• Clinical Pain
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• 제19권2호
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• pp.59-63
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• 2020

Rotator cuff tear is often cited as a reason for shoulder pain and dysfunction in patients > 40 years of age. Surgical repair of rotator cuff tear is one of the most commonly performed orthopedic surgical procedures. Until now, the success rate of surgical repair for rotator cuff tear has not been satisfactory. Many factors influence the process of rotator cuff repair such as the presence of tendinosis and fatty infiltration, but the main factor is the difficulty in achieving healing at the tendon to bone interface. There is a clinical need for bioengineering approaches to promote regeneration of the native enthesis and reduce the poor outcomes after surgical repair. Toward this end, the design and fabrication of multiphasic or hierarchically structured scaffolds have received great attention. This manuscript deals with information on the tendon to bone interface and tries to find out why a multiphasic scaffold is necessary to reproduce it and considerations that need to be taken into to make an ideal scaffold.

• Archives of Plastic Surgery
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• 제36권5호
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• pp.543-547
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• 2009

Purpose: Adhesion is the most common and troublesome complication after repair of flexor tendon injury. Recently, use of sodium hyaluronate derivatives for adhesion prevention is increasing. A commercial product, Guardix$^{(R)}$, sodium hyaluronate(NaHe) combined with carboxymethylcellulose(CMC) has been newly developed as a preventive material for adhesion. We have investigated its effect in rabbits. Methods: Twenty seven male New Zealand white rabbits were operated under ketamine anesthesia. After tendon repair in zone II of the hind paw, Guardix$^{(R)}$(experimental group) or normal saline(control group) was administered. Biomechanical tests were performed to estimate adhesion formation at 2, 4, 8, and 12 weeks after the operation. Maximum tensile load to flex the distal interphalangeal joint 50 degree from its resting state(MTL50) was measured, depicting the amount of adhesion formed. Subsequently, breaking strength was assessed. Results: There were no postoperative complications such as infection, wound dehiscence, or hematoma. MTL50 was significantly lower in the experimental group than in the control group at 4, 8, 12 weeks (p<0.05). Mean value of MTL50 was 6.64N in the experimental group and 28.53N in the control group at 12 weeks after surgery. There were no significant differences in breaking strength. Conclusion: Our results indicate that Guardix$^{(R)}$ is helpful in reducing adhesion formation and does not interfere with normal healing processes of the tendon.

• Journal of Ginseng Research
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• 제46권4호
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• pp.526-535
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• 2022

Background: During the pathogenesis of tendinopathy, the chronic inflammation caused by the injury and apoptosis leads to the generation of scars. Ginsenoside Rg1 (Rg1) is extracted from ginseng and has anti-inflammatory effects. Rg1 is a unique phytoestrogen that can activate the estrogen response element. This research aimed to explore whether Rg1 can function in the process of tendon repair through the estrogen receptor. Methods: In this research, the effects of Rg1 were evaluated in tenocytes and in a rat model of Achilles tendinitis (AT). Protein levels were shown by western blotting. qRT-PCR was employed for evaluating mRNA levels. Cell proliferation was evaluated through EdU assay and cell migration was evaluated by transwell assay and scratch test assay. Results: Rg1 up-regulated the expression of matrix-related factors and function of tendon in AT rat model. Rg1 reduced early inflammatory response and apoptosis in the tendon tissue of AT rat model. Rg1 promoted tenocyte migration and proliferation. The effects of Rg1 on tenocytes were inhibited by ICI182780. Rg1 activates the insulin-like growth factor-I receptor (IGF1R) and MAPK signaling pathway. Conclusion: Rg1 promotes injured tendon healing in AT rat model through IGF1R and MAPK signaling pathway activation.

• 한국강구조학회 논문집
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• 제29권6호
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• pp.401-410
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• 2017

본 연구에서는 긴장재로 계류된 해중 터널에서 긴장재의 느슨해짐에 따른 동적 불안정 거동에 대해 다룬다. 해중 터널의 설계는 파랑 및 조류 등 유체력에 의해 지배받는다. 특히 시간에 따라 지속적으로 크기 및 작용방향이 변하는 파랑은 해중 터널의 동적 거동을 직접적으로 야기하게 되는데, 파랑에 의한 부유 튜브의 운동은 계류선 내력의 동적 변동을 유발하게 되고, 이 힘의 변화는 계류선의 강도설계 뿐 만 아니라 피로 설계에도 직접적인 영향을 미친다. 파랑에 의한 터널의 운동이 극심할 경우, 계류선의 장력은 모두 소실될 수 있는데, 이 때 계류선이 느슨해짐에 따라 일시적으로 부유 터널의 운동에 대한 저항성이 사라져 동적 불안정 거동이 유발 될 수 있다. 이에 본 연구에서는 유체-구조동역학 해석기법을 통해 해중 터널 긴장재의 느슨해짐 발생 시 부유 튜브의 동적 불안정 거동에 대해 분석하였다. 특히 해중터널의 중요 설계 인자인 흘수, 부력-자중 비율(Buoyancy-Weight Ratio, BWR), 긴장재 기울임이 동적 불안정 거동에 미치는 영향에 대해 분석하였다.

• 대한토목학회논문집
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• 제31권3A호
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• pp.261-267
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• 2011

본 연구는 부착식 PSC 텐던에 도입된 긴장응력이 종진동 거동에 미치는 메커니즘을 규명한다. 텐던의 종방향 직선변형과 비틀림변형은 상호 연동하여 거동하고, 텐던에 도입된 긴장응력은 축강성과 비틀림강성에 영향을 미친다. 그러므로 텐던의 탄성파 속도를 계측함으로써 텐던에 도입된 긴장응력을 추정 할 수 있다. 이는 텐던의 탄성파속도가 축강성과 비틀림강성의 함수이기 때문에 가능하다. 도입 긴장력이 다른 6개의 PSC 보 시험체에 대한 종진동 실험결과를 이용하여 텐던의 종진동 특성과 도입 긴장응력 사이의 역학적 메커니즘이 검증되었다. 이를 위하여, 탄성파 속도로부터 텐던의 시스템 강성을 추정할 수 있는 시스템인식 이론이 적용 되었다. 추정 결과는 기존 문헌의 연구결과와 비교 검토되었다.

• 대한토목학회논문집
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• 제32권3A호
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• pp.183-188
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• 2012

국내 일부 가동 중 원전의 원자로건물에 부착식 텐던이 시공되어 있고, 이들에 대한 긴장력 평가는 원자로건물의 구조 건전성 평가 시 매우 중요하다. 따라서, 본 논문에서는 기존의 간접적인 부착식 텐던의 긴장력 평가방법을 개선하기 위하여 개발된 SI 기술과 충격신호 분석기술을 이용하여 실제 원자로건물에 매입된 부착식 텐던을 대상으로 긴장력을 평가하였다. 이를 위해 원자로건물에서 발생하는 변형률과 부착식 텐던에서 발생하는 응력파속도를 계측하였다. 이들을 통해 부착식 텐던의 긴장력을 평가한 결과, SI 기술과 충격신호 분석기술 모두 높은 신뢰성 있는 결과를 제시하였고, 기존의 이론적인 접근 방법에 의한 결과와도 매우 유사한 경향을 제시함으로써 본 연구진에서 개발한 부착식 텐던의 긴장력 평가방법이 매우 유용함을 확인할 수 있었다.

• Clinics in Shoulder and Elbow
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• 제26권2호
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• pp.131-139
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• 2023

Background: Massive rotator cuff tears (RCTs) are complicated by muscle atrophy, fibrosis, and intramuscular fatty degeneration, which are associated with postoperative tendon-to-bone healing failure and poor clinical outcomes. We evaluated muscle and enthesis changes in large tears with or without suprascapular nerve (SN) injury in a rat model. Methods: Sixty-two adult Sprague-Dawley rats were divided into SN injury (+) and SN injury (-) groups (n=31 each), comprising tendon (supraspinatus [SSP]/infraspinatus [ISP]) and nerve resection and tendon resection only cases, respectively. Muscle weight measurement, histological evaluation, and biomechanical testing were performed 4, 8, and 12 weeks postoperatively. Ultrastructural analysis with block face imaging was performed 8 weeks postoperatively. Results: SSP/ISP muscles in the SN injury (+) group appeared atrophic, with increased fatty tissue and decreased muscle weight, compared to those in the control and SN injury (-) groups. Immunoreactivity was only positive in the SN injury (+) group. Myofibril arrangement irregularity and mitochondrial swelling severity, along with number of fatty cells, were higher in the SN injury (+) group than in the SN injury (-) group. The bone-tendon junction enthesis was firm in the SN injury (-) group; this was atrophic and thinner in the SN injury (+) group, with decreased cell density and immature fibrocartilage. Mechanically, the tendon-bone insertion was significantly weaker in the SN injury (+) group than in the control and SN injury (+) groups. Conclusions: In clinical settings, SN injury may cause severe fatty changes and inhibition of postoperative tendon healing in large RCTs. Level of evidence: Level Basic research, controlled laboratory study.

• Clinics in Shoulder and Elbow
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• 제13권1호
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• pp.175-179
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• 2010

목적: 회전근 개의 질환은 견관절 질환 중 가장 흔하며, 퇴행성 변화와 관련한 회전근 개 파열은 임상에서 가장 흔히 경험하는 질환이다. 대상 및 방법: 회전근 개의 정상적인 생물학적 특성을 이해하는 것은 회전근 개의 퇴행성 변화를 이해하고, 병태생리를 이해하는 것에 도움이 되며 나아가서 새로운 치료방법이나 예방법을 발전시키는 기초 지식으로 중요하다 하겠다. 결과 및 결론: 이에 저자들은 회전근 개의 생물학적 정상소견과, 회전근 개 파열의 병리를 설명하는 이론에 대한 문헌 고찰과 최근 활발히 연구되고 있는 회전근 개 건섬유모세포의 세포자멸 기전등에 관한 문헌고찰 내용을 보고하고자 한다.

• Structural Engineering and Mechanics
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• 제62권5호
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• pp.595-606
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• 2017

During their life span, post-tensioned concrete structures may be exposed to thermal loads. Therefore, there has been a growing interest in research on the advanced analysis and design of post-tensioned concrete slabs subjected to thermal loads. This paper investigates the structural behaviour of post-tensioned one-way spanning concrete slabs. A nonlinear finite element model for the analysis of post- tensioned unbonded and bonded concrete slabs at elevated temperatures was developed. The interface between the tendon and surrounding concrete was also modelled, allowing the tendon to retain its profile shape during the deformation of the slab. The load-deflection behaviour, load-force behaviour in the tendon, and the failure modes are presented. The numerical analysis was conducted by the finite element ANSYS software and was carried out on two different one-way concrete slabs chosen from literature. A parametric study was conducted to investigate the effect of several selected parameters on the overall behavior of post-tensioned one-way concrete slab. These parameters include the effect of tendon bonding, the effect of thermal loading and the effect of tendon profile. Comparison between uniform thermal loading and nonuniform thermal loading showed that restrained post tensioned slab with bottom surface hotter has smaller failure load capacity.

• 제어로봇시스템학회논문지
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• 제20권9호
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• pp.964-970
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• 2014

In this study we have developed an anthropomorphic robot hand and arm by using tendon-tubes which can be used for people's everyday life as a robot's dynamic power transmission device. Most previous robot hands or arms had critical problem on dynamic optimization due to heavy weight of power transmission parts which placed on robot's finger area or arm area. In order to resolve this problem we designed light-weighted robot hand and arm by using tendon-tubes which were consisted of many articulations and links just like human's hand and arm. The most prominent property of this robot hand and arm is reduction of the weight of robot's power transmission part. Reduction of weight of robot's power transmission parts will allow us to develop energy saving and past moving robot hands and arms which can be used for artificial arms. As a first step for real development in this study we showed structural design and demonstration of simulation of possibility of a robot hand and arm by tendon-tube. In the future research we are planning to verify practicality of the robot hand and arm by applying sensing and controlling method to a specimen.