• Proceedings of the KSR Conference
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• 2010.06a
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• pp.872-879
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• 2010

High rock-fill embankment is relatively flexible, which makes crest of embankment subject to excessive amplification in displacement due to earthquake loading. To overcome problems related with site response in high embankment, it is essential to evaluate shear-wave velocity profile of the embankment with improved accuracy and reliability. In this aspect, an experimental research was performed to answer how to perform surface-wave tests and to analyze measurements at an embankment site with a sloping ground surface. Unlike flat ground surface, sloping ground may hamper and slow down propagation of surface waves due to multiple reflections and refractions in embankment. To figure out this reasoning for the effect of multiple reflections and refractions due to sloping surface, surface wave tests were performed at a reservoir embankment of Chung-Song in North KyeongSang Province. Parameters involved in surface wave tests at non-flat surface, including source directionality, geometry-related constraint and frequency components in source function, were investigated using field measurements.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.679-682
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• 2002

Resistance spot welding using air gun has been used for joining the sheet metal in automotive manufacturing process. Although air gun has many advantages, it also has the limitation to control the pressure as a factor to improve weld quality. In this study, we apply servo gun using servo motor to resistance spot welding and find the relationship between welding pressure and welding quality. Trough the experiment to change welding pressure during the welding cycle, we can make it clear that the change of welding pressure is greatly influence on the welding quality. To get in a. using response surface methodology, drew out the optimal welding pressure profile for welding quality progresses. We made an optimal profile of welding pressure which improves welding quality using response surface methodology.

• Steel and Composite Structures
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• v.17 no.6
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• pp.951-965
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• 2014

Point bending is commonly used for cambering and curving steel girders to large radii. In this system, a hydraulic ram or press is used to apply concentrated loads at selected points to obtain the required vertical (cambering) or horizontal (curving) curved profile from induced permanent deformations. This paper derives closed form solutions that relate loads to permanent deformations for horizontally curving wide flange steel beams based on their post-yield response. These solutions are presented in a parametric form to identify the relationship between key variables and their impact on the accuracy of the curving operation. It is shown that point bending could yield parabolic curved profiles that are within 1% of a desired circular curve if the span length to radius of curvature ratio (L / R) is less than 1.5 and the point loads are spaced at one third the beam length. Safe limits are then established on loads, strains and curvatures to avoid damaging the steel section. This leads to optimization of the point bending operation for inducing a circular profile in wide flange steel beams of any size.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.5 no.2
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• pp.90-97
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• 1996

The purpose of this study is the development of a lathe which can cut any pistons of oval shape with high speed, accuracy and precision by CNC (Computer Numerical Control) method. Yaxis which is the mechanism of position determination with high speed response has been added to the CNC lathe and ovality and profile has been cut under the synchronous control of C-Y-Z axes. In the case of ovality of ø 0.5mm. the productivity can be improved up to 1500rpm by high speed cutting than modeling method.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.11 s.176
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• pp.111-117
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• 2005

The vibration problems associated with gear coupled rotors have been the focus of much engineering work. These systems are complex and difficult to analyze in that they have the problems associated with conventional rotors plus those additional problems associated with the gear couplings. This paper examines the problems peculiar to the gear mesh. Because of the meshing action of gears, the elasticity of the gear teeth introduces time-varying stiffness coefficients into the governing equations of motion. This means that system response must be thought of in terms of Mathieu-type equations, where multiple-frequency response occur due to the periodic coefficients. The meshing action of the gears also couples the lateral and torsional gear motions. Gear errors, such as tooth profile and spacing errors, produce forces and torque that excite the system at multiple frequencies, some of which are much higher than shaft rotational speed. To investigate how to the time-varying stiffness in the gear teeth and the gear errors act one the dynamic response of the gear coupled rotors, a three-dimensional dynamic model with lateral-tortional oscillation is developed. The harmonic balance technique is employed to solve this mathieu-type problem.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.171-176
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• 2012

HaCaT cells are the immortalized human keratinocytes and have been extensively used to study the epidermal homeostasis and its pathophysiology. T helper cells play a role in various chronic dermatological conditions and they can affect skin barrier homeostasis. To evaluate whether HaCaT cells can be used as a model cell system to study abnormal skin barrier development in various dermatologic diseases, we analyzed the gene expression profile of epidermal differentiation markers of HaCaT cells in response to major T helper (Th) cell cytokines, such as $IFN{\gamma}$, IL-4, IL-17A and IL-22. The gene transcriptional profile of cornified envelope-associated proteins, such as filaggrin, loricrin, involucrin and keratin 10 (KRT10), in HaCaT cells was generally different from that in normal human keratinocytes (NHKs). This suggests that HaCaT cells have a limitation as a model system to study the pathophysiological mechanism associated with the Th cell cytokine-dependent changes in cornified envelope-associated proteins which are essential for normal skin barrier development. In contrast, the gene transcription profile change of human ${\beta}2$-defensin (HBD2) in response to $IFN{\gamma}$, IL-4 or IL-17A in HaCaT cells was consistent with the expression pattern of NHKs. $IFN{\gamma}$ also up-regulated transglutaminase 2 (TGM2) gene transcription in both HaCaT cells and NHKs. As an alternative cell culture system for NHKs, HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and TGM2 expression in response to $IFN{\gamma}$, IL-4 or IL-17A.

• Journal of the Korean GEO-environmental Society
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• v.9 no.4
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• pp.53-61
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• 2008

Various components including wave scattering, wave passage, and site amplification effects cause the ground motion to vary spatially. The spatially varying ground motion can significantly influence the dynamic response of longitudinal structures such as bridges and tunnels. While its effect on bridges has been extensively studied, there is a lack of study on its effect on underground tunnels. This paper develops a new procedure for simulating the tunnel response under spatially varying ground motion. The procedure utilizes the longitudinal displacement profile, which is developed from spatially variable ground motion time histories. The longitudinal displacement profile is used to perform a series of pseudo-static three dimensional finite element analyses. Results of the analyses show that the spatially variable ground motion cause longitudinal bending of the tunnel and can induce substantial axial stress on the tunnel lining. The effect can be significant at boundaries at which the material properties of the ground change in the longitudinal direction.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.2
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• pp.15-28
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• 2020

Objective : The purpose of this study was to verify the construct validity of Short Sensory Profile-2 (SSP-2) for children with Autism Spectrum Disorder (ASD). Methods : Data were collected from SSP-2 for 120 parents of ASD children. Raw data were analyzed by applying the Rasch analysis to the goodness fit of person and item, item difficulty, rating scale, and separation reliability of SSP-2. Results : 7 persons in sensory processing area and 8 persons in behavioral response area were inappropriate criteria and excluded from the analysis. Item goodness-of-fit analysis determined that the If the Mnsq value is between 0.6 and 1.4 and the Z value is outside the ±2 range for nonconformity. this study All items in the instrument were found to have appropriate criteria. Item difficulty analysis in sensory processing area was high in item 13 (.48 logit) and low in item 10 (-.54 logit). In the behavioral response area, item 25 (1.58 logit) was high and item 30 (-.68 logit) was low. In the rating scale analysis, it was found that the 3-point scale is more appropriate than the 5-point scale. The separation reliability of sensory processing area was .90 and the behavioral response area was .95. Conclusion : This study verified the construct validity of SSP-2 and expected to be applied as a useful evaluation tool for children with ASD.

• Journal of the Korean Geotechnical Society
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• v.19 no.4
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• pp.211-221
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• 2003

The response displacement method is the most frequently used method for seismic design of underground structures. This method is pseudo-static method, and the evaluations of velocity response spectrum of seismic base and response displacement of surrounding soil are the most important steps. In this study, the evaluation of velocity response spectrum of seismic base according to the Korean seismic design guide and the simple method of calculating the response displacement were studied. It was found that velocity response spectrum of seismic base can be estimated by directly integrating the ground-surface acceleration response spectrum of soil type S$_A$, and the evaluation of the response displacement using double cosine method assuming two layers of soil profile shows the advantages in the seismic design.

• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.31-44
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• 2008

The forced swim test (FST) is the most widely used model for assessing potential antidepressant activity. Although it has been shown that lateral septum is involved with the FST-related behavior, it is not clear whether antidepressant treatments could alter the FST-induced gene expression profile in the lateral septum. In the present study, the gene expression profiles in response to FST and reboxetine pretreatment were observed in the lateral septum of rats. Reboxetine is known as a most selective serotonin norepinephrine reuptake inhibitor. In addition, we compared the changes in gene expression profile between reboxetine response and nonresponse groups, which were determined by counting FST-related behavior. After FST, lateral septum from controls and reboxetine pretreated group were dissected and gene expression profiles were assessed using an Affymetrix microarray system containing 15,923 genes. Various genes with different functions were changed in reboxetine response group compared with reboxetine nonresponse group, In particular, pleiotrophin, orexin receptor 2, serotonin 2A receptor, neuropeptide Y5 receptor and thyroid hormone receptor $\beta$ were decreased in reboxetine response group, but Lim motif-containing protein kinase 1 (Limk1) and histone deacetylase 1 (HDAC1) were increased. Although further studies are required for direct roles of these genes in reboxetine response, the microarray may provide tools to find out potential target genes and signaling pathways in antidepressant response.