• 제목/요약/키워드: residual time

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Study on the changes of sulfamethnzine residues in serum and practical organs of rats orally administrated with sulfamethnzine sodium (Rat에 sulfamethazine sodium 경구투여 후 혈청 및 실질장기내 sulfamethazine의 잔류량 추이에 관한 연구)

  • 도재철;이영미;조민희;신상희;박희주;송희종;정종식
    • Korean Journal of Veterinary Service
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    • v.23 no.4
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    • pp.321-333
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    • 2000
  • In order to know the depletive changes of sulfamethazine residues in senlm and practical organs of rats orally administered with sulfamethazine sodium(SMS), the concentration of sulfamethazine was measured in serum and tissue(kidney, liver, spleen, testis, and skeletal muscle) of rats with using high performance liquid chromatography(HPLC). SMS was orally administrated to sprague-dawley male rats(body weight, 200~300g) with using sonde at the rate of 20mg/100g body weight(recommended therapeutic dose) on once a day for 3 days. There were investigated the depletive changes of the sulfamethazine in serum, kidney, liver, spleen, testis and skeletal muscle of rat at the time 8 hours, 1st, 2nd, 3rd, 4th, 5th and 6th day after administration SMS, respectively. The results obtained were summarized as follows; 1. After oral administration of the SMS, the mean concentrations of sulfamethazine in serum according to the time lapsed were showed 215.53$\pm$42.99ppm at the 8 hours after withdrawal of medicated sulfamethazine. And gradually according to the time lapsed, the concentrations of sulfamethazine residues in serum were significantly (p<.05) decreased 25.87$\pm$5.18ppm at 1st day, 2.30$\pm$0.61ppm at 3rd day and 0.11$\pm$0.02ppm at 6th day respectively. 2. The mean concentrations of sulfamethazine in kidney, liver, spleen, muscle and testis according to the time lapsed after administration SMS were showed 83.82$\pm$12.16, 81.77$\pm$12.88, 36.96$\pm$5.35, 35.96$\pm$TEX>$\pm$1.39 and 27.89$\pm$1.92 ppm at the 8 hours, respectively. And gradually according to the time lapsed, the concentrations of sulfamethazine residues in the each of samples were significantly(p<.05) decreased such as 7.15$\pm$0.26, 5.62$\pm$0.72, 2.43$\pm$0.29, 1.99$\pm$0.14 and 3.11$\pm$0.48 ppm at 1st day, 0.52$\pm$0.04, 1.32$\pm$0.22, 0.13$\pm$0.03, 0.15$\pm$0.06 and 0.26$\pm$0.11ppm at 3rd day, and 0.03$\pm$0.01, 0.11$\pm$0.03, 0.02$\pm$0.01, 0.009$\pm$0.001 and 0.02$\pm$0.01 ppm at 6th day, respectively. 3. After oral administration of the SMS to rats, the residual concentrations of sulfamethazine in skeletal muscle were significantly (p<.05) decreased 35.96$\pm$1.39 to 0.009$\pm$$\pm$0.001 ppm between 8 hours and 6th day, respectively From the 4th day, the residual concentrations of sulfamethazine were showed 0.10$\pm$0.04 ppm below 0.1 ppm at the permitted limit concentration of muscle in Korea. In conclusion, this study could be suggested the relationship between administrated period, doses of sulfonamides and residual aspects of serum and practical organs, and the importance of observing ceasing period of antibiotic drugs before forwarding livestocks to slaughter.

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Results of Radiation Therapy and Extrafascial Hysterectomy in Bulky Stage IB, IIA-B Carcinoma of the Uterine Cervix (종괴가 큰 병기 IB, IIA-B 자궁경부암에서 방사선치료와 Extrafascial Hysterectomy의 결과)

  • Kim Jin Hee;Lee Ho Jun;Choi Tae Jin;Do Cha Soon;Lee Tae Sung;Kim Ok Bae
    • Radiation Oncology Journal
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    • v.17 no.1
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    • pp.23-29
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    • 1999
  • Purpose : To evaluate the efficacy of radiation therapy and extrafascial hysterectomy in bulky stage IB, IIA-B uterine cervix cancers. Methods and Materials : Twenty four patients with bulky stage IB and IIA-B carcinoma of the uterine cervix were treated with extrafascial hysterectomy following radiation therapy due to doubts of residual disease at Department of therapeutic radiology, Keimyung University, Dongsan Hospital, from April 1986 to December 1997 According to FIGO staging system, there were 7 patients with stage IB, 9 patients with IIA and 8 patients with IIB stage whose median age was 45. Pathologic distribution showed 16 patients with squamous cell carcinoma and 8 patients with adenocarcinoma. Seven patients had tumors that are less than 5cm in size and 17 patients had tumors with larger than 5cm. The mean interval between radiation therapy and extrafascial hysterectomy was 57 days. The radiation therapy consisted of external irradition to the whole pelvis (180 cGy/fraction, mean 4100 cGy) and parametrial boost (for a mean total dose of 5000 cGy) with midline shield (4H 10 cm), followed by intracavitary irradiation up to 7500 cGy to point A (maximum 8500 cGy). The maximum follow up duration was 107 months and mean follow up duration was 42 months. Results :Ten out of 24 patients (41.7%) had residual disease found at the time of extrafascial hysterectomies. Five year overall survival rate (5Y OSR) and five year disease free survival rate (5Y DFSR) were 63.6% and 62.5% respectively. Five year overall survival rate for stage IB and IIA was 71.4% and 50% for stage IIB. There was a significant difference in 5Y OSR and 5Y DFSR between patients with and those without residual disease (negative vs positive, 83.3% vs. 40% (P=0.01), 83.3% vs 36% (P=0.01) respectively). There was a notable tendency of better survival with adenocarcinoma than with squamous cell carcinoma (adenocarcinoma vs squamous cell carcinoma, 85.7% vs. 53.3% (P=0.1), 85.7% vs. 50.9% (P=0.1) of 5Y OSR and 5Y DFS respectivey). Total dose to A point did not make a significant difference in survival rate or the existence of residual lesion (< 7500 cGy, ${\geq}$ 7500 cOy). It was also noted that significantly more frequent local failures have occurred in patients with positive residual disease compared with negative residual disease (5/10 vs. 0/14, p=0.003), There was no death related to the treatment. Conclusion : There was no improvement of residual disease and to the overall survival rate in spite of increased total dose to point A. We conclude that there is a possible beneficial effect of radiation therapy followed by extrafaseial hysterectomy in survival for adenocarcinoma of bulky stage IB and IIA-B uterine cervix. We need to confirm this with longer follow up and with large number of patients.

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The Impact of the Amount of Displacement of Percutaneous Osteotomy on the Clinical Result in Bunionette (소건막류에서 경피적 절골술의 전위 정도가 임상 결과에 미치는 영향)

  • Bae, Su-Young;Lee, Seung-Joo;Chung, Hyung-Jin
    • Journal of Korean Foot and Ankle Society
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    • v.19 no.2
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    • pp.63-68
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    • 2015
  • Purpose: The purpose of this study was to report impacts of the amount of displacement of percutaneous osteotomy on the clinical and radiologic results in the treatment of bunionette deformities. Materials and Methods: We retrospectively reviewed 36 cases of bunionette deformities treated with percutaneous modified Kramer osteotomies from 2009 to 2013. We measured amounts of displacement on anteroposterior and lateral plain radiographs as well as multiple parameters which represent degrees of the bunionette deformities. We also recorded radiological healing time, clinical healing time, residual symptoms, and the time of returning to daily activity. Results: No meaningful correlation was found between severity of preoperative deformity and amount of displacement of the osteotomy. The amount of displacement on a horizontal plane did not affect the healing time, duration of symptoms, or time of returning to daily activity. However, large sagittal displacement was related to duration of postoperative symptoms. Conclusion: Findings of this study suggest that the displacement in percutaneous osteotomy for bunionette deformity does not affect clinical results and healing time. We believe that we do not need to be excessively cautious about how large the displacement we make during the percutaneous modified Kramer osteotomy for the bunionette deformity.

ALC(Autoclaved Lightweight Concrete) Hardness Prediction by Multiple Regression Analysis (다중회귀분석을 이용한 ALC 경도예측에 관한 연구)

  • Kim, Kwang-Soo;Baek, Seung-Hoon;Chung, Soon-Suk
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.7 no.2
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    • pp.101-111
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    • 2012
  • In the ALC(Autoclaved lightweight concrete) manufacturing process, if the pre-cured semi-cake is removed after proper time is passed, it will be hard to retain the moisture and be easily cracked. Therefore, in this research, we took the research by multiple regression analysis to find relationship between variables for the prediction the hardness that is the control standard of the removal time. We study the relationship between Independent variables such as the V/T(Vibration Time), V/T movement, expansion height, curing time, placing temperature, Rising and C/S ratio and the Dependent variables, the hardness by multiple regression analysis. In this study, first, we calculated regression equation by the regression analysis, then we tried phased regression analysis, best subset regression analysis and residual analysis. At last, we could verify curing time, placing temperature, Rising and C/S ratio influence to the hardness by the estimated regression equation.

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The Effects of the Application Time of Buprofezin 25% WP on the Density of the Brown Planthopper(Nilaparvata lugens Stal) (Buprofezin 25% WP의 처리시기와 벼멸구(Nilaparvata lugens Stal) 밀도억제효과)

  • 배윤환;이준호;현재선
    • Korean journal of applied entomology
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    • v.31 no.4
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    • pp.551-559
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    • 1992
  • These studies were conducted to investigate the biological effects of buprofezin 25% WP on the adult of the brown planthopper (BPH) and its control effects on the BPH population, when buprofezin was treated on different days after the introduction of the BPH adult to the potted rice. Also age structures of the BPH population at the time of buprofezin treatment were observed. The results were as follows: Buprofezin (7.0 g a.i./l0 a) could reduce the longevity and fecundity of the newly emerged female but did not affect the biology of older female, and it did not affect the biology of the male. The larval densities at the time of buprofezin treatment was reduced to nearly zero after treatment. The higher the residual effect and the proportion of larvae at the time of buprofezin treatment were, the higher its con¬trol effect on the BPH population was. In case of buprofezin 7.0 g a.i./l0a treatment, the time interval of treatment that could show the highest control effect was about 10 days (from 18 days after the adult introduction to the adult emergence days of next generation).

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Development of the Continuous-Time HGDM with Binomial Sensitivity Factor (이항 반응 계수를 가진 연속 시간형 HGDM의 개발)

  • Park, Joong-Yang;Kim, Seong-Hee;Park, Jae-Heong
    • The Transactions of the Korea Information Processing Society
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    • v.6 no.12
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    • pp.3490-3499
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    • 1999
  • The hyper-geometric distribution software reliability growth model (HGDM) was recently developed and successfully applied to the problem of estimating the number of initial faults residual in a software at the beginning of the test-and-debug phase. Though the HGDM is a time-domain software reliability growth model(SRGM), it is not possible to compare the HGDM with other time-domain SRGMs. Furthermore the usual software reliability can not be computed. These drawbacks are derived from fact that the HGDM is not described in terms of the execution time. Thus we develop a continuous-time HGDM with binomial sensitivity factor in order to remove these drawbacks. Statistical characteristics of the suggested model are studied and its applicability is then examined by analyzing real test data sets. It is empirically shown that the continuous-time HGDM with binomial sensitivity factor can be used as an alternative to the current HGDM.

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Improved Method to Select Targets in Phase Gradient Autofocus on Real Time Processing (실시간 처리를 위한 PGA 표적 선택기법 개선)

  • Lee, Hankil;Kim, Donghwan;Son, Inhye
    • The Journal of Korean Institute of Information Technology
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    • v.17 no.10
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    • pp.57-63
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    • 2019
  • Motion errors which are caused by several reasons, non-ideal path, errors of navigation systems, and radar system errors, have to be corrected. Motion compensation methods can compensate the motion error, but not exactly. To correct these residual errors, several autofocus methods are invented. A popular method is phase gradient autofocus (PGA). PGA does not assume specific circumstances, such as isolated point targets and shapes of errors. PGA is an iterative and adaptive method, so that the processing time is the main problem for the real time processing. In this paper, the improved method to select targets for PGA is proposed to reduce processing time. The variances of image pixels are used to select targets with high SNR. The processing of PGA with these targets diminishes the processing time and iterations effectively. The processed results with real radar data, obtained by flight tests, show that the proposed method compensates errors well, and reduce working time.

Gram-Schmidt process based adaptive time-reversal processing (그람슈미트 과정 기반의 적응형 시역전 처리)

  • Donghyeon Kim;Gihoon Byun;J. S. Kim;Kee-Cheol Shin
    • The Journal of the Acoustical Society of Korea
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    • v.43 no.2
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    • pp.184-199
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    • 2024
  • Residual crosstalk has been considered as a major drawback of conventional time-reversal processing in the case of simultaneous multiple focusing. In this paper, the Gram-Schmidt process is applied to time-reversal processing to mitigate crosstalk in ocean waveguides for multiple probe sources. Experimental data-based numerical simulations confirm that nulls can be placed at multiple locations, and it is shown that different signals can be simultaneously focused at different probe source locations, ensuring distortionless responses in terms of active time-reversal processing. This focusing property is also shown to be much less affected by a reduction in the number of receivers than the adaptive time-reversal mirror method. The proposed method is shown to be effective in eliminating crosstalk in passive multi-input multi-output communications using sea-going data.

Baleen Whale Sound Synthesis using a Modified Spectral Modeling (수정된 스펙트럴 모델링을 이용한 수염고래 소리 합성)

  • Jun, Hee-Sung;Dhar, Pranab K.;Kim, Cheol-Hong;Kim, Jong-Myon
    • The KIPS Transactions:PartB
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    • v.17B no.1
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    • pp.69-78
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    • 2010
  • Spectral modeling synthesis (SMS) has been used as a powerful tool for musical sound modeling. This technique considers a sound as a combination of a deterministic plus a stochastic component. The deterministic component is represented by the series of sinusoids that are described by amplitude, frequency, and phase functions and the stochastic component is represented by a series of magnitude spectrum envelopes that functions as a time varying filter excited by white noise. These representations make it possible for a synthesized sound to attain all the perceptual characteristics of the original sound. However, sometimes considerable phase variations occur in the deterministic component by using the conventional SMS for the complex sound such as whale sounds when the partial frequencies in successive frames differ. This is because it utilizes the calculated phase to synthesize deterministic component of the sound. As a result, it does not provide a good spectrum matching between original and synthesized spectrum in higher frequency region. To overcome this problem, we propose a modified SMS that provides good spectrum matching of original and synthesized sound by calculating complex residual spectrum in frequency domain and utilizing original phase information to synthesize the deterministic component of the sound. Analysis and simulation results for synthesizing whale sounds suggest that the proposed method is comparable to the conventional SMS in both time and frequency domain. However, the proposed method outperforms the SMS in better spectrum matching.

Smart Battery System of Lithium ion Batteries (리튬이온전지의 Smart Battery System)

  • Kim Hyun-Soo;Moon Seong-In;Yun Mun-Soo;Ko Beyng-Hi;Park Sang-Kun;Shin Dong-O;Yoo Seong-Mo;Lee Seung-Ho
    • Journal of the Korean Electrochemical Society
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    • v.4 no.3
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    • pp.132-137
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    • 2001
  • Recently, the demand for notebook PC with lithium ion batteries has steadily increased and consumers require them to adopt a SBP(smart battery pack) able to predict the remaining capacity and the run time of batteries precisely. The SBP is composed of a protection If, by which safety of lithium ion batteries is maintained against overcharge, overdischarge and overcurrent, and a smart IC, which calculates the remaining capacity and the remaining run time. The protection IC shut abmormal current down by using overcharge/overdischarge FET. A SBS(smart battery system) is composed of a system host, a smart battery and a smart battery charger. The smart ICs for SBP will be required to provide a low cost, low current consumption and small size. There will need to develop a microcomputer control type IC and an optimum algorism which is able to predict the residual capacity and the residual run time precisely. SBS will apply to many kinds of industry fields such as an electric bicycle, an electric vehicle, a load levelling and a military.