• Journal of the Korea Safety Management & Science
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• v.16 no.4
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• pp.21-29
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• 2014

In this study, we recognize that the interest about construction safety and disaster increases, and check the status of current research about construction safety. And we obtain the direction of future researches and implications for development. For this study, we analyzed the published researches in the last 11 years about construction safety, and addressed annual trends and research topics for a lot of construction safety research. And the future prospects of construction safety research were analyzed with the latest news articles.

• International conference on construction engineering and project management
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• 2005.10a
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• pp.480-485
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• 2005

This paper reviews the literature on safety culture focusing particularly on research carried out from 1998 onwards. The term 'safety culture' is clarified as it is typically applied to organizations, to safety and particularly to construction safety. Some clarifications in terms of levels of aggregation, positive safety culture and safety performance are provided by presenting appropriate empirical evidences and their theoretical developments. Safety culture is a subset of organizational culture that is thought to influence employees' attitudes and behavior in relation to an organization's ongoing health and safety performance. Implications for future research in the area are addressed, as safety culture has in recent years become the focus of much attention in all industries, and in the construction industry in particular.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.150-150
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• 2001

To investigate the genotoxic effect of 1, 1-dichloro-1-fluoroethane, which was widely used as a cleaning solvent at the electronic part industry, the micronucleus frequencies were recorded by examining polychromatic erythrocytes in bone marrows of the rodents exposed to it with different routes.(omitted)

• International Journal of Safety
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• v.6 no.2
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• pp.38-42
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• 2007

As railway signaling system is computerized, the significance on safety demonstration and assessment has been increased. Therefore, railway signaling system should reflect the needs for safety assessment technique. Various studies on safety assessment technique for railway signaling have been made in Europe and standardization of the requirements for safety acceptance has been initiated by IEC. In order to develop and establish the safety assessment techniques for railway signaling in Korea, we try to review safety assessment activities for signaling system via reviewing relevant case studies and consulting with experts. And also we propose the safety assessment activity/methodology for Korean railway signaling system.

• Proceedings of KOSOMES biannual meeting
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• 2018.06a
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• pp.42-42
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• 2018

• Safety and Health at Work
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• v.10 no.4
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• pp.409-419
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• 2019

Although the rare earth elements (REEs) recycling industry is expected to increase worldwide in hightech industry, regulations for worker safety have yet to be established. This study was conducted to understand the potential hazard/risk of REE recycling and to support the establishment of regulations or standards. We review the extensive literature on the toxicology, occupational safety, and health issues, and epidemiological surveys related to the REEs, and propose suitable management measures. REE recycling has four key steps such as collection, dismantling, separation, and processing. In these processes, hazardous substances, such as REEs-containing dust, metals, and chemicals, were used or occurred, including the risk of ignition and explosion, and the workers can be easily exposed to them. In addition, skin irritation and toxicities for respiratory, nervous, and cardiovascular systems with the liver toxicity were reported; however, more supplementary data are needed, owing to incompleteness. Therefore, monitoring systems concerning health, environmental impacts, and safety need to be established, based on additional research studies. It is also necessary to develop innovative and environment-friendly recycling technologies, analytical methods, and biomarkers with government support. Through these efforts, the occupational safety and health status will be improved, along with the establishment of advanced REE recycling industry.

• Biomolecules & Therapeutics
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• v.23 no.6
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• pp.597-603
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• 2015

Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. Their locomotor activities and rotarod retention time were significantly (p<0.05) decreased. However, no significant change was observed in learning or memory function. In histopathological analysis, neural cells of the animals treated with the high dose (5 mg/kg) of JWH-081 or JWH-210 showed distorted nuclei and nucleus membranes in the core shell of nucleus accumbens, suggesting neurotoxicity. Our results suggest that JWH-081 and JWH-210 may be neurotoxic substances through changing neuronal cell damages, especially in the core shell part of nucleus accumbens. To confirm our findings, further studies are needed in the future.

• Biomolecules & Therapeutics
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• v.25 no.3
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• pp.288-295
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• 2017

The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and rifampin on the expression and activities of organic anion-transporting peptide (OATP) and cytochrome P450 (CYP450) 2C9 and CYP3A4 were investigated in vitro. HEK293 cells and primary human hepatocytes overexpressing the target genes were treated with bosentan and various concentrations of rifampin, which decreased the uptake activities of OATP transporters in a dose-dependent manner. In primary human hepatocytes, CYP2C9 and CYP3A4 gene expression and activities decreased upon treatment with $20{\mu}M$ $bosentan+200{\mu}M$ rifampin. Rifampin also reduced gene expression of OATP1B1, OATP1B3, and OATP2B1 transporter, and inhibited bosentan influx in human hepatocytes at increasing concentrations. These results confirm rifampin- and bosentan-induced interactions between OATP transporters and CYP450.

• Proceedings of the KIEE Conference
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• 2008.09a
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• pp.276-278
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• 2008

본 연구에서는 하이브리드 자동차의 고전원 전기장치 및 고전원 배선에서 인체의 직접 접촉 및 간접접촉에 의한 자전사고틀 방지하기 절연저항의 측정 방법을 제시하였다. 하이브리드 자동차에서 절연저항은 ISO 및 ECE, FMVSS, Attachment 등의 국외규격에서 $100{\Omega}/Vdc$, $500{\Omega}/Vac$ 이상을 유지하도록 규정하고 있다. 하지만 하이브리드 및 전기자동차의 구조에 맞는 절연저항 측정 방법에 대한 정확한 방법이 제시되어 있지 않기 때문에 본 연구에서는 하이브리드 및 전기자동차의 절연저항 측정 방법에 있어 외국의 규격에서 제시하고 있는 방법과 비교를 통하여 실제 차량에서 적용한 수 있는 절연저항 측정 기법을 제시할 것이다.

• Proceedings of the KIEE Conference
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• 2009.04a
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• pp.200-202
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• 2009

본 논문에서는 수소연료전지자동차의 고전압 시스템에서 직 간접접촉에 의한 인체 감전사고를 방지하기 위한 전기안전 평가기법인 절연저항과 전기적연속성 등에 대하여 분석하였다. ISO, UNECE, Japan Attachment 등의 외국 규격에서는 감전보호를 위한 평가 기준을 제시하고 있지만 세부적인 평가방법에 대해서는 명확하게 규정하고 있지 않기 때문에 전기안전 평가를 위한 측정방법 및 측정장비에 대한 최소한의 기준 정립이 필요한 실정이다. 따라서 본 연구에서는 전기안전 평가기법에 대한 HFCV 실차 상태의 실험을 통하여 나타난 문제점 분석을 통하여 감전보호를 위한 전기안전 평가기법 중 전기적 연속성 및 절연저항에 대한 측정방법과 측정장비의 사양에 대하여 제시하고자 한다.