• Journal of Institute of Control, Robotics and Systems
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• v.17 no.11
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• pp.1082-1089
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• 2011

Most engineered systems are designed with high levels of system redundancies to satisfy required reliability requirements under adverse events, resulting in high systems' LCCs (Life-Cycle Costs). Recent years have seen a surge of interest and tremendous advance in PHM (Prognostics and Health Management) methods that detect, diagnose, and predict the effects of adverse events. The PHM methods enable proactive maintenance decisions, giving rise to adaptive reliability. In this paper, we present a RAP (Resilience Allocation Problem) whose goal is to allocate reliability and PHM efficiency to components in an engineering context. The optimally allocated reliability and PHM efficiency levels serve as the design specifications for the system RBDO (Reliability-Based Design Optimization) and the system PHM design, which can be used to derive the detailed design of components and PHM units. The RAP is demonstrated using a simplified aircraft control actuator design problem resulting in a highly resilient actuator with optimally allocated reliability, PHM efficiency and redundancy for the given parameter settings.

• Animal Bioscience
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• v.35 no.6
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• pp.791-803
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• 2022

Genome/gene-editing (GE) techniques, characterized by a low technological barrier, high efficiency, and broad application among organisms, are now being employed not only in medical science but also in agriculture/veterinary science. Different engineered CRISPR/Cas9s have been identified to expand the application of this technology. In pig production, GE is a precise new breeding technology (NBT), and promising outcomes in improving economic traits, such as growth, lean or healthy meat production, animal welfare, and disease resistance, have already been documented and reviewed. These promising achievements in porcine gene editing, including the Myostatin gene knockout (KO) in indigenous breeds to improve lean meat production, the uncoupling protein 1 (UCP1) gene knock-in to enhance piglet thermogenesis and survival under cold stress, the generation of GGTA1 and CMP-N-glycolylneuraminic acid hydroxylase (CMAH) gene double KO (dKO) pigs to produce healthy red meat, and the KO or deletion of exon 7 of the CD163 gene to confer resistance to porcine reproductive and respiratory syndrome virus infection, are described in the present article. Other related approaches for such purposes are also discussed. The current trend of global regulations or legislation for GE organisms is that they are exempted from classification as genetically modified organisms (GMOs) if no exogenes are integrated into the genome, according to product-based and not process-based methods. Moreover, an updated case study in the EU showed that current GMO legislation is not fit for purpose in term of NBTs, which contribute to the objectives of the EU's Green Deal and biodiversity strategies and even meet the United Nations' sustainable development goals for a more resilient and sustainable agri-food system. The GE pigs generated via NBT will be exempted from classification as GMOs, and their global valorization and commercialization can be foreseen.