• The Korean Journal of Physiology and Pharmacology
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• v.23 no.1
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• pp.47-54
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• 2019

Estrogen withdrawal in post-menopausal women leads to overactivation of osteoclasts, which contributes to the development of osteoporosis. Inflammatory cytokines are known as one of mechanisms of osteoclast activation after estrogen deficiency. SPA0355 is a thiourea derivative that has been investigated for its antioxidant and anti-inflammatory activities. However, its efficacy in bone resorption has not been previously investigated. The aim of this study was to investigate the impact of SPA0355 on the development of osteoporosis and to explore its mode of action. In vitro experiments showed that SPA0355 inhibited receptor activator of $NF-{\kappa}B$ ligand (RANKL)-induced osteoclastogenesis in primary bone marrow-derived macrophages. This effect appears to be independent of estrogen receptor activation as ICI 180,782 failed to abrogate its effects on osteoclasts. Further signaling studies revealed that SPA0355 suppressed activation of the MAPKs, Akt, and $NF-{\kappa}B$ pathways. SPA0355 also increased osteoblastic differentiation, as evidenced by its effects on alkaline phosphatase activity and mineralization nodule formation. Intraperitoneal administration of SPA0355 to ovariectomized mice prevented bone loss, as verified by three-dimensional images and bone morphometric parameters derived from ${\mu}CT$ analysis. Noticeably, SPA0355 did not show hepatotoxicity and nephrotoxicity and also had little effect on hematological parameters. Taken together, the results indicate that SPA0355 may protect against bone loss in ovariectomized mice by stimulation of osteoblast differentiation and by inhibition of osteoclast resorption. Therefore, SPA0355 is a safe and potential candidate for management of postmenopausal osteoporosis.

• Journal of Ecology and Environment
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• v.43 no.1
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• pp.31-42
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• 2019

Background: Han River estuary is a national wetland reserve near the Demilitarized Zone (DMZ) between South Korea and North Korea. This trans-boundary estuary area has been well preserved and shows distinctive plant communities along the salinity gradient. To elucidate energy flows and nutrient cycling in this area, we studied trophic relations between the dominant sesarmid crab, Sesarma dehaani, and food sources in three wetlands with different environments along the estuarine gradients. Results: Stable isotope signatures (${\delta}^{13}C$ and ${\delta}^{15}N$) of the crabs were significantly different among the sites and body size classes. Seasonal changes in ${\delta}^{13}C$ of small crabs were distinct from those of large individuals at all the sites. The isotopic values and fatty acid profiles of the crabs were more different among the sites in September than in May. In May, large-sized crabs utilized more plant materials compared to other dietary sources in contrast to small-sized crabs as revealed by a stable isotope mixing modeling, whereas contributions to diets of crabs were not dominated by a specific diet for different body size in September except at site 1. Based on PCA loadings, fatty acid content of $18:3{\omega}3$, known as a biomarker of plant materials, was the main factor to separate size groups of crabs in May and September. The ${\delta}^{13}C$ value of sediment had high correlation with those of small-sized crabs at site 1 and 2 when 1-month time lag was applied to the value for crabs during the surveyed period. Conclusions: Based on the stable isotope and fatty acid results, the consumption habits of S. dehaani appear to be distinguished by sites and their size. In particular, smaller size of S. dehaani appears to be more dependent on fewer food sources and is influenced more by the diet sources from the sediments in Han River estuary.

• Journal of Preventive Medicine and Public Health
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• v.52 no.5
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• pp.333-343
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• 2019

Objectives: This study aimed to evaluate the association between dental implants and cognitive function in community-dwelling older adults. Methods: Data were collected from the baseline survey (2016-2017) of the Korean Frailty and Aging Cohort Study. The study sample comprised 1115 community-dwelling people aged 70 years to 84 years who had 0-19 natural teeth. Dental implants and natural teeth were identified by panoramic radiography, while the cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The association between dental implants and cognitive function was analyzed by multiple linear regression. Sensitivity analysis was performed to test for potential bias. Results: The mean number of natural teeth in the study population was 9.50 (standard deviation [SD], 6.42), and the mean MMSE-KC score was 24.93 (SD, 3.55). In the simple univariate analysis, tooth replacement, age, sex, smoking status, alcohol consumption, body mass index, osteoporosis, number of natural teeth, periodontitis, chewing discomfort, tooth-brushing frequency, education level, monthly household income, participation in economic activity, living alone, and marital status had a significant impact on the association. After adjusting for confounders, the association between dental implants and cognitive function remained significant (B, 0.85; standard error, 0.40; p<0.05). Age, body mass index, periodontitis, tooth-brushing frequency, and education level were also significantly associated with cognitive function. The results of the sensitivity analyses were consistent with those of the primary analysis. Conclusions: Dental implants were associated with cognitive function in older adults living in the community. Dental implants as tooth replacements may play a role in preserving cognitive function.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.4
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• pp.161-167
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• 2019

Recently, demand forecasting techniques have been actively studied due to interest in stable power supply with surging power demand, and increase in spread of smart meters that enable real-time power measurement. In this study, we proceeded the deep learning prediction model experiments which learns actual measured power usage data of home and outputs the forecasting result. And we proceeded pre-processing with moving average method. The predicted value made by the model is evaluated with the actual measured data. Through this forecasting, it is possible to lower the power supply reserve ratio and reduce the waste of the unused power. In this paper, we conducted experiments on three types of networks: Multi Layer Perceptron (MLP), Recurrent Neural Network (RNN), and Long Short Term Memory (LSTM) and we evaluate the results of each scheme. Evaluation is conducted with following method: MSE(Mean Squared Error) method and MAE(Mean Absolute Error).

• Journal of Gastric Cancer
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• v.19 no.2
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• pp.202-211
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• 2019

Purpose: Poor physiological reserve for withstanding major cancer surgery in older adults is an important concern in the selection of patients for oncologic gastrectomy. The present study aimed to analyze mortality patterns among patients who underwent gastrectomy for cancer according to age groups. The primary outcomes of this study were early- and middleterm results: 30-day and 3-, 6-, 12-, and 36-month mortality rates. Materials and Methods: A retrospective review of 288 patients who underwent surgical resection for gastric cancer in two centers was carried out. Patients were stratified into four groups according to age: 29-50 years (group I, n=27), 51-65 years (group II, n=117), 66-75 years (group III, n=81), and 76-92 years (group IV, n=58). Statistical calculations focused on the differences in the survival rates between groups I and II as well as between groups II and IV. Results: The middle-aged patients (group II) had significantly better 3-year survival than either the youngest (group I) or the oldest patients (group IV). The 6-month mortality rates were 16.9% in group III and 29.3% in group IV. Two-thirds of the patients from groups III and IV who died between 2 and 6 months after surgery had an uneventful postoperative course. Conclusions: Age is an important prognostic factor of middle-term survival after gastrectomy for cancer. Geriatric assessment and better patient selection for major surgery for cancer are required to improve the outcome of gastrectomy for cancer in patients aged over 75 years.

• Korean Journal of Construction Engineering and Management
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• v.20 no.3
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• pp.105-112
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• 2019

Due to abnormal high temperature, electric power demand has exceeded the backup power reserved for emergency case, hence, resulting in a major power outage. In today's overcrowded cities, the unexpected disruption in energy supply and demand is a major threat to the enormous economic damage and urban malfunctions. Existing methods for estimating the demand of the emergency power source do not lend themselves to predict the actual demand in the spatial dimension of the city. In addition, the reserve power is arbitrarily distributed in the case of emergency. This paper presents a method that predicts the emergency power demand using the spatial distribution of emergency power demand by applying the daily energy consumption intensity and emergency power demand according to urban spatial information and building use.

• Archives of Plastic Surgery
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• v.46 no.3
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• pp.198-203
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• 2019

Background Professional affiliation between medical centers and professional sports teams can be mutually beneficial in the provision of healthcare and marketing strategy. Anecdotal evidence suggests a link between trauma volume and sporting events; however, there is limited data. This study aims to characterize the incidence of operative hand and facial trauma during professional baseball home games. Methods A retrospective review of surgical cases for traumatic hand or facial injuries at a level 1 center between 1999 and 2012 was performed. Demographic information including date of injury, admission status, and operative repair were collected. Patients were grouped based on whether their trauma occurred on the date of a home game. Results Operative hand and facial trauma occurred at a rate of 33.4 injuries per 100 days with home games, compared to 22.2 injuries per 100 days (incidence rate ratios, 1.50; 95% confidence interval, 1.34-1.69). When home games were played, patients were more likely to present as a result of motorcycle accidents (3.1% vs. 1.5%; P=0.04) or bicycle accidents (5.0% vs. 2.6%; P=0.01). Other mechanisms of trauma were not statistically different. There was an increase incidence of injuries during home games in August; weekly variability showed an increased incidence during the weekends. Conclusions There was an increased rate of operative hand and facial injuries on dates with professional home games. The incidence of injuries during home games was higher in the late summer and on the weekends. Further analysis may allow improved resource allocation and strategies for injury prevention and treatment.

• Asia-Pacific Journal of Business
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• v.11 no.3
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• pp.123-136
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• 2020

Purpose - This study is to verify the impact of the documentation of key audit matters on the value relevance of accounting information in accordance with the revised accounting audit standards in 2017. Investors will be able to identify the company's significant financial risks through key audit matters and use them to make investment decisions. Design/methodology/approach - From 2011 to 2019, the final sample is 290, based on the December settlement of accounts listed on the securities market. Ohlson (1995) was used to verify the incremental link between net income and the book value as a determinant of corporate value. Findings - First, the key audit matters in the financial industry was found to have a negative (-) effect that was significant to the value relevance of accounting Information. In addition, the value of the interaction between the key audit matters and the net income is a significant (+) relationship with the share price and the value of the interaction between the key audit matters and the book value is a significant (-) relationship with the share price. This means that the key audit matters is the determining factor of corporate value, positively reflects the accounting information in net income and negatively reflects the accounting information in book value. Second, among the key audit matters, the fair value assessment of financial instruments and the adequacy of premiums reserve have a significant impact on the value relevance of accounting information. Research implications or Originality - The results of this study suggest that investors recognize key audit matters as information about the company's major financial risks and reflect them differently in the value relevance of accounting information.

• Proceedings of The Korean Society of Agricultural and Forest Meteorology Conference
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• 2013.11a
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• pp.30-31
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• 2013

Land use and land cover change (LULCC) due to human activities directly affects natural systems and contributes to changes in carbon exchange and climate through a range of feedbacks. How land use and land cover changes affect carbon exchanges can be assessed using multiyear measurement data from micrometeorological flux towers. The objective of the research is to assess the impact of land use and land cover change on carbon exchange in a heterogeneous cropland area. The heterogeneous cropland area in Haenam, South Korea is also subjected to a land conversion due to rural development. Therefore, the impact of the change in land utilization in this area on carbon exchange should be assessed to monitor the cycle of energy, water, and carbon dioxide between this key agricultural ecosystem and the atmosphere. We are currently conducting the research based on 10 years flux measurement data from Haenam Koflux site and examining the LULCC patterns in the same temporal scale to evaluate whether the LULCC in the surrounding site and the resulting heterogeneity (or diversity) have a significant impact on carbon exchange. Haenam cropland is located near the southwestern coast of the Korean Peninsula with land cover types consisting of scattered rice paddies and various croplands (seasonally cultivated crops). The LULCC will be identified and quantified using remote sensing satellite data and then analyzing the relationships between LULCC and flux footprint of $CO_2$ from tower flux measurement. We plan to calculate annual flux footprint climatology map from 2003 to 2012 from the 10 years flux observation database. Eventually, these results will be used to quantify how the system's effective performance and reserve capacity contribute to moving the system towards more sustainable configuration. Broader significance of this research is to understand the co-evolution of the Haenam agricultural ecosystem and its societal counterpart which are assumed to be self-organizing hierarchical open systems.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.261-261
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• 2017

최근 전 세계적으로 지구온난화로 인한 집중호우, 가뭄, 태풍 등 자연재해가 빈번하게 일어나고 있다. 이에 2016년 유엔기후변화협약당사국총회(COP22)에서는 지구온난화의 심각성을 인식하고, 한국의 2030년 온실가스 배출 전망치(BAU) 대비 37% 감축 달성과 같이 국가별로 온실가스 감축 목표를 선정하였다. 이를 달성하기 위해 국내에서는 현재까지 사용되지 않았던 자연에너지원의 활용이 부각되고 있으며, 특히 미활용에너지 중 하천수의 온도차에너지가 활발히 논의되고 있다. 하지만 미활용에너지 활용에 앞서 에너지원으로의 적정성 분석이 반드시 필요하다. 본 연구에서는 국내 5대강 중 한강권역을 대상으로 하천수 온도차에너지의 부존량 또는 이용가능량을 산정하고자 하였다. 한강본류 6개 하천유지유량 고시지점을 대상으로 해당 지점의 30년간(1987~2016년) 유량자료를 이용하여 유황 및 계절별 유량변동 특성을 분석하였고, 부존량 및 이용가능량을 검토하였다. 부존량 및 이용가능량 분석을 위해서는 선행 연구에서 적용된 하천유지유량, 하천수사용허가량 및 용수수요량 등을 고려한 산정식을 적용하였다. 본 연구는 미활용에너지인 하천수 온도차에너지의 실제 이용가능량을 분석하여 새로운 에너지원으로 활용할 수 있는지 평가하기 위해 수행되었다. 본 연구의 결과는 하천수 온도차에너지의 온실가스 감축을 위한 화석에너지의 대체에너지로서 새로운 가능성을 평가하는 지표가 될 것이라 기대된다. 또한 하천수 온도차에너지의 실제적인 적용을 위해서는 추후 연구를 통해 생태계 등 환경에 미치는 영향을 분석하고, 설치 및 유지비용에 따른 경제성 평가가 필요할 것으로 판단된다.