• Journal of Biomedical Engineering Research
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• v.38 no.2
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• pp.82-88
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• 2017

Enlargement of the lateral ventricles have been identified as a surrogate marker of neurological disorders. Quantitative measure of the lateral ventricle from MRI would enable earlier and more accurate clinical diagnosis in monitoring disease progression. Even though it requires an automated or semi-automated segmentation method for objective quantification, it is difficult to define lateral ventricles due to insufficient contrast and brightness of structural imaging. In this study, we proposed a fully automated lateral ventricle segmentation method based on a graph cuts algorithm combined with atlas-based segmentation and connected component labeling. Initially, initial seeds for graph cuts were defined by atlas-based segmentation (ATS). They were adjusted by partial volume images in order to provide accurate a priori information on graph cuts. A graph cuts algorithm is to finds a global minimum of energy with minimum cut/maximum flow algorithm function on graph. In addition, connected component labeling used to remove false ventricle regions. The proposed method was validated with the well-known tools using the dice similarity index, recall and precision values. The proposed method was significantly higher dice similarity index ($0.860{\pm}0.036$, p < 0.001) and recall ($0.833{\pm}0.037$, p < 0.001) compared with other tools. Therefore, the proposed method yielded a robust and reliable segmentation result.

• Journal of Power Electronics
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• v.13 no.3
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• pp.469-478
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• 2013

This paper proposes a novel scheme for the current controller for the grid-side converter (GSC) of permanent-magnet synchronous generator (PMSG) wind turbines to eliminate the high-order harmonics in the grid currents under grid voltage disturbances. The voltage unbalance and harmonics in three-phase systems cause grid current distortions. In order to mitigate the input current distortions, multi-loop current controllers are applied, where the positive-sequence component is regulated by proportional-integral (PI) controllers, and the negative-sequence and high-order harmonic components are regulated by proportional-resonance (PR) controllers. For extracting the positive/negative-sequence and harmonic components of the grid voltages and currents without a phase delay or magnitude reduction, composite observers are applied, which give faster and more precise estimation results. In addition, an active damping method using PR controllers to damp the grid current component of the resonant frequency is employed to improve the operating stability of VSCs with inductor-capacitor-inductor (LCL) filters. The validity of the proposed method is verified by simulation and experimental results.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.606-611
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• 2003

Byakangelicin, 9-(2,3-dihydroxy-2-methylbutoxy)-4-methoxy-7H- furo[3,2-g][l]benzopyran-7-one (BKG), a component of Angelicae dahuricae Radix, is considered to be an inhibitor of aldose reductase for the treatment of diabetic cataract. An analytical method for the isolation of BKG developed by high-performance liquid chromatography has been reported. No literature on the metabolism of BKG, however, has been found. With the purpose of identifying new metabolites of BKG, BKG (100 mg/kg) was orally administered to Sprague-Dawley rats via a gavage. Using a metabolic cage, urine was collected for 24 h, and the urine samples were extracted by liquid-liquid extraction. For structural identification of new urinary metabolites of BKG, various instrumental analyses were conducted by gas-chromatography/mass spectrometry, high-performance liquid chromatography/diode array detector, liquid chromatography/mass spectroscopy with thermospray interface and $^1H$ nuclear magnetic resonance spectroscopy. Two metabolites produced from the Ο-demethylation or Ο-dealkylation of BKG were newly identified, and another new but unknown metabolite was assumed to be the hydroxylated form of BKG. These results indicate that the major metabolic products of BKG are formed by Ο-demethylation or Ο-dealkylation of BKG side chains.

• Investigative Magnetic Resonance Imaging
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• v.13 no.1
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• pp.81-87
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• 2009

Purpose : We sought to evaluate enhancement of plaque with gadolinium-based contrast agent by magnetic resonance imaging (MRI) in comparison with histopathology, namely lipid-rich and macrophage-rich components that were two representative characteristics of plaque vulnerability using atherosclerotic rabbit aorta in order to determine which histopathologic component is relevant to the enhancement. Materials and Methods : New Zealand white rabbit (n=4, weight 3.0 to 3.5 kg, all male) was used for animal model of atherosclerosis. Atherosclerotic aortic lesions were induced by high-cholesterol diet and double balloon injury. T1-weight axial images were acquired before and after gadolinium-based contrast agent using a 3-T MRI. MR images and the matched histopathological sections (n=35) were divided into 4 quadrants or 3 (n=130). Enhancement ratio (ER, ER=SIpost/SIpre) on MRI was calculated for each quadrant and compared with histopathology in regard to lipid-rich and macrophage-rich areas. Results : Lipid-rich quadrants were 72 and fibrous quadrants were 58. The number of quadrants which had macrophage-rich areas was 105 and that of quadrants which did not have macrophage-rich areas was 25. ER was significantly higher in lipid-rich quadrants than in fibrous quadrants (mean ER 2.25c$\pm$0.41 vs. 2.72$\pm$0.65, p=0.013). ER poorly correlated with macrophage-rich areas when lipid-component was controlled (correlation coefficient -0.203, p=0.236). Conclusion : Lipid-rich plaques showed stronger enhancement than fibrous plaques using a standard gadolinium-based extracellular contrast agent. Macrophage infiltration did not correlate with degree of enhancement. Further study is warranted that account for optimal time of imaging after contrast injection using various plaque models from early to advanced stages and all possible parameters associated with contrast enhancement.

• KIEE International Transactions on Power Engineering
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• v.3A no.3
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• pp.139-147
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• 2003

The paper presents a novel approach of constructing the state matrix of the multi-machine power system for SSR (subsynchronous resonance) analysis using the linearized equations of individual devices including electrical transmission network dynamics. The machine models in the local d-q reference frame are integrated with the network models in the common R-I reference frame by simply transforming their output equations into the R-I frame where the transformed output is used as the input to the network dynamics or vice versa. The salient feature of the formulation is that it allows for modular construction of various component models without rearranging the overall state space formulation. This universal SSR small signal stability program provides a flexible tool for systematic analyses of SSR small-signal stability impacts of both conventional devices such as generation systems and novel devices such as power electronic apparatus and their controllers. The paper also presents its application results to IEEE benchmark models.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.7
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• pp.1210-1216
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• 2003

Topology optimization is applied to determine the layout of a structural component with a specified frequency by minimizing the difference between the specified structural frequency and a given frequency. The homogenization design method is employed and the topology design problem is solved by the optimality criteria method. The value of a weighting factor in the optimality criteria plays an important role in this topology design problem. The modified optimality criteria method approximated by using the binomial expansion is suggested to determine the suitable value of the weighting factor, which makes convergence stable. If a given frequency is set as an excited frequency, it is possible to avoid resonance by moving away the specified structural frequency from the given frequency. The results of several test problems are compared with previous works and show the validity of the proposed algorithm.

• Journal of Power System Engineering
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• v.13 no.6
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• pp.88-94
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• 2009

In this paper, vibration characteristics after applying variable speed control to fans with a rated speed used in a power plant are studied by performing experiments and analyzing finite element models. Then the campbell diagram is presented to verify the reason of the abnormal vibration measured from fan structure during variable operation of Forced Draft Fan & Induced Draft Fan. According to results, it is found that amplitude of acceleration increases abruptly when a 2X harmonic component meets the natural frequency of fan rotor. Therefore it is very important thing that investigate exactly dynamic characteristics for the rotor at variable speed zone before applying variable speed control to a rotor with a rated speed.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2005.11a
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• pp.101-106
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• 2005

This paper presents a new microwave oscillator incorporating a corrugated coplanar waveguide (CCPW) electromagnetic bandgap (EBG) structure as its terminating resonance component. The use of a compact CCPW EBG structure was effective in reducing the phase noise and improving the harmonic characteristics of the microwave oscillator circuit without additional backside processing and drastic size increment. The fully planar CCPW oscillator oscillating at the frequency of 5.41 GHz showed a phase noise characteristic of -90.7 dBc/Hz at 100kHz offset and a second harmonic suppression of 42.67 dB.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.947-950
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• 2007

In this study, vibration analysis of a refrigerator was carried out to reduce vibration by considering grommet. When the refrigerator machine room is modeled by finite element method, spring elements are added to constructions of the FEmodel for each component and update. To design the grommet of refrigerator, FEmodel must have vibration characteristics of each components such as baseplate, pipe and compressor it self. The modal analyses are conducted to validate suggested approach when the components of machine room are assembled together. And, in this study, optimal design of grommet is conducted to avoid the resonance at the operating frequency of refrigerator. The experimental and FEM result of suggested design showed good agreement and are presented here.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.12
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• pp.2273-2277
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• 2010

In this paper a 2.4GHz CMOS colpitts type microwave oscillator was designed and fabricated using H-spice and Cadence Spetre. There are 140MHz difference between the oscillation frequency and the resonance frequency of a tank circuit of the designed oscillator. The difference is seemed to be due to the parasitic component of the transistor. The inductors used in this design are the spiral inductors proposed in other papers. Cascode current source was used as a bias circuit of a oscillator and the output transistor of the current source is used as the oscillation transistor. A common drain buffer amplifier was used at the output of the oscillator. The measured oscillation frequency and output power of the oscillator are 2.173GHz and -5.53dBm.