• Current Optics and Photonics
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• v.5 no.2
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• pp.141-146
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• 2021

We have evaluated the suppression effect of atmospheric-turbulence-induced optical scintillation in terrestrial free-space optical (FSO) communication systems using a gain-saturated erbium-doped fiber amplifier (EDFA). The variation of EDFA output signal power has been measured with different amounts of gain saturation and modulation indices of the optical input signal. From the measured results, we have found that the peak-to-peak power variation was decreased drastically below 2 kHz of modulation frequency, in both 3-dB and 6-dB gain compression cases. Then, the power spectral density (PSD) of optical scintillation has been calculated with Butterworth-type transfer function. In the calculation, different levels of atmospheric-turbulence-induced optical scintillation have been taken into account with different values of the Butterworth cut-off frequency. Finally, the suppression effect of optical scintillation has been estimated with the measured frequency response of the EDFA and the calculated PSD of the optical scintillation. From our estimated results, the atmospheric-turbulence-induced optical scintillation could be suppressed efficiently, as long as the EDFA were operated in a deeply gain-saturated region.

• Journal of Broadcast Engineering
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• v.23 no.4
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• pp.519-525
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• 2018

This paper deals with noise suppression of multi-channel data captured by microphone array using multi-channel Wiener filter. Multi-channel Wiener filter does not rely on information about the direction of the target speech and can be partitioned into an MVDR (Minimum Variance Distortionless Response) spatial filter and a single channel spectral filter. The acoustic transfer function between the single speech source and microphones can be estimated by subspace decomposition of multi-channel Wiener filter. The errors are incurred in the estimation of the acoustic transfer function due to the errors in the estimation of correlation matrices, which in turn results in speech distortion in the MVDR filter. To alleviate the speech distortion in the MVDR filter, diagonal loading is applied. In the experiments, database with seven microphones was used and MFCC distance was measured to demonstrate the effectiveness of the diagonal loading.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.2
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• pp.108-115
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• 2003

Suppression of cellular immunity is the host responses to surgical stress. When the body is exposed to surgical stress, decreased immunocyte function is one of the surgical stress-induced biologic responses. In all patients exposed to the surgical stress, peripheral blood lymphocyte numbers and function were suppressed until at least 2 weeks postoperatively. This immunosuppression was mainly due to a decrease of helper-inducer T cells, cytotoxic T cells, natural killer cells, and an increase of suppressor T cells. The blood levels of interleukin-6(IL-6) cytokine increase in response to surgical stress and cause an increase of so-called acute phase reactants, including C-reactive protein(CRP). In the previously damaged patients group, expected to early stress expose, immunosuppression was more developed than other normal groups. Cellular immunosuppression by surgical stress was mainly due to an increase of lymphocyte subsets that depress cellular immunity coupled with a decrease of the subsets that promote it. Overproduction of CRP in response to surgical stress may play an important role in the development of immunosuppression.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.5
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• pp.445-450
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• 2016

In this paper we study the effect of chaos in nonuniform instability with optical fiber based IoT networks. The transient response of optically controlled fiber has also described. Nonlinear optical fiber effects especially fiber scattering in networks has emerged as the essential means active optical devices. The paradigm instability in fiber Internet serves as a test for fundamental study of chaos and its suppression and exploitation in practical application in optical communication. This paper attempts to present a survey and some of our research findings on the nature of chaotic effect on Internet based optical communication. The transient response in optical fiber has been evaluated theoretically by calculating the variation of the scattering function. The lines has used under open ended termination containing optically induced region. The scattered optical waves in a fiber used in optic communications are temporally unstable above certain threshold intensity.

• Molecules and Cells
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• v.20 no.2
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• pp.196-200
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• 2005

The neurofibromatosis type2 (NF2) tumor suppressor gene product, merlin, is structurally related to the ezrin-radixin-moesin (ERM) family of proteins that anchor the actin cytoskeleton to specific membrane proteins and participate in cell signaling. However, the basis of the tumor suppressing activity of merlin is not well understood. Previously, we identified a role of merlin as an inhibitor of the Ras-ERK signaling pathway. Recent studies have suggested that phosphorylation of merlin, as of other ERM proteins, may regulate its function. To determine whether phosphorylation of merlin affects its suppression of Ras-ERK signaling, we generated plasmids expressing full-length merlin with substitutions of serine 518, a potential phosphorylation site. A substitution that mimics constitutive phosphorylation (S518D) abrogated the ability of merlin to suppress effects of the Ras-ERK signaling pathway such as Ras-induced SRE transactivation, Elk-mediated SRE transactivation, Ras-induced ERK phosphorylation and Ras-induced focus formation. On the other hand, an S518A mutant, which mimics nonphosphorylated merlin, acted like wild type merlin. These observations show that mimicking merlin phosphorylation impairs not only growth suppression by merlin but also its inhibitory action on the Ras-ERK signaling pathway.

• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.373-380
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• 2019

Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors $S1P_1$ and $S1P_2$ on cell motility have been investigated. However, the function of $S1P_3$ has been poorly investigated. In this study, the roles of $S1P_3$ on inflammatory response were investigated in primary peritoneal macrophages. $S1P_3$ receptor was induced along with sphingosine kinase 1 by stimulation of lipopolysaccharide (LPS). LPS treatment induced inflammatory genes, such iNOS, COX-2, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$. TY52156, an antagonist of $S1P_3$ suppressed the induction of inflammatory genes in a concentration dependent manner. Suppression of iNOS and COX-2 induction was further confirmed by western blotting and NO measurement. Suppression of $IL-1{\beta}$ induction was also confirmed by western blotting and ELISA. Caspase 1, which is responsible for $IL-1{\beta}$ production, was similarly induced by LPS and suppressed by TY52156. Therefore, we have shown $S1P_3$ induction in the inflammatory conditions and its pro-inflammatory roles. Targeting $S1P_3$ might be a strategy for regulating inflammatory diseases.

• Structural Engineering and Mechanics
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• v.82 no.3
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• pp.283-294
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• 2022

An inerter is a passive mechanical element whose inertance can be thousands of times its own physical mass. This paper discusses the application of an inerter-based passive control system, termed rotational inertial double-tuned mass damper (RIDTMD), to mitigate human-induced floor vibrations. First, the acceleration frequency response function of the floor with an RIDTMD is first derived. It is then employed to determine the optimal design parameters of the RIDTMD using the extended fixed-points technique. Based on a theoretical analysis, design-oriented empirical functions are proposed for the RIDTMD optimal parameters, whose performance for floor vibration control is evaluated by numerical examples, in which three typical human-induced load types are considered: walking, jumping, and bouncing. The results indicate that the applicability and effectiveness of the RIDTMD for human-induced floor vibration control are robust for various load types, load frequencies, and floor natural frequencies. For the same mass ratio, the RIDTMD is better than the TMD in reducing the floor vibration amplitude and improving the effective frequency suppression bandwidth, and for the same vibration suppression effect, the mass of the RIDTMD is much lighter than that of the TMD.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.67.2-68
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• 2003

A rice cultivar, Taebaegbyeo, is highly resistant to rice blast and moderately resistant to bacterial leaf blight (BLB) caused by Magnaporthe grisea and Xanthomonas oryzae pv. oryzae, respectively. To study the rice disease resistance mechanism, we generated rice deletion M3 mutants by gamma-ray irradiation. Blast and BLB responses of 16,000 M3 mutants were screened by inoculating mixtures of 4 races (KJ-201, H-1113a, KI-313, KI-409) of M. grisea and 3 Korean races of X. oryzae pv. oryzae. We selected so far 21 M3 mutants of Taebaegbyeo showing high susceptibility to the diseases. One of the mutants, KCT-6417, was susceptible to KI-1113a race of M. grisea, suggesting the deletion of a race-specific blast resistance gene in the mutant. To isolate rice genes involved in blast resistance and defense response, we take a PCR-based suppression subtractive hybridization approach using cDNAs of blast-inoculated wild type and the KCT-6417 as a tester and a driver, respectively. Genes specifically expressed in the wild type will be presented. The selected genes would give us a clue to understand mechanism for the race specific resistance and defense responses against M. grisea H-1113a in Taebaegbyeo.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5747-5751
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• 2013

Golgi phosphoprotein 2 (GOLPH2) is a very important biomarker in a variety of diseases. Its biological function is not clear, particularly in gastric cancer. To investigate the role of GOLPH2 in human gastric cancer, and determine its effect on the Th1 lymphocyte response, its expression and that of IL-12A were measured by real-time PCR and immunohistochemistry. The relationship between GOLPH2 and IL-12A was analysed statistically. The effect of GOLPH2 on the Th1 lymphocyte response was investigated with an in vitro co-culture system. The results showed that in human gastric cancer, the expression of GOLPH2 was significantly higher and the expression of IL-12A was lower than in normal gastric mucosal tissues, and the expression levels of GOLPH2 and IL-12A were negatively correlated. In addition, obvious down-regulation of the Th1 response was observed when lymphocytes were co-cultured with gastric cancer SGC7901 cells over-expressing GOLPH2. GOLPH2 down-regulated the expression of IL-12A, and inhibited the expression of TNF-${\alpha}$ and IFN-${\gamma}$. The results indicated that GOLPH2 down-regulates the Th1 response via suppression of IL-12A in human gastric cancer, and this might provide a target for the prevention and treatment.

• ETRI Journal
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• v.35 no.3
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• pp.538-541
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• 2013

A compact microstrip lowpass filter (LPF) with an elliptic function response is proposed. A high equivalent capacitance and inductance between the structures of the resonator result in the sharp transition band of 0.04 GHz from 4 GHz to 4.04 GHz with an attenuation level of -3 dB and -20 dB, respectively. To improve the LPF rejection band, multiple open stubs are connected to the proposed resonator. A filter with a 3-dB cut-off frequency at 4 GHz is designed, fabricated, and measured, and agreement between the measured and simulated results is achieved. The results show that a stopband bandwidth of 131% with a suppression level better than -20 dB is obtained while achieving a compact size with a wide stopband.