• 대한한방내과학회지
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• 제37권4호
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• pp.609-623
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• 2016

Objective: This study was undertaken to investigate the effects of Mori folium on insulin resistance and adipose tissue inflammation in an experimental mouse model of obesity.Methods: Obesity was induced in C57BL/6 mice by feeding them a high-fat diet. The mice were divided into four groups (n=6): a normal diet, high-fat diet, high-fat diet with 40 mg of Mori folium, and high-fat diet with 800 mg of Mori folium groups. After 13 wk, the body weights, fasting blood glucose and fasting serum insulin levels, insulin resistance (homeostatic model assessment) levels, oral glucose tolerance test levels, epididymal fat and liver weights, and gene expression of tumor necrosis factor-α, interleukin-6, and interferon-γ were measured. In addition, adipose tissue macrophages were analyzed by fluorescence-activated cell sorting.Results: Mori folium significantly reduced blood glucose levels, oral glucose tolerance levels, and liver weights. It also reduced adipose tissue macrophage numbers and tumor necrosis factor receptor-α gene expression.Conclusions: These results show that Mori folium has insulin resistance reduction and anti-inflammatory effects in an experimental mouse model of obesity.

• 산업기술연구
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• 제25권B호
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• pp.63-71
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• 2005

This paper is an experimental result of investigating lateral soil movements at piled bridge abutments by using the centrifuge model facility. Three different centrifuge model experiments, changing the methods of ground improvement at bridge abutment on the soft clayey soil (no improvement, preconsolidation and plastic board drains (PBD), sand compaction pile (SCP) + PBD), were carried out to figure out which method is the most appropriate for resisting against the lateral soil movements. In the centrifuge modelling, construction process in field was reconstructed as close as possible. Displacements of abutment model, ground movement, vertical earth pressure, cone resistance after soil improvement and distribution of water content were monitored during and after centrifuge model tests. As results of centrifuge model experiments, preconsolidation method with PBD was found to be the most effective against the lateral soil movement by analyzing results about displacements of abutment model, ground movement and cone resistance. Increase of shear strength by preconsolidation method resulted in increasing the resistance against lateral soil movement effectively although SCP could mobilize the resistance against lateral soil movement. It was also found that installment with PBD beneath the backfill of bridge abutment induced effective drainage of excess pore water pressure during the consolidation by embanking at the back of the abutment and resulted in increasing the shear strength of clay soil foundation and eventually increasing the resistance of lateral soil movement against piles of bridge abutment.

• Molecules and Cells
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• 제25권1호
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• pp.119-123
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• 2008

Pyrimidine antagonists including 5-Fluorouracil (5-FU) have been used in chemotherapy for cancer patients for over 40 years. 5-FU, especially, is a mainstay treatment for colorectal cancer. It is a pro-drug that is converted to the active drug via the nucleic acid biosynthetic pathway. The metabolites of 5-FU inhibit normal RNA and DNA function, and induce apoptosis of cancer cells. One of the major obstacles to successful chemotherapy is the resistance of cancer cells to anti-cancer drugs. Therefore, it is important to elucidate resistance mechanisms to improve the efficacy of chemotherapy. We have used C. elegans as a model system to investigate the mechanism of resistance to 5-FU, which induces germ cell death and inhibits larval development in C. elegans. We screened 5-FU resistant mutants no longer arrested as larvae by 5-FU. We obtained 18 mutants out of 72,000 F1 individuals screened, and mapped them into three complementation groups. We propose that C. elegans could be a useful model system for studying mechanisms of resistance to anti-cancer drugs.

• Tribology and Lubricants
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• 제12권4호
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• pp.52-59
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• 1996

The results of the electrical contact conductivity of multi-contact spots accounting the surface roughness and the non-conductive films of different origins such as air, water, cutting oil, and machining oil are presented. The array of metal spheres compressed between two flat plates has been used for simulation of the contact behavior of multiple contact of solids, under normal loading. Measurement of electrical contact resistance has been made using the equipment providing the adequate accuracy in the range of micro Ohms. The data on electrical contact resistance have been compared with theoretical predictions using the multiple contact model of constriction resistance. The effect of single spot number and array on conductivity of contact has been evaluated. The results of the experiments show that the contact resistance are closely related to the number of loading cycles, form of surface roughness, and presence of non-conductive films that reduce the size of the real electrical contact spots.

• 약학회지
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• 제56권6호
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• pp.364-365
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• 2012

Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.

• 품질경영학회지
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• 제42권3호
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• pp.387-406
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• 2014

Purpose: The widespread use of social network services (SNS) has caused users concern about the disclosure of their privacy or personal information. The purpose of this study is to analyze the factors of privacy concern and self presentation that affect the user resistance in the use of social network service. Methods: This study verifies the factors that affecting the user resistance in SNS. The research model suggested in this study is tested via a survey of 260 SNS users. SPSS and Smart PLS had been used to test the suggested hypotheses. Results: This study shows that privacy experience, privacy awareness, self esteem, and social desirability significantly influence perceived risk and that privacy awareness, self esteem, self efficacy, and perceived risk significantly influence perceived trust. It also verifies that perceived risk and perceived trust positively affect user resistance. Conclusion: This paper suggests that high awareness on privacy of SNS user encourages the SNS companies to consider the privacy protection mechanism for eliminating various factors that affecting the risk. This study also shows that the privacy calculus model applies to understanding the mechanism on resistance of SNS user.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 1993년도 Proceedings of International Conference for Agricultural Machinery and Process Engineering
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• pp.1176-1185
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• 1993

The purpose of this study is to propose a new dynamic model of wheels and agricultural tractors through verification of the existence of " lift resistance " and "perpendicular adhesion" which also can be called " contra-retractive adhesion". The existence of these forces was proved through experiments including the development of a sensor which can measure the forces acting on a wheel accurately. Consequently " perpendicular adhesion ratio" which is defined as the ratio of the perpendicular adhesion to the distributed load was observed to be in the range of 0.05 to 0.3. This means the influence of the " lift resistance " is comparable to that of motion resistance in wheel dynamics. The perpendicular adhesion ratio was observed to decrease logarithmically with the increase of ground contact pressure, and to increase linearly with increase of the travel speed of the wheel . Some examples to express the new dynamic model compared to the conventional dynamics are explained.

• 대한조선학회논문집
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• 제48권6호
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• pp.544-551
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• 2011

The internal flows of moonpool usually causes huge added resistance on drillships, and those are very complex to analyze. Therefore, not only experimental approaches but also numerical simulations are required for better investigations when dealing with the hydrodynamic problems of moonpool. In the present research, numerical simulations are used to find out why the resistance increases by moonpool on a running drillship. That is, the three-dimensional numerical simulations and model tests are carried out to examine the characteristics of internal flow and added resistance by changing the section of the moonpool in both longitudinal and transverse directions. Finally, based on the present studies, an optimized shape of the moonpool is suggested, which effectively reduces added resistance, and that is confirmed with three-dimensional numerical simulations and model tests.

• Journal of Mechanical Science and Technology
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• 제19권6호
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• pp.1338-1346
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• 2005

Effects of thermal contact resistance between heater and susceptor, susceptor and graphite board in a MOCVD reactor on temperature distribution and film growth rate were analyzed. One-dimensional thermal resistance model considering thermal contact resistance and heat transfer area was made up at first to find the temperature drop at the surface of graphite board. This one-dimensional model predicted the temperature drop of 18K at the board surface. Temperature distribution of a reactor wall from the three-dimensional computational fluid dynamics analysis including the gap at the wafer position showed the temperature drop of 20K. Film growth rates of InP and GaAs were predicted using computational fluid dynamics technique with chemical reaction model. Temperature distribution from the three-dimensional heat transfer calculation was used as a thermal boundary condition to the film growth rate simulations. Temperature drop due to the thermal contact resistance affected to the GaAs film growth a little but not to the InP film growth.

• Journal of Crop Science and Biotechnology
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• 제11권3호
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• pp.177-180
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• 2008

Worldwide, cyst nematode(Heterodera glycines Ichinohe) is the most destructive pathogen of cultivated soybean. In the USA, current annual yield losses are estimated to be nearly a billion dollars. Crop losses are primarily reduced by the use of resistant cultivars. Nematode populations are variable and have adapted to reproduce on resistant cultivars over time because resistance primarily traces to two soybean accessions. It is important to use diverse resistance sources to develop new nematode resistant cultivars. Soybean PI 494182 is a recent introduction from Japan and found to be resistant to multiple nematode populations. It is yellow seeded and maturity group 0. We have determined inheritance of resistance in PI 494182 using $F_{2:3}$ families derived from cross PI 494182 X cv. Skylla. Skylla is a susceptible parent. Three nematode populations, races 1, 3, and 5, corresponding to HG types 2.5.7, 0, and 2.5.7 were used to bioassay 162 $F_{2:3}$ families in greenhouse experiments. Based on Chi-square tests, a two-gene model is proposed for resistance to race 1 and a three-gene model is proposed for conditioning resistance to both races 3 and 5. Correlation coefficient analysis indicated that some genes conditioning resistance to races 1, 3, and 5 are shared or closely linked with each other. These results will be useful to soybean breeders for developing soybean cultivars for broad resistance to nematodes.