• Korean Journal of Clinical Laboratory Science
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• v.41 no.1
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• pp.11-23
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• 2009

Chromosomal rearrangements are major pathology in hematological malignancies. The detection of minimal residual disease (MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis of patients. Recently, quantification of these gene transcripts based on real-time quantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hamatological malignancy patients. The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN at Chonnam National University Hwasun Hospital from Jan. 2006 to Aug. 2008. The fusion transcript was quntified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651~10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395~0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929~12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetic analysis or FISH. Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancies.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.1
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• pp.122-127
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• 2013

The hypochlorite ion ($OCl^-$) is a widely used disinfecting agent in pig rearing in Korea, but its residual effect on $CH_4$ production from pig slurry is unclear. The objective of this study was to investigate the inhibition effects of residual $OCl^-$ on $CH_4$ production during the initial anaerobic digestion stage of pig slurry. Three organic concentrations (9.9, 26.2 and 43.7 g/L) of volatile solids (VS) were tested with the addition of 52.3 mg/L $OCl^-$, ten times of the typical concentration used in Korea, or without $OCl^-$ (Control) in anaerobic batch culture. The culture was run under mesophilic ($38^{\circ}C$) conditions for 20 d. At the lowest organic concentration with $OCl^-$, the VS degradation was 10.3% lower (p<0.05) than Control, while at the higher organic concentration with $OCl^-$, it did not differ from Control. $CH_4$ yields were higher in the control treatments than their $OCl^-$ counterpart cultures, and $CH_4$ yields of Control and $OCl^-$ treatments at the organic concentrations of 9.9, 26.2 and 43.7 g/L differed in the probability level (p) of 0.31, 0.04, and 0.06, respectively. Additionally, $CH_4$ concentration increased steeply and reached 70.0% within 4 d in the absence $OCl^-$, but a gradual increase up to 60.0% was observed in 6 d in the $OCl^-$ treated cultures. The $R_m$ (the maximum specific $CH_4$ production rate) and ${\lambda}$ (lag phase time) of 9.9 g/L with $OCl^-$ were 8.1 ml/d and 25.6 d, while the $R_m$ was increased to 15.1 ml/d, and ${\lambda}$ was reduced to 11.4 d in PS-III (higher organic concentration) with $OCl^-$. The results suggest that a prolonged fermentation time was necessary for the methanogens to overcome the initial $OCl^-$ inhibitory effect, and an anaerobic reactor operated with high organic loadings was more advantageous to mitigate the inhibitory effect of residual hypochlorite ion.

• Applied Biological Chemistry
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• v.47 no.2
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• pp.238-243
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• 2004

To investigate the changes in content of residual pesticides for safety production of young radishes in the production steps in greenhouse and to evaluate the safety of young radishes in the final consuming step, biological half-life of pesticides (diazinon, endosulfan) in packaging products was studied. Samples were collected regularly from 2 hours to 10 days after the distribution of pesticides in young radishes. The contents of residual pesticides in young radishes during cultivating in greenhouse as the levels of distribution concentrations reduced with time. During 10 days of pesticides distribution, decomposition rate of pesticides were diazinon > endosulfan. A half-life of endosulfan was 0.6 day longer than diazinon because endosulfan derived persistent endosulfan sulfate. To produce the safe young radish, after the distribution of the pesticides the desirable harvest time based on maximum residue limit (MRL) was 6th day diazinon for and 10th day for endosulfan.

• Journal of Broadcast Engineering
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• v.24 no.5
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• pp.703-712
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• 2019

Single image Super-Resolution (SISR) aims to generate a visually pleasing high-resolution image from its degraded low-resolution measurement. In recent years, deep learning - based super - resolution methods have been actively researched and have shown more reliable and high performance. A typical method is WaveletSRNet, which restores high-resolution images through wavelet coefficient learning based on feature maps of images. However, there are two disadvantages in WaveletSRNet. One is a big processing time due to the complexity of the algorithm. The other is not to utilize feature maps efficiently when extracting input image's features. To improve this problems, we propose an efficient single image super resolution method, named RDB-WaveletSRNet. The proposed method uses the residual dense block to effectively extract low-resolution feature maps to improve single image super-resolution performance. We also adjust appropriated growth rates to solve complex computational problems. In addition, wavelet packet decomposition is used to obtain the wavelet coefficients according to the possibility of large scale ratio. In the experimental result on various images, we have proven that the proposed method has faster processing time and better image quality than the conventional methods. Experimental results have shown that the proposed method has better image quality by increasing 0.1813dB of PSNR and 1.17 times faster than the conventional method.

• Journal of Applied Biological Chemistry
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• v.62 no.1
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• pp.11-17
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• 2019

Strawberries are one of the main commodities in Korea and have been exported over 40 million dollar. Because the strawberry cultivation using hydroponics has increased, treatment of pesticide by drenching draw interest recently. However, detailed researches for drenching treatment of pesticide are limited, which results in difficulties in proper pesticide applications in agricultural fields. To activate use of drenching and improve safety in agricultural products, In this study, time-dependent residual characteristic of pesticides were compared with between different applications of pesticides in strawberries. The characteristics of azoxystrobin, prochloraz and thiamethoxam were investigated with drenching treatment at different applications: the time of treatment, concentration etc. at hydroponic cultivation for 40 days. Azoxystrobin and prochloraz were not detected at 14 day after application. Thiamethoxam was detected from 0.02 to 0.85 mg/kg. Crop uptake of pesticides was strongly affected with octanol-water partition coefficient and solubility in water. Residual amount in crops are highly dependent on the concentration of active ingredient of pesticides.

• Journal of the Korean earth science society
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• v.32 no.3
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• pp.249-264
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• 2011

A multi-Gaussian kriging approach extended to space-time domain is presented for uncertainty modeling as well as time-series mapping of environmental variables. Within a multi-Gaussian framework, normal score transformed environmental variables are first decomposed into deterministic trend and stochastic residual components. After local temporal trend models are constructed, the parameters of the models are estimated and interpolated in space. Space-time correlation structures of stationary residual components are quantified using a product-sum space-time variogram model. The ccdf is modeled at all grid locations using this space-time variogram model and space-time kriging. Finally, e-type estimates and conditional variances are computed from the ccdf models for spatial mapping and uncertainty analysis, respectively. The proposed approach is illustrated through a case of time-series Particulate Matter 10 ($PM_{10}$) concentration mapping in Incheon Metropolitan city using monthly $PM_{10}$ concentrations at 13 stations for 3 years. It is shown that the proposed approach would generate reliable time-series $PM_{10}$ concentration maps with less mean bias and better prediction capability, compared to conventional spatial-only ordinary kriging. It is also demonstrated that the conditional variances and the probability exceeding a certain thresholding value would be useful information sources for interpretation.

• The Journal of the Acoustical Society of Korea
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• v.26 no.3E
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• pp.87-96
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• 2007

In this paper we propose a new noise reduction algorithm for stationary and nonstationary noisy environments. Our algorithm classifies the speech and noise signal contributions in time-frequency bins, and is not based on a spectral algorithm or a minimum statistics approach. It relies on calculating the ratio of the standard deviation of the noisy power spectrum in time-frequency bins to its normalized time-frequency average. We show that good quality can be achieved for enhancement speech signal by choosing appropriate values for ${\delta}_t\;and\;{\delta}_f$. The proposed method greatly reduces the noise while providing enhanced speech with lower residual noise and somewhat higher mean opinion score (MOS), background intrusiveness (BAK) and signal distortion (SIG) scores than conventional methods.

• IEMEK Journal of Embedded Systems and Applications
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• v.8 no.6
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• pp.311-318
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• 2013

In this paper, we consider a new packet scheduling algorithm for real-time traffic in the HSDPA system that has been introduced for the WCDMA system, in order to provide high transmission rates. The objective of the design is to meet the maximum tolerable delay and consider channel assignment based on the received SIR for real-time traffic users. The proposed scheduling algorithm shows that the users are ranked by the ratios of the bits in the buffer to the residual time for transmission as priority order; then the ranked users are assigned certain number of channels based on the SIR value table. The simulation results show that the proposed algorithm can provide a lower packet drop rate, and satisfy real time quality of service (QoS) requirements.

• Journal of Korean Institute of Industrial Engineers
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• v.32 no.4
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• pp.369-372
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• 2006

Suppose that a customer arrives at the GI/M/1/K queueing system when there are customers in the system, $n,m{\geq}0,\;n+m{\leq}K$. Sooner or later, the number of customers in the system will reach . In this paper, we present the Laplace transform of the remaining interarrival time upon reaching level, for the first time, since a customer arrived when there are customers in the system.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2004.10a
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• pp.245-249
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• 2004

This paper describes the vibration characteristics of Nd:YAG laser welding plates analyzed time-average Electronic Speckle Pattern Interferometry(ESPI). In laser welding, the travel speed has influence on a mechanical properties, such as elastic modules, response frequencies and so on, which is resulted on a residual stress of the welding zone. the response frequencies related to elastic modules are determined by time-average ESPI and the results, as compared to each condition, are used to estimate optimal condition of travel speed.