• Title/Summary/Keyword: response-surface

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The Relationships between Abdominal Temperature and Some Thermoregulatory Responses in Male Broiler Chickens

  • Zhou, W.T.;Fujita, M.;Ito, T.;Yamamoto, S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.10 no.6
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    • pp.652-656
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    • 1997
  • This study was conducted to determine the relationships between abdominal temperature (Tabd) and some thermoregulatory responses, such as heat production (HP), heart rate (HR), respiration rate (RR), temperature of external ear tract (Tee), comb surface temperature (Tcs) and shank skin temperature (Tss), for revealing the role of deep body temperature in the thermoregulation of broiler chickens. Tabd was divided into 5 zones of 40-41, 41-42, 42-43, 43-44 and $44-45^{\circ}C$, and maintained for 3 hours in each zone by varying environmental temperature from 11 to $33^{\circ}C$. HP and HR had a greater increase with Tabd above $42.5^{\circ}C$. RR increased markedly with Tabd above $41.5^{\circ}C$, and reached a maximum when Tabd was at $42.5^{\circ}C$, then began to decrease. In addition, HP and HR increased significantly with decrease RR during the decreasing phase of panting. Tcs and Tss changed rapidly with Tabd when Tabd was below $41.5^{\circ}C$, and increased more slowly above $41.5^{\circ}C$. Tee was lower than Tabd, and its increase was less than that of Tabd. These results suggest that changes in thermoregulatory responses are induced by an increase in abdominal temperature. Tabd increases to adjust the ratio of sensible and evaporative heat loss when Tabd is below $42.5^{\circ}C$, while the ability in body temperature regulation gradually disappears when abdominal temperature exceeds $42.5^{\circ}C$ and heat balance can not be maintained.

Intestinal Alkaline Phosphatase: Potential Roles in Promoting Gut Health in Weanling Piglets and Its Modulation by Feed Additives - A Review

  • Melo, A.D.B.;Silveira, H.;Luciano, F.B.;Andrade, C.;Costa, L.B.;Rostagno, M.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.1
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    • pp.16-22
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    • 2016
  • The intestinal environment plays a critical role in maintaining swine health. Many factors such as diet, microbiota, and host intestinal immune response influence the intestinal environment. Intestinal alkaline phosphatase (IAP) is an important apical brush border enzyme that is influenced by these factors. IAP dephosphorylates bacterial lipopolysaccharides (LPS), unmethylated cytosine-guanosine dinucleotides, and flagellin, reducing bacterial toxicity and consequently regulating toll-like receptors (TLRs) activation and inflammation. It also desphosphorylates extracellular nucleotides such as uridine diphosphate and adenosine triphosphate, consequently reducing inflammation, modulating, and preserving the homeostasis of the intestinal microbiota. The apical localization of IAP on the epithelial surface reveals its role on LPS (from luminal bacteria) detoxification. As the expression of IAP is reported to be downregulated in piglets at weaning, LPS from commensal and pathogenic gram-negative bacteria could increase inflammatory processes by TLR-4 activation, increasing diarrhea events during this phase. Although some studies had reported potential IAP roles to promote gut health, investigations about exogenous IAP effects or feed additives modulating IAP expression and activity yet are necessary. However, we discussed in this paper that the critical assessment reported can suggest that exogenous IAP or feed additives that could increase its expression could show beneficial effects to reduce diarrhea events during the post weaning phase. Therefore, the main goals of this review are to discuss IAP's role in intestinal inflammatory processes and present feed additives used as growth promoters that may modulate IAP expression and activity to promote gut health in piglets.

Arthroscopic Evaluation for Endoscopic ACL Reconstruction Using a Multi-stranded Hamstring Tendon Graft and EndoButton (슬괵 건을 이용한 전방십자인대 재건술후 2차 관절경적 평가)

  • Lee, Kwang-Won;Lee, Byeong-Ki;Ryu, Chang-Soo;Keum, Teok-Seop;Choy, Won-Sik;Kim, Joon-Sik
    • Journal of the Korean Arthroscopy Society
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    • v.2 no.2
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    • pp.124-128
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    • 1998
  • From Feb. 1996 to Feb. 1997. among sixty-four patients of anterior cruciate ligament(ACL) reconstruction using multi-stranded hamstring tendon and EndoButton fixation, twenty-five patients of volunteer, 15 men and 10 women, from 16 to 50 years of age(mean 27.6 years) underwent arthroscopic evaluation. Arthroscopic evaluation was routinely performed one year after surgery along with an examination of stability. The purpose of this study was to arthroscopically evaluate the morphological changes that occurred in hamstring tendon autograft one year after ACL reconstruction. Both of the tendon graft and the adjacent fibrous tissues were observed for gross appearance and physical properties with probing and response to passive anterior translation. Biopsy samples were taken from the surrounding fibrous tissue and the tendon graft. Grossly, we found a well-defined ligamentous structure with good tension tested with a probe. A common finding was that the reconstructed ligaments were embedded in a layer of the synovium, and blood vessels could be seen on the anterior surface of the ligament. The biopsy tissue was placed in formalin solution and subjected to histological preparation by hematoxylin and eosin staining method. The hamstring tendon graft appeared histologically normal under light microscopic finding. There were a few vessels located between existing collagen bundles, and the vessels had an orderly pattern. The surrounding fibrous tissue envelope was covered with synovium. We pleased with preliminary findings in our evaluation.

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Properties of Calcium Lactate Prepared from Calcined Littleneck Clam Ruditapes philippinarum Shell Powder (바지락(Ruditapes philippinarum) 패각 소성분말로 제조한 젖산칼슘의 특성)

  • Lee, Gyoon-Woo;Yoon, In Seong;Lee, Hyun Ji;Lee, Jung Suck;Kim, Jin-Soo;Heu, Min Soo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.49 no.4
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    • pp.436-444
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    • 2016
  • Clamshells, which comprise more than 50% of a clam’s weight, are a major byproduct of the clam industry and are mainly composed of insoluble calcium carbonate. This study investigates the use of clamshells as a natural calcium resource. Highly soluble powdered calcium lactate (LCCL) was prepared from the calcined powdered shells of littleneck clams (LCCP) using response surface methodology (RSM) to predict optimum conditions. These conditions, as derived from pH, solubility, and yield of 11 LCCLs manufactured according to the RSM model, were 1.80 M lactic acid and 1.13 M LCCP. The actual values of pH (6.98), solubility (93.99%), and yield (351.23%) under the optimized conditions were as predicted. The derived LCCL exhibited a strong buffering capacity in the range of pH 2.78-3.90 when combined with less than 2 mL of 1 N HCl. The ranges of calcium content and solubility of LCCL were 7.7-17.5 g/100 g and 96.6-98.9%, respectively. Fourier transform infrared spectroscopy (FT-IR) of the LCCL identified it as calcium lactate pentahydrate, and field emission scanning electron microscopy (FESEM) revealed an irregular and rod-like microstructure. These results confirm the potential use of clamshells, converted to highly soluble organic acid calcium, as an additive to enhance calcium content in food ingredients.

The Effects of 120Hz High Frequency Electroacupuncture on the Cold-Restraint-Induced Gastric Mucosal Damages (Cold-Restraint 스트레스 유발 위점막손상에 미치는 고빈도 120Hz 전침의 효과)

  • Jo, Mee-hyeong;Choi, Byung-tae;Jang, Kyung-jeon
    • Journal of Acupuncture Research
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    • v.20 no.3
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    • pp.177-193
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    • 2003
  • Objective : The present studies investigated the effects of 120Hz high frequency electroacupunctue(EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormone and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used. Methods: Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but he number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment. The cold-restraint stress also induced an increase in catecholamine response involving epinephrine, norepinephrine and dopamine, but an slight decline were observed in EA pre-treated rats compared with cold-restrained rats. Results: The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained ones, $PGE_2$ content in the gastric mucosa of EA pre-treated rats was also different from that observed in cold-restrained rats. Cold-restraint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor(TNF)-${\alpha}$, but these expression were down-regulated in EA pre-treated rats. Immunohistochemecal analysis showed that while the inhibitory-${\kappa}B{\alpha}$ an TNF-${\alpha}$ immunoreaction in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls. Conclusions : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through a activation of pituitary adrenal system. it could be concluded that 120 hz high frequency electroacupuncture affords a good protective potential against stress-induce gastrointestinal dysfunction.

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A Study on the Structure Strength of Wing In Ground effect Ship (표면 효과익선(WIG)의 구조 강도에 관한 연구)

  • 고재용;박석주;정성호;박성현
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2002.11a
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    • pp.95-100
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    • 2002
  • The wing in ground effect (WIG) ship is an energy saying vessel that uses the lift from its air-wing along with the lift increase from the ground effect by flying low above the sea surface. The WIG Ship should consist of thin plate in order to float on the sea and to fly in the air. Therefore, the structure of WIG, Ship has very thin and light shell plate and stiffener like stringer and frame has comparatively large cross section area. This structure makes shell plate nearly pure shear field when shell plate is pressed by in-plane load. This complex thin plate structure of WIG Ship can he considered as a closed section beam which makes it possible to analyze structure response of WIG Ship affected by shear load and bending load. In this respect, the present study will show basic theory for analysing shear stress and focus on the analysis of structure strength of model WIC Ship's wing.

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The Development of Performance Analysis Code for Conceptual Design of Jet Fighters (전투기의 개념설계를 위한 성능해석 프로그램 개발)

  • Kim, Taewoo;Choi, Hyunmin;Choi, Byungryul;Lee, Sungjin;Nam, Hwajin;Choi, Donghoon;Cho, Jinsoo
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.41 no.5
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    • pp.404-414
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    • 2013
  • In the conceptual design phase of jet fighters, the trade study is performed repeatedly for a selection of the baseline configuration. The automation of repeated trade study makes possible to select efficiently the baseline configuration. In this study, the performance analysis code was developed for the automation of trade study. The code was consists of the module of shape generation, the module of weight estimation, the module of mission performance analysis. 3D CAD Model can be generated by the module of shape generation and Weight can be estimated by using the empirical equation in the module of weight estimation. The module of mission performance analysis was able to calculate the mission performance about the arbitrary mission profile. In addition, the optimal mission performance can be calculated by using optimization method. By performing the validation, the code was confirmed to be able to apply to the conceptual design phase.

Reliability Prediction of Electronic Arm Fire Device Applying Sensitivity Analysis (민감도 해석을 적용한 전자식 점화안전장치의 신뢰도 추정)

  • Kim, Dong-seong;Jang, Seung-gyo;Lee, Hyo-Nam;Son, Young Kap
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.46 no.5
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    • pp.393-401
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    • 2018
  • Reliability prediction of an electronic arm fire device(EAFD) was studied which is applied to prevent accidental ignition in a solid rocket motor. For predicting the reliability, the main components of the EAFD were first defined(Control unit, LEEFI, TBI) and the operating principle of each component was analyzed. Performance modeling of each part is established using selected input variables through system analysis. When complex analysis is required, we approximated it with polynomial equation using response surface method. Monte-Carlo simulation is applied to performance modeling to estimate the design reliability.

Numerical Study about Behavior of an Ejecting Projectile for Varying Initial Conditions (초기 조건 변화에 따른 사출 운동체의 거동에 관한 수치적 연구)

  • Jo, Sung Min;Kwon, Oh Joon
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.47 no.11
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    • pp.761-767
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    • 2019
  • In the present study, analyses of initial behavior of an air-launched projectile for varying initial conditions are performed by coupling computational fluid dynamics and 6 degrees of freedom calculations. Accuracy of the present numerical methods is validated by comparing the present result with the measured data. Launching safety analyses are carried out for various ejecting conditions by considering weight of the projectile and magnitude of front and rear ejector forces as the major parameters of initial behavior of the projectile. A response surface of the projectile launching safety is obtained in the range of the major parameters. In all the conditions of zero rear ejector force, unsafe launching behavior is observed. As the weight of the projectile decreases, the initial launching behavior becomes more unsafe.

Computation of Dynamic Fluid-Structure Interaction in a 2-Dimensional Laminar Channel Flow Divided by a Plate (판으로 나뉘어진 2차원 충류 채널유동에서 동적 유체-구조물 상호작용 수치해석)

  • Namkoong, Kak;Choi, Hyoung-Gwon;Yoo, Jung-Yul
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.26 no.12
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    • pp.1738-1746
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    • 2002
  • In the FSI (Fluid-Structure Interaction) problems, two different governing equations are to be solved together. One is fur the fluid and the other for the structure. Furthermore, a kinematic constraint should be imposed along the boundary between the fluid and the structure. We use the combined formulation, which incorporates both the fluid and structure equations of motion into a single coupled variational equation so that it is not necessary to calculate the fluid force on the surface of structure explicitly when solving the equations of motion of the structure. A two-dimensional channel flow divided by a Bernoulli-Euler beam is considered and the dynamic response of the beam under the influence of channel flow is studied. The Navier-Stokes equations are solved using a P2P1 Galerkin finite element method with ALE (Arbitrary Lagrangian-Eulerian) algorithm. The internal structural damping effect is not considered in this study and numerical results are compared with a previous work fer steady case. In addition to the Reynolds number, two non-dimensional parameters, which govern this fluid-structure system, are proposed. It is found that the larger the dynamic viscosity and density of the fluid are, the larger the damping of the beam is. Also, the added mass is found to be linearly proportional to the density of the fluid.