better their attitude had a positive effect on the fire response performance. Lastly, the control offices' control competence was analyzed to have a moderating effects on the effect of the apartment residents and control staff's safety awareness level on the fire response performance. These results showed that the change in the model's R² value showed an increasing trend in stages as the value increased more in the stage 2 than the stage 1 and even more in the stage 3 with the interaction terms of the moderating variables added. For this reason, the control offices' control competence which was a moderating variable was analyzed to have a moderating effect on the effect of residents and control staff's safety awareness level on the fire response performance.

• Journal of Science and Technology Studies
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• v.2 no.2 s.4
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• pp.145-189
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• 2002

This paper explores into the potential contribution of welfare science and technology(WST) to meeting the challenges of ageing. Drawing on the literature about gerontechnology, this paper considers the application of scientific knowledge for welfare of an aging population. WST for the improvement of the daily functioning of the elderly people can not only prevent, delay or compensate for the declines or impairments of coginitive and physical functions (by assistive technology) but also enhance personal ability to overcome problems either by supporting the person's abilities (by supportive technology) or by changing the environment (by public welfare technology). This paper draws attention to a paradigm change in the conceptualization of disability and its ramifications for the role of technology and aging. A range of approaches such as Barrier-Free design, Universal Design points to new directions of WST in which products and services are devised to improve the quality of life for all people, and hence enhancing the socio-economic vitality. It is suggested that the future of welfare science and technology will be based in large measure on its goal to reduce or prevent individual and structural lag in the relationships between people and their environments. Addressing issues of the broader physical and social environment will emphasize the goal of prevention and the view that environmental needs for aging population are changing over time.

• Tuberculosis and Respiratory Diseases
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• v.42 no.4
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• pp.548-554
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• 1995

Background: Cardiogenic pulmonary edema increases nonspecific airway responsiveness in humans and animals. Increased extravascular lung water from overt pulmonary edema to subclinical interstitial edema is a common finding in patients with chronic renal failure. Several studies carried out to assess pulmonary function disturbances in this condition have documented a reduction in forced expiratory volume that usually reverses after hemodialysis, suggesting airway edema as the underlying mechanism. This interstitial edema may also lead to nonspecific bronchial hyperresponsiveness. We hypothesized that patients with chronic renal failure may present nonspecific bronchial hyperresponsiveness due to subclinical interstitial pulmonary edema. Methods: We studied 18 chronic renal failure undergoing regular hemodialysis 3 times a week(New York Heart Association Class II) without concomittent disease. These patients were checked pulmonary function test and metacholine provocation test before hemodialysis and same procedure was repeated if responsive, after hemodialysis. Results: 1) 12 out of 18 patients before hemodialysis were reactive in metacholine provocation test(66.7%) before hemodialysis. This airway hyperresponsiveness were decreased after hemodialysis. 2) Pulmonary function was improved after hemodialysis and change in $FEV_1$ was correlated with change in weight(r=-0.62, p<0.01). 3) There was a close correlation between log $PD_{20}$ and $FEF_{25}$, which is one of the variables of the peripheral airways(r=0.58, p<0.05). Conclusion: We speculated interstitial pulmonary edema may play a significant role in bronchial hyperresponsiveness and lung function impaired in patients with chronic renal failure.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.30 no.4
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• pp.70-80
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• 2012

There isn't much of discussion about survey of traditional Korean garden with a perspective of Pungsu. Strictly speaking, it is difficult to list the names of gardens in which Pungsu theory is applied. But it is necessary to study in depth the Korean garden in mountain in relation with Pungsu. The reason is as follow; First, Pung-su and gardening both reflect man's responsive attitude and approach toward nature. Second, selecting a site for a garden requires aesthetic eyes to consider the harmony with the surrounding landscape and its compositions, where the perspective of Pungsu can play as an important component at work. Third, Pungsus complementary function justifies the correlation between Pungsu and Korean gardens. Gardens can be viewed as a solution to complement negative elements of Pungsu on site. This article tries to study the relationship between Pungsu and Korean garden in mountain in terms of Pungsu aesthetics. In Kosan Yoon Sun-Do's Buyong-dong garden, excavated perspectives of Pungsu aesthetics are fell into two categories; the spatial frame based on Pungsu topography and the dimension of enjoyment through visual angles between essential points. The former can be said as Pungsu topography as a mental image which was constructed by selected points and given Pungsu meanings; the latter is visual angles between those points by which make it possible to see and enjoy in comfortable sights. In such way making and enjoying Buyong-dong garden with full of Pungsu oriented meanings and aesthetics, Kosan Yoon Sun-Do enjoyed and sublimated his experience in nature into art.