• Genomics & Informatics
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• 제2권4호
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• pp.163-166
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• 2004

• 한국지진공학회논문집
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• 제25권3호
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• pp.129-135
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• 2021

After the manual shutdown of the Wolseong nuclear power plant due to an earthquake in Gyeongju in 2016, anxiety about the earthquake safety of nuclear power plants has become a major social issue. The shear wall structure used as a major structural element in nuclear power plants is widely used as a major structural member because of its high resistance to horizontal loads such as earthquakes. However, due to the complexity of the structure, it is challenging to predict the dynamic characteristics of the structure. In this study, a three-story shear wall structure is fabricated, and the in-structure response characteristics of the shear wall structure are evaluated through shaking table tests. The test is performed using the Gyeongju earthquake that occurred in 2016, and the response characteristics due to the domestic earthquake are evaluated.

• The Journal of Asian Finance, Economics and Business
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• 제8권7호
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• pp.423-431
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• 2021

This research (1) examines the effect of stock ownership structure on capital structure; (2) explains the effect of stock ownership structure on corporate value; and (3) investigates the influence of capital structure on corporate value. This research is categorized as a quantitative research, which is directed to test various theories. In this study, the population of all consumption companies listed on the Indonesia Stock Exchange (IDX) consist of 38 companies. Population data in this study are all consumption companies, which have gone public in the period from 2010 to 2015. In this study, given the objectives and problem formulation and hypothesis, the analysis method used is Generalized Structural Component Analysis (GSCA). Ownership structure has a significant effect on capital structure; ownership structure has no significant effect on corporate value; capital structure has a significant effect on corporate value; corporate value has a significant effect on capital structure. Previous research found different results. Some researchers found a positive relationship and other researchers found a negative relationship, and there are studies that found both significant and non-significant effects. The inconsistency of previous research results prompted the researchers to examine the effect of ownership structure on capital structure and corporate value.

• Molecules and Cells
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• 제43권11호
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• pp.935-944
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• 2020

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with hypoxia-inducible transcription factors (HIF1α and HIF2α) or aryl hydrocarbon receptor (AhR). Here, we have shown that ARNT interacts with DDB1 and CUL4-associated factor 15 (DCAF15), and the aryl sulfonamides, indisulam and E7820, induce its proteasomal degradation through Cullin-RING finger ligase 4 containing DCAF15 (CRL4^DCAF15) E3 ligase. Moreover, the two known neo-substrates of aryl sulfonamide, RNA-binding motif protein 39 (RBM39) and RNA-binding motif protein 23 (RBM23), are not required for ARNT degradation. In line with this finding, aryl sulfonamides inhibited the transcriptional activities of HIFs and AhR associated with ARNT. Our results collectively support novel regulatory roles of aryl sulfonamides in both hypoxic and xenobiotic responses.

• Bulletin of the Korean Chemical Society
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• 제25권8호
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• pp.1241-1243
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• 2004

• Bulletin of the Korean Chemical Society
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• 제25권12호
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• pp.1937-1940
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• 2004

• 정보관리학회지
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• 제28권1호
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• pp.145-170
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• 2011

본 연구는 연구문헌의 지식구조를 반영하는 의미기반 지식조직체계의 실험적 모형을 제시하는 것을 목적으로 한다. 이를 위해 한국연구재단의 기초학문자료센터에 대한 사례분석을 하였다. 기초학문자료센터 연구성과물 DB와 학술용어 DR의 개념클래스 및 인스턴스를 대상으로 연구문헌의 지식구조를 파악하였으며, 기초학문자료센터 시스템의 학술적 이해형성 기능을 분석하였다. 또한 연구문헌의 지식구조와 색인어의 관계를 분석하였다. 이러한 분석을 통해 지식구조와 색인어의 관계구조, 26개의 연구문헌 지식구조 공리 및 11개의 의미관계 추론규칙으로 구성되는 온톨로지 모형, 즉 연구문헌의 지식구조와 그 의미관계에 의한 실험적 지식조직체계 모형을 제시하였다.

• Steel and Composite Structures
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• 제16권3호
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• pp.289-303
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• 2014

In recent, development of construction and design technology gives taller, larger and heavier steel framed structures. With the tendency of increasing high-rise building, this study is strongly related to structural system, one of significant components in structural design. This study presents an innovative structural system, with high performance steel material, diagrid. Its detail, structural analysis, and structural experiments are all included for the development of new structures.

• 한국해안·해양공학회논문집
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• 제25권6호
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• pp.357-364
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• 2013

이전 연구에서는 부유구조체의 동요저감을 위해 폰툰과 반잠수식 부유구조체 형식을 결합하여 하이브리드 부유구조체를 제안한 바 있다. 하이브리드 부유구조체는 입사파랑에 대한 동요감소에는 효과적이었으나 부유구조체에 충분한 부력을 제공할 수 없는 단점이 있었다. 이와 같은 단점을 보완하기 위해 본 연구에서는 새로운 형식의 콤비네이션 부유구조체를 제안하였다. 입사 파랑하중에 대한 부유구조체의 동요감소 효과를 비교하기위해 폰툰, 콤비네이션 그리고 하이브리드 부유구조체에 대한 수치해석을 동수역학 해석프로그램 ANSYS AQWA를 이용하여 수행하였다. 본 연구에서 제안된 콤비네이션 부유구조체가 다른 부유구조체에 비해 동요감소에 효과적인 것을 확인할 수 있었다. 따라서 콤비네이션 부유구조체는 앞으로 개발될 초대형 부유구조체 건설을 위한 신형식 부유구조체로서 매우 유용하게 사용될 것으로 판단된다.

• Molecules and Cells
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• 제42권10호
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• pp.729-738
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• 2019

Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule. The ZZ-type zinc finger (ZZ) domain binds to target proteins and promotes higher-oligomerization of p62. This mechanism is an important step in routing target proteins to the autophagosome. Here, we determined the crystal structure of the PB1 homo-dimer and modeled the p62 PB1 oligomers. These oligomer models were represented by a cylindrical helix and were compared with the previously determined electron microscopic map of a PB1 oligomer. To accurately compare, we mathematically calculated the lead length and radius of the helical oligomers. Our PB1 oligomer model fits the electron microscopy map and is both bendable and stretchable as a flexible helical filament.